Seven-transmembrane receptors

Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor

Palczewski, K., Kumasaka, T., Hori, T., Behnke, C. A., Motoshima, H., Fox, B. A., Trong, I. L., Teller, D. C., Okada, T., Stenkamp, R. E., et al. (2000) · Science · doi:10.1126/science.289.5480.739 · Cited by 5,637

Type-Specific Regulation of Adenylyl Cyclase by G Protein βγ Subunits

Tang, W.-J., & Gilman, A. G. (1991) · Science · doi:10.1126/science.1962211 · Cited by 1,091

The physiology, signaling, and pharmacology of dopamine receptors

Beaulieu, J.-M., & Gainetdinov, R. R. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.002642 · Cited by 2,763

AKAP signalling complexes: focal points in space and time

Wong, W., & Scott, J. D. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1527 · Cited by 1,073

Dopamine: Functions, Signaling, and Association with Neurological Diseases

Klein, M. O., Battagello, D. S., Cardoso, A. R., Hauser, D. N., Bittencourt, J. C., & Correa, R. G. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-018-0632-3 · Cited by 1,073

Crystal structure of opsin in its G-protein-interacting conformation

Scheerer, P., Park, J. H., Hildebrand, P. W., Kim, Y. J., Krauß, N., Choe, H.-W., Hofmann, K. P., & Ernst, O. P. (2008) · Nature · doi:10.1038/nature07330 · Cited by 1,059

G Protein–Coupled Receptor Rhodopsin

Palczewski, K. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142743 · Cited by 764

Activation of Platelet Function Through G Protein–Coupled Receptors

Offermanns, S. (2006) · Circulation Research · doi:10.1161/01.res.0000251742.71301.16 · Cited by 725

Signaling pathways controlling skeletal muscle mass

Egerman, M. A., & Glass, D. J. (2014) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.857291 · Cited by 555

Regulation of affect by the lateral septum: implications for neuropsychiatry

Sheehan, T. P., Chambers, R. A., & Russell, D. S. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.04.009 · Cited by 514

Regulation, signaling, and physiological functions of G-Proteins

Syrovatkina, V., Alegre, K. O., Dey, R., & Huang, X.-Y. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.08.002 · Cited by 498

Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy

Cabezas-Wallscheid, N., Buettner, F., Sommerkamp, P., Klimmeck, D., Ladel, L., Thalheimer, F. B., Pastor-Flores, D., Roma, L. P., Renders, S., Zeisberger, P., et al. (2017) · Cell · doi:10.1016/j.cell.2017.04.018 · Cited by 454

The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

Pols, T. W. H., Noriega, L. G., Nomura, M., Auwerx, J., & Schoonjans, K. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2010.12.004 · Cited by 454

A melanocyte lineage program confers resistance to MAP kinase pathway inhibition

Johannessen, C. M., Johnson, L. A., Piccioni, F., Townes, A., Frederick, D. T., Donahue, M. K., Narayan, R., Flaherty, K. T., Wargo, J. A., Root, D. E., et al. (2013) · Nature · doi:10.1038/nature12688 · Cited by 452

Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling

Shukla, A. K., Xiao, K., & Lefkowitz, R. J. (2011) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2011.06.003 · Cited by 418

Role of β-Adrenoceptor Signaling in Skeletal Muscle: Implications for Muscle Wasting and Disease

Lynch, G. S., & Ryall, J. G. (2008) · Physiological Reviews · doi:10.1152/physrev.00028.2007 · Cited by 410

The Highly Conserved DRY Motif of Class A G Protein-Coupled Receptors: Beyond the Ground State

Rovati, G. E., Capra, V., & Neubig, R. R. (2007) · Molecular Pharmacology · doi:10.1124/mol.106.029470 · Cited by 392

Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4

Chen, W., ten Berge, D., Brown, J., Ahn, S., Hu, L. A., Miller, W. E., Caron, M. G., Barak, L. S., Nusse, R., & Lefkowitz, R. J. (2003) · Science · doi:10.1126/science.1082808 · Cited by 334

Regulation of the immune response and inflammation by histamine and histamine receptors

O’Mahony, L., Akdis, M., & Akdis, C. A. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.06.051 · Cited by 313

How Does the Eye Breathe?

Schmidt, M., Giessl, A., Laufs, T., Hankeln, T., Wolfrum, U., & Burmester, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209909200 · Cited by 316

G-Protein–Coupled Receptors in Heart Disease

Wang, J., Gareri, C., & Rockman, H. A. (2018) · Circulation Research · doi:10.1161/circresaha.118.311403 · Cited by 303

New Roles for β-Arrestins in Cell Signaling: Not Just for Seven-Transmembrane Receptors

Lefkowitz, R. J., Rajagopal, K., & Whalen, E. J. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.11.007 · Cited by 301

Improved tools to study astrocytes

Yu, X., Nagai, J., & Khakh, B. S. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-0264-8 · Cited by 298

The evolution of eyes and visually guided behaviour

Nilsson, D.-E. (2009) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2009.0083 · Cited by 258

Retroviral spread by induction of virological synapses

Jolly, C., & Sattentau, Q. J. (2004) · Traffic · doi:10.1111/j.1600-0854.2004.00209.x · Cited by 240

Dynamic Regulation of a GPCR-Tetraspanin-G Protein Complex on Intact Cells: Central Role of CD81 in Facilitating GPR56-Gαq/11Association

Little, K. D., Hemler, M. E., & Stipp, C. S. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-12-0886 · Cited by 211

Norepinephrine modulates the motility of resting and activated microglia via different adrenergic receptors

Gyoneva, S., & Traynelis, S. F. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.458901 · Cited by 204

Rapid actions of androgens

Michels, G., & Hoppe, U. C. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.08.004 · Cited by 198

The bile acid membrane receptor TGR5: a valuable metabolic target

Pols, T. W. H., Noriega, L. G., Nomura, M., Auwerx, J., & Schoonjans, K. (2011) · Digestive Diseases · doi:10.1159/000324126 · Cited by 185

Role of cAMP and phosphodiesterase signaling in liver health and disease

Wahlang, B., McClain, C., Barve, S., & Gobejishvili, L. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.06.005 · Cited by 168

Human β-Cell Proliferation and Intracellular Signaling: Part 3

Stewart, A. F., Hussain, M. A., García-Ocaña, A., Vasavada, R. C., Bhushan, A., Bernal-Mizrachi, E., & Kulkarni, R. N. (2015) · Diabetes · doi:10.2337/db14-1843 · Cited by 142

Functional Characterization of Rhodopsin Monomers and Dimers in Detergents

Jastrzebska, B., Maeda, T., Zhu, L., Fotiadis, D., Filipek, S., Engel, A., Stenkamp, R. E., & Palczewski, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408691200 · Cited by 134

Essential role of Hrs in a recycling mechanism mediating functional resensitization of cell signaling

Hanyaloglu, A. C., McCullagh, E., & von Zastrow, M. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600688 · Cited by 119

Functional modulation of human monocytes derived DCs by anaphylatoxins C3a and C5a

Li, K., Fazekasova, H., Wang, N., Peng, Q., Sacks, S. H., Lombardi, G., & Zhou, W. (2012) · Immunobiology · doi:10.1016/j.imbio.2011.07.033 · Cited by 108

Immune regulation and the eye.

Stein-Streilein, J. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.08.002 · Cited by 99

G-protein coupled receptor, PI3K and Rho signaling pathways regulate the cascades of Tau and amyloid-β in Alzheimer’s disease

Desale, S. E., Chidambaram, H., & Chinnathambi, S. (2021) · Molecular Biomedicine · doi:10.1186/s43556-021-00036-1 · Cited by 99

Multi-functionality of proteins involved in GPCR and G protein signaling: making sense of structure–function continuum with intrinsic disorder-based proteoforms

Fonin, A. V., Darling, A. L., Kuznetsova, I. M., Turoverov, K. K., & Uversky, V. N. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03276-1 · Cited by 91

The Dictyostelium repertoire of seven transmembrane domain receptors

Prabhu, Y., & Eichinger, L. (2006) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2006.04.003 · Cited by 87

Distinct G protein–coupled receptor recycling pathways allow spatial control of downstream G protein signaling

Bowman, S. L., Shiwarski, D. J., & Puthenveedu, M. A. (2016) · Journal of Cell Biology · doi:10.1083/jcb.201512068 · Cited by 83

Hyaluronic acid–GPRC5C signalling promotes dormancy in haematopoietic stem cells

Zhang, Y. W., Mess, J., Aizarani, N., Mishra, P., Johnson, C., Romero-Mulero, M. C., Rettkowski, J., Schönberger, K., Obier, N., Jäcklein, K., et al. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00931-x · Cited by 72

GPCRomics of homeostatic and disease-associated human microglia

Hsiao, C.-C., Sankowski, R., Prinz, M., Smolders, J., Huitinga, I., & Hamann, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.674189 · Cited by 59

Endosomal trafficking in metabolic homeostasis and diseases

Gilleron, J., & Zeigerer, A. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00737-9 · Cited by 57

Targeting G protein coupled receptor-related pathways as emerging molecular therapies

Ghanemi, A. (2015) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2013.07.007 · Cited by 53

New insights in the control of vascular permeability: vascular endothelial-cadherin and other players

Trani, M., & Dejana, E. (2015) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000137 · Cited by 52

G Protein-Coupled Receptor Heterocomplexes in Neuropsychiatric Disorders

Moreno, J. L., Holloway, T., & González-Maeso, J. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-386931-9.00008-8 · Cited by 30

Heterotrimeric G Proteins: Insights into the Neurobiology of Mood Disorders

Gonzalez-Maeso, J., & Meana, J. (2006) · Current Neuropharmacology · doi:10.2174/157015906776359586 · Cited by 29

Modeling the Orthosteric Binding Site of the G Protein-Coupled Odorant Receptor OR5K1

Nicoli, A., Haag, F., Marcinek, P., He, R., Kreißl, J., Stein, J., Marchetto, A., Dunkel, A., Hofmann, T., Krautwurst, D., et al. (2023) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.2c00752 · Cited by 28

Quantitative profiling of integrin αvβ3 on single cells with quantum dot labeling to reveal the phenotypic heterogeneity of glioblastoma

Wang, T., Li, G., Wang, D., Li, F., Men, D., Hu, T., Xi, Y., & Zhang, X.-E. (2019) · Nanoscale · doi:10.1039/c9nr01105f · Cited by 22

Dissociable effects of systemic and orbitofrontal administration of adrenoceptor antagonists on yohimbine-induced motor impulsivity

Adams, W. K., Barrus, M. M., Zeeb, F. D., Cocker, P. J., Benoit, J., & Winstanley, C. A. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.03.034 · Cited by 20

GRKs and β-Arrestins: “Gatekeepers” of Mitochondrial Function in the Failing Heart

Sorriento, D., Gambardella, J., Fiordelisi, A., Iaccarino, G., & Illario, M. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00064 · Cited by 16

Modeling the Orthosteric Binding Site of the G Protein-Coupled Odorant Receptor OR5K1

Nicoli, A., Haag, F., Marcinek, P., He, R., Kreißl, J., Stein, J., Marchetto, A., Dunkel, A., Hofmann, T., Krautwurst, D., et al. (2022) · doi:10.1101/2022.06.01.494157 · Cited by 2

Functional classification of GNAI1 disorder variants in Caenorhabditis elegans uncovers conserved and cell-specific mechanisms of dysfunction

Salama, R., Peet, E., Morrione, T. L., Durant, S., Seager, M., Rennie, M., Scarlata, S., & Nechipurenko, I. (2025) · GENETICS · doi:10.1093/genetics/iyaf216 · Cited by 2