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Alzheimer’s disease

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PLEIOTROPIC EFFECTS OF STATINS

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Vascular cognitive impairment

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Subcortical ischaemic vascular dementia

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Brain Cholesterol: Long Secret Life Behind a Barrier

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Linking lipids to Alzheimer's disease: cholesterol and beyond

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Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts

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Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo

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The safety of statins in clinical practice

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Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10

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Aggregation of vascular risk factors and risk of incident Alzheimer disease

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Alzheimer’s disease: the cholesterol connection

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Statin Adverse Effects: A Review of the Literature and Evidence for a Mitochondrial Mechanism

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Vascular factors and risk of dementia: design of the Three-City Study and baseline characteristics of the study population.

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Is Breakdown of the Blood-Brain Barrier Responsible for Lacunar Stroke, Leukoaraiosis, and Dementia?

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NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo

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Mevalonate pathway: A review of clinical and therapeutical implications

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Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins

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Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

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The Alzheimer's disease Beta-secretase enzyme, BACE1

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Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics

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How does diabetes accelerate Alzheimer disease pathology?

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Statins for the prevention of dementia

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Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis

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Lipoprotein receptors in the nervous system

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A novel anti-inflammatory role for simvastatin in inflammatory arthritis.

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Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe

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High total cholesterol levels in late life associated with a reduced risk of dementia

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Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study

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Cellular Cholesterol Depletion Triggers Shedding of the Human Interleukin-6 Receptor by ADAM10 and ADAM17 (TACE)

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Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease

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Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors

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Exclusively targeting β-secretase to lipid rafts by GPI-anchor addition up-regulates β-site processing of the amyloid precursor protein

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Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains

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Isoprenoids as mediators of the biological effects of statins

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Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases

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Type 2 Diabetes as a Risk Factor for Alzheimer's Disease: The Confounders, Interactions, and Neuropathology Associated With This Relationship

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Diet and risk of dementia: Does fat matter?: The Rotterdam Study

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Atorvastatin for the Treatment of Mild to Moderate Alzheimer Disease: Preliminary Results

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Loss of apolipoprotein E receptor LR11 in Alzheimer disease

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Cholesterol and the Biology of Alzheimer's Disease

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Outcomes in 45 Patients With Statin-Associated Myopathy

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Oxysterols and neurodegenerative diseases

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Associations Between Serum Cholesterol Levels and Cerebral Amyloidosis

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Statin Safety: An Overview and Assessment of the Data—2005

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Compartmentalization of β-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

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Statins and Cognitive Function: A Systematic Review

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Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology

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Membrane rafts in Alzheimer's disease beta-amyloid production

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Mechanisms of Statin-mediated Inhibition of Small G-protein Function

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Cardiovascular risk factors and dementia

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Mechanisms for cellular cholesterol transport: Defects and human disease

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Cholesterol and Alzheimer’s Disease; From Risk Genes to Pathological Effects

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Neuropsychological Contributions to the Early Identification of Alzheimer’s Disease

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Associations of Anti-Hypertensive Treatments with Alzheimer's Disease, Vascular Dementia, and Other Dementias

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Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice

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Alzheimer disease and Down syndrome: factors in pathogenesis

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Regulation of Cholesterol Homeostasis by the Liver X Receptors in the Central Nervous System

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Statin use and risk of dementia or Alzheimer's disease: a systematic review and meta-analysis of observational studies

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Statins for the prevention of dementia

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Combination Therapy in Alzheimer???s Disease: A Review of Current Evidence

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Statins Reduce Amyloid-β Production through Inhibition of Protein Isoprenylation

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Expression of Liver X Receptor Target Genes Decreases Cellular Amyloid β Peptide Secretion

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Ontogenesis and regulation of cholesterol metabolism in the central nervous system of the mouse

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Alzheimer's disease: the lipid connection

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Liver X Receptor Agonist Treatment Ameliorates Amyloid Pathology and Memory Deficits Caused by High-Fat Diet in APP23 Mice

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Neuroplasticity in Alzheimer's disease

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ABCA1 and Scavenger Receptor Class B, Type I, Are Modulators of Reverse Sterol Transport at an in Vitro Blood-Brain Barrier Constituted of Porcine Brain Capillary Endothelial Cells

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Apolipoprotein E and cholesterol in aging and disease in the brain

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Alzheimer disease therapy: Can the amyloid cascade be halted?

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Sex and race differences in the association between statin use and the incidence of Alzheimer disease

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Age-dependent rescue by simvastatin of Alzheimer’s disease cerebrovascular and memory deficits

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Brain cholesterol in normal and pathological aging

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The involvement of lipid rafts in Alzheimer's disease (Review)

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Role of Vascular Risk Factors and Vascular Dysfunction in Alzheimer's Disease

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Modulation of Statin-Activated Shedding of Alzheimer APP Ectodomain by ROCK

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Vascular Dementia Prevention: A Risk Factor Analysis

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Clinical implications for statin pleiotropy

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LR11/SorLA Expression Is Reduced in Sporadic Alzheimer Disease but not in Familial Alzheimer Disease

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Statins: Multiple neuroprotective mechanisms in neurodegenerative diseases

Wang, Q., Yan, J., Chen, X., Li, J., Yang, Y., Weng, J., Deng, C., & Yenari, M. A. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2010.04.006 · Cited by 130

The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease: It's time for reconciliation

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Apolipoprotein E Recycling: Implications for Dyslipidemia and Atherosclerosis

Heeren, J., Beisiegel, U., & Grewal, T. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000201282.64751.47 · Cited by 123

Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease

Marzolo, M.-P., & Bu, G. (2009) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2008.10.005 · Cited by 122

Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice

Tong, X.-K., Nicolakakis, N., Fernandes, P., Ongali, B., Brouillette, J., Quirion, R., & Hamel, E. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.06.003 · Cited by 122

Circulating Biomarkers of Cognitive Decline and Dementia

Solfrizzi, V., D'Introno, A., Colacicco, A. M., Capurso, C., Todarello, O., Pellicani, V., Capurso, S. A., Pietrarossa, G., Santamato, V., Capurso, A., et al. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2005.06.015 · Cited by 120