Cited by 445Regulation of Appetite and ObesityNeural and Behavioral Psychology StudiesMemory and Neural Mechanisms

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Hunger selectively modulates corticolimbic activation to food stimuli in humans

LaBar, Kevin S., Gitelman, Darren R., Parrish, Todd B., Kim, Yun-Hee, Nobre, Anna C., Mesulam, M. -Marsel·2001·Behavioral Neuroscience

DOI 10.1037/0735-7044.115.2.493

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Abstract

Functional magnetic resonance imaging (fMRI) was used to determine whether visual responses to food in the human amygdala and related corticolimbic structures would be selectively altered by changes in states of hunger. Participants viewed images of motivationally relevant (food) and motivationally irrelevant (tool) objects while undergoing fMRI in alternately hungry and satiated conditions. Food-related visual stimuli elicited greater responses in the amygdala, parahippocampal gyrus. and anterior fusiform gyrus when participants were in a hungry state relative to a satiated state. The state-dependent activation of these brain structures did not generalize to the motivationally irrelevant objects. These results support the hypothesis that the amygdala and associated inferotemporal regions are involved in the integration of subjective interoceptive states with relevant sensory cues processed along the ventral visual stream.

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“…orbitofrontal cortex [OFC], amygdala, dorsal and ventral striatum, hypothalamus, insula) when hungry, and that high-calorie food cues elicit greater response in these regions relative to low-calorie food images (Killgore et al., 2003; LaBar et al., 2001; Stoeckel et al., 2008; Wang et al., 2004).”
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Authors: LaBar, K. S., Gitelman, D. R., Parrish, T. B., Kim, Y.-H., Nobre, A. C., & Mesulam, M. M.
Affiliations: Duke University (US)
Northwestern University (US)
University of Oxford (GB)
ORCID: LaBar, Kevin S.
Gitelman, Darren R.
Parrish, Todd B.
Kim, Yun-Hee
Nobre, Anna C.
Mesulam, M. -Marsel
Venue: Behavioral Neuroscience
Publisher: American Psychological Association (APA)
Published: 2001
Volume: 115
Issue: 2
Pages: 493-500
ISSN: 0735-7044 (ISSN-L)
1939-0084
DOI: 10.1037/0735-7044.115.2.493
OpenAlex: W1980443792
Cited by: 444
References: 67
Citations by year: 2026: 7 · 2025: 9 · 2024: 9 · 2023: 8 · 2022: 10 · 2021: 22 · 2020: 11 · 2019: 16 · 2018: 23 · 2017: 21 · 2016: 22 · 2015: 33 · 2014: 23 · 2013: 29 · 2012: 35
FWCI: 2.14
Type: journal article
Language: en
Open access: closed
Locations: Behavioral Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (NS3086303)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: hunger, satiety, food stimuli, amygdala, corticolimbic system, parahippocampal gyrus, ventral stream, interoception, food motivation
MeSH terms: Adult, Amygdala, Attention, Brain Mapping, Cerebral Cortex, Cues, Eating, Female, Humans, Hunger, Limbic System, Magnetic Resonance Imaging, Male, Motivation, Neural Pathways, Satiety Response, Temporal Lobe, Visual Perception

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Hunger selectively modulates corticolimbic activation to food stimuli in humans

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