Uncoupling protein‐3: a new member of the mitochondrial carrier family with tissue‐specific expression

Brown Adipose Tissue: Function and Physiological Significance

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Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

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Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice

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Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β-cell dysfunction, and type 2 diabetes.

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Uncoupling: new approaches to an old problem of bioenergetics

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Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3

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Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities

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Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells

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Energy metabolism in uncoupling protein 3 gene knockout mice

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Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity.

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Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean

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UCP1: The only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency

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A signalling role for 4‐hydroxy‐2‐nonenal in regulation of mitochondrial uncoupling

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Mitochondrial uncoupling, ROS generation and cardioprotection

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Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function

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Effect of Exercise Intensity, Duration and Mode on Post-Exercise Oxygen Consumption

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Mitochondrial H + Leak and ROS Generation: An Odd Couple

Brookes, P. S. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.10.016 · Cited by 447

Medicinal strategies in the treatment of obesity

Bray, G. A., & Tartaglia, L. A. (2000) · Nature · doi:10.1038/35007544 · Cited by 432

Superoxide Activates Mitochondrial Uncoupling Protein 2 from the Matrix Side

Echtay, K. S., Murphy, M. P., Smith, R. A. J., Talbot, D. A., & Brand, M. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208262200 · Cited by 388

The TRH neuron: a hypothalamic integrator of energy metabolism

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Transport function and regulation of mitochondrial uncoupling proteins 2 and 3

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Uncoupling proteins 2 and 3 are highly active H + transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone)

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Molecular mechanisms linking calorie restriction and longevity

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Regulation of leptin production: sympathetic nervous system interactions

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Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets.

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UCP2 and UCP3 rise in starved rat skeletal muscle but mitochondrial proton conductance is unchanged

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Physiological Increases in Uncoupling Protein 3 Augment Fatty Acid Oxidation and Decrease Reactive Oxygen Species Production Without Uncoupling Respiration in Muscle Cells

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The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3

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Mitochondrial Uncoupling: A Key Contributor to Reduced Cardiac Efficiency in Diabetes

Boudina, S., & Abel, E. D. (2006) · Physiology · doi:10.1152/physiol.00008.2006 · Cited by 199

Fatty acid cycling mechanism and mitochondrial uncoupling proteins

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Obesity, diabetes and the central nervous system

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Glutathionylation Acts as a Control Switch for Uncoupling Proteins UCP2 and UCP3

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A Reservoir of Brown Adipocyte Progenitors in Human Skeletal Muscle

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An alternative function for human uncoupling protein 3: protection of mitochondria against accumulation of nonesterified fatty acids inside the mitochondrial matrix

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Mitochondrial uncoupling and lifespan

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Mitochondrial proton leak and the uncoupling protein 1 homologues

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Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle

Lebon, V., Dufour, S., Petersen, K. F., Ren, J., Jucker, B. M., Slezak, L. A., Cline, G. W., Rothman, D. L., & Shulman, G. I. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200111775 · Cited by 174

The regulation and turnover of mitochondrial uncoupling proteins

Azzu, V., Jastroch, M., Divakaruni, A. S., & Brand, M. D. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.02.035 · Cited by 146

Mitochondrial Dysfunction in COPD Patients with Low Body Mass Index

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Upregulation of uncoupling proteins by oral administration of capsiate, a nonpungent capsaicin analog

Masuda, Y., Haramizu, S., Oki, K., Ohnuki, K., Watanabe, T., Yazawa, S., Kawada, T., Hashizume, S.-I., & Fushiki, T. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00828.2002 · Cited by 143

Regulation of UCP1, UCP2, and UCP3 mRNA Expression in Brown Adipose Tissue, White Adipose Tissue, and Skeletal Muscle in Rats by Estrogen

Pedersen, S. B., Bruun, J. M., Kristensen, K., & Richelsen, B. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5763 · Cited by 134

The efficiency of cellular energy transduction and its implications for obesity

Harper, M.-E., Green, K., & Brand, M. D. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155357 · Cited by 121

Triiodothyronine‐mediated upregulation of UCP2 and UCP3 mRNA expression in human skeletal muscle without coordinated induction of mitochondrial respiratory chain genes

Barbe, P., Larrouy, D., Boulanger, C., Chevillotte, E., Viguerie, N., Thalamas, C., Oliva Trastoy, M., Roques, M., Vidal, H., & Langin, D. (2001) · The FASEB Journal · doi:10.1096/fj.00-0502fje · Cited by 118

The uncoupling protein 2 modulates the cytokine balance in innate immunity☆

ROUSSET, S., EMRE, Y., JOINLAMBERT, O., HURTAUD, C., RICQUIER, D., & CASSARDDOULCIER, A. (2006) · Cytokine · doi:10.1016/j.cyto.2006.07.012 · Cited by 114

Homologues of the uncoupling protein from brown adipose tissue (UCP1): UCP2, UCP3, BMCP1 and UCP4

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Effects of Adenoviral Overexpression of Uncoupling Protein-2 and -3 on Mitochondrial Respiration in Insulinoma Cells**This work was supported by V.A. Medical Research Funds and NIH Grants DK-25295 and HD-29569.

Hong, Y., Fink, B. D., Dillon, J. S., & Sivitz, W. I. (2001) · Endocrinology · doi:10.1210/endo.142.1.7889 · Cited by 107

Physiological Levels of Mammalian Uncoupling Protein 2 Do Not Uncouple Yeast Mitochondria

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Mitochondrial Uncoupling: Role of Uncoupling Protein Anion Carriers and Relationship to Thermogenesis and Weight Control “The Benefits of Losing Control”

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Upregulation of uncoupling protein-3 in skeletal muscle during exercise: a potential antioxidant function

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Decreased fatty acid synthesis due to mitochondrial uncoupling in adipose tissue

Rossmeisl, M., Syrový, I., Baumruk, F., Flachs, P., Janovska, P., & Kopecký, J. (2000) · The FASEB Journal · doi:10.1096/fj.99-0965com · Cited by 89

Human Uncoupling Protein‐3 and Obesity: An Update

Hesselink, M. K. C., Mensink, M., & Schrauwen, P. (2003) · Obesity Research · doi:10.1038/oby.2003.192 · Cited by 85

Increased uncoupling protein 3 content does not affect mitochondrial function in human skeletal muscle in vivo

Hesselink, M. K. C., Greenhaff, P. L., Constantin-Teodosiu, D., Hultman, E., Saris, W. H. M., Nieuwlaat, R., Schaart, G., Kornips, E., & Schrauwen, P. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16653 · Cited by 82

Impact of endotoxin on UCP homolog mRNA abundance, thermoregulation, and mitochondrial proton leak kinetics

Yu, X. X., Barger, J. L., Boyer, B. B., Brand, M. D., Pan, G., & Adams, S. H. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.2.e433 · Cited by 81

Gene Expression Profiling in Vastus Lateralis Muscle During an Acute Exacerbation of COPD

Crul, T., Testelmans, D., Spruit, M., Troosters, T., Gosselink, R., Geeraerts, I., Decramer, M., & Gayan-Ramirez, G. (2010) · Cellular Physiology and Biochemistry · doi:10.1159/000303054 · Cited by 79

Uncoupling Proteins: Role in Insulin Resistance and Insulin Insufficiency

B.Chan, C., & Harper, M.-E. (2006) · Current Diabetes Reviews · doi:10.2174/157339906777950660 · Cited by 71

First evidence and characterization of an uncoupling protein in fungi kingdom: CpUCP of Candida parapsilosis

Jarmuszkiewicz, W., Milani, G., Fortes, F., Schreiber, A. Z., Sluse, F. E., & Vercesi, A. E. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01138-8 · Cited by 67

Mitochondrial uncoupling proteins in mammals and plants

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Insights into brown adipose tissue evolution and function from non-model organisms

Jastroch, M., Oelkrug, R., & Keipert, S. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.169425 · Cited by 55

Expression of UCP3 in CHO cells does not cause uncoupling, but controls mitochondrial activity in the presence of glucose

Mozo, J., Ferry, G., Studeny, A., Pecqueur, C., Rodriguez, M., Boutin, J. A., & Bouillaud, F. (2006) · Biochemical Journal · doi:10.1042/bj20050494 · Cited by 52

Genetic and physiologic analysis of the role of uncoupling protein 3 in human energy homeostasis.

Chung, W. K., Luke, A., Cooper, R. S., Rotini, C., Vidal-Puig, A., Rosenbaum, M., Chua, M., Solanes, G., Zheng, M., Zhao, L., et al. (1999) · Diabetes · doi:10.2337/diabetes.48.9.1890 · Cited by 48

Fasting, lipid metabolism, and triiodothyronine in rat gastrocnemius muscle: interrelated roles of uncoupling protein 3, mitochondrial thioesterase, and coenzyme Q

Moreno, M., Lombardi, A., De Lange, P., Silvestri, E., Ragni, M., Lanni, A., & Goglia, F. (2003) · The FASEB Journal · doi:10.1096/fj.02-0839fje · Cited by 42

Uncoupling Protein-3 Content Is Decreased in Peripheral Skeletal Muscle of Patients with COPD

Gosker, H. R., Schrauwen, P., Hesselink, M. K. C., Schaart, G., van der Vusse, G. J., Wouters, E. F. M., & Schols, A. M. W. J. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00089802 · Cited by 42

Expression of uncoupling protein 3 is upregulated in skeletal muscle during sepsis

Sun, X., Wray, C., Tian, X., Hasselgren, P.-O., & Lu, J. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00446.2002 · Cited by 36

Reconstitution of novel mitochondrial uncoupling proteins UCP2 and UCP3

Žáčkova, M., & Ježek, P. (2002) · Bioscience Reports · doi:10.1023/a:1016009022186 · Cited by 25