Neurotoxicity induces cleavage of p35 to p25 by calpain

Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality.

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Alzheimer's Disease: Genes, Proteins, and Therapy

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Neurodegenerative Tauopathies

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Amyloid Precursor Protein Processing and Alzheimer's Disease

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Excitotoxicity and stroke: Identifying novel targets for neuroprotection

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SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

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Lipopolysaccharide-Induced Inflammation Exacerbates Tau Pathology by a Cyclin-Dependent Kinase 5-Mediated Pathway in a Transgenic Model of Alzheimer's Disease

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Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

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Insulin Receptor Substrate-2 Deficiency Impairs Brain Growth and Promotes Tau Phosphorylation

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Disruption of neurogenesis by amyloid β‐peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease

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Green tea epigallocatechin-3-gallate (EGCG) reduces β-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice

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Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases

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Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway

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Block of Long-Term Potentiation by Naturally Secreted and Synthetic Amyloid β-Peptide in Hippocampal Slices Is Mediated via Activation of the Kinases c-Jun N-Terminal Kinase, Cyclin-Dependent Kinase 5, and p38 Mitogen-Activated Protein Kinase as well as Metabotropic Glutamate Receptor Type 5

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The molecular bases of Alzheimer’s disease and other neurodegenerative disorders

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Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set

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Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity

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Delivery of peptide and protein drugs over the blood–brain barrier

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Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory

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Role of tau protein in Alzheimer’s disease: The prime pathological player

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The Generation of a 17 kDa Neurotoxic Fragment: An Alternative Mechanism by which Tau Mediates β-Amyloid-Induced Neurodegeneration

Park, S.-Y., & Ferreira, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1125-05.2005 · Cited by 262

Cdk5 deregulation in the pathogenesis of Alzheimer's disease

Cruz, J. C., & Tsai, L.-H. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.07.001 · Cited by 258

The neuroprotective effects of glucagon-like peptide 1 in Alzheimer’s and Parkinson’s disease: An in-depth review

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Dietary salt promotes cognitive impairment through tau phosphorylation

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Rapid Tyrosine Phosphorylation of Neuronal Proteins Including Tau and Focal Adhesion Kinase in Response to Amyloid-β Peptide Exposure: Involvement of Src Family Protein Kinases

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A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains

Tseng, H.-C., Zhou, Y., Shen, Y., & Tsai, L.-H. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02934-4 · Cited by 198

Deregulated Cdk5 activity is involved in inducing Alzheimer's disease

Shukla, V., Skuntz, S., & Pant, H. C. (2012) · Archives of Medical Research · doi:10.1016/j.arcmed.2012.10.015 · Cited by 185

Neuronal Cell Death in Alzheimers Disease and a Neuroprotective Factor, Humanin

Niikura, T., Tajima, H., & Kita, Y. (2006) · Current Neuropharmacology · doi:10.2174/157015906776359577 · Cited by 184

BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer’s disease

Chami, L., & Checler, F. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-52 · Cited by 168

Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD

Kitazawa, M., Cheng, D., & LaFerla, F. M. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05901.x · Cited by 165

Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats

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Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia

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Does modulation of tau hyperphosphorylation represent a reasonable therapeutic strategy for Alzheimer’s disease? From preclinical studies to the clinical trials

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Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer’s brains

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Traffic at the intersection of neurotrophic factor signaling and neurodegeneration

Salehi, A., Delcroix, J.-D., & Mobley, W. C. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)00038-3 · Cited by 131

Downregulation of miR-124 in MPTP-treated mouse model of Parkinson’s disease and MPP iodide-treated MN9D cells modulates the expression of the calpain/cdk5 pathway proteins.

Kanagaraj, N., Beiping, H., Dheen, S. T., & Tay, S. S. W. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.039 · Cited by 130

General aspects of neurodegeneration

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WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines

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Nuclear localization of Cdk5 is a key determinant in the postmitotic state of neurons

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Calpain-Mediated Tau Cleavage: A Mechanism Leading to Neurodegeneration Shared by Multiple Tauopathies

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Mice lacking phosphatase PP2A subunit PR61/B’δ ( Ppp2r5d ) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3β

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Curcumin Ameliorates Neuroinflammation, Neurodegeneration, and Memory Deficits in p25 Transgenic Mouse Model that Bears Hallmarks of Alzheimer’s Disease

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Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment

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Mediators of tau phosphorylation in the pathogenesis of Alzheimer’s disease

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Upstream Signaling Pathways Leading to the Activation of Double-stranded RNA-dependent Serine/Threonine Protein Kinase in β-Amyloid Peptide Neurotoxicity

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The cell cycle as a therapeutic target for Alzheimer's disease

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Tau Phosphorylation by Cyclin-dependent Kinase 5/p39 during Brain Development Reduces Its Affinity for Microtubules

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Beta-amyloid disrupted synaptic vesicle endocytosis in cultured hippocampal neurons

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The role of tau in Alzheimer's disease

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Physiological Roles of β-amyloid in Regulating Synaptic Function: Implications for AD Pathophysiology

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Improved reversal learning and altered fear conditioning in transgenic mice with regionally restricted p25 expression

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Insulin rescues amyloid β-induced impairment of hippocampal long-term potentiation

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Role of the JAKs/STATs pathway in the intracellular calcium changes induced by interleukin-6 in hippocampal neurons

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The Calcium-Dependent Protease Calpain in Neuronal Remodeling and Neurodegeneration

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Role of Tau Protein in Neurodegenerative Diseases and Development of Its Targeted Drugs: A Literature Review

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Activated Cyclin-Dependent Kinase 5 Promotes Microglial Phagocytosis of Fibrillar β-Amyloid by Up-regulating Lipoprotein Lipase Expression

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Calpain-mediated tau fragmentation is altered in Alzheimer’s disease progression

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Retinoic acid isomers protect hippocampal neurons from amyloid-β induced neurodegeneration

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Cdk5 Levels Oscillate during the Neuronal Cell Cycle

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First BRET‐based screening assay performed in budding yeast leads to the discovery of CDK5/p25 interaction inhibitors

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Skeletal muscle calpain acts through nitric oxide and neural miRNAs to regulate acetylcholine release in motor nerve terminals

Zhu, H., Bhattacharyya, B. J., Lin, H., & Gomez, C. M. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.0224-13.2013 · Cited by 26

MiR-137–3p rescue motoneuron death by targeting calpain-2

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Arsenic and Tau Phosphorylation: A Mechanistic Review

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The potential role of cyclin-dependent kinase 5 in focal cortical dysplasia.

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