The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Toll-like receptors in the induction of the innate immune response
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Receptor-Dependent Mechanisms of Cell Stimulation by Bacterial Endotoxin
Ulevitch, R. J., & Tobias, P. S. (1995) · Annual Review of Immunology · doi:10.1146/annurev.iy.13.040195.002253 · Cited by 1,442 · cited 1×
“Recognition of molecular motifs on pathogens Studies of the pathogenesis of Gram-negative septic shock led to a new level of understanding of mechanisms of innate immunit”
BackgroundSelf-citationECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway
Kopp, E., Medzhitov, R., Carothers, J., Xiao, C., Douglas, I., Janeway, C. A., & Ghosh, S. (1999) · Genes & Development · doi:10.1101/gad.13.16.2059 · Cited by 334
Research works printed but not linked: 56
- Hoffmann, J. A., Kafatos, F. C., Janeway, C. A. & Ezekowitz, R. A. Phylogenetic perspectives in innate immunity. Science 284, 1313–1318 (1999). · DOI · Paper page
- Aderem, A. & Underhill, D. M. Mechanisms of phagocytosis in macrophages. Annu. Rev. Immunol. 17, 593–623 (1999). · DOI · Paper page
- Janeway, C. A. Jr & Medzhitov, R. Introduction: the role of innate immunity in the adaptive immune response. Semin. Immunol. 10, 349–350 ( 1998).
- Ulevitch, R. J. & Tobias, P. S. Recognition of gram-negative bacteria and endotoxin by the innate immune system. Curr. Opin. Immunol. 11, 19–22 (1999). · DOI · Paper page
- Raetz, C. R. Biochemistry of endotoxins. Annu. Rev. Biochem. 59, 129–170 (1990). · DOI · Paper page
- Darveau, R. P. Lipid A diversity and the innate host response to bacterial infection. Curr. Opin. Microbiol. 1, 36–42 (1998). · DOI
- Lien, E. et al. Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide. J. Clin. Invest. 105, 497–504 (2000). · DOI · Paper page
- Poltorak, A., Ricciardi-Castagnoli, P., Citterio, S. & Beutler, B. Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation. Proc. Natl Acad. Sci. USA 97, 2163–2167 (2000). · DOI · Paper page
- Henderson, B., Poole, S. & Wilson, M. Bacterial modulins: a novel class of virulence factors which cause host tissue pathology by inducing cytokine synthesis. Microbiol. Rev. 60, 316–341 (1996). · DOI · Paper page
- Brennan, P. J. & Nikaido, H. The envelope of mycobacteria. Annu. Rev. Biochem. 64, 29 –63 (1995). · DOI · Paper page
- Kalambaheti, T., Bulach, D. M., Rajakumar, K. & Adler, B. Genetic organization of the lipopolysaccharide O-antigen biosynthetic locus of Leptospira borgpetersenii serovar Hardjobovis. Microb. Pathogen. 27, 105–117 ( 1999). · DOI
- Mitchison, M. et al. Identification and characterization of the dTDP-rhamnose biosynthesis and transfer genes of the lipopolysaccharide-related rfb locus in Leptospira interrogans serovar Copenhageni. J. Bacteriol. 179, 1262–1267 (1997). · DOI
- Chaffin, W. L., Lopez-Ribot, J.L., Casanova, M., Gozalbo, D. & Martinez, J. P. Cell wall and secreted proteins of Candida albicans: identification, function, and expression. Microbiol. Mol. Biol. Rev. 62, 130– 180 (1998). · DOI · Paper page
- Tachado, S. D. et al. Signal transduction in macrophages by glycosylphosphatidylinositols of Plasmodium, Trypanosoma, and Leishmania: activation of protein tyrosine kinases and protein kinase C by inositolglycan and diacylglycerol moieties. Proc. Natl Acad. Sci. USA 94, 4022–4027 (1997). · DOI
- Descoteaux, A., Matlashewski, G. & Turco, S. J. Inhibition of macrophage protein kinase C-mediated protein phosphorylation by Leishmania donovani lipophosphoglycan. J. Immunol. 149, 3008–3015 (1992). · DOI
- Schumann, R. R. et al. Structure and function of lipopolysaccharide binding protein . Science 249, 1429–1431 (1990). · DOI · Paper page
- Wright, S. D., Ramos, R. A., Tobias, P. S., Ulevitch, R. J. & Mathison, J. C. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249, 1431–1433 (1990). · DOI · Paper page
- Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J. M. & Hoffmann, J. A. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86, 973–983 ( 1996). · DOI · Paper page
- Williams, M. J., Rodriguez, A., Kimbrell, D. A. & Eldon, E. D. The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense. EMBO J. 16, 6120–6130 (1997). · DOI · Paper page
- Poltorak, A. et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282, 2085 –2088 (1998). · DOI · Paper page
- Qureshi, S. T. et al. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J. Exp. Med. 189, 615– 625 (1999). [Erratum, J. Exp. Med. 189, following 1518 (1999)]. · DOI · Paper page
- Hoshino, K. et al. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product . J. Immunol. 162, 3749– 3752 (1999). · DOI · Paper page
- Imler, J. L. & Hoffmann, J. A. Signaling mechanisms in the antimicrobial host defense of Drosophila. Curr. Opin. Microbiol. 3, 16–22 (2000 ). · DOI
- Anderson, K. V. Toll signaling pathways in the innate immune response. Curr. Opin. Immunol. 12, 13–19 ( 2000). · DOI · Paper page
- Medzhitov, R., Preston-Hurlburt, P. & Janeway, C. A. Jr A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388, 394–397 ( 1997). · DOI
- Rock, F. L., Hardiman, G., Timans, J. C., Kastelein, R. A. & Bazan, J. F. A family of human receptors structurally related to Drosophila Toll. Proc. Natl Acad. Sci. USA 95, 588–593 (1998). · DOI · Paper page
- Yang, R. B. et al. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature 395, 284– 288 (1998). · DOI · Paper page
- Kirschning, C. J., Wesche, H., Merrill, A. T. & Rothe, M. Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide . J. Exp. Med. 188, 2091– 2097 (1998). · DOI · Paper page
- Underhill, D. M. et al. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 401, 811–815 (1999). · DOI · Paper page
- Heine, H. et al. Cutting edge: cells that carry A null allele for toll-like receptor 2 are capable of responding to endotoxin. J. Immunol. 162, 6971–6975 (1999). · DOI
- Shimazu, R. et al. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med. 189, 1777–1782 (1999). · DOI · Paper page
- Flo, T. H. et al. Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide . J. Immunol. 164, 2064– 2069 (2000). · DOI · Paper page
- Takeuchi, O. et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11, 443–451 (1999). · DOI · Paper page
- Lien, E. et al. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J. Biol. Chem. 274, 33419–33425 (1999). · DOI · Paper page
- Takeuchi, O. et al. Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor. J. Immunol. 164, 554 –557 (2000). · DOI · Paper page
- Hirschfeld, M. et al. Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2. J. Immunol. 163, 2382–2386 ( 1999). · DOI · Paper page
- Ohashi, K., Burkart, V., Flohe, S. & Kolb, H. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J. Immunol. 164, 558– 561 (2000). · DOI · Paper page
- Means, T. K. et al. The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors. J. Immunol. 163, 6748–6755 ( 1999). · DOI · Paper page
- Means, T. K. et al. Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis. J. Immunol. 163, 3920–3927 (1999). · DOI · Paper page
- Brightbill, H. D. et al. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science 285, 732–736 (1999). · DOI
- Underhill, D. M., Ozinsky, A., Smith, K. D. & Aderem, A. Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages. Proc. Natl Acad. Sci. USA 96, 14459–14463 (1999). · DOI · Paper page
- Chaudhary, P. M. et al. Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans. Blood 91, 4020–4027 ( 1998). · DOI
- Takeuchi, O. et al. TLR6: a novel member of an expanding toll-like receptor family . Gene 231, 59–65 (1999). · DOI · Paper page
- Levashina, E. A. et al. Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila. Science 285, 1917–1919 (1999). · DOI · Paper page
- Medzhitov, R. et al. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol. Cell 2, 253– 258 (1998). · DOI · Paper page
- Yang, R. B., Mark, M. R., Gurney, A. L. & Godowski, P. J. Signaling events induced by lipopolysaccharide-activated toll-like receptor 2. J. Immunol. 163, 639– 643 (1999). · DOI · Paper page
- Muzio, M., Natoli, G., Saccani, S., Levrero, M. & Mantovani, A. The human toll signaling pathway: divergence of nuclear factor κB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6). J. Exp. Med. 187, 2097–2101 (1998). · DOI · Paper page
- Medzhitov, R. & Janeway, C. Jr Innate immune recognition: mechanisms and pathways. Immunol. Rev. 173, 89–97 (2000). · DOI · Paper page
- Wesche, H., Henzel, W. J., Shillinglaw, W., Li, S. & Cao, Z. MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 7, 837–847 (1997). · DOI · Paper page
- Cao, Z., Xiong, J., Takeuchi, M., Kurama, T. & Goeddel, D. V. TRAF6 is a signal transducer for interleukin-1. Nature 383, 443–446 ( 1996). · DOI · Paper page
- Ninomiya-Tsuji, J. et al. The kinase TAK1 can activate the NIK-I κB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature 398, 252–256 (1999). · DOI · Paper page
- Irie, T., Muta, T. & Takeshige, K. TAK1 mediates an activation signal from toll-like receptor(s) to nuclear factor-κB in lipopolysaccharide-stimulated macrophages. FEBS Lett. 467, 160–164 (2000). · DOI
- Kawai, T., Adachi, O., Ogawa, T., Takeda, K. & Akira, S. Unresponsiveness of MyD88-deficient mice to endotoxin . Immunity 11, 115–122 (1999). · DOI · Paper page
- Lomaga, M. A. et al. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev. 13, 1015–1024 (1999). · DOI · Paper page
- Thomas, J. A. et al. Impaired cytokine signaling in mice lacking the IL-1 receptor- associated kinase. J. Immunol. 163, 978– 984 (1999). · DOI · Paper page
- Wesche, H. et al. IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J. Biol. Chem. 274, 19403–19410 (1999). · DOI · Paper page
Cited by
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030
Toll-like receptors: critical proteins linking innate and acquired immunity
Akira, S., Takeda, K., & Kaisho, T. (2001) · Nature Immunology · doi:10.1038/90609 · Cited by 4,777
Raetz, C. R. H., & Whitfield, C. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135414 · Cited by 4,404
The Danger Model: A Renewed Sense of Self
Matzinger, P. (2002) · Science · doi:10.1126/science.1071059 · Cited by 4,205
Interferon-γ: an overview of signals, mechanisms and functions
Schroder, K., Hertzog, P. J., Ravasi, T., & Hume, D. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603252 · Cited by 4,120
The TNF and TNF Receptor Superfamilies
Locksley, R. M., Killeen, N., & Lenardo, M. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00237-9 · Cited by 3,650
The immunopathogenesis of sepsis
Cohen, J. (2002) · Nature · doi:10.1038/nature01326 · Cited by 2,742
Kadowaki, N., Ho, S., Antonenko, S., de Waal Malefyt, R., Kastelein, R. A., Bazan, F., & Liu, Y.-J. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.6.863 · Cited by 1,964
Novel Signal Transduction Pathway Utilized by Extracellular HSP70
Asea, A., Rehli, M., Kabingu, E., Boch, J. A., Baré, O., Auron, P. E., Stevenson, M. A., & Calderwood, S. K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200497200 · Cited by 1,510
Viruses and interferon: a fight for supremacy
Katze, M. G., He, Y., & Gale, M. (2002) · Nature Reviews Immunology · doi:10.1038/nri888 · Cited by 1,419
Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4
Termeer, C., Benedix, F., Sleeman, J., Fieber, C., Voith, U., Ahrens, T., Miyake, K., Freudenberg, M., Galanos, C., & Simon, J. C. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20001858 · Cited by 1,378
Sunlight and Vitamin D: A global perspective for health
Wacker, M., & Holick, M. F. (2013) · Dermato-Endocrinology · doi:10.4161/derm.24494 · Cited by 1,156
Phagocytosis of Microbes: Complexity in Action
Underhill, D. M., & Ozinsky, A. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.103001.114744 · Cited by 1,124
Hyaluronan as an Immune Regulator in Human Diseases
Jiang, D., Liang, J., & Noble, P. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00052.2009 · Cited by 1,060
HMGB1 SIGNALS THROUGH TOLL-LIKE RECEPTOR (TLR) 4 AND TLR2
Yu, M., Wang, H., Ding, A., Golenbock, D. T., Latz, E., Czura, C. J., Fenton, M. J., Tracey, K. J., & Yang, H. (2006) · Shock · doi:10.1097/01.shk.0000225404.51320.82 · Cited by 832
Vabulas, R. M., Ahmad-Nejad, P., da Costa, C., Miethke, T., Kirschning, C. J., Häcker, H., & Wagner, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103217200 · Cited by 805
Theoharides, T. C., Alysandratos, K.-D., Angelidou, A., Delivanis, D.-A., Sismanopoulos, N., Zhang, B., Asadi, S., Vasiadi, M., Weng, Z., Miniati, A., et al. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.12.014 · Cited by 680
Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells
Galon, J., Franchimont, D., Hiroi, N., Frey, G., Boettner, A., Ehrhart-Bornstein, M., O’shea, J. J., Chrousos, G. P., & Bornstein, S. R. (2002) · The FASEB Journal · doi:10.1096/fj.01-0245com · Cited by 606
Boksa, P. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.03.005 · Cited by 603
Liévin-Le Moal, V., & Servin, A. L. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.19.2.315-337.2006 · Cited by 568
Lee, J. Y., Ye, J., Gao, Z., Youn, H. S., Lee, W. H., Zhao, L., Sizemore, N., & Hwang, D. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305213200 · Cited by 524
Bellocchio, S., Montagnoli, C., Bozza, S., Gaziano, R., Rossi, G., Mambula, S. S., Vecchi, A., Mantovani, A., Levitz, S. M., & Romani, L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.3059 · Cited by 515
Bouchon, A., Hernández-Munain, C., Cella, M., & Colonna, M. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.8.1111 · Cited by 460
Saberi, M., Woods, N.-B., de Luca, C., Schenk, S., Lu, J. C., Bandyopadhyay, G., Verma, I. M., & Olefsky, J. M. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.09.006 · Cited by 456
“The ‘‘sensors’’ that potentially link obesity to inflammation are the Toll-like family of receptors (Tlrs); Tlrs are pattern recognition receptors that play critical roles in innate immunity (Aderem and Ulevitch, 2000; Wolowczuk et al., 2008).”
BackgroundZhang, Z., Ohto, U., Shibata, T., Krayukhina, E., Taoka, M., Yamauchi, Y., Tanji, H., Isobe, T., Uchiyama, S., Miyake, K., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.09.011 · Cited by 461
Ma, C., Fan, R., Ahmad, H., Shi, Q., Comin-Anduix, B., Chodon, T., Koya, R. C., Liu, C.-C., Kwong, G. A., Radu, C. G., et al. (2011) · Nature Medicine · doi:10.1038/nm.2375 · Cited by 441
FRANCHIMONT, D. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1321.009 · Cited by 408
Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors
Chuang, T.-H., & Ulevitch, R. J. (2004) · Nature Immunology · doi:10.1038/ni1066 · Cited by 374
Self-citationChen, C.-Y., Peng, W.-H., Tsai, K.-D., & Hsu, S.-L. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.09.028 · Cited by 358
Reiling, N., Hölscher, C., Fehrenbach, A., Kröger, S., Kirschning, C. J., Goyert, S., & Ehlers, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.7.3480 · Cited by 352
Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability
Randow, F., & Seed, B. (2001) · Nature Cell Biology · doi:10.1038/ncb1001-891 · Cited by 316
Litvak, V., Ramsey, S. A., Rust, A. G., Zak, D. E., Kennedy, K. A., Lampano, A. E., Nykter, M., Shmulevich, I., & Aderem, A. (2009) · Nature Immunology · doi:10.1038/ni.1721 · Cited by 295
Self-citationSignal integration between IFNγ and TLR signalling pathways in macrophages
Schroder, K., Sweet, M. J., & Hume, D. A. (2006) · Immunobiology · doi:10.1016/j.imbio.2006.05.007 · Cited by 288
Pinhal-Enfield, G., Ramanathan, M., Hasko, G., Vogel, S. N., Salzman, A. L., Boons, G.-J., & Leibovich, S. J. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63698-x · Cited by 278
Chichlowski, M., De Lartigue, G., German, J. B., Raybould, H. E., & Mills, D. A. (2012) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31824fb899 · Cited by 276
Nagaoka, I., Hirota, S., Niyonsaba, F., Hirata, M., Adachi, Y., Tamura, H., & Heumann, D. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.6.3329 · Cited by 258
Raes, G., Brys, L., Dahal, B. K., Brandt, J., Grooten, J., Brombacher, F., Vanham, G., Noël, W., Bogaert, P., Boonefaes, T., et al. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0304212 · Cited by 246
Haeberle, H. A., Takizawa, R., Casola, A., Brasier, A. R., Dieterich, H., van Rooijen, N., Gatalica, Z., & Garofalo, R. P. (2002) · The Journal of Infectious Diseases · doi:10.1086/344644 · Cited by 237
Species-specific Regulation of Toll-like Receptor 3 Genes in Men and Mice
Heinz, S., Haehnel, V., Karaghiosoff, M., Schwarzfischer, L., Müller, M., Krause, S. W., & Rehli, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301476200 · Cited by 202
Toll-Like Receptor 2 Is Required for Optimal Control of Listeria monocytogenes Infection
Torres, D., Barrier, M., Bihl, F., Quesniaux, V. J. F., Maillet, I., Akira, S., Ryffel, B., & Erard, F. (2004) · Infection and Immunity · doi:10.1128/iai.72.4.2131-2139.2004 · Cited by 191
The host response to naturally-derived extracellular matrix biomaterials
Morris, A. H., Stamer, D. K., & Kyriakides, T. R. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.01.002 · Cited by 180
Xu, H., Sobue, T., Thompson, A., Xie, Z., Poon, K., Ricker, A., Cervantes, J., Diaz, P. I., & Dongari‐Bagtzoglou, A. (2014) · Cellular Microbiology · doi:10.1111/cmi.12216 · Cited by 179
Neural regulators of innate immune responses and inflammation
Pavlov, V. A., & Tracey, K. J. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4102-3 · Cited by 174
The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens
He, Y.-W., Li, H., Zhang, J., Hsu, C.-L., Lin, E., Zhang, N., Guo, J., Forbush, K. A., & Bevan, M. J. (2004) · Nature Immunology · doi:10.1038/ni1021 · Cited by 171
Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studies
Barochia, A., Solomon, S., Cui, X., Natanson, C., & Eichacker, P. Q. (2011) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2011.558190 · Cited by 169
NF-κB, an Evolutionarily Conserved Mediator of Immune and Inflammatory Responses
Xiao, C., & Ghosh, S. (2005) · Advances in Experimental Medicine and Biology · doi:10.1007/0-387-24180-9_5 · Cited by 167
Kleiman, A., & Tuckermann, J. P. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.05.009 · Cited by 165
Differential functional effects of biomaterials on dendritic cell maturation
Park, J., & Babensee, J. E. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.06.006 · Cited by 156
Viruses as adjuvants for autoimmunity: evidence from Coxsackievirus‐induced myocarditis
Fairweather, D., Frisancho‐Kiss, S., & Rose, N. R. (2005) · Reviews in Medical Virology · doi:10.1002/rmv.445 · Cited by 155
Tanaka, M., Kishimoto, Y., Sasaki, M., Sato, A., Kamiya, T., Kondo, K., & Iida, K. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9364364 · Cited by 154
Lohmann, P., Luna, R. A., Hollister, E. B., Devaraj, S., Mistretta, T.-A., Welty, S. E., & Versalovic, J. (2014) · Pediatric Research · doi:10.1038/pr.2014.85 · Cited by 146
Pagan, J. K., Wylie, F. G., Joseph, S., Widberg, C., Bryant, N. J., James, D. E., & Stow, J. L. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00006-x · Cited by 130
Zeng, Z., Gong, H., Li, Y., Jie, K., Ding, C., Shao, Q., Liu, F., Zhan, Y., Nie, C., Zhu, W., et al. (2013) · Experimental Lung Research · doi:10.3109/01902148.2013.808285 · Cited by 128
Hirota, Y., Cha, J., Yoshie, M., Daikoku, T., & Dey, S. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108180108 · Cited by 125
Shiratsuchi, A., Watanabe, I., Takeuchi, O., Akira, S., & Nakanishi, Y. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.4.2039 · Cited by 112
Ma, Q., Kinneer, K., Ye, J., & Chen, B. J. (2003) · Molecular Pharmacology · doi:10.1124/mol.64.2.211 · Cited by 107
Genetic polymorphisms in sepsis
Dahmer, M. K., Randolph, A., Vitali, S., & Quasney, M. W. (2005) · Pediatric Critical Care Medicine · doi:10.1097/01.pcc.0000161970.44470.c7 · Cited by 101
Low‐density lipoprotein receptors regulate microglial inflammation through c‐Jun N‐terminal kinase
Pocivavsek, A., Burns, M. P., & Rebeck, G. W. (2009) · Glia · doi:10.1002/glia.20772 · Cited by 96
Mast Cells in Allergic and Inflammatory Diseases
Sismanopoulos, N., Delivanis, D.-A., Alysandratos, K.-D., Angelidou, A., Therianou, A., Kalogeromitros, D., & C. Theoharides, T. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212800165997 · Cited by 87
Early life stress inhibits expression of a novel innate immune pathway in the developing hippocampus
Wei, L., Simen, A., Mane, S., & Kaffman, A. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.239 · Cited by 71
The innate immune system in Alzheimer's disease
Boutajangout, A., & Wisniewski, T. (2013) · International Journal of Cell Biology · doi:10.1155/2013/576383 · Cited by 69
Concanavalin A induced expression of Toll-like receptors in murine peritoneal macrophages in vitro
Sodhi, A., Tarang, S., & Kesherwani, V. (2007) · International Immunopharmacology · doi:10.1016/j.intimp.2006.11.014 · Cited by 67
Involvement of Innate Immunity in the Development of Inflammatory and Autoimmune Diseases
TLASKALOVÁ-HOGENOVÁ, H., TUCKOVÁ, L., STEPÁNKOVÁ, R., HUDCOVIC, T., PALOVÁ-JELÍNKOVÁ, L., KOZÁKOVÁ, H., ROSSMANN, P., SANCHEZ, D., CINOVÁ, J., HRNČÍŘ, T., et al. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1361.122 · Cited by 68
ten Brink, T., Damanik, F., Rotmans, J. I., & Moroni, L. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202301939 · Cited by 71
Peptidoglycan and lipopolysaccharide synergistically enhance bone resorption and osteoclastogenesis
Kishimoto, T., Kaneko, T., Ukai, T., Yokoyama, M., Ayon Haro, R., Yoshinaga, Y., Yoshimura, A., & Hara, Y. (2012) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2011.01452.x · Cited by 56
Stabilin Receptors Clear LPS and Control Systemic Inflammation
Cabral, F., Al-Rahem, M., Skaggs, J., Thomas, T. A., Kumar, N., Wu, Q., Fadda, P., Yu, L., Robinson, J. M., Kim, J., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103337 · Cited by 38
Wilson, C. L., Mann, J., Walsh, M., Perrugoria, M. J., Oakley, F., Wright, M. C., Brignole, C., Di Paolo, D., Perri, P., Ponzoni, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0083391 · Cited by 31
Berkiks, I., Garcia-Segura, L. M., Nassiri, A., Mesfioui, A., Ouichou, A., Boulbaroud, S., Bahbiti, Y., Lopez-Rodriguez, A. B., Hasnaoui, E., & El Hessni, A. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.11.037 · Cited by 30
Lopetuso, L. R., Jia, R., Wang, X.-M., Jia, L.-G., Petito, V., Goodman, W. A., Meddings, J. B., Cominelli, F., Reuter, B. K., & Pizarro, T. T. (2017) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000001035 · Cited by 28
Dendritic cell responses to self‐assembled monolayers of defined chemistries
Shankar, S. P., Petrie, T. A., García, A. J., & Babensee, J. E. (2010) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32487 · Cited by 28
Cho, Y.-C., Vuong, H. L., Ha, J., Lee, S., Park, J., Wibow, A. E., & Cho, S. (2020) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x20500548 · Cited by 15
(2011) · PubMed
Metadata
- Authors
- Aderem, A., & Ulevitch, R. J.
- Venue
- Nature
- Published
- 2000-08-17
- Volume
- 406
- Issue
- 6797
- Pages
- 782-787
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1930598094
- Cited by
- 3,064
- References
- 2
- FWCI
- 67.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- www.springer.com/tdm (vor)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.