Live or let die: the cell's response to p53

Surfing the p53 network

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Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

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A Chemical Inhibitor of p53 That Protects Mice from the Side Effects of Cancer Therapy

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DNA damage activates p53 through a phosphorylation–acetylation cascade

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Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound

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A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

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ASPP Proteins Specifically Stimulate the Apoptotic Function of p53

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Mechanisms of p53-dependent apoptosis

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Mitochondrial membrane permeabilization in cell death

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Integrating cell-signalling pathways with NF-κB and IKK function

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Malignant astrocytic glioma: genetics, biology, and paths to treatment

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TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis

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Control of apoptosis by p53

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p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

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Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

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mCSM: Predicting the effects of mutations in proteins using graph-based signatures

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Serine and one-carbon metabolism in cancer

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Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials

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The Interplay between the Glucocorticoid Receptor and Nuclear Factor-κB or Activator Protein-1: Molecular Mechanisms for Gene Repression

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Molecular mechanisms of fluoride toxicity

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Integration of interferon-α/β signalling to p53 responses in tumour suppression and antiviral defence

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Inhibiting the p53–MDM2 interaction: an important target for cancer therapy

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Acetylation of the p53 DNA-binding domain regulates apoptosis induction.

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Life in the balance: how BH3-only proteins induce apoptosis

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Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

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Structure-Based Design of Spiro-oxindoles as Potent, Specific Small-Molecule Inhibitors of the MDM2−p53 Interaction

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Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

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Role of p53 in Cell Death and Human Cancers

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Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy

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Modeling the Therapeutic Efficacy of p53 Restoration in Tumors

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The casein kinase 1 family: participation in multiple cellular processes in eukaryotes

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PRIMA-1 reactivates mutant p53 by covalent binding to the core domain

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Signaling to p53: ribosomal proteins find their way

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The expanding universe of p53 targets

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eRNAs Are Required for p53-Dependent Enhancer Activity and Gene Transcription

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MDM2 inhibitors for cancer therapy

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Proliferation of aneuploid human cells is limited by a p53-dependent mechanism

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p53 and E2f: partners in life and death

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Sirtuins: critical regulators at the crossroads between cancer and aging

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Transcription-independent pro-apoptotic functions of p53

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Small-Molecule Inhibitors of the MDM2–p53 Protein–Protein Interaction (MDM2 Inhibitors) in Clinical Trials for Cancer Treatment

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Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses

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Structural Basis of DNA Recognition by p53 Tetramers

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BID regulation by p53 contributes to chemosensitivity

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Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX

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PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

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HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53

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The p53 response to DNA damage

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Selective Evolution of Stromal Mesenchyme with p53 Loss in Response to Epithelial Tumorigenesis

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Amplification of Mdmx (or Mdm4 ) Directly Contributes to Tumor Formation by Inhibiting p53 Tumor Suppressor Activity

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Targeting the MDM2–p53 Protein–Protein Interaction for New Cancer Therapy: Progress and Challenges

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MDM2 small-molecule antagonist RG7112 activates p53 signaling and regresses human tumors in preclinical cancer models

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p53 Functions through Stress- and Promoter-Specific Recruitment of Transcription Initiation Components before and after DNA Damage

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A threshold mechanism mediates p53 cell fate decision between growth arrest and apoptosis.

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Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo

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PRIMA-1MET synergizes with cisplatin to induce tumor cell apoptosis

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Cell fate decision mediated by p53 pulses

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A nuclear poly(ADP-Ribose)-dependent signalosome confers DNA damage-induced IκB kinase activation.

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Functional Analysis of the Roles of Posttranslational Modifications at the p53 C Terminus in Regulating p53 Stability and Activity

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MDMX: from bench to bedside

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p21/CDKN1A Mediates Negative Regulation of Transcription by p53

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Human NK Cells Are Alerted to Induction of p53 in Cancer Cells by Upregulation of the NKG2D Ligands ULBP1 and ULBP2

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Changes in Regenerative Capacity through Lifespan

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The c‐myc Promoter: Still MysterY and Challenge

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The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression

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Targeting the p53–MDM2 interaction to treat cancer

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A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network

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Identification and Characterization of the First Small Molecule Inhibitor of MDMX

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p53 Upregulates Death Receptor 4 Expression through an Intronic p53 Binding Site

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Reactivation of mutant p53: molecular mechanisms and therapeutic potential

Selivanova, G., & Wiman, K. G. (2007) · Oncogene · doi:10.1038/sj.onc.1210295 · Cited by 186

p53 and regulation of DNA damage recognition during nucleotide excision repair

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Potent and orally active small-molecule inhibitors of the MDM2-p53 interaction

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Solution structure of p53 core domain: Structural basis for its instability

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Role for KAP1 Serine 824 Phosphorylation and Sumoylation/Desumoylation Switch in Regulating KAP1-mediated Transcriptional Repression

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Divide and conquer: nucleotide excision repair battles cancer and ageing

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Apoptotic Cell Death Under Hypoxia

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Nitric oxide induces CD4 + CD25 + Foxp3 − regulatory T cells from CD4 + CD25 − T cells via p53, IL-2, and OX40

Niedbala, W., Cai, B., Liu, H., Pitman, N., Chang, L., & Liew, F. Y. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703725104 · Cited by 156

Cell-cycle arrest and senescence in TP53-wild type renal carcinoma by enhancer RNA-P53-bound enhancer regions 2 (p53BER2) in a p53-dependent pathway

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PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression

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Therapeutics targeting p53-MDM2 interaction to induce cancer cell death

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Cancer-derived p53 mutants suppress p53-target gene expression--potential mechanism for gain of function of mutant p53

Vikhanskaya, F., Lee, M. K., Mazzoletti, M., Broggini, M., & Sabapathy, K. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm099 · Cited by 145

hTERT: a novel endogenous inhibitor of the mitochondrial cell death pathway

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Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2

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Cell Type- and Promoter-specific Roles of Ser18 Phosphorylation in Regulating p53 Responses

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The UMD TP53 database and website: update and revisions

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Glycogen synthase kinase 3-dependent phosphorylation of Mdm2 regulates p53 abundance

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DNA Damage-Induced Phosphorylation of MdmX at Serine 367 Activates p53 by Targeting MdmX for Mdm2-Dependent Degradation

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The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans

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The beneficial effects of spirulina focusing on its immunomodulatory and antioxidant properties

Maddaly, R. (2010) · Nutrition and Dietary Supplements · doi:10.2147/nds.s9838 · Cited by 127

Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3

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DNA repair and aging: The impact of the p53 family

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Perp Is a Mediator of p53-Dependent Apoptosis in Diverse Cell Types

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Regulation of DNA damage recognition and nucleotide excision repair: another role for p53

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Mdm2 and aurora kinase a inhibitors synergize to block melanoma growth by driving apoptosis and immune clearance of tumor cells

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