The DOI matches its Crossref record; 137 of the 142 references it cites were found in a registry or an index; 14 of the 136 sources its claims cite were checked for support.
Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery
Open accessAbstract
Oxytocin (OT) and arginine-vasopressin (AVP) act in the brain to regulate social cognition/social behavior and in the periphery to influence a variety of physiological processes. Although the chemical structures of OT and AVP as well as their receptors are quite similar, OT and AVP can have distinct or even opposing actions. Here, we review the increasing body of evidence that exogenously administered and endogenously released OT and AVP can activate each other’s canonical receptors (i.e., cross-talk) and examine the possibility that receptor cross-talk following the synaptic and non-synaptic release of OT and AVP contributes to their distinct roles in the brain and periphery. Understanding the consequences of cross-talk between OT and AVP receptors will be important in identifying how these peptides control social cognition and behavior and for the development of drugs to treat a variety of psychiatric disorders.
Overview
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Written from the paper’s full text.
TL;DR
This review argues that oxytocin (OT) and arginine-vasopressin (AVP) can activate each other’s canonical receptors, especially at high concentrations, producing receptor cross-talk in the brain and periphery. It suggests that distinct or opposing effects of OT and AVP often depend more on which receptor is activated than on which peptide is present, with implications for intranasal OT/AVP studies and psychiatric drug development.
Key findings
- OT and AVP share seven of nine amino acid sequences, differing only at positions 3 and 8; their receptors are structurally similar, with about 25% sequence identity among human OTR, V1aR, V1bR, and V2R and 85% homology between V1aR and OTR.
- Receptor selectivity is limited: there can be around 10–100-fold differences in selectivity of OTRs and AVP receptors for OT and AVP; AVP has similar affinity for OTRs, V1aRs, and V1bRs, while OT may have higher affinity for OTRs than V1aRs or V1bRs.
- Cross-talk is supported in both periphery and brain: peripherally administered OT can act via V1aRs for analgesia, locomotor reduction, adjacent lying, and social huddling, while AVP can act via OTRs for uterine contractions and social investigation; centrally, OT can act via V1aRs for flank marking, and both OT and AVP can act via OTRs for social recognition and social reward.
- In Syrian hamsters, both OT and AVP induce flank marking dose-dependently, but AVP is around 100-fold more potent than OT; selective V1aR, not OTR, agonists/antagonists mediate this effect. Intranasal OT/AVP at commonly used 20–40 IU produces supraphysiological peripheral levels and likely activates OTRs, V1aRs, V1bRs, and V2Rs.
Methods
- Narrative review; no new experimental data, sample, or primary analysis are reported.
- The authors synthesize evidence from in vitro and in vivo receptor selectivity assays, behavioral pharmacology with selective OT/AVP receptor agonists and antagonists, genetic manipulations including knockouts, anatomical and electron microscopic studies, and microdialysis/peptide release studies across species.
- Main analysis is qualitative integration of these findings to assess when exogenous or endogenous OT and AVP may cross-activate each other’s receptors.
Limitations
- The paper states that much of the discussed data were collected in males despite major sex differences in OT and AVP systems, and that there is no “gold standard” for defining receptor selectivity.
- The paper states that selectivity estimates come from different assays, limited tissues, and only a few species, and that brain levels of peptide produced by intranasal administration are not well understood.
- The paper states that little is known about how frequently OT/AVP synapses contain the corresponding receptors, that OT/AVP receptors cannot currently be identified with immunohistochemistry, and that cross-talk following endogenously released peptides remains to be confirmed; evident from the text, this is a narrative rather than systematic review.
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Claims the paper makes
62 Not checked yet · 36 Own interpretation · 3 Partly supported · 1 Supported so far · 1 Own result · accuracy not yet measured
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Central administration of OT or AVP induces scratching behavior in wild-type and OTR knock-out male and female mice but not in V1aR knock-out mice [40].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.1 OT acting via V1aRs
What the sources say
- Partly supportedcites [40] Schorscher-Petcu A Sotocinal S Ciura S Dupre A Ritchie J Sorge RE Crawley JN Hu SB Nishimori K Young LJ Tribollet E Quirion R Mogil JS Oxytocin-induced analgesia and scratching are mediated by the vasopressin-1A receptor in the mouse J Neurosci 30 2010 8274 84 20554879 PMC2902996 sourceExperimental — accuracy not yet measured
The Results (Oxytocin- and vasopressin-induced scratching; page not available) report that centrally administered OT induced scratching in wild-type and OTR-knockout mice but not V1aR-knockout mice; AVP induced scratching in wild-type mice but not V1aR-knockout mice. The Discussion also describes scratching elicited by both peptides as intact in OTR-knockout mice. Our copy does not establish the claimed scratching response separately in male and female mice; its sex-specific results concern nociceptive assays. (LLM, conf=0.83)
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Partly supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“The few studies that have compared the effects of intranasally administered OT and AVP in humans have reported that these peptides do not have opposing roles.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 4. Receptor cross-talk in response to exogenously administered peptides
What the sources say
- Partly supportedcites [84] Rilling JK DeMarco AC Hackett PD Thompson R Ditzen B Patel R Pagnoni G Effects of intranasal oxytocin and vasopressin on cooperative behavior and associated brain activity in men Psychoneuroendocrinology 37 2012 447 461 21840129 PMC3251702 sourceExperimental — accuracy not yet measured
The Discussion (AVP effects on brain and behavior; page unavailable) reports that AVP increased reciprocation of cooperation, contrary to the authors’ prediction that it would decrease cooperation. The Discussion (OT and AVP effects on amygdala functional connectivity; page unavailable) also reports a similar effect for both peptides. But the Results (Behavior; page unavailable) find significant OT–AVP differences in cooperation after particular partner actions, so the broad claim that they do not have opposing roles needs qualification. (LLM, conf=0.84)
- Partly supportedcites [86] Chen X Hackett PD DeMarco AC Feng C Stair S Haroon E Ditzen B Pagnoni G Rilling JK Effects of oxytocin and vasopressin on the neural response to unreciprocated cooperation within brain regions involved in stress and anxiety in men and women Brain Imaging Behav 10 2016 581 93 26040978 PMC4670292 sourceExperimental — accuracy not yet measured
The Conclusion reports that intranasal OT attenuated the neural response to unreciprocated cooperation in men, while AVP showed a trend in the same direction—not an opposing effect. In women, OT had an effect under a different partner condition and AVP had no effect. This supports the claim for this study’s measured response, but the paper does not establish that the few human studies comparing the peptides generally report non-opposing roles. (LLM, conf=0.84)
- Partly supportedcites [87] Patel N Grillon C Pavletic N Rosen D Pine DS Ernst M Oxytocin and vasopressin modulate risk-taking Physiol Behav 139 2015 254 60 25446228 PMC4274653 sourceExperimental — accuracy not yet measured
The Discussion reports that intranasal OT and AVP both produced risk-averse effects in healthy humans, rather than opposing effects on risk-taking. Their effects occurred under different conditions, however, and this paper does not establish the broader claim that the few human studies comparing the peptides have generally reported non-opposing roles. No page number is available in our copy. (LLM, conf=0.84)
- Partly supportedcites [88] Rilling JK Demarco AC Hackett PD Chen X Gautam P Stair S Haroon E Thompson R Ditzen B Patel R Pagnoni G Sex differences in the neural and behavioral response to intranasal oxytocin and vasopressin during human social interaction Psychoneuroendocrinology 39 2014 237 48 24157401 PMC3842401 sourceExperimental — accuracy not yet measured
The Results (§3.1; page not provided) report that both OT and AVP increased activity in several brain regions in men during the choice to cooperate, supporting an example of non-opposing effects. But substantial overlap appeared in only one of four contrasts, and the Discussion (§4.2.3) describes their effects as incompletely overlapping. The paper does not establish the broader claim that studies comparing the peptides in humans have found no opposing roles. (LLM, conf=0.82)
- Partly supportedcites [89] Feng C Hackett PD DeMarco AC Chen X Stair S Haroon E Ditzen B Pagnoni G Rilling JK Oxytocin and vasopressin effects on the neural response to social cooperation are modulated by sex in humans Brain Imaging Behav 9 2015 754 64 25416642 sourceExperimental — accuracy not yet measured
The discussion (p. 18) reports that intranasal OT and AVP affected neural responses to reciprocated cooperation in the same direction, suggesting similar effects in that setting. It also cautions that their effects occurred in different brain regions and that studies have found opposing effects in other contexts. The claim omits those limits and generalizes the finding to the peptides’ roles in humans. (LLM, conf=0.88)
- Partly supportedcites [90] Li T Chen X Mascaro J Haroon E Rilling JK Intranasal oxytocin, but not vasopressin, augments neural responses to toddlers in human fathers Horm Behav 2017 PMC5565399 28161387 sourceExperimental — accuracy not yet measured
The Results (sections 3.3 and 3.4; pages not provided) report that intranasal OT augmented fathers’ neural responses to pictures of their own children, while AVP had no significant effect on the measured responses. Those findings are not opposing effects, but this paper does not establish that the few human studies comparing OT and AVP have generally reported non-opposing roles. (LLM, conf=0.83)
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Partly supported
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“A more global form of OT and AVP release can occur when these neuropeptides are released from non-synaptic regions of neurons (e.g., dendrites) (Figure 6) [108; 109; 110].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 5. Is there cross-talk in response to endogenously released OT and AVP?
What the sources say
- Supportedcites [108] Leng G Ludwig M Neurotransmitters and peptides: whispered secrets and public announcements J Physiol 586 2008 5625 32 18845614 PMC2655398 source
The Abstract describes dendrites as a source of oxytocin and vasopressin release and says peptide-containing vesicles generally are not localized to synapses. The Conclusions describe the resulting peptide release as spreading through the brain and acting at distant receptors, supporting the characterization of this release as more global. (LLM, conf=0.93)
- Not checked yetcites [109] Landgraf R Neumann ID Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication Front Neuroendocrinol 25 2004 150 176 15589267 source
- Not checked yetcites [110] Engelmann M Wotjak CT Ebner K Landgraf R Behavioural impact of intraseptally released vasopressin and oxytocin in rats Exp Physiol 85 Spec No 2000 125S 130S 10795914 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
None of the sources cited for this claim have been checked yet.
In the paper
“For example, studies employing recombinant expression systems to examine selectivity of human, rat, and mouse OT and AVP receptors have shown that only the human OTR is selective for OT using a standard criterion [34; 35] (Table 1).”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 1. Introduction
What the sources say
- Not checked yetcites [34] Manning M Stoev S Chini B Durroux B Mouillac B Guillon G Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: research tools and potential therapeutic agents Neumann ID Landgraf R Advances in Vasopressin and Oxytocin: From genes to behavior Elsevier 2008 473 512 18655903 source
- Not checked yetcites [35] Manning M Misicka A Olma A Bankowski K Stoev S Chini B Durroux T Mouillac B Corbani M Guillon G Oxytocin and vasopressin agonists and antagonists as research tools and potential therapeutics Journal of Neuroendocrinology 24 2012 609 628 22375852 PMC3490377 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Here, we review the increasing body of evidence that exogenously administered and endogenously released OT and AVP can activate each other’s canonical receptors (i.e., cross-talk)”
- Also stated in: § 1. Introduction · plain
“Recently, however, there has been increasing evidence that OT and AVP can act on each other’s canonical receptors in potentially important ways.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > Abstract
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Also stated in: § 1. Introduction · plain
None of the sources cited for this claim have been checked yet.
In the paper
“Nevertheless, it appears that there can be differences of around 10–100 fold in the selectivity of OTRs and AVP receptors for OT and AVP.”
- Also stated in: § 4. Receptor cross-talk in response to exogenously administered peptides · hedged
“Existing data suggest that there are 10–100 fold differences in the selectivity of OT and AVP for OTRs, V1aRs, and V1bRs”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 1. Introduction
What the sources say
- Not checked yetcites [28] Chini B Mouillac B Ala Y Balestre MN Trumpp-Kallmeyer S Hoflack J Elands J Hibert M Manning M Jard S Tyr115 is the key residue for determining agonist selectivity in the V1a vasopressin receptor EMBO J 14 1995 2176 2182 7774575 PMC398323 source
- Not checked yetcites [29] Hawtin SR Wesley VJ Parslow RA Patel S Wheatley M Critical role of a subdomain of the N-terminus of the V1a vasopressin receptor for binding agonists but not antagonists; functional rescue by the oxytocin receptor N-terminus Biochemistry 39 2000 13524 33 11063589 source
- Not checked yetcites [30] Kimura T Makino Y Saji F Takemura M Inoue T Kikuchi T Kubota Y Azuma C Nobunaga T Tokugawa Y Molecular characterization of a cloned human oxytocin receptor Eur J Endocrinol 131 1994 385 90 7921228 source
- Not checked yetcites [31] Lolait SJ O’Carroll AM Brownstein MJ Molecular biology of vasopressin receptors Ann N Y Acad Sci 771 1995 273 92 8597406 source
- Not checked yetcites [32] Thibonnier M Coles P Thibonnier A Shoham M The basic and clinical pharmacology of nonpeptide vasopressin receptor antagonists Annu Rev Pharmacol Toxicol 41 2001 175 202 11264455 source
- Not checked yetcites [33] Song Z McCann KE McNeill JK Larkin TE Huhman KL Albers HE Oxytocin induces social communication by activating arginine-vasopressin V1a receptors and not oxytocin receptors Psychoneuroendocrinology 50C 2014 14 19 PMC4252597 25173438 source
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Also stated in: § 4. Receptor cross-talk in response to exogenously administered peptides · hedged
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“This overall lack of receptor selectivity is not surprising when one considers that these receptors have a high degree of structural homology (e.g., 85% between V1aR and OTR) (Figure 4).”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 1. Introduction
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
None of the sources cited for this claim have been checked yet.
In the paper
“Although the chemical structures of OT and AVP as well as their receptors are quite similar, OT and AVP can have distinct or even opposing actions.”
- Also stated in: § 1. Introduction · boosted
“Although the chemical structures of OT and AVP as well as their receptors are quite similar, there is substantial evidence that these nonapeptides (i.e., nine amino acid peptides) can have distinct or even opposing roles in the regulation of many behavioral and physiological functions [3; 4; 5; 6; 7].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > Abstract
What the sources say
- Not checked yetcites [3] Neumann ID Landgraf R Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors Trends Neurosci 35 2012 649 659 22974560 source
- Not checked yetcites [4] Legros JJ Inhibitory effect of oxytocin on corticotrope function in humans: are vasopressin and oxytocin ying-yang neurohormones? Psychoneuroendocrinology 26 2001 649 655 11500247 source
- Not checked yetcites [5] Stoop R Neuromodulation by oxytocin and vasopressin Neuron 76 2012 142 159 23040812 source
- Not checked yetcites [6] Heinrichs M von Dawans B Domes G Oxytocin, vasopressin, and human social behavior Front Neuroendocrinol 30 2009 548 57 19505497 source
- Not checked yetcites [7] Carter CS Grippo AJ Pournajafi-Nazarloo H Ruscio MG Porges SW Oxytocin, vasopressin and sociality Prog Brain Res 170 2008 331 6 18655893 source
boosted- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Also stated in: § 1. Introduction · boosted
In the paper
“In addition, selective V1aR but not OTR antagonists inhibit both OT- and AVP- induced analgesia in wild-type mice.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 2. Cross-talk between OT and AVP administered peripherally > 2.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [40] Schorscher-Petcu A Sotocinal S Ciura S Dupre A Ritchie J Sorge RE Crawley JN Hu SB Nishimori K Young LJ Tribollet E Quirion R Mogil JS Oxytocin-induced analgesia and scratching are mediated by the vasopressin-1A receptor in the mouse J Neurosci 30 2010 8274 84 20554879 PMC2902996 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“Peripheral administration of OT or AVP induces analgesia in OTR but not in V1aR knock-out male and female mice [40].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 2. Cross-talk between OT and AVP administered peripherally > 2.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [40] Schorscher-Petcu A Sotocinal S Ciura S Dupre A Ritchie J Sorge RE Crawley JN Hu SB Nishimori K Young LJ Tribollet E Quirion R Mogil JS Oxytocin-induced analgesia and scratching are mediated by the vasopressin-1A receptor in the mouse J Neurosci 30 2010 8274 84 20554879 PMC2902996 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- It may state two separate claims as one. 38
- Probably not a substantial claim. 3
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“These data have, however, found OT and AVP can have differential effects on neural activity (i.e., BOLD fMRI responses) and cognition, at least in some cases although the effects of OT are more robust [84; 86; 87; 88; 89; 90].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 4. Receptor cross-talk in response to exogenously administered peptides
What the sources say
- Partly supportedcites [84] Rilling JK DeMarco AC Hackett PD Thompson R Ditzen B Patel R Pagnoni G Effects of intranasal oxytocin and vasopressin on cooperative behavior and associated brain activity in men Psychoneuroendocrinology 37 2012 447 461 21840129 PMC3251702 sourceExperimental — accuracy not yet measured
The Discussion (Effects of partner type on brain and behavior; page unavailable) reports different BOLD responses and cooperative behaviors after OT and AVP treatment, supporting differential effects in this task. It does not support the qualification that OT effects were more robust: the Results (Neuroimaging; page unavailable) report more widespread AVP-related increases in amygdala connectivity, and the Discussion (AVP effects on brain and behavior; page unavailable) describes robust behavioral effects of AVP. (LLM, conf=0.88)
- Partly supportedcites [86] Chen X Hackett PD DeMarco AC Feng C Stair S Haroon E Ditzen B Pagnoni G Rilling JK Effects of oxytocin and vasopressin on the neural response to unreciprocated cooperation within brain regions involved in stress and anxiety in men and women Brain Imaging Behav 10 2016 581 93 26040978 PMC4670292 sourceExperimental — accuracy not yet measured
The Conclusion (page unavailable) reports effects of OT on BOLD responses in men and women, while AVP showed only a trend in men and no effect in women, supporting the neural-activity comparison. The Discussion §4.4 (page unavailable) says OT had no effect on behavioral responses and does not establish differential effects of OT and AVP on cognition. That part of the attributed claim is unsupported by this paper. (LLM, conf=0.85)
- Partly supportedcites [87] Patel N Grillon C Pavletic N Rosen D Pine DS Ernst M Oxytocin and vasopressin modulate risk-taking Physiol Behav 139 2015 254 60 25446228 PMC4274653 sourceExperimental — accuracy not yet measured
The Discussion reports different effects of OT and AVP on risk-taking decisions, supporting the cognitive-behavioral part of the claim. It proposes functional neuroimaging as future work rather than reporting BOLD fMRI responses, and it does not establish that OT’s effects are more robust than AVP’s. Page numbers are unavailable in our copy. (LLM, conf=0.88)
- Partly supportedcites [88] Rilling JK Demarco AC Hackett PD Chen X Gautam P Stair S Haroon E Thompson R Ditzen B Patel R Pagnoni G Sex differences in the neural and behavioral response to intranasal oxytocin and vasopressin during human social interaction Psychoneuroendocrinology 39 2014 237 48 24157401 PMC3842401 sourceExperimental — accuracy not yet measured
The Results (section 3.1, page unavailable) report that OT and AVP activation maps substantially overlapped in only one of four contrasts, supporting differential effects on fMRI activity. The Discussion (section 4.1, page unavailable) reports effects on cooperation, but our copy does not establish a differential effect on cognition or that OT’s effects were more robust than AVP’s. (LLM, conf=0.84)
- Partly supportedcites [89] Feng C Hackett PD DeMarco AC Chen X Stair S Haroon E Ditzen B Pagnoni G Rilling JK Oxytocin and vasopressin effects on the neural response to social cooperation are modulated by sex in humans Brain Imaging Behav 9 2015 754 64 25416642 sourceExperimental — accuracy not yet measured
The discussion (p. 18) says OT and AVP affected BOLD responses in different brain regions, but their effects on social cognition in this cooperation task appeared similar; it also reports opposing effects in other contexts. OT’s neural findings met the stricter statistical threshold, whereas AVP’s emerged only at a more liberal threshold (pp. 14–15), supporting greater robustness for these neural results. The paper does not establish that OT’s effects on cognition are generally more robust. (LLM, conf=0.83)
- Partly supportedcites [90] Li T Chen X Mascaro J Haroon E Rilling JK Intranasal oxytocin, but not vasopressin, augments neural responses to toddlers in human fathers Horm Behav 2017 PMC5565399 28161387 sourceExperimental — accuracy not yet measured
The Discussion reports that OT increased fathers’ neural responses to pictures of their toddlers, whereas AVP had no effect in this study. That supports differential BOLD responses and a stronger observed OT effect in this setting. The Results report no significant effect of either treatment on subjective cry ratings, so this paper does not establish the claimed differential effects on cognition. (LLM, conf=0.86)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Partly supported
None of the sources cited for this claim have been checked yet.
In the paper
“In mammals, OT is considered to have only one canonical receptor (i.e., OTR) while AVP is thought to have three: V1aR, V1bR and V2R [16; 17; 18].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 1. Introduction
What the sources say
- Not matchedcites [16] Caldwell HK Young WS III Oxytocin and Vasopressin: Genetics and behavioral implications Lim R Neuroactive Proteins and Peptides Springer New York 2006 573 607
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked yetcites [17] Barberis C Tribollet E Vasopressin and oxytocin receptors in the central nervous system Crit Rev Neurobiol 10 1996 119 54 8853957 source
- Not checked yetcites [18] Hasunuma I Toyoda F Okada R Yamamoto K Kadono Y Kikuyama S Roles of arginine vasotocin receptors in the brain and pituitary of submammalian vertebrates Int Rev Cell Mol Biol 304 2013 191 225 23809437 source
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Not matched
None of the sources cited for this claim have been checked yet.
In the paper
“Oxytocin (OT) and arginine-vasopressin (AVP) act in the brain to regulate social cognition/social behavior and in the periphery to influence a variety of physiological processes.”
- Also stated in: § 1. Introduction · plain
“Oxytocin (OT) and arginine-vasopressin (AVP) are important chemical signals that act in the brain to regulate a large number of adaptive social behaviors and in the periphery to coordinate a diverse group of physiological functions [1; 2].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > Abstract
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Also stated in: § 1. Introduction · plain
None of the sources cited for this claim have been checked yet.
In the paper
“In mammalian brain OTRs and V1aRs are robustly expressed in many regions but their distributions often differ [9; 21; 22] (Figure 3).”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 1. Introduction
What the sources say
- Not checked yetcites [9] Dumais KM Veenema AH Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior Front Neuroendocrinol 40 2016 1 23 25951955 PMC4633405 source
- Not checked yetcites [21] Veinante P Freund-Mercier MJ Distribution of oxytocin- and vasopressin-binding sites in the rat extended amygdala: a histoautoradiographic study J Comp Neurol 383 1997 305 325 9205043 source
- Not checked yetcites [22] Smith CJ Poehlmann ML Li S Ratnaseelan AM Bredewold R Veenema AH Age and sex differences in oxytocin and vasopressin V1a receptor binding densities in the rat brain: focus on the social decision-making network Brain Struct Funct 222 2017 981 1006 27389643 PMC5334374 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“These effects of OT and AVP can be inhibited by selective V1aR but not OTR antagonists.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 2. Cross-talk between OT and AVP administered peripherally > 2.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [37] Hicks C Ramos L Reekie T Misagh GH Narlawar R Kassiou M McGregor IS Body temperature and cardiac changes induced by peripherally administered oxytocin, vasopressin and the non-peptide oxytocin receptor agonist WAY 267,464: a biotelemetry study in rats Br J Pharmacol 171 2014 2868 87 24641248 PMC4243861 source
- Not checked yetcites [38] Loyens E Vermoesen K Schallier A Michotte Y Smolders I Proconvulsive effects of oxytocin in the generalized pentylenetetrazol mouse model are mediated by vasopressin 1a receptors Brain Res 1436 2012 43 50 22208648 source
- Not checked yetcites [39] Gupta J Russell R Wayman C Hurley D Jackson V Oxytocin-induced contractions within rat and rabbit ejaculatory tissues are mediated by vasopressin V1A receptors and not oxytocin receptors Br J Pharmacol 155 2008 118 26 18552879 PMC2527840 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Peripherally administered OT and AVP produce similar effects in reducing heart rate and body temperature, inducing contractions in ejaculatory tissues, and in promoting seizure susceptibility in male rats and rabbits [37; 38; 39].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 2. Cross-talk between OT and AVP administered peripherally > 2.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [37] Hicks C Ramos L Reekie T Misagh GH Narlawar R Kassiou M McGregor IS Body temperature and cardiac changes induced by peripherally administered oxytocin, vasopressin and the non-peptide oxytocin receptor agonist WAY 267,464: a biotelemetry study in rats Br J Pharmacol 171 2014 2868 87 24641248 PMC4243861 source
- Not checked yetcites [38] Loyens E Vermoesen K Schallier A Michotte Y Smolders I Proconvulsive effects of oxytocin in the generalized pentylenetetrazol mouse model are mediated by vasopressin 1a receptors Brain Res 1436 2012 43 50 22208648 source
- Not checked yetcites [39] Gupta J Russell R Wayman C Hurley D Jackson V Oxytocin-induced contractions within rat and rabbit ejaculatory tissues are mediated by vasopressin V1A receptors and not oxytocin receptors Br J Pharmacol 155 2008 118 26 18552879 PMC2527840 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“V1bRs appear to have a much more restricted distribution, although they are expressed prominently in the hippocampus and at lower levels in the hypothalamus and amygdala [23; 24].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 1. Introduction
What the sources say
- Not checked yetcites [23] Young WS Li J Wersinger SR Palkovits M The vasopressin 1b receptor is prominent in the hippocampal area CA2 where it is unaffected by restraint stress or adrenalectomy Neuroscience 143 2006 1031 1039 17027167 PMC1748954 source
- Not checked yetcites [24] Stevenson EL Caldwell HK The vasopressin 1b receptor and the neural regulation of social behavior Hormones and Behavior 61 2012 277 282 22178035 PMC3310934 source
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“AVP has a similar affinity for OTRs, V1aRs, and V1bRs while OT may have a higher affinity for OTRs than V1aRs or V1bRs [28; 29; 30; 31; 32; 33].”
- Also stated in: § 4. Receptor cross-talk in response to exogenously administered peptides · plain
“AVP has similar affinities for OT and AVP receptors while OT has a higher affinity for OT receptors than AVP receptors.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 1. Introduction
What the sources say
- Not checked yetcites [28] Chini B Mouillac B Ala Y Balestre MN Trumpp-Kallmeyer S Hoflack J Elands J Hibert M Manning M Jard S Tyr115 is the key residue for determining agonist selectivity in the V1a vasopressin receptor EMBO J 14 1995 2176 2182 7774575 PMC398323 source
- Not checked yetcites [29] Hawtin SR Wesley VJ Parslow RA Patel S Wheatley M Critical role of a subdomain of the N-terminus of the V1a vasopressin receptor for binding agonists but not antagonists; functional rescue by the oxytocin receptor N-terminus Biochemistry 39 2000 13524 33 11063589 source
- Not checked yetcites [30] Kimura T Makino Y Saji F Takemura M Inoue T Kikuchi T Kubota Y Azuma C Nobunaga T Tokugawa Y Molecular characterization of a cloned human oxytocin receptor Eur J Endocrinol 131 1994 385 90 7921228 source
- Not checked yetcites [31] Lolait SJ O’Carroll AM Brownstein MJ Molecular biology of vasopressin receptors Ann N Y Acad Sci 771 1995 273 92 8597406 source
- Not checked yetcites [32] Thibonnier M Coles P Thibonnier A Shoham M The basic and clinical pharmacology of nonpeptide vasopressin receptor antagonists Annu Rev Pharmacol Toxicol 41 2001 175 202 11264455 source
- Not checked yetcites [33] Song Z McCann KE McNeill JK Larkin TE Huhman KL Albers HE Oxytocin induces social communication by activating arginine-vasopressin V1a receptors and not oxytocin receptors Psychoneuroendocrinology 50C 2014 14 19 PMC4252597 25173438 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Also stated in: § 4. Receptor cross-talk in response to exogenously administered peptides · plain
In the paper
“A highly selective OTR agonist failed to induce flank marking and a highly selective OTR antagonist failed to inhibit the induction of flank marking by OT.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [33] Song Z McCann KE McNeill JK Larkin TE Huhman KL Albers HE Oxytocin induces social communication by activating arginine-vasopressin V1a receptors and not oxytocin receptors Psychoneuroendocrinology 50C 2014 14 19 PMC4252597 25173438 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Peripheral administration of a selective OTR antagonist, but not a selective V1aR antagonist, inhibits OT- and AVP-induced increases in social investigation suggesting that both peptides are acting through the OTR [49].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 2. Cross-talk between OT and AVP administered peripherally > 2.2 AVP acting via OTRs
What the sources say
- Not checked yetcites [49] Ramos L Hicks C Caminer A Couto K Narlawar R Kassiou M McGregor IS MDMA (‘Ecstasy’), oxytocin and vasopressin modulate social preference in rats: A role for handling and oxytocin receptors Pharmacol Biochem Behav 150–151 2016 115 123 27725273 source
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“In OTR null mice social exploration and social recognition are reduced, while aggression is increased when compared to wild-type mice.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [53] Sala M Braida D Lentini D Busnelli M Bulgheroni E Capurro V Finardi A Donzelli A Pattini L Rubino T Parolaro D Nishimori K Parenti M Chini B Pharmacologic rescue of impaired cognitive flexibility, social deficits, increased aggression, and seizure susceptibility in oxytocin receptor null mice: a neurobehavioral model of autism Biol Psychiatry 69 2011 875 882 21306704 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“A highly selective OTR but not a highly selective V1aR antagonist significantly reduced the duration of social recognition suggesting that OT and AVP regulate social recognition by acting on OTRs.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.2 AVP acting via OTRs
What the sources say
- Not checked yetcites [65] Song Z Larkin TE Malley MO Albers HE Oxytocin (OT) and arginine-vasopressin (AVP) act on OT receptors and not AVP V1a receptors to enhance social recognition in adult Syrian hamsters (Mesocricetus auratus) Horm Behav 81 2016 20 7 26975586 source
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Peripheral administration of either OT or AVP also increases social huddling in response to threatening stimuli (i.e., cat fur) and these effects are inhibited by a selective V1aR antagonist [45].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 2. Cross-talk between OT and AVP administered peripherally > 2.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [45] Bowen MT McGregor IS Oxytocin and vasopressin modulate the social response to threat: a preclinical study Int J Neuropsychopharmacol 17 2014 1621 1633 24807123 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“When housed in winter-like conditions female voles form partner preferences for other females. Injection of OT into the lateral septum prevents the formation of these partner preferences, an effect that is blocked by co-administration of OT with a V1aR but not an OTR antagonist.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [54] Anacker AM Christensen JD LaFlamme EM Grunberg DM Beery AK Septal oxytocin administration impairs peer affiliation via V1a receptors in female meadow voles Psychoneuroendocrinology 68 2016 156 62 26974500 PMC4851907 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“A selective V1aR, but not an OTR antagonist, inhibits adjacent lying following peripheral administration of OT or AVP.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 2. Cross-talk between OT and AVP administered peripherally > 2.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [44] Ramos L Hicks C Kevin R Caminer A Narlawar R Kassiou M McGregor IS Acute prosocial effects of oxytocin and vasopressin when given alone or in combination with 3,4-methylenedioxymethamphetamine in rats: involvement of the V1A receptor Neuropsychopharmacology 38 2013 2249 59 23676791 PMC3773675 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“In contrast, not only did a selective V1aR agonist induce flank marking, a selective V1aR antagonist inhibited the ability of OT to induce flank marking.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [33] Song Z McCann KE McNeill JK Larkin TE Huhman KL Albers HE Oxytocin induces social communication by activating arginine-vasopressin V1a receptors and not oxytocin receptors Psychoneuroendocrinology 50C 2014 14 19 PMC4252597 25173438 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Both OT and AVP administered peripherally also increase social investigation in male rats.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 2. Cross-talk between OT and AVP administered peripherally > 2.2 AVP acting via OTRs
What the sources say
- Not checked yetcites [49] Ramos L Hicks C Caminer A Couto K Narlawar R Kassiou M McGregor IS MDMA (‘Ecstasy’), oxytocin and vasopressin modulate social preference in rats: A role for handling and oxytocin receptors Pharmacol Biochem Behav 150–151 2016 115 123 27725273 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Although both OT and AVP inhibit neuronal signaling in dorsal root ganglia, these effects can be inhibited by a selective V1aR antagonist but not by an OTR antagonist.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 2. Cross-talk between OT and AVP administered peripherally > 2.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [41] Qiu F Qiu CY Cai H Liu TT Qu ZW Yang Z Li JD Zhou QY Hu WP Oxytocin inhibits the activity of acid-sensing ion channels through the vasopressin, V1A receptor in primary sensory neurons Br J Pharmacol 171 2014 3065 76 24641084 PMC4055206 source
- Not checked yetcites [42] Kubo A Shinoda M Katagiri A Takeda M Suzuki T Asaka J Yeomans DC Iwata K Oxytocin alleviates orofacial mechanical hypersensitivity associated with infraorbital nerve injury through vasopressin-1A receptors of the rat trigeminal ganglia Pain 158 2017 649 659 28072605 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“While intracerebroventricular (ICV) injection of OT or AVP can restore wild-type levels of these behaviors, the effects of OT and AVP are inhibited by a selective V1aR antagonist.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [53] Sala M Braida D Lentini D Busnelli M Bulgheroni E Capurro V Finardi A Donzelli A Pattini L Rubino T Parolaro D Nishimori K Parenti M Chini B Pharmacologic rescue of impaired cognitive flexibility, social deficits, increased aggression, and seizure susceptibility in oxytocin receptor null mice: a neurobehavioral model of autism Biol Psychiatry 69 2011 875 882 21306704 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Both OT and AVP induce flank marking in a dose-dependent manner, although AVP is around 100-fold more potent than OT in inducing the behavior (Figure 5).”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [33] Song Z McCann KE McNeill JK Larkin TE Huhman KL Albers HE Oxytocin induces social communication by activating arginine-vasopressin V1a receptors and not oxytocin receptors Psychoneuroendocrinology 50C 2014 14 19 PMC4252597 25173438 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“There is also evidence to suggest that OT can act on V1bRs as well as OTRs and that AVP can act on OTRs as well as V1bRs to induce glucagon secretion from pancreatic islet cells in male mice [52].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 2. Cross-talk between OT and AVP administered peripherally > 2.3 OT acting via V1bRs
What the sources say
- Not checked yetcites [52] Fujiwara Y Hiroyama M Sanbe A Yamauchi J Tsujimoto G Tanoue A Mutual regulation of vasopressin- and oxytocin-induced glucagon secretion in V1b vasopressin receptor knockout mice J Endocrinol 192 2007 361 9 17283236 source
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“There is considerable evidence that exogenously administered OT can act on V1aRs in the periphery and several examples that exogenously administered AVP can act on peripheral OTRs to influence both physiological and behavioral endpoints.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 4. Receptor cross-talk in response to exogenously administered peptides
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In the brain, there is strong support for the hypothesis that OT can act on V1aRs and that AVP can act on OTRs to influence several different behaviors.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 4. Receptor cross-talk in response to exogenously administered peptides
boosteddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“The commonly used intranasal concentrations of OT and AVP (i.e., 20 IU to 40 IU) produce high, supraphysiological levels of peptide in the periphery, and these concentrations are likely high enough to also produce biologically active levels in the brain [2].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 4. Receptor cross-talk in response to exogenously administered peptides
What the sources say
- Not checked yetcites [2] Leng G Ludwig M Intranasal Oxytocin: Myths and Delusions Biol Psychiatry 79 2016 243 50 26049207 source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Because OT and AVP as well as their canonical receptors display strikingly similar chemical structures, it is not surprising that there can be substantial cross-talk between these peptides and OTRs and V1aRs [79].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 4. Receptor cross-talk in response to exogenously administered peptides
What the sources say
- Not checked yetcites [79] Ragnauth AK Goodwillie A Brewer C Muglia LJ Pfaff DW Kow LM Vasopressin stimulates ventromedial hypothalamic neurons via oxytocin receptors in oxytocin gene knockout male and female mice Neuroendocrinology 80 2004 92 9 15528951 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“There is also some evidence to suggest that OT and AVP act exclusively on V1aRs to influence some behaviors (e.g., social communication) and that OT and AVP act exclusively on OTRs to influence other behaviors (e.g., social reward).”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 4. Receptor cross-talk in response to exogenously administered peptides
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The potential for receptor cross-talk would likely be reduced by local synaptic release of neuropeptide and the anatomical segregation of OT and AVP receptors.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 5. Is there cross-talk in response to endogenously released OT and AVP?
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Thus, differences in the effects of OT and AVP could simply be the result of different doses and/or differences in the selectivity of OTRs for OT in humans.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 4. Receptor cross-talk in response to exogenously administered peptides
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“If the presence of both OT and AVP receptors in the same synaptic regions is rare then the possibility of cross-talk following synaptic release of these neuropeptides would seem unlikely, with the exception of when these neuropeptides spillover beyond synaptic regions (i.e., synaptic spillover).”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 6. Conclusions
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“A major source of non-synaptically released OT and AVP is the magnocellular neurons in the hypothalamus, although there is also evidence that hypothalamic parvocellular neurons can also release neuropeptides from dense core vesicles non-synaptically [111].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 5. Is there cross-talk in response to endogenously released OT and AVP?
What the sources say
- Not checked yetcites [111] Castel M Morris J Belenky M Non-synaptic and dendritic exocytosis from dense-cored vesicles in the suprachiasmatic nucleus Neuroreport 7 1996 543 7 8730825 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Non-synaptic neuropeptide release is stimulated by Ca2+ coming from intracellular stores (e.g., endoplasmic reticulum) as opposed to synaptic release that is mediated by the influx of extracellular Ca2+ through voltage-gated channels [105].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 5. Is there cross-talk in response to endogenously released OT and AVP?
What the sources say
- Not checked yetcites [105] Buijs RM Van Heerikhuize JJ Vasopressin and oxytocin release in the brain--a synaptic event Brain Res 252 1982 71 6 7172022 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Rather, OT and AVP can activate each other’s receptors, particularly when present at high levels, resulting in the potential for substantial cross-talk between the OT and AVP systems.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 6. Conclusions
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Studies in hamsters have found that ICV or hypothalamic injection of α-MSH induces flank marking behavior and that α-MSH-induced flank marking is blocked by central administration of a selective V1a antagonist [33].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 5. Is there cross-talk in response to endogenously released OT and AVP?
What the sources say
- Not checked yetcites [33] Song Z McCann KE McNeill JK Larkin TE Huhman KL Albers HE Oxytocin induces social communication by activating arginine-vasopressin V1a receptors and not oxytocin receptors Psychoneuroendocrinology 50C 2014 14 19 PMC4252597 25173438 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“As such, it is important to consider the possibility that intranasal administration of OT or AVP produces a global activation of both OT and AVP receptors.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 4. Receptor cross-talk in response to exogenously administered peptides
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds.
None of the sources cited for this claim have been checked yet.
In the paper
“For example, in hamsters the lateral septum contains large numbers of V1aRs but few, if any, AVP containing fibers or cell bodies have been identified with immunohistochemistry [112; 113; 114; 115].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 5. Is there cross-talk in response to endogenously released OT and AVP?
What the sources say
- Not checked yetcites [112] Johnson AE Barberis C Albers HE Castration reduces vasopressin receptor binding in the hamster hypothalamus Brain Res 674 1995 153 8 7773686 source
- Not checked yetcites [113] Albers HE Rowland CM Ferris CF Arginine-vasopressin immunoreactivity is not altered by photoperiod or gonadal hormones in the Syrian hamster (Mesocricetus auratus) Brain Res 539 1991 137 142 2015498 source
- Not checked yetcites [114] Dubois-Dauphin M Pevet P Tribollet E Dreifuss JJ Vasopressin in the brain of the golden hamster: The distribution of vasopressin binding sites and of immunoreactivity to the vasopressin-related glycopeptide Journal of Comparative Neurology 300 1990 535 548 2148751 source
- Not checked yetcites [115] Young LJ Wang Z Cooper TT Albers HE Vasopressin (V1a) receptor binding, mRNA expression and transcriptional regulation by androgen in the Syrian hamster brain J Neuroendocrinol 12 2000 1179 85 11106975 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Although much more work needs to be done, these data suggest that certain classes of social behavior are mediated by OTRs while other classes of social behavior are mediated by V1aRs.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 6. Conclusions
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Several different social behaviors can be influenced by both OT and AVP, but this influence appears to be mediated by only one of their receptors.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 6. Conclusions
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These high levels of peptide have the potential to result in significant amounts of receptor cross-talk in the periphery as well as in the brain resulting in the activation of large numbers of OT and AVP receptors.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 6. Conclusions
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Rests on an assumption: Intranasal administration of oxytocin and vasopressin produces supraphysiological concentrations of these peptides in peripheral tissues.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“For example, although OT and AVP increase social communication, social recognition, and social reward, the effects of these neuropeptides on social communication are mediated by V1aRs and their effects on social recognition and social reward are mediated by OTRs.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 6. Conclusions
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
The paper relies on this without support.
Intranasal administration of oxytocin and vasopressin produces supraphysiological concentrations of these peptides in peripheral tissues.
“Intranasal OT and AVP administration, which is currently in use in clinical trials, produces supraphysiological levels of these peptides in peripheral tissues.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“For example, social cognition and reward processing can be mediated by OXT and OXTR, while social communication relies more on arginine-vasopressin (AVP) and its receptor (V1aR; Song and Albers, 2018).”
From Music's context-dependent influence on oxytocin, social bonding, and emotion regulation: a systematic review (2026) · cites this paper as Song and Albers, 2018
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Since OXT and AVP share structural similarities and can activate each other's receptors, this phenomenon, “cross-talk” (Song and Albers, 2018), is likely to participate in shaping social behaviors in musical contexts.”
From Music's context-dependent influence on oxytocin, social bonding, and emotion regulation: a systematic review (2026) · cites this paper as Song and Albers, 2018
In the citing paper
“These radioligands are now known to bind to both receptor types when they are used in primate brain37.”
From Effect of age and autism spectrum disorder on oxytocin receptor density in the human basal forebrain and midbrain (2018) · cites this paper as [48]
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Metadata
- Authors
- Song, Z., & Albers, H. E.
- Affiliations
- Georgia State University (US)
- Corresponding author
- Albers, H. Elliott
- Venue
- Frontiers in Neuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 51
- Pages
- 14-24
- ISSN
- 0091-3022 (ISSN-L)
- PMC
- PMC5906207
- OpenAlex
- W2767130940
- Semantic Scholar
- 4dbbf2abe3c48e55106808bf85319d02973b36d1
- Cited by
- 244
- References
- 142
- Citations by year
- 2026: 22 · 2025: 32 · 2024: 30 · 2023: 30 · 2022: 25 · 2021: 29 · 2020: 36 · 2019: 18 · 2018: 21
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Frontiers in Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NSF (IOS-0923301)
- NIH (MH110212, MH109302)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, vasopressin, receptor cross-talk, oxytocin receptor, vasopressin receptor, social cognition, social behavior, psychiatric drug development
- MeSH terms
- Animals, Arginine Vasopressin, Mental Disorders, Female, Humans, Male, Oxytocin, Social Behavior, Receptors, Vasopressin, Receptors, Oxytocin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-10-08, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-10-08 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Cited sources are checked with a language model’s help (gpt-6-sol).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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