Statins and the risk of dementia

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Brain Infarction and the Clinical Expression of Alzheimer Disease<subtitle>The Nun Study</subtitle>

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Increased caveolin-1 expression in Alzheimer’s disease brain

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Association of Early-Onset Alzheimer Disease With Elevated Low-Density Lipoprotein Cholesterol Levels and Rare Genetic Coding Variants of APOB

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Neuroinflammation: a potential therapeutic target

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Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's disease

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Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer’s disease mouse models with abundant Aβ in plasma

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Cholesterol and Alzheimer’s Disease Risk: A Meta-Meta-Analysis

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Lipids and Cognition

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Lack of LDL receptor aggravates learning deficits and amyloid deposits in Alzheimer transgenic mice

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The effects of ABCA1 on cholesterol efflux and Aβ levels in vitro and in vivo

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Association of Aortic Atherosclerosis with Cerebral β-Amyloidosis and Learning Deficits in a Mouse Model of Alzheimer's Disease

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Lipid metabolism in Alzheimer’s disease

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Statins use and risk of depression: A systematic review and meta-analysis

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Atorvastatin and pitavastatin improve cognitive function and reduce senile plaque and phosphorylated tau in aged APP mice

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Cholesterol-independent Effects of Statins and New Therapeutic Targets: Ischemic Stroke and Dementia

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Greasing the wheels of Aβ clearance in Alzheimer's Disease: The role of lipids and apolipoprotein E

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Lipid metabolism and neuroinflammation in Alzheimer’s disease: a role for liver X receptors

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Cholesterol as a key player in amyloid β-mediated toxicity in Alzheimer’s disease

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Cholesterol and statins in Alzheimer’s disease: current controversies.

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Type 2 diabetes, related conditions, in relation and dementia: An opportunity for prevention?

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Role of amyloid beta in lipid homeostasis

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Effect of statins on Alzheimer’s disease biomarkers in cerebrospinal fluid

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Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and Alzheimer disease risk: a meta-analysis.

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A potential role for alterations of zinc and zinc transport proteins in the progression of Alzheimer's disease

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Statins reduce the neurofibrillary tangle burden in a mouse model of tauopathy

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The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimers Disease

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Independent Cognitive Effects of Atrophy and Diffuse Subcortical and Thalamico-Cortical Cerebrovascular Disease in Dementia

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Imaging of cerebrovascular pathology in animal models of Alzheimer's disease

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Statin use and risk of depression: a Swedish national cohort study

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Statins use and risk of dementia: A dose–response meta analysis

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Biliverdin reductase‐A: a novel drug target for atorvastatin in a dog pre‐clinical model of Alzheimer disease

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Cholesterol in neurologic disorders of the elderly: stroke and Alzheimer’s disease

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Neuroinflammation in Alzheimer’s disease: Pleiotropic roles for cytokines and neuronal pentraxins

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Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes

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ApoER2 expression increases Aβ production while decreasing Amyloid Precursor Protein (APP) endocytosis: possible role in the partitioning of APP into lipid rafts and in the regulation of γ-secretase activity

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Simvastatin is the Statin that Most Efficiently Protects Against Kainate-Induced Excitotoxicity and Memory Impairment

Ramirez, C., Tercero, I., Pineda, A., & Burgos, J. S. (2011) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-101653 · Cited by 67

Anti-inflammatory and Immune Therapy for Alzheimers Disease: Current Status and Future Directions

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Cholesterol homeostasis failure in the brain: Implications for synaptic dysfunction and cognitive decline

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Membrane dynamics, cholesterol homeostasis, and Alzheimer's disease

Chauhan, N. B. (2003) · Journal of Lipid Research · doi:10.1194/jlr.r300010-jlr200 · Cited by 64

Alzheimer's disease--a dysfunction in cholesterol and lipid metabolism

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Proprotein convertase subtilisin/kexin type 9 (PCSK9) in Alzheimer’s disease: a genetic and proteomic multi-cohort study

Picard, C., Poirier, A., Bélanger, S., Labonté, A., Auld, D., Poirier, J., & on behalf of the PREVENT-AD Research Group (2019) · PLOS ONE · doi:10.1371/journal.pone.0220254 · Cited by 59

Guidelines for the treatment of Alzheimer’s disease from the Italian Association of Psychogeriatrics

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ApoAI deficiency results in marked reductions in plasma cholesterol but no alterations in amyloid-β pathology in a mouse model of Alzheimer's disease-like cerebral amyloidosis

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ACAT inhibition and amyloid beta reduction

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The role of DHCR24 in the pathogenesis of AD: re-cognition of the relationship between cholesterol and AD pathogenesis

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Genetic association of low density lipoprotein receptor and Alzheimer's disease

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Pitavastatin decreases tau levels via the inactivation of Rho/ROCK

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LDL receptor knock-out mice show impaired spatial cognition with hippocampal vulnerability to apoptosis and deficits in synapses

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Statins: drugs for Alzheimer’s disease?

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Cognitive Performance and Plasma Levels of Homocysteine, Vitamin B12, Folate and Lipids in Patients with Alzheimer Disease

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Angiopoietin like-4 as a novel vascular mediator in capillary cerebral amyloid angiopathy

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ACAT as a drug target for Alzheimer’s disease

Huttunen, H. J., & Kovacs, D. M. (2008) · Neurodegenerative Diseases · doi:10.1159/000113705 · Cited by 43

Do statins prevent Alzheimer's disease? A narrative review

Daneschvar, H. L., Aronson, M. D., & Smetana, G. W. (2015) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2015.08.012 · Cited by 42

High-risk elderly patients PROSPER from cholesterol-lowering therapy

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Cholesterol-lowering drugs reduce APP processing to Aβ by inducing APP dimerization

Langness, V. F., van der Kant, R., Das, U., Wang, L., Chaves, R. D. S., & Goldstein, L. S. B. (2021) · Molecular Biology of the Cell · doi:10.1091/mbc.e20-05-0345 · Cited by 41

Anti-amyloidogenic effect of Allium sativum in Alzheimer’s transgenic model Tg2576

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Age-related influence of the HDL receptor SR-BI on synaptic plasticity and cognition

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Dietary Cholesterol and Its Effect on Tau Protein: A Study in Apolipoprotein E-Deficient and P301L Human Tau Mice

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Cholesterol and Alzheimer's disease

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Do Statins Have Antidepressant Effects?

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Progress in the development of new drugs in Alzheimer's disease

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Systematic review of the efficacy of statins for the treatment of Alzheimer’s disease

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CETP polymorphisms influence cholesterol metabolism but not Alzheimer's disease risk

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Impact of Statin Use on Dementia Incidence in Elderly Men and Women with Ischemic Heart Disease

Kim, M.-Y., Jung, M., Noh, Y., Shin, S., Hong, C. H., Lee, S., & Jung, Y.-S. (2020) · Biomedicines · doi:10.3390/biomedicines8020030 · Cited by 23

Is the distinction between Alzheimer's disease and vascular dementia possible and relevant?

Ravona-Springer, R., Davidson, M., & Noy, S. (2003) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2003.5.1/rravonaspringer · Cited by 18

Cyclopamine Modulates γ-Secretase-mediated Cleavage of Amyloid Precursor Protein by Altering Its Subcellular Trafficking and Lysosomal Degradation

Vorobyeva, A. G., Lee, R., Miller, S., Longen, C., Sharoni, M., Kandelwal, P. J., Kim, F. J., Marenda, D. R., & Saunders, A. J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.591792 · Cited by 16

Association analysis of genes involved in cholesterol metabolism located within the linkage region on chromosome 10 and Alzheimer’s disease

Riemenschneider, M., Mahmoodzadeh, S., Eisele, T., Klopp, N., Schwarz, S., Wagenpfeil, S., Diehl, J., Mueller, U., Foerstl, H., Illig, T., et al. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.01.001 · Cited by 14

ACAT1 as a Therapeutic Target and its Genetic Relationship with Alzheimer's Disease

Alavez-Rubio, J. S., & Juarez-Cedillo, T. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666190823125245 · Cited by 12

Systematic Review of Atorvastatin for the Treatment of Alzheimer's Disease

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