Cited by 79Retinal Development and DisordersRetinal Diseases and TreatmentsNeuroscience and Neural Engineering

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Bioengineering strategies for restoring vision

Cehajic-Kapetanovic, Jasmina, Singh, Mandeep S., Zrenner, Eberhart, MacLaren, Robert E.·2022·Nature Biomedical Engineering

DOI 10.1038/s41551-021-00836-4

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Abstract

Late-stage retinal degenerative disease involving photoreceptor loss can be treated by optogenetic therapy, cell transplantation and retinal prostheses. These approaches aim to restore light sensitivity to the retina as well as visual perception by integrating neuronal responses for transmission to the cortex. In age-related macular degeneration, some cell-based therapies also aim to restore photoreceptor-supporting tissue to prevent complete photoreceptor loss. In the earlier stages of degeneration, gene-replacement therapy could attenuate retinal-disease progression and reverse loss of function. And gene-editing strategies aim to correct the underlying genetic defects. In this Review, we highlight the most promising gene therapies, cell therapies and retinal prostheses for the treatment of retinal disease, discuss the benefits and drawbacks of each treatment strategy and the factors influencing whether functional tissue is reconstructed and repaired or replaced with an electronic device, and summarize upcoming technologies for enhancing the restoration of vision.

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A Reinterpretation of Cell Transplantation: GFP Transfer From Donor to Host Photoreceptors
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Human ESC–derived retinal epithelial cell sheets potentiate rescue of photoreceptor cell loss in rats with retinal degeneration
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In vivo genome editing rescues photoreceptor degeneration via a Cas9/RecA-mediated homology-directed repair pathway
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Advances in visual prostheses: engineering and biological challenges
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See all 79

Authors: Cehajic-Kapetanovic, J., Singh, M. S., Zrenner, E., & MacLaren, R. E.
Affiliations: Johns Hopkins University (US)
University of Tübingen (DE)
University of Oxford (GB)
ORCID: Cehajic-Kapetanovic, Jasmina
Singh, Mandeep S.
Zrenner, Eberhart
MacLaren, Robert E.
Venue: Nature Biomedical Engineering
Publisher: Springer Science and Business Media LLC
Published: 2022-01-31
Volume: 7
Issue: 4
Pages: 387-404
ISSN: 2157-846X (ISSN-L)
DOI: 10.1038/s41551-021-00836-4
OpenAlex: W4210615010
Cited by: 79
References: 207
Citations by year: 2026: 8 · 2025: 24 · 2024: 19 · 2023: 19 · 2022: 9
FWCI: 1.85
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Biomedical Engineering (publishedVersion)
PubMed (publishedVersion)
Funders: Oxford Biomedical Research Centre.
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Keywords: vision restoration, retinal degeneration, photoreceptor loss, optogenetic therapy, cell transplantation, retinal prosthesis, age-related macular degeneration, gene therapy, genome editing, visual perception
MeSH terms: Humans, Retina, Retinal Degeneration, Vision, Ocular, Cell Transplantation, Bioengineering

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