The DOI matches its Crossref record; 104 of the 104 references it cites were found in a registry or an index.
Oxidants, oxidative stress and the biology of ageing
Abstract
Living in an oxygenated environment has required the evolution of effective cellular strategies to detect and detoxify metabolites of molecular oxygen known as reactive oxygen species. Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span.
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“During aging and neurodegeneration, there is a decrease in normal antioxidant and anti-inflammatory defense mechanisms, making the brain more susceptible to the detrimental effects of oxidative stress [44,45,46].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [45]
In the citing paper
“Indeed, most neurological disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), inflammatory injuries and senility are the result of age-linked inflammation and/or oxidative stress increase [44,45].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [45]
In the citing paper
“There is considerably strong evidence to clarify that inflammation and oxidative stress play a fundamental role in the onset and progression of neurodegenerative diseases [45],”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [45]
In the citing paper
“A complex antioxidant defense system, including both endogenous and exogenous antioxidants, protect cells from ROS-induced toxicity (Finkel and Holbrook 2000).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Finkel and Holbrook 2000
In the citing paper
“One of the hallmarks of aging is elevated oxidative stress and inflammation (Finkel and Holbrook, 2000).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Finkel and Holbrook, 2000
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Metadata
- Authors
- Finkel, T., & Holbrook, N. J.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Finkel, Toren
- Holbrook, Nikki J.
- ORCID
- Finkel, Toren
- Venue
- Nature
- Published
- 2000-11
- Volume
- 408
- Issue
- 6809
- Pages
- 239-247
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2101861123
- Cited by
- 9,413
- References
- 104
- Citations by year
- 2026: 194 · 2025: 337 · 2024: 330 · 2023: 384 · 2022: 413 · 2021: 447 · 2020: 488 · 2019: 502 · 2018: 487 · 2017: 510 · 2016: 464 · 2015: 428 · 2014: 475 · 2013: 457 · 2012: 478
- FWCI
- 10.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- oxidizing agents, oxidative stress, aging, reactive oxygen species, lifespan, oxygen metabolism, cellular detoxification
- MeSH terms
- Aging, Animals, Energy Intake, Humans, Longevity, Signal Transduction, Oxidants, Cellular Senescence, Reactive Oxygen Species, Oxidative Stress
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