SNAP receptors implicated in vesicle targeting and fusion

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961

The organization of cytoplasm at the presynaptic active zone of a central nervous system synapse

Landis, D. M. D., Hall, A. K., Weinstein, L. A., & Reese, T. S. (1988) · Neuron · doi:10.1016/0896-6273(88)90140-7 · Cited by 333

SNAREs — engines for membrane fusion

Jahn, R., & Scheller, R. H. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2002 · Cited by 2,635

THE SYNAPTIC VESICLE CYCLE

Südhof, T. C. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131412 · Cited by 2,547

Membrane Fusion: Grappling with SNARE and SM Proteins

Südhof, T. C., & Rothman, J. E. (2009) · Science · doi:10.1126/science.1161748 · Cited by 2,027

Comparative Genomics of the Eukaryotes

Rubin, G. M., Yandell, M. D., Wortman, J. R., Gabor, G. L., Miklos, Nelson, C. R., Hariharan, I. K., Fortini, M. E., Li, P. W., Apweiler, R., et al. (2000) · Science · doi:10.1126/science.287.5461.2204 · Cited by 1,698

Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse

Geppert, M., Goda, Y., Hammer, R. E., Li, C., Rosahl, T. W., Stevens, C. F., & Südhof, T. C. (1994) · Cell · doi:10.1016/0092-8674(94)90556-8 · Cited by 1,483

Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle

Südhof, T. C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.022 · Cited by 1,197

Candidate gene studies of ADHD: a meta-analytic review

Gizer, I. R., Ficks, C., & Waldman, I. D. (2009) · Human Genetics · doi:10.1007/s00439-009-0694-x · Cited by 1,020

Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects

Sweeney, S. T., Broadie, K., Keane, J., Niemann, H., & O'Kane, C. J. (1995) · Neuron · doi:10.1016/0896-6273(95)90290-2 · Cited by 938

Secretory Granule Exocytosis

Burgoyne, R. D., & Morgan, A. (2003) · Physiological Reviews · doi:10.1152/physrev.00031.2002 · Cited by 934

Calcium Channel Regulation and Presynaptic Plasticity

Catterall, W. A., & Few, A. P. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.005 · Cited by 647

Synapsins as Regulators of Neurotransmitter Release

Hilfiker, S., Pieribone, V. A., Czernik, A. J., Kao, H.-T., Augustine, G. J., & Greengard, P. (1999) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1999.0378 · Cited by 537

Snares and Munc18 in synaptic vesicle fusion

Rizo, J., & Südhof, T. C. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn898 · Cited by 539

ATP-dependent inositide phosphorylation required for Ca2+-activated secretion

Hay, J. C., Fisette, P. L., Jenkins, G. H., Fukami, K., Takenawa, T., Anderson, R. A., & Martin, T. F. J. (1995) · Nature · doi:10.1038/374173a0 · Cited by 506

An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming

Richmond, J. E., Weimer, R. M., & Jorgensen, E. M. (2001) · Nature · doi:10.1038/35085583 · Cited by 437

Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)

Crowder, K. M., Gunther, J. M., Jones, T. A., Hale, B. D., Zhang, H. Z., Peterson, M. R., Scheller, R. H., Chavkin, C., & Bajjalieh, S. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15268 · Cited by 415

Astrocytes as secretory cells of the central nervous system: idiosyncrasies of vesicular secretion

Verkhratsky, A., Matteoli, M., Parpura, V., Mothet, J., & Zorec, R. (2016) · The EMBO Journal · doi:10.15252/embj.201592705 · Cited by 397

Mechanisms of biphasic insulin-granule exocytosis – roles of the cytoskeleton, small GTPases and SNARE proteins

Wang, Z., & Thurmond, D. C. (2009) · Journal of Cell Science · doi:10.1242/jcs.034355 · Cited by 386

Structural Changes Are Associated with Soluble N-Ethylmaleimide-sensitive Fusion Protein Attachment Protein Receptor Complex Formation

Fasshauer, D., Otto, H., Eliason, W. K., Jahn, R., & Brünger, A. T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.44.28036 · Cited by 378

Fzo1p Is a Mitochondrial Outer Membrane Protein Essential for the Biogenesis of Functional Mitochondria in Saccharomyces cerevisiae

Rapaport, D., Brunner, M., Neupert, W., & Westermann, B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.20150 · Cited by 370

Differential Control of the Releasable Vesicle Pools by SNAP-25 Splice Variants and SNAP-23

Sørensen, J. B., Nagy, G., Varoqueaux, F., Nehring, R. B., Brose, N., Wilson, M. C., & Neher, E. (2003) · Cell · doi:10.1016/s0092-8674(03)00477-x · Cited by 364

Identification of a Novel Syntaxin- and Synaptobrevin/VAMP-binding Protein, SNAP-23, Expressed in Non-neuronal Tissues

Ravichandran, V., Chawla, A., & Roche, P. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.23.13300 · Cited by 354

Rab4 and cellubrevin define different early endosome populations on the pathway of transferrin receptor recycling.

Daro, E., van der Sluijs, P., Galli, T., & Mellman, I. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9559 · Cited by 343

SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils.

Chapman, E. R., An, S., Barton, N., & Jahn, R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47003-2 · Cited by 295

The exocyst defrocked, a framework of rods revealed

Munson, M., & Novick, P. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1097 · Cited by 290

Syntaxin 13 Mediates Cycling of Plasma Membrane Proteins via Tubulovesicular Recycling Endosomes

Prekeris, R., Klumperman, J., Chen, Y. A., & Scheller, R. H. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.4.957 · Cited by 286

Synaptotagmin I Functions as a Calcium Sensor to Synchronize Neurotransmitter Release

Yoshihara, M., & Littleton, J. T. (2002) · Neuron · doi:10.1016/s0896-6273(02)01065-6 · Cited by 285

Changes in hippocampal morphology and neuroplasticity induced by adolescent THC treatment are associated with cognitive impairment in adulthood

Rubino, T., Realini, N., Braida, D., Guidi, S., Capurro, V., Viganò, D., Guidali, C., Pinter, M., Sala, M., Bartesaghi, R., et al. (2009) · Hippocampus · doi:10.1002/hipo.20554 · Cited by 282

Mechanisms of SNARE proteins in membrane fusion

Jahn, R., Cafiso, D. C., & Tamm, L. K. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00668-x · Cited by 248

Time scales of membrane fusion revealed by direct imaging of vesicle fusion with high temporal resolution

Haluska, C. K., Riske, K. A., Marchi-Artzner, V., Lehn, J.-M., Lipowsky, R., & Dimova, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602766103 · Cited by 240

SNAREing immunity: the role of SNAREs in the immune system

Stow, J. L., Manderson, A. P., & Murray, R. Z. (2006) · Nature Reviews Immunology · doi:10.1038/nri1980 · Cited by 235

UNC-11, a Caenorhabditis elegans AP180 Homologue, Regulates the Size and Protein Composition of Synaptic Vesicles

Nonet, M. L., Holgado, A. M., Brewer, F., Serpe, C. J., Norbeck, B. A., Holleran, J., Wei, L., Hartwieg, E., Jorgensen, E. M., & Alfonso, A. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.7.2343 · Cited by 235

VAMP‐2 and cellubrevin are expressed in pancreatic beta‐cells and are essential for Ca(2+)‐but not for GTP gamma S‐induced insulin secretion.

Regazzi, R., Wollheim, C. B., Lang, J., Theler, J. M., Rossetto, O., Montecucco, C., Sadoul, K., Weller, U., Palmer, M., & Thorens, B. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07273.x · Cited by 233

Markers of axonal injury in post mortem human brain

Sherriff, F. E., Bridges, L. R., Gentleman, S. M., Sivaloganathan, S., & Wilson, S. (1994) · Acta Neuropathologica · doi:10.1007/bf00389495 · Cited by 233

Astrocyte lipid metabolism is critical for synapse development and function in vivo

van Deijk, A. F., Camargo, N., Timmerman, J., Heistek, T., Brouwers, J. F., Mogavero, F., Mansvelder, H. D., Smit, A. B., & Verheijen, M. H. G. (2017) · Glia · doi:10.1002/glia.23120 · Cited by 201

Rapid Plasmenylethanolamine-Selective Fusion of Membrane Bilayers Catalyzed by an Isoform of Glyceraldehyde-3-Phosphate Dehydrogenase: Discrimination between Glycolytic and Fusogenic Roles of Individual Isoforms

Glaser, P. E., & Gross, R. W. (1995) · Biochemistry · doi:10.1021/bi00038a013 · Cited by 210

Mechanism of neurotransmitter release coming into focus

Rizo, J. (2018) · Protein Science · doi:10.1002/pro.3445 · Cited by 210

The Biogenesis of Chylomicrons

Mansbach, C. M., & Siddiqi, S. A. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135801 · Cited by 206

Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion

Diao, J., Grob, P., Cipriano, D. J., Kyoung, M., Zhang, Y., Shah, S., Nguyen, A., Padolina, M., Srivastava, A., Vrljic, M., et al. (2012) · eLife · doi:10.7554/elife.00109 · Cited by 170

The R-SNARE Endobrevin/VAMP-8 Mediates Homotypic Fusion of Early Endosomes and Late Endosomes

Antonin, W., Holroyd, C., Tikkanen, R., Höning, S., & Jahn, R. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.10.3289 · Cited by 156

Distinct Initial SNARE Configurations Underlying the Diversity of Exocytosis

Kasai, H., Takahashi, N., & Tokumaru, H. (2012) · Physiological Reviews · doi:10.1152/physrev.00007.2012 · Cited by 150

SNARE-complex disassembly by NSF follows synaptic-vesicle fusion

Littleton, J. T., Barnard, R. J. O., Titus, S. A., Slind, J., Chapman, E. R., & Ganetzky, B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221450198 · Cited by 140

A Selective Transport Route from Golgi to Late Endosomes That Requires the Yeast Gga Proteins

Black, M. W., & Pelham, H. R. B. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.3.587 · Cited by 140

SNAREopathies: Diversity in Mechanisms and Symptoms

Verhage, M., & Sørensen, J. B. (2020) · Neuron · doi:10.1016/j.neuron.2020.05.036 · Cited by 121

Mechanisms and Function of Dendritic Exocytosis

Kennedy, M. J., & Ehlers, M. D. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.032 · Cited by 132

Expression of β-Amyloid Induced Age-Dependent Presynaptic and Axonal Changes in Drosophila

Zhao, X.-L., Wang, W.-A., Tan, J.-X., Huang, J.-K., Zhang, X., Zhang, B.-Z., Wang, Y.-H., YangCheng, H.-Y., Zhu, H.-L., Sun, X.-J., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3699-09.2010 · Cited by 130

Membrane trafficking along the phagocytic pathway

Berón, W., Alvarez-Dominguez, C., Mayorga, L., & Stahl, P. D. (1995) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)88958-8 · Cited by 129

Analysis of knock-out mice to determine the role of HPC-1/syntaxin 1A in expressing synaptic plasticity

Fujiwara, T., Mishima, T., Kofuji, T., Chiba, T., Tanaka, K., Yamamoto, A., & Akagawa, K. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0289-06.2006 · Cited by 125

Cytoplasm to vacuole trafficking of aminopeptidase I requires a t‐SNARE–Sec1p complex composed of Tlg2p and Vps45p

Abeliovich, H., Darsow, T., & Emr, S. D. (1999) · The EMBO Journal · doi:10.1093/emboj/18.21.6005 · Cited by 126

Rab3A Is Involved in Transport of Synaptic Vesicles to the Active Zone in Mouse Brain Nerve Terminals

Leenders, A. G. M., da Silva, F. H. L., Ghijsen, W. E. J. M., & Verhage, M. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.10.3095 · Cited by 115

Extracellular vesicles and intercellular communication in the central nervous system

Lizarraga‐Valderrama, L. R., & Sheridan, G. K. (2021) · FEBS Letters · doi:10.1002/1873-3468.14074 · Cited by 107

Identification of two pathways mediating protein targeting from ER to lipid droplets

Song, J., Mizrak, A., Lee, C.-W., Cicconet, M., Lai, Z. W., Tang, W.-C., Lu, C.-H., Mohr, S. E., Farese, R. V., & Walther, T. C. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00974-0 · Cited by 106

Developmentally Regulated Switch in Alternatively Spliced SNAP-25 Isoforms Alters Facilitation of Synaptic Transmission

Bark, C., Bellinger, F. P., Kaushal, A., Mathews, J. R., Partridge, L. D., & Wilson, M. C. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1940-04.2004 · Cited by 101

Targeted deletion of miR-132/-212 impairs memory and alters the hippocampal transcriptome

Hansen, K. F., Sakamoto, K., Aten, S., Price, K. H., Loeser, J., Hesse, A. M., Page, C. E., Pelz, C., Arthur, J. S. C., Impey, S., et al. (2016) · Learning & Memory · doi:10.1101/lm.039578.115 · Cited by 100

A role for SNAP25 in internalization of kainate receptors and synaptic plasticity

Selak, S., Paternain, A. V., Aller, I. M., Picó, E., Rivera, R., & Lerma, J. (2009) · Neuron · doi:10.1016/j.neuron.2009.07.017 · Cited by 95

Syntaxin 7 Complexes with Mouse Vps10p Tail Interactor 1b, Syntaxin 6, Vesicle-associated Membrane Protein (VAMP)8, and VAMP7 in B16 Melanoma Cells

Wade, N., Bryant, N. J., Connolly, L. M., Simpson, R. J., Luzio, J. P., Piper, R. C., & James, D. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010838200 · Cited by 89

A secretagogin locus of the mammalian hypothalamus controls stress hormone release

Romanov, R. A., Alpár, A., Zhang, M., Zeisel, A., Calas, A., Landry, M., Fuszard, M., Shirran, S. L., Schnell, R., Dobolyi, Á., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201488977 · Cited by 85

Synaptogenesis in the CNS: An Odyssey from Wiring Together to Firing Together

Munno, D. W., & Syed, N. I. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.045062 · Cited by 86

Got1p and Sft2p: membrane proteins involved in traffic to the Golgi complex

Conchon, S., Cao, X., Barlowe, C., & Pelham, H. R. B. (1999) · The EMBO Journal · doi:10.1093/emboj/18.14.3934 · Cited by 85

An Ancient Duplication of Exon 5 in the Snap25 Gene Is Required for Complex Neuronal Development/Function

Johansson, J. U., Ericsson, J., Janson, J., Beraki, S., Stanić, D., Mandic, S. A., Wikström, M. A., Hökfelt, T., Ögren, S. O., Rozell, B., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000278 · Cited by 83

Conserved Prefusion Protein Assembly in Regulated Exocytosis

Rickman, C., Jiménez, J. L., Graham, M. E., Archer, D. A., Soloviev, M., Burgoyne, R. D., & Davletov, B. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-07-0620 · Cited by 74

Syntaxin 13 is a developmentally regulated SNARE involved in neurite outgrowth and endosomal trafficking

Hirling, H., Steiner, P., Chaperon, C., Marsault, R., Regazzi, R., & Catsicas, S. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00076.x · Cited by 69

RalA-Exocyst Interaction Mediates GTP-dependent Exocytosis

Wang, L., Li, G., & Sugita, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400522200 · Cited by 68

Tomosyn Negatively Regulates CAPS-Dependent Peptide Release at Caenorhabditis elegans Synapses

Gracheva, E. O., Burdina, A. O., Touroutine, D., Berthelot-Grosjean, M., Parekh, H., & Richmond, J. E. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2339-07.2007 · Cited by 65

F-Actin Is Concentrated in Nonrelease Domains at Frog Neuromuscular Junctions

Dunaevsky, A., & Connor, E. A. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06007.2000 · Cited by 64

DNA Variation in the SNAP25 Gene Confers Risk to ADHD and Is Associated with Reduced Expression in Prefrontal Cortex

Hawi, Z., Matthews, N., Wagner, J., Wallace, R. H., Butler, T. J., Vance, A., Kent, L., Gill, M., & Bellgrove, M. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060274 · Cited by 64

Human SCAMP5, a novel secretory carrier membrane protein, facilitates calcium-triggered cytokine secretion by interaction with snare machinery

Han, C., Chen, T., Yang, M., Li, N., Liu, H., & Cao, X. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802002 · Cited by 56

SNARE-Mediated Exocytosis in Neuronal Development

Urbina, F. L., & Gupton, S. L. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00133 · Cited by 48

A microRNA negative feedback loop downregulates vesicle transport and inhibits fear memory

Mathew, R. S., Tatarakis, A., Rudenko, A., Johnson-Venkatesh, E. M., Yang, Y. J., Murphy, E. A., Todd, T. P., Schepers, S. T., Siuti, N., Martorell, A. J., et al. (2016) · eLife · doi:10.7554/elife.22467 · Cited by 39

Synaptotagmin II could confer Ca2+ sensitivity to phagocytosis in human neutrophils

Lindmark, I. M., Karlsson, A., Serrander, L., Francois, P., Lew, D., Rasmusson, B., Stendahl, O., & Nüße, O. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(02)00209-4 · Cited by 28

Overexpression of neuronal Sec1 enhances axonal branching in hippocampal neurons

Steiner, P., Sarria, J.-C. F., Huni, B., Marsault, R., Catsicas, S., & Hirling, H. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00225-7 · Cited by 28

A Perspective on the Role of microRNA-128 Regulation in Mental and Behavioral Disorders

Ching, A.-S., & Ahmad-Annuar, A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00465 · Cited by 24

Syntaxin-3 is dispensable for basal neurotransmission and synaptic plasticity in postsynaptic hippocampal CA1 neurons

Shi, S., Ma, K., Bin, N.-R., Harada, H., Xie, X., Huang, M., Liu, H., Lee, S., Wang, X. F., Adachi, R., et al. (2020) · Scientific Reports · doi:10.1038/s41598-019-57388-6 · Cited by 17