Spherical Nucleic Acids

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429

The Optical Properties of Metal Nanoparticles: The Influence of Size, Shape, and Dielectric Environment

Kelly, K. L., Coronado, E., Zhao, L. L., & Schatz, G. C. (2003) · The Journal of Physical Chemistry B · doi:10.1021/jp026731y · Cited by 10,594

In vitro selection of RNA molecules that bind specific ligands

Ellington, A. D., & Szostak, J. W. (1990) · Nature · doi:10.1038/346818a0 · Cited by 9,812

Crystal structure of the nucleosome core particle at 2.8 Å resolution

Luger, K., Mäder, A. W., Richmond, R. K., Sargent, D. F., & Richmond, T. J. (1997) · Nature · doi:10.1038/38444 · Cited by 9,466

Semiconductor Nanocrystals as Fluorescent Biological Labels

Bruchez, M., Moronne, M., Gin, P., Weiss, S., & Alivisatos, A. P. (1998) · Science · doi:10.1126/science.281.5385.2013 · Cited by 8,613

Controlled Nucleation for the Regulation of the Particle Size in Monodisperse Gold Suspensions

FRENS, G. (1973) · Nature Physical Science · doi:10.1038/physci241020a0 · Cited by 8,336

A DNA-based method for rationally assembling nanoparticles into macroscopic materials

Mirkin, C. A., Letsinger, R. L., Mucic, R. C., & Storhoff, J. J. (1996) · Nature · doi:10.1038/382607a0 · Cited by 6,683

Shape‐Controlled Synthesis of Metal Nanocrystals: Simple Chemistry Meets Complex Physics?

Xia, Y., Xiong, Y., Lim, B., & Skrabalak, S. E. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200802248 · Cited by 5,702

Preparation and Growth Mechanism of Gold Nanorods (NRs) Using Seed-Mediated Growth Method

Nikoobakht, B., & El-Sayed, M. A. (2003) · Chemistry of Materials · doi:10.1021/cm020732l · Cited by 5,069

Determining the Size and Shape Dependence of Gold Nanoparticle Uptake into Mammalian Cells

Chithrani, B. D., Ghazani, A. A., & Chan, W. C. W. (2006) · Nano Letters · doi:10.1021/nl052396o · Cited by 4,879

Nanostructures in Biodiagnostics

Rosi, N. L., & Mirkin, C. A. (2005) · Chemical Reviews · doi:10.1021/cr030067f · Cited by 4,603

Selective Colorimetric Detection of Polynucleotides Based on the Distance-Dependent Optical Properties of Gold Nanoparticles

Elghanian, R., Storhoff, J. J., Mucic, R. C., Letsinger, R. L., & Mirkin, C. A. (1997) · Science · doi:10.1126/science.277.5329.1078 · Cited by 4,399

Nanoparticle therapeutics: an emerging treatment modality for cancer

Davis, M. E., Chen, Z., & Shin, D. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2614 · Cited by 4,233

Organization of 'nanocrystal molecules' using DNA

Alivisatos, A. P., Johnsson, K. P., Peng, X., Wilson, T. E., Loweth, C. J., Bruchez, M. P., & Schultz, P. G. (1996) · Nature · doi:10.1038/382609a0 · Cited by 2,962

DNA in a material world

Seeman, N. C. (2003) · Nature · doi:10.1038/nature01406 · Cited by 2,782

Scanometric DNA Array Detection with Nanoparticle Probes

Taton, T. A., Mirkin, C. A., & Letsinger, R. L. (2000) · Science · doi:10.1126/science.289.5485.1757 · Cited by 2,411

Nanoparticle-Based Bio-Bar Codes for the Ultrasensitive Detection of Proteins

Nam, J.-M., Thaxton, C. S., & Mirkin, C. A. (2003) · Science · doi:10.1126/science.1088755 · Cited by 2,390

Nonviral vectors for gene delivery

Mintzer, M. A., & Simanek, E. E. (2009) · Chemical Reviews · doi:10.1021/cr800409e · Cited by 2,366

Gold Nanoparticles for Biology and Medicine

Giljohann, D. A., Seferos, D. S., Daniel, W. L., Massich, M. D., Patel, P. C., & Mirkin, C. A. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200904359 · Cited by 2,356

One-Pot Colorimetric Differentiation of Polynucleotides with Single Base Imperfections Using Gold Nanoparticle Probes

Storhoff, J. J., Elghanian, R., Mucic, R. C., Mirkin, C. A., & Letsinger, R. L. (1998) · Journal of the American Chemical Society · doi:10.1021/ja972332i · Cited by 2,271

THE PRINCIPLES DETERMINING THE STRUCTURE OF COMPLEX IONIC CRYSTALS

Pauling, L. (1929) · Journal of the American Chemical Society · doi:10.1021/ja01379a006 · Cited by 2,025

Oligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation

Rosi, N. L., Giljohann, D. A., Thaxton, C. S., Lytton-Jean, A. K. R., Han, M. S., & Mirkin, C. A. (2006) · Science · doi:10.1126/science.1125559 · Cited by 1,988

Particle size-dependent organ distribution of gold nanoparticles after intravenous administration

De Jong, W. H., Hagens, W. I., Krystek, P., Burger, M. C., Sips, A. J. A. M., & Geertsma, R. E. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2007.12.037 · Cited by 1,615

DNA-guided crystallization of colloidal nanoparticles

Nykypanchuk, D., Maye, M. M., van der Lelie, D., & Gang, O. (2008) · Nature · doi:10.1038/nature06560 · Cited by 1,530

A molecular ruler based on plasmon coupling of single gold and silver nanoparticles

Sönnichsen, C., Reinhard, B. M., Liphardt, J., & Alivisatos, A. P. (2005) · Nature Biotechnology · doi:10.1038/nbt1100 · Cited by 1,523

DNA-programmable nanoparticle crystallization

Park, S. Y., Lytton-Jean, A. K. R., Lee, B., Weigand, S., Schatz, G. C., & Mirkin, C. A. (2008) · Nature · doi:10.1038/nature06508 · Cited by 1,515

What Controls the Melting Properties of DNA-Linked Gold Nanoparticle Assemblies?

Jin, R., Wu, G., Li, Z., Mirkin, C. A., & Schatz, G. C. (2003) · Journal of the American Chemical Society · doi:10.1021/ja021096v · Cited by 1,359

A Colorimetric Lead Biosensor Using DNAzyme-Directed Assembly of Gold Nanoparticles

Liu, J., & Lu, Y. (2003) · Journal of the American Chemical Society · doi:10.1021/ja034775u · Cited by 1,347

Colorimetric Detection of Mercuric Ion (Hg2+) in Aqueous Media using DNA‐Functionalized Gold Nanoparticles

Lee, J., Han, M. S., & Mirkin, C. A. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200700269 · Cited by 1,308

Maximizing DNA Loading on a Range of Gold Nanoparticle Sizes

Hurst, S. J., Lytton-Jean, A. K. R., & Mirkin, C. A. (2006) · Analytical Chemistry · doi:10.1021/ac0613582 · Cited by 1,214

DNA Origami with Complex Curvatures in Three-Dimensional Space

Han, D., Pal, S., Nangreave, J., Deng, Z., Liu, Y., & Yan, H. (2011) · Science · doi:10.1126/science.1202998 · Cited by 1,214

Templated Techniques for the Synthesis and Assembly of Plasmonic Nanostructures

Jones, M. R., Osberg, K. D., Macfarlane, R. J., Langille, M. R., & Mirkin, C. A. (2011) · Chemical Reviews · doi:10.1021/cr1004452 · Cited by 1,159

Nanoparticle Superlattice Engineering with DNA

Macfarlane, R. J., Lee, B., Jones, M. R., Harris, N., Schatz, G. C., & Mirkin, C. A. (2011) · Science · doi:10.1126/science.1210493 · Cited by 1,137

Fast Colorimetric Sensing of Adenosine and Cocaine Based on a General Sensor Design Involving Aptamers and Nanoparticles

Liu, J., & Lu, Y. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200502589 · Cited by 956

Synthesis and Characterization of Hydrophobic, Organically-Soluble Gold Nanocrystals Functionalized with Primary Amines

Leff, D. V., Brandt, L., & Heath, J. R. (1996) · Langmuir · doi:10.1021/la960445u · Cited by 924

Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer’s disease

Georganopoulou, D. G., Chang, L., Nam, J.-M., Thaxton, C. S., Mufson, E. J., Klein, W. L., & Mirkin, C. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409336102 · Cited by 835

Nanomedicine: Developing smarter therapeutic and diagnostic modalities☆

FAROKHZAD, O., & LANGER, R. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.011 · Cited by 800

Observation of a Quadrupole Plasmon Mode for a Colloidal Solution of Gold Nanoprisms

Millstone, J. E., Park, S., Shuford, K. L., Qin, L., Schatz, G. C., & Mirkin, C. A. (2005) · Journal of the American Chemical Society · doi:10.1021/ja043245a · Cited by 756

Bio-Bar-Code-Based DNA Detection with PCR-like Sensitivity

Nam, J.-M., Stoeva, S. I., & Mirkin, C. A. (2004) · Journal of the American Chemical Society · doi:10.1021/ja049384+ · Cited by 744

An SNP map of the human genome generated by reduced representation shotgun sequencing

Altshuler, D., Pollara, V. J., Cowles, C. R., Van Etten, W. J., Baldwin, J., Linton, L., & Lander, E. S. (2000) · Nature · doi:10.1038/35035083 · Cited by 729

Nano-Flares: Probes for Transfection and mRNA Detection in Living Cells

Seferos, D. S., Giljohann, D. A., Hill, H. D., Prigodich, A. E., & Mirkin, C. A. (2007) · Journal of the American Chemical Society · doi:10.1021/ja0776529 · Cited by 710

Programmed Assembly of DNA Functionalized Quantum Dots

Mitchell, G. P., Mirkin, C. A., & Letsinger, R. L. (1999) · Journal of the American Chemical Society · doi:10.1021/ja991662v · Cited by 685

Rapid Aggregation of Gold Nanoparticles Induced by Non-Cross-Linking DNA Hybridization

Sato, K., Hosokawa, K., & Maeda, M. (2003) · Journal of the American Chemical Society · doi:10.1021/ja034876s · Cited by 663

DNA-nanoparticle superlattices formed from anisotropic building blocks

Jones, M. R., Macfarlane, R. J., Lee, B., Zhang, J., Young, K. L., Senesi, A. J., & Mirkin, C. A. (2010) · Nature Materials · doi:10.1038/nmat2870 · Cited by 638

Gene Regulation with Polyvalent siRNA−Nanoparticle Conjugates

Giljohann, D. A., Seferos, D. S., Prigodich, A. E., Patel, P. C., & Mirkin, C. A. (2009) · Journal of the American Chemical Society · doi:10.1021/ja808719p · Cited by 637

Accelerated Color Change of Gold Nanoparticles Assembled by DNAzymes for Simple and Fast Colorimetric Pb2+ Detection

Liu, J., & Lu, Y. (2004) · Journal of the American Chemical Society · doi:10.1021/ja046628h · Cited by 635

Synthesis of branched 'nanotrees' by controlled seeding of multiple branching events

Dick, K. A., Deppert, K., Larsson, M. W., Mårtensson, T., Seifert, W., Wallenberg, L. R., & Samuelson, L. (2004) · Nature Materials · doi:10.1038/nmat1133 · Cited by 617

DNA Cage Delivery to Mammalian Cells

Walsh, A. S., Yin, H., Erben, C. M., Wood, M. J. A., & Turberfield, A. J. (2011) · ACS Nano · doi:10.1021/nn2005574 · Cited by 599

Synthesis and Magnetic Studies of Uniform Iron Nanorods and Nanospheres

Park, S.-J., Kim, S., Lee, S., Khim, Z. G., Char, K., & Hyeon, T. (2000) · Journal of the American Chemical Society · doi:10.1021/ja001628c · Cited by 581

Three-Dimensional Plasmon Rulers

Liu, N., Hentschel, M., Weiss, T., Alivisatos, A. P., & Giessen, H. (2011) · Science · doi:10.1126/science.1199958 · Cited by 580

Gene therapy progress and prospects: magnetic nanoparticle-based gene delivery

Dobson, J. (2006) · Gene Therapy · doi:10.1038/sj.gt.3302720 · Cited by 562

Oligonucleotide Loading Determines Cellular Uptake of DNA-Modified Gold Nanoparticles

Giljohann, D. A., Seferos, D. S., Patel, P. C., Millstone, J. E., Rosi, N. L., & Mirkin, C. A. (2007) · Nano Letters · doi:10.1021/nl072471q · Cited by 552

Polyvalent DNA Nanoparticle Conjugates Stabilize Nucleic Acids

Seferos, D. S., Prigodich, A. E., Giljohann, D. A., Patel, P. C., & Mirkin, C. A. (2009) · Nano Letters · doi:10.1021/nl802958f · Cited by 551

Colorimetric detection of DNA, small molecules, proteins, and ions using unmodified gold nanoparticles and conjugated polyelectrolytes

Xia, F., Zuo, X., Yang, R., Xiao, Y., Kang, D., Vallée-Bélisle, A., Gong, X., Yuen, J. D., Hsu, B. B. Y., Heeger, A. J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005632107 · Cited by 539

Silver Nanoparticle−Oligonucleotide Conjugates Based on DNA with Triple Cyclic Disulfide Moieties

Lee, J.-S., Lytton-Jean, A. K. R., Hurst, S. J., & Mirkin, C. A. (2007) · Nano Letters · doi:10.1021/nl071108g · Cited by 500

Nanoparticles that communicate in vivo to amplify tumour targeting

Park, J., Lin, K., Singh, N., Schwöppe, C., Mesters, R. M., Berdel, W. E., Ruoslahti, E. I., Sailor, M. J., von Maltzhan, G., & Bhatia, S. N. (2010) · DSpace@MIT (Massachusetts Institute of Technology) · Cited by 500

The Role Radius of Curvature Plays in Thiolated Oligonucleotide Loading on Gold Nanoparticles

Hill, H. D., Millstone, J. E., Banholzer, M. J., & Mirkin, C. A. (2009) · ACS Nano · doi:10.1021/nn800726e · Cited by 498

Synthesis and characterization of stable aqueous dispersions of silver nanoparticles through the Tollens processElectronic supplementary information (ESI) available: photographs of silver mirror, and of stable dispersions of silver nanoparticles from mixing diluted silvering solutions under sonication at various times. See http://www.rsc.org/suppdata/jm/b1/b107469e/

Yin, Y., Li, Z., Zhong, Z., Gates, B. D., Xia, Y., & Venkateswaran, S. (2002) · Journal of Materials Chemistry · doi:10.1039/b107469e · Cited by 484

Label‐Free Colorimetric Detection of Lead Ions with a Nanomolar Detection Limit and Tunable Dynamic Range by using Gold Nanoparticles and DNAzyme

Wang, Z., Lee, J. H., & Lu, Y. (2008) · Advanced Materials · doi:10.1002/adma.200703181 · Cited by 446

The Importance of the CTAB Surfactant on the Colloidal Seed-Mediated Synthesis of Gold Nanorods

Smith, D. K., & Korgel, B. A. (2008) · Langmuir · doi:10.1021/la703625a · Cited by 440

Modeling Organic Surfaces with Self‐Assembled Monolayers

Bain, C. D., & Whitesides, G. M. (1989) · Angewandte Chemie International Edition in English · doi:10.1002/anie.198905061 · Cited by 433

Gold Nanoparticle-Mediated Transfection of Mammalian Cells

Sandhu, K. K., McIntosh, C. M., Simard, J. M., Smith, S. W., & Rotello, V. M. (2002) · Bioconjugate Chemistry · doi:10.1021/bc015545c · Cited by 430

Selective Release of Multiple DNA Oligonucleotides from Gold Nanorods

Wijaya, A., Schaffer, S. B., Pallares, I. G., & Hamad-Schifferli, K. (2009) · ACS Nano · doi:10.1021/nn800702n · Cited by 420

Magnetic, Electronic, and Structural Characterization of Nonstoichiometric Iron Oxides at the Nanoscale

Redl, F. X., Black, C. T., Papaefthymiou, G. C., Sandstrom, R. L., Yin, M., Zeng, H., Murray, C. B., & O'Brien, S. P. (2004) · Journal of the American Chemical Society · doi:10.1021/ja046808r · Cited by 412

Nanoparticle-based bio-barcode assay redefines “undetectable” PSA and biochemical recurrence after radical prostatectomy

Thaxton, C. S., Elghanian, R., Thomas, A. D., Stoeva, S. I., Lee, J.-S., Smith, N. D., Schaeffer, A. J., Klocker, H., Horninger, W., Bartsch, G., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904719106 · Cited by 388

Control of enhanced Raman scattering using a DNA-based assembly process of dye-coded nanoparticles

Graham, D., Thompson, D. G., Smith, W. E., & Faulds, K. (2008) · Nature Nanotechnology · doi:10.1038/nnano.2008.189 · Cited by 377

Nanodiagnostics: application of nanotechnology in molecular diagnostics

Jain, K. (2003) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.3.2.153 · Cited by 372

Light-Induced Release of DNA from Gold Nanoparticles: Nanoshells and Nanorods

Huschka, R., Zuloaga, J., Knight, M. W., Brown, L. V., Nordlander, P., & Halas, N. J. (2011) · Journal of the American Chemical Society · doi:10.1021/ja204578e · Cited by 367

Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions.

Matsumoto, A., Naito, M., Itakura, H., Ikemoto, S., Asaoka, H., Hayakawa, I., Kanamori, H., Aburatani, H., Takaku, F., & Suzuki, H. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.23.9133 · Cited by 358

DNA-based magnetic nanoparticle assembly acts as a magnetic relaxation nanoswitch allowing screening of DNA-cleaving agents

Perez, J. M., O'Loughin, T., Simeone, F. J., Weissleder, R., & Josephson, L. (2002) · Journal of the American Chemical Society · doi:10.1021/ja017773n · Cited by 355

Asymmetric Functionalization of Gold Nanoparticles with Oligonucleotides

Xu, X., Rosi, N. L., Wang, Y., Huo, F., & Mirkin, C. A. (2006) · Journal of the American Chemical Society · doi:10.1021/ja061980b · Cited by 337

Viral gene therapy strategies: from basic science to clinical application

Young, L. S., Searle, P. F., Onion, D., & Mautner, V. (2006) · The Journal of Pathology · doi:10.1002/path.1896 · Cited by 313

A Thermodynamic Investigation into the Binding Properties of DNA Functionalized Gold Nanoparticle Probes and Molecular Fluorophore Probes

Lytton-Jean, A. K. R., & Mirkin, C. A. (2005) · Journal of the American Chemical Society · doi:10.1021/ja052255o · Cited by 308

Three-Layer Composite Magnetic Nanoparticle Probes for DNA

Stoeva, S. I., Huo, F., Lee, J.-S., & Mirkin, C. A. (2005) · Journal of the American Chemical Society · doi:10.1021/ja055056d · Cited by 298

The DNA-Mediated Formation of Supramolecular Mono- and Multilayered Nanoparticle Structures

Taton, T. A., Mucic, R. C., Mirkin, C. A., & Letsinger, R. L. (2000) · Journal of the American Chemical Society · doi:10.1021/ja0007962 · Cited by 295

DNA engineering and its application to nanotechnology

Seeman, N. C. (1999) · Trends in Biotechnology · doi:10.1016/s0167-7799(99)01360-8 · Cited by 291

Nano-flares for mRNA Regulation and Detection

Prigodich, A. E., Seferos, D. S., Massich, M. D., Giljohann, D. A., Lane, B. C., & Mirkin, C. A. (2009) · ACS Nano · doi:10.1021/nn9003814 · Cited by 284

A Gold‐Nanoparticle‐Based Real‐Time Colorimetric Screening Method for Endonuclease Activity and Inhibition

Xu, X., Han, M. S., & Mirkin, C. A. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200605249 · Cited by 283

Synthesis, Functionalization, and Bioconjugation of Monodisperse, Silica‐Coated Gold Nanoparticles: Robust Bioprobes

Liu, S. H., & Han, M. Y. (2005) · Advanced Functional Materials · doi:10.1002/adfm.200400427 · Cited by 282

Stepwise surface encoding for high-throughput assembly of nanoclusters

Maye, M. M., Nykypanchuk, D., Cuisinier, M., van der Lelie, D., & Gang, O. (2009) · Nature Materials · doi:10.1038/nmat2421 · Cited by 266

Colorimetric Cu2+ Detection Using DNA‐Modified Gold‐Nanoparticle Aggregates as Probes and Click Chemistry

Xu, X., Daniel, W. L., Wei, W., & Mirkin, C. A. (2010) · Small · doi:10.1002/smll.200901691 · Cited by 256

Colorimetric Screening of DNA‐Binding Molecules with Gold Nanoparticle Probes

Han, M. S., Lytton‐Jean, A. K. R., Oh, B., Heo, J., & Mirkin, C. A. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200504277 · Cited by 229

A glossary of DNA structures from A to Z

Ghosh, A., & Bansal, M. (2003) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444903003251 · Cited by 226

Remote Optical Switch for Localized and Selective Control of Gene Interference

Lee, S. E., Liu, G. L., Kim, F., & Lee, L. P. (2009) · Nano Letters · doi:10.1021/nl802689k · Cited by 224

Thematic review series: the immune system and atherogenesis. Recent insights into the biology of macrophage scavenger receptors

Greaves, D. R., & Gordon, S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.r400011-jlr200 · Cited by 211

Cationic Silica Nanoparticles as Gene Carriers: Synthesis, Characterization and Transfection Efficiency In vitro and In vivo

Kumar, M. N. V. R., Sameti, M., Mohapatra, S. S., Kong, X., Lockey, R. F., Bakowsky, U., Lindenblatt, G., Schmidt, C. H., & Lehr, C.-M. (2004) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2004.120 · Cited by 198

A Reactive Peptidic Linker for Self-Assembling Hybrid Quantum Dot−DNA Bioconjugates

Medintz, I. L., Berti, L., Pons, T., Grimes, A. F., English, D. S., Alessandrini, A., Facci, P., & Mattoussi, H. (2007) · Nano Letters · doi:10.1021/nl070782v · Cited by 196

Multimodal Gadolinium‐Enriched DNA–Gold Nanoparticle Conjugates for Cellular Imaging

Song, Y., Xu, X., MacRenaris, K. W., Zhang, X., Mirkin, C. A., & Meade, T. J. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200904666 · Cited by 196

Influence of a Terminal Functionality on the Physical Properties of Surfactant-Stabilized Gold Nanoparticles

Johnson, S. R., Evans, S. D., & Brydson, R. (1998) · Langmuir · doi:10.1021/la9711342 · Cited by 188

Polyvalent Nucleic Acid Nanostructures

Cutler, J. I., Zhang, K., Zheng, D., Auyeung, E., Prigodich, A. E., & Mirkin, C. A. (2011) · Journal of the American Chemical Society · doi:10.1021/ja203375n · Cited by 180

Global non-viral gene transfer to the primate brain following intravenous administration

Zhang, Y., Schlachetzki, F., & Pardridge, W. M. (2003) · Molecular Therapy · doi:10.1016/s1525-0016(02)00018-7 · Cited by 178

Microarray-Based Multiplexed Scanometric Immunoassay for Protein Cancer Markers Using Gold Nanoparticle Probes

Kim, D., Daniel, W. L., & Mirkin, C. A. (2009) · Analytical Chemistry · doi:10.1021/ac9018389 · Cited by 174

Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: Design and rationale for the Thrombin-Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2°P)-TIMI 50 trial

Morrow, D. A., Scirica, B. M., Fox, K. A. A., Berman, G., Strony, J., Veltri, E., Bonaca, M. P., Fish, P., McCabe, C. H., & Braunwald, E. (2009) · American Heart Journal · doi:10.1016/j.ahj.2009.06.027 · Cited by 172

Building oligonucleotide therapeutics using non-natural chemistries

Wilson, C., & Keefe, A. D. (2006) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2006.10.001 · Cited by 165

Using Nanoparticle Optics Assay for Direct Observation of the Function of Antimicrobial Agents in Single Live Bacterial Cells

Kyriacou, S. V., Brownlow, W. J., & Xu, X. N. (2003) · Biochemistry · doi:10.1021/bi0351110 · Cited by 165

Regulating Immune Response Using Polyvalent Nucleic Acid−Gold Nanoparticle Conjugates

Massich, M. D., Giljohann, D. A., Seferos, D. S., Ludlow, L. E., Horvath, C. M., & Mirkin, C. A. (2009) · Molecular Pharmaceutics · doi:10.1021/mp900172m · Cited by 163

Coating Carboxylic Acids on Amorphous Iron Nanoparticles

Kataby, G., Cojocaru, M., Prozorov, R., & Gedanken, A. (1999) · Langmuir · doi:10.1021/la981001w · Cited by 162

DNA‐Based Micelles: Synthesis, Micellar Properties and Size‐Dependent Cell Permeability

Liu, H., Zhu, Z., Kang, H., Wu, Y., Sefan, K., & Tan, W. (2010) · Chemistry – A European Journal · doi:10.1002/chem.200901546 · Cited by 162

Polyvalent Oligonucleotide Iron Oxide Nanoparticle “Click” Conjugates

Cutler, J. I., Zheng, D., Xu, X., Giljohann, D. A., & Mirkin, C. A. (2010) · Nano Letters · doi:10.1021/nl100477m · Cited by 161

Tunable Reactivation of Nanoparticle-Inhibited β-Galactosidase by Glutathione at Intracellular Concentrations

Verma, A., Simard, J. M., Worrall, J. W. E., & Rotello, V. M. (2004) · Journal of the American Chemical Society · doi:10.1021/ja046572r · Cited by 160

Synthetically programmable nanoparticle superlattices using a hollow three-dimensional spacer approach

Auyeung, E., Cutler, J. I., Macfarlane, R. J., Jones, M. R., Wu, J., Liu, G., Zhang, K., Osberg, K. D., & Mirkin, C. A. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2011.222 · Cited by 158

In vivo fate of phosphorothioate antisense oligodeoxynucleotides: predominant uptake by scavenger receptors on endothelial liver cells

Bijsterbosch, M. K. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.16.3290 · Cited by 154

Photothermal Release of Single-Stranded DNA from the Surface of Gold Nanoparticles Through Controlled Denaturating and Au−S Bond Breaking

Poon, L. C.-H., Zandberg, W. F., Hsiao, D., Erno, Z., Sen, D., Gates, B. D., & Branda, N. R. (2010) · ACS Nano · doi:10.1021/nn1016346 · Cited by 154

Self‐Assembled Monolayer Mediated Silica Coating of Silver Triangular Nanoprisms

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