Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

The Inflammasome

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Death Receptors: Signaling and Modulation

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A role for mitochondria in nlrp3 inflammasome activation

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The Inflammasomes

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Gout-associated uric acid crystals activate the NALP3 inflammasome

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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

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Cryopyrin activates the inflammasome in response to toxins and ATP

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

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Activation and regulation of the inflammasomes

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Thioredoxin-interacting protein links oxidative stress to inflammasome activation

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The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

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Non-canonical inflammasome activation targets caspase-11

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The Inflammasomes: Guardians of the Body

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Inflammasomes in health and disease

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The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

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Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

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The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

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Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

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Signaling in innate immunity and inflammation

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Understanding the mechanism of IL-1β secretion

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Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

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Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

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GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

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Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf

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Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages

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The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

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Caspases in apoptosis and beyond

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The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation

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The P2X7 Receptor: A Key Player in IL-1 Processing and Release

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Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

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Inflammasomes and Their Roles in Health and Disease

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The Nalp3 inflammasome is essential for the development of silicosis

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The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

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Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

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Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

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The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

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ATP Activates a Reactive Oxygen Species-dependent Oxidative Stress Response and Secretion of Proinflammatory Cytokines in Macrophages

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The inflammasome: an integrated view

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TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity

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Mechanism of NLRP3 inflammasome activation

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Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice

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TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

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The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

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Toll‐like receptors and adaptor molecules in liver disease: Update†

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The inflammasome: a danger sensing complex triggering innate immunity

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Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

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Pharmacological Inhibitors of the NLRP3 Inflammasome

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The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3

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Autophagy Links Inflammasomes to Atherosclerotic Progression

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Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome

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Nonclassical IL-1β Secretion Stimulated by P2X7 Receptors Is Dependent on Inflammasome Activation and Correlated with Exosome Release in Murine Macrophages

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Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella

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The Inflammasome Mediates UVB-Induced Activation and Secretion of Interleukin-1β by Keratinocytes

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Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

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Inflammasome Components NALP 1 and 3 Show Distinct but Separate Expression Profiles in Human Tissues Suggesting a Site-specific Role in the Inflammatory Response

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Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases

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Salmonellae interactions with host processes

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Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo

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A 360° view of the inflammasome: Mechanisms of activation, cell death, and diseases

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Regulation of Legionella Phagosome Maturation and Infection through Flagellin and Host Ipaf

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Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4

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Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium

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Uric Acid Is a Danger Signal Activating NALP3 Inflammasome in Lung Injury Inflammation and Fibrosis

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NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes

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ASC filament formation serves as a signal amplification mechanism for inflammasomes

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The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection

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NLRs at the intersection of cell death and immunity

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Short hairpin RNA (shRNA): design, delivery, and assessment of gene knockdown

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Differential Requirement of P2X7 Receptor and Intracellular K+ for Caspase-1 Activation Induced by Intracellular and Extracellular Bacteria

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A Molecular Platform in Neurons Regulates Inflammation after Spinal Cord Injury

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Inflammasome-independent regulation of IL-1-family cytokines

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Serum Amyloid A Activates the NLRP3 Inflammasome via P2X7 Receptor and a Cathepsin B-Sensitive Pathway

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P2X7-Dependent Release of Interleukin-1β and Nociception in the Spinal Cord following Lipopolysaccharide

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Sensing damage by the NLRP3 inflammasome

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Staphylococcus aureus Evades Lysozyme-Based Peptidoglycan Digestion that Links Phagocytosis, Inflammasome Activation, and IL-1β Secretion

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Concerted Activation of the AIM2 and NLRP3 Inflammasomes Orchestrates Host Protection against Aspergillus Infection

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The Role of Interferons in Inflammation and Inflammasome Activation

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The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation

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Obesity-associated NLRC4 inflammasome activation drives breast cancer progression

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Sensing pathogens and danger signals by the inflammasome

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Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota

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