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Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery
Open accessAbstract
Oxytocin (OT) and arginine-vasopressin (AVP) act in the brain to regulate social cognition/social behavior and in the periphery to influence a variety of physiological processes. Although the chemical structures of OT and AVP as well as their receptors are quite similar, OT and AVP can have distinct or even opposing actions. Here, we review the increasing body of evidence that exogenously administered and endogenously released OT and AVP can activate each other’s canonical receptors (i.e., cross-talk) and examine the possibility that receptor cross-talk following the synaptic and non-synaptic release of OT and AVP contributes to their distinct roles in the brain and periphery. Understanding the consequences of cross-talk between OT and AVP receptors will be important in identifying how these peptides control social cognition and behavior and for the development of drugs to treat a variety of psychiatric disorders.
Overview
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TL;DR
This review argues that oxytocin (OT) and arginine-vasopressin (AVP) can activate each other’s canonical receptors, especially at high concentrations, producing receptor cross-talk in the brain and periphery. It suggests that distinct or opposing effects of OT and AVP often depend more on which receptor is activated than on which peptide is present, with implications for intranasal OT/AVP studies and psychiatric drug development.
Key findings
- OT and AVP share seven of nine amino acid sequences, differing only at positions 3 and 8; their receptors are structurally similar, with about 25% sequence identity among human OTR, V1aR, V1bR, and V2R and 85% homology between V1aR and OTR.
- Receptor selectivity is limited: there can be around 10–100-fold differences in selectivity of OTRs and AVP receptors for OT and AVP; AVP has similar affinity for OTRs, V1aRs, and V1bRs, while OT may have higher affinity for OTRs than V1aRs or V1bRs.
- Cross-talk is supported in both periphery and brain: peripherally administered OT can act via V1aRs for analgesia, locomotor reduction, adjacent lying, and social huddling, while AVP can act via OTRs for uterine contractions and social investigation; centrally, OT can act via V1aRs for flank marking, and both OT and AVP can act via OTRs for social recognition and social reward.
- In Syrian hamsters, both OT and AVP induce flank marking dose-dependently, but AVP is around 100-fold more potent than OT; selective V1aR, not OTR, agonists/antagonists mediate this effect. Intranasal OT/AVP at commonly used 20–40 IU produces supraphysiological peripheral levels and likely activates OTRs, V1aRs, V1bRs, and V2Rs.
Methods
- Narrative review; no new experimental data, sample, or primary analysis are reported.
- The authors synthesize evidence from in vitro and in vivo receptor selectivity assays, behavioral pharmacology with selective OT/AVP receptor agonists and antagonists, genetic manipulations including knockouts, anatomical and electron microscopic studies, and microdialysis/peptide release studies across species.
- Main analysis is qualitative integration of these findings to assess when exogenous or endogenous OT and AVP may cross-activate each other’s receptors.
Limitations
- The paper states that much of the discussed data were collected in males despite major sex differences in OT and AVP systems, and that there is no “gold standard” for defining receptor selectivity.
- The paper states that selectivity estimates come from different assays, limited tissues, and only a few species, and that brain levels of peptide produced by intranasal administration are not well understood.
- The paper states that little is known about how frequently OT/AVP synapses contain the corresponding receptors, that OT/AVP receptors cannot currently be identified with immunohistochemistry, and that cross-talk following endogenously released peptides remains to be confirmed; evident from the text, this is a narrative rather than systematic review.
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Claims the paper makes
66 Not checked yet · 36 Own interpretation · 1 Own result
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In the paper
“For example, studies employing recombinant expression systems to examine selectivity of human, rat, and mouse OT and AVP receptors have shown that only the human OTR is selective for OT using a standard criterion [34; 35] (Table 1).”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 1. Introduction
What the sources say
- Not checked yetcites [34] Manning M Stoev S Chini B Durroux B Mouillac B Guillon G Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: research tools and potential therapeutic agents Neumann ID Landgraf R Advances in Vasopressin and Oxytocin: From genes to behavior Elsevier 2008 473 512 18655903 source
- Not checked yetcites [35] Manning M Misicka A Olma A Bankowski K Stoev S Chini B Durroux T Mouillac B Corbani M Guillon G Oxytocin and vasopressin agonists and antagonists as research tools and potential therapeutics Journal of Neuroendocrinology 24 2012 609 628 22375852 PMC3490377 source
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Here, we review the increasing body of evidence that exogenously administered and endogenously released OT and AVP can activate each other’s canonical receptors (i.e., cross-talk)”
- Also stated in: § 1. Introduction · plain
“Recently, however, there has been increasing evidence that OT and AVP can act on each other’s canonical receptors in potentially important ways.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > Abstract
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- Also stated in: § 1. Introduction · plain
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In the paper
“Nevertheless, it appears that there can be differences of around 10–100 fold in the selectivity of OTRs and AVP receptors for OT and AVP.”
- Also stated in: § 4. Receptor cross-talk in response to exogenously administered peptides · hedged
“Existing data suggest that there are 10–100 fold differences in the selectivity of OT and AVP for OTRs, V1aRs, and V1bRs”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 1. Introduction
What the sources say
- Not checked yetcites [28] Chini B Mouillac B Ala Y Balestre MN Trumpp-Kallmeyer S Hoflack J Elands J Hibert M Manning M Jard S Tyr115 is the key residue for determining agonist selectivity in the V1a vasopressin receptor EMBO J 14 1995 2176 2182 7774575 PMC398323 source
- Not checked yetcites [29] Hawtin SR Wesley VJ Parslow RA Patel S Wheatley M Critical role of a subdomain of the N-terminus of the V1a vasopressin receptor for binding agonists but not antagonists; functional rescue by the oxytocin receptor N-terminus Biochemistry 39 2000 13524 33 11063589 source
- Not checked yetcites [30] Kimura T Makino Y Saji F Takemura M Inoue T Kikuchi T Kubota Y Azuma C Nobunaga T Tokugawa Y Molecular characterization of a cloned human oxytocin receptor Eur J Endocrinol 131 1994 385 90 7921228 source
- Not checked yetcites [31] Lolait SJ O’Carroll AM Brownstein MJ Molecular biology of vasopressin receptors Ann N Y Acad Sci 771 1995 273 92 8597406 source
- Not checked yetcites [32] Thibonnier M Coles P Thibonnier A Shoham M The basic and clinical pharmacology of nonpeptide vasopressin receptor antagonists Annu Rev Pharmacol Toxicol 41 2001 175 202 11264455 source
- Not checked yetcites [33] Song Z McCann KE McNeill JK Larkin TE Huhman KL Albers HE Oxytocin induces social communication by activating arginine-vasopressin V1a receptors and not oxytocin receptors Psychoneuroendocrinology 50C 2014 14 19 PMC4252597 25173438 source
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- Also stated in: § 4. Receptor cross-talk in response to exogenously administered peptides · hedged
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“This overall lack of receptor selectivity is not surprising when one considers that these receptors have a high degree of structural homology (e.g., 85% between V1aR and OTR) (Figure 4).”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 1. Introduction
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Although the chemical structures of OT and AVP as well as their receptors are quite similar, OT and AVP can have distinct or even opposing actions.”
- Also stated in: § 1. Introduction · boosted
“Although the chemical structures of OT and AVP as well as their receptors are quite similar, there is substantial evidence that these nonapeptides (i.e., nine amino acid peptides) can have distinct or even opposing roles in the regulation of many behavioral and physiological functions [3; 4; 5; 6; 7].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > Abstract
What the sources say
- Not checked yetcites [3] Neumann ID Landgraf R Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors Trends Neurosci 35 2012 649 659 22974560 source
- Not checked yetcites [4] Legros JJ Inhibitory effect of oxytocin on corticotrope function in humans: are vasopressin and oxytocin ying-yang neurohormones? Psychoneuroendocrinology 26 2001 649 655 11500247 source
- Not checked yetcites [5] Stoop R Neuromodulation by oxytocin and vasopressin Neuron 76 2012 142 159 23040812 source
- Not checked yetcites [6] Heinrichs M von Dawans B Domes G Oxytocin, vasopressin, and human social behavior Front Neuroendocrinol 30 2009 548 57 19505497 source
- Not checked yetcites [7] Carter CS Grippo AJ Pournajafi-Nazarloo H Ruscio MG Porges SW Oxytocin, vasopressin and sociality Prog Brain Res 170 2008 331 6 18655893 source
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- Also stated in: § 1. Introduction · boosted
In the paper
“In addition, selective V1aR but not OTR antagonists inhibit both OT- and AVP- induced analgesia in wild-type mice.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 2. Cross-talk between OT and AVP administered peripherally > 2.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [40] Schorscher-Petcu A Sotocinal S Ciura S Dupre A Ritchie J Sorge RE Crawley JN Hu SB Nishimori K Young LJ Tribollet E Quirion R Mogil JS Oxytocin-induced analgesia and scratching are mediated by the vasopressin-1A receptor in the mouse J Neurosci 30 2010 8274 84 20554879 PMC2902996 source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Peripheral administration of OT or AVP induces analgesia in OTR but not in V1aR knock-out male and female mice [40].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 2. Cross-talk between OT and AVP administered peripherally > 2.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [40] Schorscher-Petcu A Sotocinal S Ciura S Dupre A Ritchie J Sorge RE Crawley JN Hu SB Nishimori K Young LJ Tribollet E Quirion R Mogil JS Oxytocin-induced analgesia and scratching are mediated by the vasopressin-1A receptor in the mouse J Neurosci 30 2010 8274 84 20554879 PMC2902996 source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Structure-activity studies as well as the central injection of highly selective V1a agonists and antagonists indicates that AVP acts on V1aRs to stimulate flank marking [59; 60].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [59] Albers HE Pollock J Simmons WH Ferris CF A V1-like receptor mediates vasopressin-induced flank marking behavior in hamster hypothalamus J Neurosci 6 1986 2085 9 3016215 PMC6568576 source
- Not checked yetcites [60] Ferris CF Singer EA Meenan DM Albers HE Inhibition of vasopressin-stimulated flank marking behavior by V1-receptor antagonists Eur J Pharmacol 154 1988 153 9 2976377 source
hedgeddirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Injection of AVP into several brain sites including the anterior hypothalamus (AH), the lateral septum (LS), and the periaqueductal gray (PAG), induce robust bouts of flank marking [55; 56; 57; 58].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [55] Hennessey AC Whitman DC Albers HE Microinjection of Arginine-Vasopressin into the Periaqueductal Gray Stimulates Flank Marking in Syrian-Hamsters (Mesocricetus-Auratus) Brain Research 569 1992 136 140 1611473 source
- Not checked yetcites [56] Ferris CF Albers HE Wesolowski SM Goldman BD Luman SE Vasopressin injected into the hypothalamus triggers a stereotypic behavior in golden hamsters Science 224 1984 521 523 6538700 source
- Not checked yetcites [57] Irvin RW Szot P Dorsa DM Potegal M Ferris CF Vasopressin in the septal area of the golden hamster controls scent marking and grooming Physiol Behav 48 1990 693 9 2082369 source
- Not checked yetcites [58] Huhman KL Babagbemi TO Albers HE Bicuculline Blocks Neuropeptide Y-Induced Phase Advances When Microinjected in the Suprachiasmatic Nucleus of Syrian-Hamsters Brain Research 675 1995 333 336 7796148 source
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In the paper
“The ability of peripheral administration of OT to reduce locomotor activity in male rats is reduced by a selective V1aR antagonist [43].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 2. Cross-talk between OT and AVP administered peripherally > 2.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [43] Hicks C Ramos L Dampney B Baracz SJ McGregor IS Hunt GE Regional c-Fos expression induced by peripheral oxytocin administration is prevented by the vasopressin 1A receptor antagonist SR49059 Brain Res Bull 127 2016 208 218 27725169 source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“There is considerable evidence that central administration of OT and AVP significantly influences the duration of social recognition in rats and mice [61; 62].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.2 AVP acting via OTRs
What the sources say
- Not checked yetcites [61] Gabor CS Phan A Clipperton-Allen AE Kavaliers M Choleris E Interplay of oxytocin, vasopressin, and sex hormones in the regulation of social recognition Behav Neurosci 126 2012 97 109 22141469 source
- Not checked yetcites [62] Albers HE The regulation of social recognition, social communication and aggression: vasopressin in the social behavior neural network Horm Behav 61 2012 283 92 22079778 source
boosteddirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Indeed, flank gland odors were found to be recognized for at least 24 hrs after a brief 3 min exposure.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.2 AVP acting via OTRs
What the sources say
- Not checked yetcites [65] Song Z Larkin TE Malley MO Albers HE Oxytocin (OT) and arginine-vasopressin (AVP) act on OT receptors and not AVP V1a receptors to enhance social recognition in adult Syrian hamsters (Mesocricetus auratus) Horm Behav 81 2016 20 7 26975586 source
plain- Asserted: passes — The authors put it forward as true.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Taken together, these data suggest that peripherally administered OT and AVP can act through V1aRs to alter physiology and behavior.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 2. Cross-talk between OT and AVP administered peripherally > 2.1 OT acting via V1aRs
hedgeddirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Central administration of OT or AVP induces scratching behavior in wild-type and OTR knock-out male and female mice but not in V1aR knock-out mice [40].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [40] Schorscher-Petcu A Sotocinal S Ciura S Dupre A Ritchie J Sorge RE Crawley JN Hu SB Nishimori K Young LJ Tribollet E Quirion R Mogil JS Oxytocin-induced analgesia and scratching are mediated by the vasopressin-1A receptor in the mouse J Neurosci 30 2010 8274 84 20554879 PMC2902996 source
plaindirect- Asserted: passes — The authors put it forward as true.
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None of the sources cited for this claim have been checked yet.
In the paper
“In the pituitary gland OT induces release of adrenocorticotropin via both OTRs and V1bRs in male mice and female rats [50; 51].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 2. Cross-talk between OT and AVP administered peripherally > 2.3 OT acting via V1bRs
What the sources say
- Not checked yetcites [50] Schlosser SF Almeida OF Patchev VK Yassouridis A Elands J Oxytocin-stimulated release of adrenocorticotropin from the rat pituitary is mediated by arginine vasopressin receptors of the V1b type Endocrinology 135 1994 2058 63 7956927 source
- Not checked yetcites [51] Nakamura K Fujiwara Y Mizutani R Sanbe A Miyauchi N Hiroyama M Yamauchi J Yamashita T Nakamura S Mori T Tsujimoto G Tanoue A Effects of vasopressin V1b receptor deficiency on adrenocorticotropin release from anterior pituitary cells in response to oxytocin stimulation Endocrinology 149 2008 4883 91 18583426 source
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In the paper
“Uterine contractions induced by OT or AVP are largely mediated by OTRs [46; 47; 48].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 2. Cross-talk between OT and AVP administered peripherally > 2.2 AVP acting via OTRs
What the sources say
- Not checked yetcites [46] Bossmar T Akerlund M Fantoni G Szamatowicz J Melin P Maggi M Receptors for and myometrial responses to oxytocin and vasopressin in preterm and term human pregnancy: effects of the oxytocin antagonist atosiban Am J Obstet Gynecol 171 1994 1634 42 7802081 source
- Not checked yetcites [47] Akerlund M Bossmar T Brouard R Kostrzewska A Laudanski T Lemancewicz A Serradeil-Le Gal C Steinwall M Receptor binding of oxytocin and vasopressin antagonists and inhibitory effects on isolated myometrium from preterm and term pregnant women Br J Obstet Gynaecol 106 1999 1047 53 10519430 source
- Not checked yetcites [48] Kawamata M Mitsui-Saito M Kimura T Takayanagi Y Yanagisawa T Nishimori K Vasopressin-induced contraction of uterus is mediated solely by the oxytocin receptor in mice, but not in humans Eur J Pharmacol 472 2003 229 34 12871758 source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“These analgesic effects of peripheral activation of V1aRs by OT and AVP may be mediated by V1aR modulation of ion channels in primary sensory neurons [41; 42].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 2. Cross-talk between OT and AVP administered peripherally > 2.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [41] Qiu F Qiu CY Cai H Liu TT Qu ZW Yang Z Li JD Zhou QY Hu WP Oxytocin inhibits the activity of acid-sensing ion channels through the vasopressin, V1A receptor in primary sensory neurons Br J Pharmacol 171 2014 3065 76 24641084 PMC4055206 source
- Not checked yetcites [42] Kubo A Shinoda M Katagiri A Takeda M Suzuki T Asaka J Yeomans DC Iwata K Oxytocin alleviates orofacial mechanical hypersensitivity associated with infraorbital nerve injury through vasopressin-1A receptors of the rat trigeminal ganglia Pain 158 2017 649 659 28072605 source
hedgedconditional- Asserted: passes — The authors put it forward as true.
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In the paper
“ICV injection of an OTR but not a V1aR agonist increased the duration of social recognition in a manner that mimicked the effects of OT and AVP.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.2 AVP acting via OTRs
What the sources say
- Not checked yetcites [65] Song Z Larkin TE Malley MO Albers HE Oxytocin (OT) and arginine-vasopressin (AVP) act on OT receptors and not AVP V1a receptors to enhance social recognition in adult Syrian hamsters (Mesocricetus auratus) Horm Behav 81 2016 20 7 26975586 source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“As with other tests of social recognition, ICV injection of OT or AVP enhances social recognition; it increased social memory of flank gland odors from 24 to 48 hrs.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.2 AVP acting via OTRs
What the sources say
- Not checked yetcites [65] Song Z Larkin TE Malley MO Albers HE Oxytocin (OT) and arginine-vasopressin (AVP) act on OT receptors and not AVP V1a receptors to enhance social recognition in adult Syrian hamsters (Mesocricetus auratus) Horm Behav 81 2016 20 7 26975586 source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“There are also studies that have found that OT can act via V1aRs to influence a range of social behaviors [53].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [53] Sala M Braida D Lentini D Busnelli M Bulgheroni E Capurro V Finardi A Donzelli A Pattini L Rubino T Parolaro D Nishimori K Parenti M Chini B Pharmacologic rescue of impaired cognitive flexibility, social deficits, increased aggression, and seizure susceptibility in oxytocin receptor null mice: a neurobehavioral model of autism Biol Psychiatry 69 2011 875 882 21306704 source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“More recently, ICV administration of OT has also been shown to induce flank marking in male hamsters [33].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [33] Song Z McCann KE McNeill JK Larkin TE Huhman KL Albers HE Oxytocin induces social communication by activating arginine-vasopressin V1a receptors and not oxytocin receptors Psychoneuroendocrinology 50C 2014 14 19 PMC4252597 25173438 source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“For example, social recognition is enhanced by optogenetically-induced OT release in the brain in female rats [63]”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.2 AVP acting via OTRs
What the sources say
- Not checked yetcites [63] Oettl LL Ravi N Schneider M Scheller MF Schneider P Mitre M da Silva Gouveia M Froemke RC Chao MV Young WS Meyer-Lindenberg A Grinevich V Shusterman R Kelsch W Oxytocin Enhances Social Recognition by Modulating Cortical Control of Early Olfactory Processing Neuron 90 2016 609 21 27112498 PMC4860033 source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Both OT and AVP administered peripherally increase a form of social interaction in male rats referred to as “adjacent lying” in which rats maintain passive side-by-side contact during their first interaction [44].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 2. Cross-talk between OT and AVP administered peripherally > 2.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [44] Ramos L Hicks C Kevin R Caminer A Narlawar R Kassiou M McGregor IS Acute prosocial effects of oxytocin and vasopressin when given alone or in combination with 3,4-methylenedioxymethamphetamine in rats: involvement of the V1A receptor Neuropsychopharmacology 38 2013 2249 59 23676791 PMC3773675 source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“administration of AVP into the septum improves social recognition in male Brattleboro rats, a mutant rat strain that naturally lacks AVP [64].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.2 AVP acting via OTRs
What the sources say
- Not checked yetcites [64] Engelmann M Landgraf R Microdialysis administration of vasopressin into the septum improves social recognition in Brattleboro rats Physiol Behav 55 1994 145 9 8140159 source
plaindirect- Asserted: passes — The authors put it forward as true.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“As a result, very high levels of OT and AVP would likely result in the activation of all OT/AVP receptors.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 4. Receptor cross-talk in response to exogenously administered peptides
hedgedconditional- Asserted: passes — The authors put it forward as true.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“There is also some evidence to suggest that OT can act on V1bRs to influence endocrine activity.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 4. Receptor cross-talk in response to exogenously administered peptides
hedgedconditional- Asserted: passes — The authors put it forward as true.
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None of the sources cited for this claim have been checked yet.
In the paper
“The few studies that have compared the effects of intranasally administered OT and AVP in humans have reported that these peptides do not have opposing roles.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 4. Receptor cross-talk in response to exogenously administered peptides
What the sources say
- Not checked yetcites [84] Rilling JK DeMarco AC Hackett PD Thompson R Ditzen B Patel R Pagnoni G Effects of intranasal oxytocin and vasopressin on cooperative behavior and associated brain activity in men Psychoneuroendocrinology 37 2012 447 461 21840129 PMC3251702 source
- Not checked yetcites [86] Chen X Hackett PD DeMarco AC Feng C Stair S Haroon E Ditzen B Pagnoni G Rilling JK Effects of oxytocin and vasopressin on the neural response to unreciprocated cooperation within brain regions involved in stress and anxiety in men and women Brain Imaging Behav 10 2016 581 93 26040978 PMC4670292 source
- Not checked yetcites [87] Patel N Grillon C Pavletic N Rosen D Pine DS Ernst M Oxytocin and vasopressin modulate risk-taking Physiol Behav 139 2015 254 60 25446228 PMC4274653 source
- Not checked yetcites [88] Rilling JK Demarco AC Hackett PD Chen X Gautam P Stair S Haroon E Thompson R Ditzen B Patel R Pagnoni G Sex differences in the neural and behavioral response to intranasal oxytocin and vasopressin during human social interaction Psychoneuroendocrinology 39 2014 237 48 24157401 PMC3842401 source
- Not checked yetcites [89] Feng C Hackett PD DeMarco AC Chen X Stair S Haroon E Ditzen B Pagnoni G Rilling JK Oxytocin and vasopressin effects on the neural response to social cooperation are modulated by sex in humans Brain Imaging Behav 9 2015 754 64 25416642 source
- Not checked yetcites [90] Li T Chen X Mascaro J Haroon E Rilling JK Intranasal oxytocin, but not vasopressin, augments neural responses to toddlers in human fathers Horm Behav 2017 PMC5565399 28161387 source
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“The high levels of peptide produced within the periphery by intranasal administration likely results in activation of peripheral OTRs, V1aRs, V1bRs, and V2Rs.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 4. Receptor cross-talk in response to exogenously administered peptides
hedgedconditional- Asserted: passes — The authors put it forward as true.
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In the paper
“Similarly, OTR knock-out mice also display significant deficits in social recognition [69; 70; 71; 72].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.2 AVP acting via OTRs
What the sources say
- Not checked yetcites [69] Macbeth AH Lee HJ Edds J Young WS 3rd Oxytocin and the oxytocin receptor underlie intrastrain, but not interstrain, social recognition Genes Brain Behav 8 2009 558 67 19531157 PMC2746010 source
- Not checked yetcites [70] Takayanagi Y Yoshida M Bielsky IF Ross HE Kawamata M Onaka T Yanagisawa T Kimura T Matzuk MM Young LJ Nishimori K Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice Proc Natl Acad Sci U S A 102 2005 16096 101 16249339 PMC1276060 source
- Not checked yetcites [71] Choleris E Little SR Mong JA Puram SV Langer R Pfaff DW Microparticle-based delivery of oxytocin receptor antisense DNA in the medial amygdala blocks social recognition in female mice Proc Natl Acad Sci U S A 104 2007 4670 5 17360582 PMC1838659 source
- Not checked yetcites [72] Lee HJ Caldwell HK Macbeth AH Tolu SG Young WS 3rd A conditional knockout mouse line of the oxytocin receptor Endocrinology 149 2008 3256 63 18356275 PMC2453083 source
plaindirect- Asserted: passes — The authors put it forward as true.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Cross-talk between OT and AVP receptors may be more limited in humans when the peptides are given at more physiological levels because in humans, OT appears to have a higher affinity for its receptors than for AVP receptors.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 4. Receptor cross-talk in response to exogenously administered peptides
hedgedconditional- Asserted: passes — The authors put it forward as true.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“As a result, it is clear that the actions of exogenously administered OT and AVP in both the periphery and the brain cannot be assumed to be the sole result of activation of their canonical receptors.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 4. Receptor cross-talk in response to exogenously administered peptides
boosted- Asserted: passes — The authors put it forward as true.
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In the paper
“Both OT and AVP injected into the ventral tegmental area (VTA), a key element in the mesolimbic reward network, enhanced social reward in male Syrian hamsters tested using the conditioned place preference (CPP) apparatus.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.2 AVP acting via OTRs
What the sources say
- Not checked yetcites [78] Song Z Borland JM Larkin TE O’Malley M Albers HE Activation of oxytocin receptors, but not arginine-vasopressin V1a receptors, in the ventral tegmental area of male Syrian hamsters is essential for the reward-like properties of social interactions Psychoneuroendocrinology 74 2016 164 172 27632574 PMC6417503 source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“A highly selective OTR but not a highly selective V1aR agonist mimicked the reward-enhancing effects of OT and AVP.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.2 AVP acting via OTRs
What the sources say
- Not checked yetcites [78] Song Z Borland JM Larkin TE O’Malley M Albers HE Activation of oxytocin receptors, but not arginine-vasopressin V1a receptors, in the ventral tegmental area of male Syrian hamsters is essential for the reward-like properties of social interactions Psychoneuroendocrinology 74 2016 164 172 27632574 PMC6417503 source
plaindirect- Asserted: passes — The authors put it forward as true.
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None of the sources cited for this claim have been checked yet.
In the paper
“Antagonism of V1aRs in several different CNS sites impairs social recognition [73; 74]”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.2 AVP acting via OTRs
What the sources say
- Not checked yetcites [73] Tobin VA Hashimoto H Wacker DW Takayanagi Y Langnaese K Caquineau C Noack J Landgraf R Onaka T Leng G Meddle SL Engelmann M Ludwig M An intrinsic vasopressin system in the olfactory bulb is involved in social recognition Nature 464 2010 413 7 20182426 PMC2842245 source
- Not checked yetcites [74] Veenema AH Bredewold R De Vries GJ Vasopressin regulates social recognition in juvenile and adult rats of both sexes, but in sex- and age-specific ways Horm Behav 61 2012 50 6 22033278 PMC3264802 source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Importantly, these studies also showed that an OTR, but not a V1aR antagonist injected into the VTA inhibits social reward.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.2 AVP acting via OTRs
What the sources say
- Not checked yetcites [78] Song Z Borland JM Larkin TE O’Malley M Albers HE Activation of oxytocin receptors, but not arginine-vasopressin V1a receptors, in the ventral tegmental area of male Syrian hamsters is essential for the reward-like properties of social interactions Psychoneuroendocrinology 74 2016 164 172 27632574 PMC6417503 source
plaindirect- Asserted: passes — The authors put it forward as true.
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None of the sources cited for this claim have been checked yet.
In the paper
“For example, social recognition in OT knock-out male mice is severely impaired [68; 69].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.2 AVP acting via OTRs
What the sources say
- Not checked yetcites [68] Ferguson JN Young LJ Hearn EF Matzuk MM Insel TR Winslow JT Social amnesia in mice lacking the oxytocin gene Nat Genet 25 2000 284 8 10888874 source
- Not checked yetcites [69] Macbeth AH Lee HJ Edds J Young WS 3rd Oxytocin and the oxytocin receptor underlie intrastrain, but not interstrain, social recognition Genes Brain Behav 8 2009 558 67 19531157 PMC2746010 source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“as discussed above, a V1aR antagonist inhibits the ability of OT to increase social recognition in OTR knock-out mice [53].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.2 AVP acting via OTRs
What the sources say
- Not checked yetcites [53] Sala M Braida D Lentini D Busnelli M Bulgheroni E Capurro V Finardi A Donzelli A Pattini L Rubino T Parolaro D Nishimori K Parenti M Chini B Pharmacologic rescue of impaired cognitive flexibility, social deficits, increased aggression, and seizure susceptibility in oxytocin receptor null mice: a neurobehavioral model of autism Biol Psychiatry 69 2011 875 882 21306704 source
plaindirect- Asserted: passes — The authors put it forward as true.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These data support the possibility that OT and AVP act on OTRs in the VTA, to regulate the expression of social reward.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.2 AVP acting via OTRs
hedgeddirect- Asserted: passes — The authors put it forward as true.
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In the paper
“It is clear, however, that peptides administered via the intranasal route produce significant alterations in cognition and neuronal activity whether they are acting peripherally and/or centrally.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 4. Receptor cross-talk in response to exogenously administered peptides
What the sources say
- Not checked yetcites [84] Rilling JK DeMarco AC Hackett PD Thompson R Ditzen B Patel R Pagnoni G Effects of intranasal oxytocin and vasopressin on cooperative behavior and associated brain activity in men Psychoneuroendocrinology 37 2012 447 461 21840129 PMC3251702 source
boosteddirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Hamsters injected with OT or AVP had a larger increase in the time spent in the chamber associated with social-interaction after conditioning compared to those injected with saline.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.2 AVP acting via OTRs
What the sources say
- Not checked yetcites [78] Song Z Borland JM Larkin TE O’Malley M Albers HE Activation of oxytocin receptors, but not arginine-vasopressin V1a receptors, in the ventral tegmental area of male Syrian hamsters is essential for the reward-like properties of social interactions Psychoneuroendocrinology 74 2016 164 172 27632574 PMC6417503 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Crosstalk may also occur among all OT/AVP receptors particularly when these peptides are administered at high concentrations.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 4. Receptor cross-talk in response to exogenously administered peptides
hedgedconditional- Asserted: passes — The authors put it forward as true.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“As a result, the data examining the hypothesis that OTRs and not V1aRs are essential for social recognition are not entirely consistent.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.2 AVP acting via OTRs
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“OT or AVP release from synaptic terminals or release from axons in passage could therefore produce a focal activation of local receptors (Figure 6).”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 5. Is there cross-talk in response to endogenously released OT and AVP?
hedgedconditional- Asserted: passes — The authors put it forward as true.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The further that non-synaptically released neuropeptides spread at high concentrations the greater potential for receptor cross-talk despite the anatomical segregation of OT and AVP receptors.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 5. Is there cross-talk in response to endogenously released OT and AVP?
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“There is only a limited amount of evidence that endogenously released OT or AVP can produce functionally significant responses by acting on each other’s receptors.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 5. Is there cross-talk in response to endogenously released OT and AVP?
plain- Asserted: passes — The authors put it forward as true.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“OT and AVP receptors are imbedded in neural circuits that are frequently anatomically separate so it is likely that the opposite effects of these peptides are more the result of which receptor is activated rather than which peptide was responsible for the activation.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 6. Conclusions
hedgedconditional- Asserted: passes — The authors put it forward as true.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“When they do it is likely that OT and AVP will produce similar effects.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 6. Conclusions
hedgedconditional- Asserted: passes — The authors put it forward as true.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Because non-synaptic release does not require a change in membrane voltage, synaptic release and non-synaptic release can occur independently of each other.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 5. Is there cross-talk in response to endogenously released OT and AVP?
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Substantial non-synaptic release of either OT or AVP could activate a large number of OT and AVP receptors indiscriminately, thereby overriding the “wiring” diagrams of OT and AVP networks.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 6. Conclusions
hedgedconditional- Asserted: passes — The authors put it forward as true.
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None of the sources cited for this claim have been checked yet.
In the paper
“α-MSH acts on melanocortin 4 receptors to induce non-synaptic release of OT but not AVP from hypothalamic neurons [118; 119].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 5. Is there cross-talk in response to endogenously released OT and AVP?
What the sources say
- Not checked yetcites [118] Sabatier N Caquineau C Dayanithi G Bull P Douglas AJ Guan XM Jiang M Van der Ploeg L Leng G Alpha-melanocyte-stimulating hormone stimulates oxytocin release from the dendrites of hypothalamic neurons while inhibiting oxytocin release from their terminals in the neurohypophysis J Neurosci 23 2003 10351 8 14614094 PMC6741015 source
- Not checked yetcites [119] Sabatier N alpha-Melanocyte-stimulating hormone and oxytocin: a peptide signalling cascade in the hypothalamus J Neuroendocrinol 18 2006 703 10 16879169 source
plaindirect- Asserted: passes — The authors put it forward as true.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, a simple notion that OT and AVP always have diametrically opposed actions is incorrect.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 6. Conclusions
plain- Asserted: passes — The authors put it forward as true.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These data provide support for the possibility that endogenously released OT can act on V1aRs to induce social behavior.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 5. Is there cross-talk in response to endogenously released OT and AVP?
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, OT and AVP receptors within these networks could be activated in very different patterns as the result of different combinations of synaptic and non-synaptic release.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 6. Conclusions
hedgeddirect- Asserted: passes — The authors put it forward as true.
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None of the sources cited for this claim have been checked yet.
In the paper
“In addition, depolarizing stimuli can induce OT and AVP release in a calcium-dependent manner in brain regions where AVP and OT fibers terminate synaptically [105; 106; 107].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 5. Is there cross-talk in response to endogenously released OT and AVP?
What the sources say
- Not checked yetcites [105] Buijs RM Van Heerikhuize JJ Vasopressin and oxytocin release in the brain--a synaptic event Brain Res 252 1982 71 6 7172022 source
- Not checked yetcites [106] Neumann I Ludwig M Engelmann M Pittman QJ Landgraf R Simultaneous microdialysis in blood and brain: oxytocin and vasopressin release in response to central and peripheral osmotic stimulation and suckling in the rat Neuroendocrinology 58 1993 637 45 8127393 source
- Not checked yetcites [107] Landgraf R Neumann I Schwarzberg H Central and peripheral release of vasopressin and oxytocin in the conscious rat after osmotic stimulation Brain Research 457 1988 219 225 3219551 source
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In any case, non-synaptic release of OT and AVP has the potential to result in substantial cross-talk among OT and AVP receptors across many brain regions.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 5. Is there cross-talk in response to endogenously released OT and AVP?
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Nevertheless, when isolated receptors do occur more global forms of neuropeptide release, such as non-synaptic release, would be required for their activation.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 5. Is there cross-talk in response to endogenously released OT and AVP?
hedgedconditional- Asserted: passes — The authors put it forward as true.
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In the paper
“Different patterns of OT and AVP receptor activation across structures within these networks could contribute to the regulation of the complex behaviors and physiological processes under their control (see [8] for a review).”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 6. Conclusions
What the sources say
- Not checked yetcites [8] Albers HE Species, sex and individual differences in the vasotocin/vasopressin system: relationship to neurochemical signaling in the social behavior neural network Front Neuroendocrinol 36 2015 49 71 25102443 PMC4317378 source
hedgedconditional- Asserted: passes — The authors put it forward as true.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Based on approaches with less anatomical resolution (i.e., receptor autoradiography) OT and AVP receptors appear to be anatomically segregated in many areas of the brain (e.g., Figure 3).”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 6. Conclusions
hedged- Asserted: passes — The authors put it forward as true.
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None of the sources cited for this claim have been checked yet.
In the paper
“The endogenous release of OT and AVP in the brain may be the result of neuropeptide release from synaptic and/or non-synaptic regions of neurons, although the relative roles of these forms of release in different populations of OT and AVP-containing cells are controversial [93; 94; 95; 96].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 5. Is there cross-talk in response to endogenously released OT and AVP?
What the sources say
- Not checked yetcites [93] Johnson ZV Young LJ Oxytocin and vasopressin neural networks: Implications for social behavioral diversity and translational neuroscience Neurosci Biobehav Rev 76 2017 87 98 28434591 PMC5407410 source
- Not checked yetcites [94] Ross HE Young LJ Oxytocin and the neural mechanisms regulating social cognition and affiliative behavior Front Neuroendocrinol 30 2009 534 47 19481567 PMC2748133 source
- Not checked yetcites [95] Knobloch HS Grinevich V Evolution of oxytocin pathways in the brain of vertebrates Front Behav Neurosci 8 2014 31 24592219 PMC3924577 source
- Not checked yetcites [96] Chini B Verhage M Grinevich V The Action Radius of Oxytocin Release in the Mammalian CNS: From Single Vesicles to Behavior Trends Pharmacol Sci 2017 28899620 source
hedgedconditional- Asserted: passes — The authors put it forward as true.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Cross-talk is likely to occur when neuropeptides are released non-synaptically and spread more globally due to volume transmission.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 6. Conclusions
hedgedconditional- Asserted: passes — The authors put it forward as true.
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None of the sources cited for this claim have been checked yet.
In the paper
“A more global form of OT and AVP release can occur when these neuropeptides are released from non-synaptic regions of neurons (e.g., dendrites) (Figure 6) [108; 109; 110].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 5. Is there cross-talk in response to endogenously released OT and AVP?
What the sources say
- Not checked yetcites [108] Leng G Ludwig M Neurotransmitters and peptides: whispered secrets and public announcements J Physiol 586 2008 5625 32 18845614 PMC2655398 source
- Not checked yetcites [109] Landgraf R Neumann ID Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication Front Neuroendocrinol 25 2004 150 176 15589267 source
- Not checked yetcites [110] Engelmann M Wotjak CT Ebner K Landgraf R Behavioural impact of intraseptally released vasopressin and oxytocin in rats Exp Physiol 85 Spec No 2000 125S 130S 10795914 source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Although “isolated” receptors appear to be a common phenomenon in the brain [116], the number of mismatches between the presence of neuropeptides and their receptors may be at least partially the result of a lack of sensitivity of the techniques used to localize neuropeptides [98; 117].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 5. Is there cross-talk in response to endogenously released OT and AVP?
What the sources say
- Not checked yetcites [98] Knobloch HS Charlet A Hoffmann LC Eliava M Khrulev S Cetin AH Osten P Schwarz MK Seeburg PH Stoop R Grinevich V Evoked axonal oxytocin release in the central amygdala attenuates fear response Neuron 73 2012 553 566 22325206 source
- Not checked yetcites [117] Grinevich V Knobloch-Bollmann HS Eliava M Busnelli M Chini B Assembling the Puzzle: Pathways of Oxytocin Signaling in the Brain Biol Psychiatry 79 2016 155 64 26001309 source
hedgedconditional- Asserted: passes — The authors put it forward as true.
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None of the sources cited for this claim have been checked yet.
In the paper
“For example, electron microscopic analysis has revealed dense core vesicles containing AVP- and OT-ir in terminals located in synaptic regions of brain areas such as the habenula, lateral septum, amygdala, supraoptic nuclei, ventromedial hypothalamus and the nucleus of the solitary tract [98; 99; 100; 101; 102; 103; 104].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 5. Is there cross-talk in response to endogenously released OT and AVP?
What the sources say
- Not checked yetcites [98] Knobloch HS Charlet A Hoffmann LC Eliava M Khrulev S Cetin AH Osten P Schwarz MK Seeburg PH Stoop R Grinevich V Evoked axonal oxytocin release in the central amygdala attenuates fear response Neuron 73 2012 553 566 22325206 source
- Not checked yetcites [99] Theodosis DT Oxytocin-immunoreactive terminals synapse on oxytocin neurones in the supraoptic nucleus Nature 313 1985 682 4 3883189 source
- Not checked yetcites [100] Peters JH McDougall SJ Kellett DO Jordan D Llewellyn-Smith IJ Andresen MC Oxytocin enhances cranial visceral afferent synaptic transmission to the solitary tract nucleus J Neurosci 28 2008 11731 40 18987209 PMC2585803 source
- Not checked yetcites [101] Griffin GD Ferri-Kolwicz SL Reyes BA Van Bockstaele EJ Flanagan-Cato LM Ovarian hormone-induced reorganization of oxytocin-labeled dendrites and synapses lateral to the hypothalamic ventromedial nucleus in female rats J Comp Neurol 518 2010 4531 45 20886620 PMC4323080 source
- Not checked yetcites [102] Buijs RM Swaab DF Immuno-electron microscopical demonstration of vasopressin and oxytocin synapses in the limbic system of the rat Cell Tissue Res 204 1979 355 65 527026 source
- Not checked yetcites [103] Voorn P Buijs RM An immuno-electronmicroscopical study comparing vasopressin, oxytocin, substance P and enkephalin containing nerve terminals in the nucleus of the solitary tract of the rat Brain Res 270 1983 169 73 6191839 source
- Not checked yetcites [104] Buijs RM Immunocytochemical demonstration of vasopressin and oxytocin in the rat brain by light and electron microscopy J Histochem Cytochem 28 1980 357 60 6989899 source
plain- Asserted: passes — The authors put it forward as true.
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None of the sources cited for this claim have been checked yet.
In the paper
“Dysfunctions in the actions of OT and AVP have been linked to psychiatric disorders such as autism, anxiety and schizophrenia.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 6. Conclusions
What the sources say
- Not checked yetcites [81] Caldwell HK Albers HE Oxytocin, Vasopressin, and the Motivational Forces that Drive Social Behaviors Curr Top Behav Neurosci 27 2016 51 103 26472550 source
- Not checked yetcites [82] Modi ME Young LJ The oxytocin system in drug discovery for autism: animal models and novel therapeutic strategies Horm Behav 61 2012 340 50 22206823 PMC3483080 source
- Not checked yetcites [83] Meyer-Lindenberg A Domes G Kirsch P Heinrichs M Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine Nat Rev Neurosci 12 2011 524 38 21852800 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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- It may state two separate claims as one. 38
- Probably not a substantial claim. 3
None of the sources cited for this claim have been checked yet.
In the paper
“In mammals, OT is considered to have only one canonical receptor (i.e., OTR) while AVP is thought to have three: V1aR, V1bR and V2R [16; 17; 18].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 1. Introduction
What the sources say
- Not matchedcites [16] Caldwell HK Young WS III Oxytocin and Vasopressin: Genetics and behavioral implications Lim R Neuroactive Proteins and Peptides Springer New York 2006 573 607
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked yetcites [17] Barberis C Tribollet E Vasopressin and oxytocin receptors in the central nervous system Crit Rev Neurobiol 10 1996 119 54 8853957 source
- Not checked yetcites [18] Hasunuma I Toyoda F Okada R Yamamoto K Kadono Y Kikuyama S Roles of arginine vasotocin receptors in the brain and pituitary of submammalian vertebrates Int Rev Cell Mol Biol 304 2013 191 225 23809437 source
hedged- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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It may state two separate claims as one.
- Not matched
None of the sources cited for this claim have been checked yet.
In the paper
“Oxytocin (OT) and arginine-vasopressin (AVP) act in the brain to regulate social cognition/social behavior and in the periphery to influence a variety of physiological processes.”
- Also stated in: § 1. Introduction · plain
“Oxytocin (OT) and arginine-vasopressin (AVP) are important chemical signals that act in the brain to regulate a large number of adaptive social behaviors and in the periphery to coordinate a diverse group of physiological functions [1; 2].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > Abstract
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
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- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Also stated in: § 1. Introduction · plain
None of the sources cited for this claim have been checked yet.
In the paper
“In mammalian brain OTRs and V1aRs are robustly expressed in many regions but their distributions often differ [9; 21; 22] (Figure 3).”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 1. Introduction
What the sources say
- Not checked yetcites [9] Dumais KM Veenema AH Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior Front Neuroendocrinol 40 2016 1 23 25951955 PMC4633405 source
- Not checked yetcites [21] Veinante P Freund-Mercier MJ Distribution of oxytocin- and vasopressin-binding sites in the rat extended amygdala: a histoautoradiographic study J Comp Neurol 383 1997 305 325 9205043 source
- Not checked yetcites [22] Smith CJ Poehlmann ML Li S Ratnaseelan AM Bredewold R Veenema AH Age and sex differences in oxytocin and vasopressin V1a receptor binding densities in the rat brain: focus on the social decision-making network Brain Struct Funct 222 2017 981 1006 27389643 PMC5334374 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“These effects of OT and AVP can be inhibited by selective V1aR but not OTR antagonists.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 2. Cross-talk between OT and AVP administered peripherally > 2.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [37] Hicks C Ramos L Reekie T Misagh GH Narlawar R Kassiou M McGregor IS Body temperature and cardiac changes induced by peripherally administered oxytocin, vasopressin and the non-peptide oxytocin receptor agonist WAY 267,464: a biotelemetry study in rats Br J Pharmacol 171 2014 2868 87 24641248 PMC4243861 source
- Not checked yetcites [38] Loyens E Vermoesen K Schallier A Michotte Y Smolders I Proconvulsive effects of oxytocin in the generalized pentylenetetrazol mouse model are mediated by vasopressin 1a receptors Brain Res 1436 2012 43 50 22208648 source
- Not checked yetcites [39] Gupta J Russell R Wayman C Hurley D Jackson V Oxytocin-induced contractions within rat and rabbit ejaculatory tissues are mediated by vasopressin V1A receptors and not oxytocin receptors Br J Pharmacol 155 2008 118 26 18552879 PMC2527840 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Peripherally administered OT and AVP produce similar effects in reducing heart rate and body temperature, inducing contractions in ejaculatory tissues, and in promoting seizure susceptibility in male rats and rabbits [37; 38; 39].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 2. Cross-talk between OT and AVP administered peripherally > 2.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [37] Hicks C Ramos L Reekie T Misagh GH Narlawar R Kassiou M McGregor IS Body temperature and cardiac changes induced by peripherally administered oxytocin, vasopressin and the non-peptide oxytocin receptor agonist WAY 267,464: a biotelemetry study in rats Br J Pharmacol 171 2014 2868 87 24641248 PMC4243861 source
- Not checked yetcites [38] Loyens E Vermoesen K Schallier A Michotte Y Smolders I Proconvulsive effects of oxytocin in the generalized pentylenetetrazol mouse model are mediated by vasopressin 1a receptors Brain Res 1436 2012 43 50 22208648 source
- Not checked yetcites [39] Gupta J Russell R Wayman C Hurley D Jackson V Oxytocin-induced contractions within rat and rabbit ejaculatory tissues are mediated by vasopressin V1A receptors and not oxytocin receptors Br J Pharmacol 155 2008 118 26 18552879 PMC2527840 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“V1bRs appear to have a much more restricted distribution, although they are expressed prominently in the hippocampus and at lower levels in the hypothalamus and amygdala [23; 24].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 1. Introduction
What the sources say
- Not checked yetcites [23] Young WS Li J Wersinger SR Palkovits M The vasopressin 1b receptor is prominent in the hippocampal area CA2 where it is unaffected by restraint stress or adrenalectomy Neuroscience 143 2006 1031 1039 17027167 PMC1748954 source
- Not checked yetcites [24] Stevenson EL Caldwell HK The vasopressin 1b receptor and the neural regulation of social behavior Hormones and Behavior 61 2012 277 282 22178035 PMC3310934 source
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“AVP has a similar affinity for OTRs, V1aRs, and V1bRs while OT may have a higher affinity for OTRs than V1aRs or V1bRs [28; 29; 30; 31; 32; 33].”
- Also stated in: § 4. Receptor cross-talk in response to exogenously administered peptides · plain
“AVP has similar affinities for OT and AVP receptors while OT has a higher affinity for OT receptors than AVP receptors.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 1. Introduction
What the sources say
- Not checked yetcites [28] Chini B Mouillac B Ala Y Balestre MN Trumpp-Kallmeyer S Hoflack J Elands J Hibert M Manning M Jard S Tyr115 is the key residue for determining agonist selectivity in the V1a vasopressin receptor EMBO J 14 1995 2176 2182 7774575 PMC398323 source
- Not checked yetcites [29] Hawtin SR Wesley VJ Parslow RA Patel S Wheatley M Critical role of a subdomain of the N-terminus of the V1a vasopressin receptor for binding agonists but not antagonists; functional rescue by the oxytocin receptor N-terminus Biochemistry 39 2000 13524 33 11063589 source
- Not checked yetcites [30] Kimura T Makino Y Saji F Takemura M Inoue T Kikuchi T Kubota Y Azuma C Nobunaga T Tokugawa Y Molecular characterization of a cloned human oxytocin receptor Eur J Endocrinol 131 1994 385 90 7921228 source
- Not checked yetcites [31] Lolait SJ O’Carroll AM Brownstein MJ Molecular biology of vasopressin receptors Ann N Y Acad Sci 771 1995 273 92 8597406 source
- Not checked yetcites [32] Thibonnier M Coles P Thibonnier A Shoham M The basic and clinical pharmacology of nonpeptide vasopressin receptor antagonists Annu Rev Pharmacol Toxicol 41 2001 175 202 11264455 source
- Not checked yetcites [33] Song Z McCann KE McNeill JK Larkin TE Huhman KL Albers HE Oxytocin induces social communication by activating arginine-vasopressin V1a receptors and not oxytocin receptors Psychoneuroendocrinology 50C 2014 14 19 PMC4252597 25173438 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Also stated in: § 4. Receptor cross-talk in response to exogenously administered peptides · plain
In the paper
“A highly selective OTR agonist failed to induce flank marking and a highly selective OTR antagonist failed to inhibit the induction of flank marking by OT.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [33] Song Z McCann KE McNeill JK Larkin TE Huhman KL Albers HE Oxytocin induces social communication by activating arginine-vasopressin V1a receptors and not oxytocin receptors Psychoneuroendocrinology 50C 2014 14 19 PMC4252597 25173438 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Peripheral administration of a selective OTR antagonist, but not a selective V1aR antagonist, inhibits OT- and AVP-induced increases in social investigation suggesting that both peptides are acting through the OTR [49].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 2. Cross-talk between OT and AVP administered peripherally > 2.2 AVP acting via OTRs
What the sources say
- Not checked yetcites [49] Ramos L Hicks C Caminer A Couto K Narlawar R Kassiou M McGregor IS MDMA (‘Ecstasy’), oxytocin and vasopressin modulate social preference in rats: A role for handling and oxytocin receptors Pharmacol Biochem Behav 150–151 2016 115 123 27725273 source
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“In OTR null mice social exploration and social recognition are reduced, while aggression is increased when compared to wild-type mice.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [53] Sala M Braida D Lentini D Busnelli M Bulgheroni E Capurro V Finardi A Donzelli A Pattini L Rubino T Parolaro D Nishimori K Parenti M Chini B Pharmacologic rescue of impaired cognitive flexibility, social deficits, increased aggression, and seizure susceptibility in oxytocin receptor null mice: a neurobehavioral model of autism Biol Psychiatry 69 2011 875 882 21306704 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“A highly selective OTR but not a highly selective V1aR antagonist significantly reduced the duration of social recognition suggesting that OT and AVP regulate social recognition by acting on OTRs.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.2 AVP acting via OTRs
What the sources say
- Not checked yetcites [65] Song Z Larkin TE Malley MO Albers HE Oxytocin (OT) and arginine-vasopressin (AVP) act on OT receptors and not AVP V1a receptors to enhance social recognition in adult Syrian hamsters (Mesocricetus auratus) Horm Behav 81 2016 20 7 26975586 source
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Peripheral administration of either OT or AVP also increases social huddling in response to threatening stimuli (i.e., cat fur) and these effects are inhibited by a selective V1aR antagonist [45].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 2. Cross-talk between OT and AVP administered peripherally > 2.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [45] Bowen MT McGregor IS Oxytocin and vasopressin modulate the social response to threat: a preclinical study Int J Neuropsychopharmacol 17 2014 1621 1633 24807123 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“When housed in winter-like conditions female voles form partner preferences for other females. Injection of OT into the lateral septum prevents the formation of these partner preferences, an effect that is blocked by co-administration of OT with a V1aR but not an OTR antagonist.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [54] Anacker AM Christensen JD LaFlamme EM Grunberg DM Beery AK Septal oxytocin administration impairs peer affiliation via V1a receptors in female meadow voles Psychoneuroendocrinology 68 2016 156 62 26974500 PMC4851907 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“A selective V1aR, but not an OTR antagonist, inhibits adjacent lying following peripheral administration of OT or AVP.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 2. Cross-talk between OT and AVP administered peripherally > 2.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [44] Ramos L Hicks C Kevin R Caminer A Narlawar R Kassiou M McGregor IS Acute prosocial effects of oxytocin and vasopressin when given alone or in combination with 3,4-methylenedioxymethamphetamine in rats: involvement of the V1A receptor Neuropsychopharmacology 38 2013 2249 59 23676791 PMC3773675 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“In contrast, not only did a selective V1aR agonist induce flank marking, a selective V1aR antagonist inhibited the ability of OT to induce flank marking.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [33] Song Z McCann KE McNeill JK Larkin TE Huhman KL Albers HE Oxytocin induces social communication by activating arginine-vasopressin V1a receptors and not oxytocin receptors Psychoneuroendocrinology 50C 2014 14 19 PMC4252597 25173438 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Both OT and AVP administered peripherally also increase social investigation in male rats.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 2. Cross-talk between OT and AVP administered peripherally > 2.2 AVP acting via OTRs
What the sources say
- Not checked yetcites [49] Ramos L Hicks C Caminer A Couto K Narlawar R Kassiou M McGregor IS MDMA (‘Ecstasy’), oxytocin and vasopressin modulate social preference in rats: A role for handling and oxytocin receptors Pharmacol Biochem Behav 150–151 2016 115 123 27725273 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Although both OT and AVP inhibit neuronal signaling in dorsal root ganglia, these effects can be inhibited by a selective V1aR antagonist but not by an OTR antagonist.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 2. Cross-talk between OT and AVP administered peripherally > 2.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [41] Qiu F Qiu CY Cai H Liu TT Qu ZW Yang Z Li JD Zhou QY Hu WP Oxytocin inhibits the activity of acid-sensing ion channels through the vasopressin, V1A receptor in primary sensory neurons Br J Pharmacol 171 2014 3065 76 24641084 PMC4055206 source
- Not checked yetcites [42] Kubo A Shinoda M Katagiri A Takeda M Suzuki T Asaka J Yeomans DC Iwata K Oxytocin alleviates orofacial mechanical hypersensitivity associated with infraorbital nerve injury through vasopressin-1A receptors of the rat trigeminal ganglia Pain 158 2017 649 659 28072605 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“While intracerebroventricular (ICV) injection of OT or AVP can restore wild-type levels of these behaviors, the effects of OT and AVP are inhibited by a selective V1aR antagonist.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [53] Sala M Braida D Lentini D Busnelli M Bulgheroni E Capurro V Finardi A Donzelli A Pattini L Rubino T Parolaro D Nishimori K Parenti M Chini B Pharmacologic rescue of impaired cognitive flexibility, social deficits, increased aggression, and seizure susceptibility in oxytocin receptor null mice: a neurobehavioral model of autism Biol Psychiatry 69 2011 875 882 21306704 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Both OT and AVP induce flank marking in a dose-dependent manner, although AVP is around 100-fold more potent than OT in inducing the behavior (Figure 5).”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 3.0 Cross-talk between OT and AVP administered in the brain > 3.1 OT acting via V1aRs
What the sources say
- Not checked yetcites [33] Song Z McCann KE McNeill JK Larkin TE Huhman KL Albers HE Oxytocin induces social communication by activating arginine-vasopressin V1a receptors and not oxytocin receptors Psychoneuroendocrinology 50C 2014 14 19 PMC4252597 25173438 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“There is also evidence to suggest that OT can act on V1bRs as well as OTRs and that AVP can act on OTRs as well as V1bRs to induce glucagon secretion from pancreatic islet cells in male mice [52].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 2. Cross-talk between OT and AVP administered peripherally > 2.3 OT acting via V1bRs
What the sources say
- Not checked yetcites [52] Fujiwara Y Hiroyama M Sanbe A Yamauchi J Tsujimoto G Tanoue A Mutual regulation of vasopressin- and oxytocin-induced glucagon secretion in V1b vasopressin receptor knockout mice J Endocrinol 192 2007 361 9 17283236 source
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“There is considerable evidence that exogenously administered OT can act on V1aRs in the periphery and several examples that exogenously administered AVP can act on peripheral OTRs to influence both physiological and behavioral endpoints.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 4. Receptor cross-talk in response to exogenously administered peptides
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In the brain, there is strong support for the hypothesis that OT can act on V1aRs and that AVP can act on OTRs to influence several different behaviors.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 4. Receptor cross-talk in response to exogenously administered peptides
boosteddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“These data have, however, found OT and AVP can have differential effects on neural activity (i.e., BOLD fMRI responses) and cognition, at least in some cases although the effects of OT are more robust [84; 86; 87; 88; 89; 90].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 4. Receptor cross-talk in response to exogenously administered peptides
What the sources say
- Not checked yetcites [84] Rilling JK DeMarco AC Hackett PD Thompson R Ditzen B Patel R Pagnoni G Effects of intranasal oxytocin and vasopressin on cooperative behavior and associated brain activity in men Psychoneuroendocrinology 37 2012 447 461 21840129 PMC3251702 source
- Not checked yetcites [86] Chen X Hackett PD DeMarco AC Feng C Stair S Haroon E Ditzen B Pagnoni G Rilling JK Effects of oxytocin and vasopressin on the neural response to unreciprocated cooperation within brain regions involved in stress and anxiety in men and women Brain Imaging Behav 10 2016 581 93 26040978 PMC4670292 source
- Not checked yetcites [87] Patel N Grillon C Pavletic N Rosen D Pine DS Ernst M Oxytocin and vasopressin modulate risk-taking Physiol Behav 139 2015 254 60 25446228 PMC4274653 source
- Not checked yetcites [88] Rilling JK Demarco AC Hackett PD Chen X Gautam P Stair S Haroon E Thompson R Ditzen B Patel R Pagnoni G Sex differences in the neural and behavioral response to intranasal oxytocin and vasopressin during human social interaction Psychoneuroendocrinology 39 2014 237 48 24157401 PMC3842401 source
- Not checked yetcites [89] Feng C Hackett PD DeMarco AC Chen X Stair S Haroon E Ditzen B Pagnoni G Rilling JK Oxytocin and vasopressin effects on the neural response to social cooperation are modulated by sex in humans Brain Imaging Behav 9 2015 754 64 25416642 source
- Not checked yetcites [90] Li T Chen X Mascaro J Haroon E Rilling JK Intranasal oxytocin, but not vasopressin, augments neural responses to toddlers in human fathers Horm Behav 2017 PMC5565399 28161387 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“The commonly used intranasal concentrations of OT and AVP (i.e., 20 IU to 40 IU) produce high, supraphysiological levels of peptide in the periphery, and these concentrations are likely high enough to also produce biologically active levels in the brain [2].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 4. Receptor cross-talk in response to exogenously administered peptides
What the sources say
- Not checked yetcites [2] Leng G Ludwig M Intranasal Oxytocin: Myths and Delusions Biol Psychiatry 79 2016 243 50 26049207 source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Because OT and AVP as well as their canonical receptors display strikingly similar chemical structures, it is not surprising that there can be substantial cross-talk between these peptides and OTRs and V1aRs [79].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 4. Receptor cross-talk in response to exogenously administered peptides
What the sources say
- Not checked yetcites [79] Ragnauth AK Goodwillie A Brewer C Muglia LJ Pfaff DW Kow LM Vasopressin stimulates ventromedial hypothalamic neurons via oxytocin receptors in oxytocin gene knockout male and female mice Neuroendocrinology 80 2004 92 9 15528951 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“There is also some evidence to suggest that OT and AVP act exclusively on V1aRs to influence some behaviors (e.g., social communication) and that OT and AVP act exclusively on OTRs to influence other behaviors (e.g., social reward).”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 4. Receptor cross-talk in response to exogenously administered peptides
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The potential for receptor cross-talk would likely be reduced by local synaptic release of neuropeptide and the anatomical segregation of OT and AVP receptors.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 5. Is there cross-talk in response to endogenously released OT and AVP?
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Thus, differences in the effects of OT and AVP could simply be the result of different doses and/or differences in the selectivity of OTRs for OT in humans.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 4. Receptor cross-talk in response to exogenously administered peptides
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“If the presence of both OT and AVP receptors in the same synaptic regions is rare then the possibility of cross-talk following synaptic release of these neuropeptides would seem unlikely, with the exception of when these neuropeptides spillover beyond synaptic regions (i.e., synaptic spillover).”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 6. Conclusions
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“A major source of non-synaptically released OT and AVP is the magnocellular neurons in the hypothalamus, although there is also evidence that hypothalamic parvocellular neurons can also release neuropeptides from dense core vesicles non-synaptically [111].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 5. Is there cross-talk in response to endogenously released OT and AVP?
What the sources say
- Not checked yetcites [111] Castel M Morris J Belenky M Non-synaptic and dendritic exocytosis from dense-cored vesicles in the suprachiasmatic nucleus Neuroreport 7 1996 543 7 8730825 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Non-synaptic neuropeptide release is stimulated by Ca2+ coming from intracellular stores (e.g., endoplasmic reticulum) as opposed to synaptic release that is mediated by the influx of extracellular Ca2+ through voltage-gated channels [105].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 5. Is there cross-talk in response to endogenously released OT and AVP?
What the sources say
- Not checked yetcites [105] Buijs RM Van Heerikhuize JJ Vasopressin and oxytocin release in the brain--a synaptic event Brain Res 252 1982 71 6 7172022 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Rather, OT and AVP can activate each other’s receptors, particularly when present at high levels, resulting in the potential for substantial cross-talk between the OT and AVP systems.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 6. Conclusions
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Studies in hamsters have found that ICV or hypothalamic injection of α-MSH induces flank marking behavior and that α-MSH-induced flank marking is blocked by central administration of a selective V1a antagonist [33].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 5. Is there cross-talk in response to endogenously released OT and AVP?
What the sources say
- Not checked yetcites [33] Song Z McCann KE McNeill JK Larkin TE Huhman KL Albers HE Oxytocin induces social communication by activating arginine-vasopressin V1a receptors and not oxytocin receptors Psychoneuroendocrinology 50C 2014 14 19 PMC4252597 25173438 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“As such, it is important to consider the possibility that intranasal administration of OT or AVP produces a global activation of both OT and AVP receptors.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 4. Receptor cross-talk in response to exogenously administered peptides
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds.
None of the sources cited for this claim have been checked yet.
In the paper
“For example, in hamsters the lateral septum contains large numbers of V1aRs but few, if any, AVP containing fibers or cell bodies have been identified with immunohistochemistry [112; 113; 114; 115].”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 5. Is there cross-talk in response to endogenously released OT and AVP?
What the sources say
- Not checked yetcites [112] Johnson AE Barberis C Albers HE Castration reduces vasopressin receptor binding in the hamster hypothalamus Brain Res 674 1995 153 8 7773686 source
- Not checked yetcites [113] Albers HE Rowland CM Ferris CF Arginine-vasopressin immunoreactivity is not altered by photoperiod or gonadal hormones in the Syrian hamster (Mesocricetus auratus) Brain Res 539 1991 137 142 2015498 source
- Not checked yetcites [114] Dubois-Dauphin M Pevet P Tribollet E Dreifuss JJ Vasopressin in the brain of the golden hamster: The distribution of vasopressin binding sites and of immunoreactivity to the vasopressin-related glycopeptide Journal of Comparative Neurology 300 1990 535 548 2148751 source
- Not checked yetcites [115] Young LJ Wang Z Cooper TT Albers HE Vasopressin (V1a) receptor binding, mRNA expression and transcriptional regulation by androgen in the Syrian hamster brain J Neuroendocrinol 12 2000 1179 85 11106975 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Although much more work needs to be done, these data suggest that certain classes of social behavior are mediated by OTRs while other classes of social behavior are mediated by V1aRs.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 6. Conclusions
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Several different social behaviors can be influenced by both OT and AVP, but this influence appears to be mediated by only one of their receptors.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 6. Conclusions
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These high levels of peptide have the potential to result in significant amounts of receptor cross-talk in the periphery as well as in the brain resulting in the activation of large numbers of OT and AVP receptors.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 6. Conclusions
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Rests on an assumption: Intranasal administration of oxytocin and vasopressin produces supraphysiological concentrations of these peptides in peripheral tissues.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“For example, although OT and AVP increase social communication, social recognition, and social reward, the effects of these neuropeptides on social communication are mediated by V1aRs and their effects on social recognition and social reward are mediated by OTRs.”
§ Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery > 6. Conclusions
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
The paper relies on this without support.
Intranasal administration of oxytocin and vasopressin produces supraphysiological concentrations of these peptides in peripheral tissues.
“Intranasal OT and AVP administration, which is currently in use in clinical trials, produces supraphysiological levels of these peptides in peripheral tissues.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“For example, social cognition and reward processing can be mediated by OXT and OXTR, while social communication relies more on arginine-vasopressin (AVP) and its receptor (V1aR; Song and Albers, 2018).”
From Music's context-dependent influence on oxytocin, social bonding, and emotion regulation: a systematic review (2026) · cites this paper as Song and Albers, 2018
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Since OXT and AVP share structural similarities and can activate each other's receptors, this phenomenon, “cross-talk” (Song and Albers, 2018), is likely to participate in shaping social behaviors in musical contexts.”
From Music's context-dependent influence on oxytocin, social bonding, and emotion regulation: a systematic review (2026) · cites this paper as Song and Albers, 2018
In the citing paper
“These radioligands are now known to bind to both receptor types when they are used in primate brain37.”
From Effect of age and autism spectrum disorder on oxytocin receptor density in the human basal forebrain and midbrain (2018) · cites this paper as [48]
Citations
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The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
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Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
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Social amnesia in mice lacking the oxytocin gene
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Evoked axonal oxytocin release in the central amygdala attenuates fear response
Knobloch, H. S., Charlet, A., Hoffmann, L. C., Eliava, M., Khrulev, S., Cetin, A. H., Osten, P., Schwarz, M. K., Seeburg, P. H., Stoop, R., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.030 · Cited by 1,049
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Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior
Ross, H. E., & Young, L. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.004 · Cited by 856 · cited 1×
“The endogenous release of OT and AVP in the brain may be the result of neuropeptide release from synaptic and/or non-synaptic regions of neurons, although the relative roles of these forms of release in different populations of OT and AVP-containing cells are controversial [93; 94; 95; 96].”
BackgroundPervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice
Takayanagi, Y., Yoshida, M., Bielsky, I. F., Ross, H. E., Kawamata, M., Onaka, T., Yanagisawa, T., Kimura, T., Matzuk, M. M., Young, L. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505312102 · Cited by 806
Oxytocin, vasopressin, and human social behavior
Heinrichs, M., von Dawans, B., & Domes, G. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.005 · Cited by 799
Cited by
Sorted by citations
Oxytocin, Neural Plasticity, and Social Behavior
Froemke, R. C., & Young, L. J. (2021) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-102320-102847 · Cited by 480
“Some actions of oxytocin are mediated via vasopressin receptors and vice versa (Chini et al. 2008, Schorscher-Petcu et al. 2010, Xiao et al. 2017, Song & Albers 2018).”
BackgroundIs oxytocin “nature’s medicine”
Carter, C. S., Kenkel, W. M., MacLean, E. L., Wilson, S. R., Perkeybile, A. M., Yee, J. R., Ferris, C. F., Nazarloo, H. P., Porges, S. W., Davis, J. M., et al. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019398 · Cited by 394
AMPK: Potential Therapeutic Target for Ischemic Stroke
Jiang, S., Li, T. X., Ji, T., Yi, W., Yang, Z. P., Wang, S., Yang, Y., & Gu, C. (2018) · Theranostics · doi:10.7150/thno.25674 · Cited by 256
Jensen-Cody, S. O., Flippo, K. H., Claflin, K. E., Yavuz, Y., Sapouckey, S. A., Walters, G. C., Usachev, Y. M., Atasoy, D., Gillum, M. P., & Potthoff, M. J. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.06.008 · Cited by 166
Universal nomenclature for oxytocin–vasotocin ligand and receptor families
Theofanopoulou, C., Gedman, G. L., Cahill, J. A., Boeckx, C. A., & Jarvis, E. D. (2021) · Nature · doi:10.1038/s41586-020-03040-7 · Cited by 125
Metadata
- Authors
- Song, Z., & Albers, H. E.
- Affiliations
- Georgia State University (US)
- Corresponding author
- Albers, H. Elliott
- Venue
- Frontiers in Neuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 51
- Pages
- 14-24
- ISSN
- 0091-3022 (ISSN-L)
- PMC
- PMC5906207
- OpenAlex
- W2767130940
- Semantic Scholar
- 4dbbf2abe3c48e55106808bf85319d02973b36d1
- Cited by
- 244
- References
- 142
- Citations by year
- 2026: 22 · 2025: 32 · 2024: 30 · 2023: 30 · 2022: 25 · 2021: 29 · 2020: 36 · 2019: 18 · 2018: 21
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Frontiers in Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NSF (IOS-0923301)
- NIH (MH110212, MH109302)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, vasopressin, receptor cross-talk, oxytocin receptor, vasopressin receptor, social cognition, social behavior, psychiatric drug development
- MeSH terms
- Animals, Arginine Vasopressin, Mental Disorders, Female, Humans, Male, Oxytocin, Social Behavior, Receptors, Vasopressin, Receptors, Oxytocin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-10-08, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-10-08 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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