Jalview Version 2—a multiple sequence alignment editor and analysis workbench

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Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

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Structure of activated transcription complex Pol II–DSIF–PAF–SPT6

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POT1 loss-of-function variants predispose to familial melanoma

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Hypoxia induces rapid changes to histone methylation and reprograms chromatin

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Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma

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Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors

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Auxin-related gene families in abiotic stress response in Sorghum bicolor

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Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human Diseases

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The prdm family: expanding roles in stem cells and development

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A heterochromatin-dependent transcription machinery drives piRNA expression

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Structure of the HIV-1 RNA packaging signal

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Structural mechanism of cGAS inhibition by the nucleosome

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Structural basis for iron piracy by pathogenic Neisseria

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Mismatch Repair Genes Mlh1 and Mlh3 Modify CAG Instability in Huntington's Disease Mice: Genome-Wide and Candidate Approaches

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Terminating contamination: large-scale search identifies more than 2,000,000 contaminated entries in GenBank

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Sequencing Y Chromosomes Resolves Discrepancy in Time to Common Ancestor of Males Versus Females

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Characterization of the spectrum of insecticidal activity of a double-stranded RNA with targeted activity against western corn rootworm (Diabrotica virgifera virgifera LeConte)

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A Comprehensive Benchmark Study of Multiple Sequence Alignment Methods: Current Challenges and Future Perspectives

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Gene family innovation, conservation and loss on the animal stem lineage

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Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax

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Molecular mechanism of APC/C activation by mitotic phosphorylation

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Crystal structure of human stearoyl–coenzyme A desaturase in complex with substrate

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Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis

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Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance

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Peroxisomal lactate dehydrogenase is generated by translational readthrough in mammals

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Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni

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The use and domestication of Theobroma cacao during the mid-Holocene in the upper Amazon

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Structural biology of heme binding in the Staphylococcus aureus Isd system

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A subset of the diverse COG0523 family of putative metal chaperones is linked to zinc homeostasis in all kingdoms of life

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Structure of complete Pol II–DSIF–PAF–SPT6 transcription complex reveals RTF1 allosteric activation

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Structure of Hsp90–p23–GR reveals the Hsp90 client-remodelling mechanism

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The evolution and population diversity of human-specific segmental duplications

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Loops Govern SH2 Domain Specificity by Controlling Access to Binding Pockets

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Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex

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Mapping the Phosphoproteome of Influenza A and B Viruses by Mass Spectrometry

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Structure of the STRA6 receptor for retinol uptake

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Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases

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Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function

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Role of Hydrophobins in Aspergillus fumigatus

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Partitioning of MLX-family transcription factors to lipid droplets regulates metabolic gene expression

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The social and structural architecture of the yeast protein interactome

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Conformational buffering underlies functional selection in intrinsically disordered protein regions

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Structural basis for transcriptional start site control of HIV-1 RNA fate

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Medin co-aggregates with vascular amyloid-β in Alzheimer’s disease

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Shaping development through mechanical strain: the transcriptional basis of diet‐induced phenotypic plasticity in a cichlid fish

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Filamentous fungal carbon catabolite repression supports metabolic plasticity and stress responses essential for disease progression

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Pseudohyphal growth of the emerging pathogen Candida auris is triggered by genotoxic stress through the S phase checkpoint

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Neuropeptide repertoire and 3D anatomy of the ctenophore nervous system

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Rumen methanogenic genotypes differ in abundance according to host residual feed intake phenotype and diet type

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Species richness of jellyfishes (Scyphozoa: Discomedusae) in the Tropical Eastern Pacific: missed taxa, molecules, and morphology match in a biodiversity hotspot

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Hfq CLASH uncovers sRNA-target interaction networks linked to nutrient availability adaptation

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Differential evolution of voltage-gated sodium channels in tetrapods and teleost fishes

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ATP synthase evolution on a cross-braced dated tree of life

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Radiation of nitrogen‐metabolizing enzymes across the tree of life tracks environmental transitions in Earth history

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Evolutionary analysis of the most polymorphic gene family in falciparum malaria

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Design of highly functional genome editors by modeling the universe of CRISPR-Cas sequences

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Crystal structure of a mucus-binding protein repeat reveals an unexpected functional immunoglobulin binding activity

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Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients

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CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes

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SARS-CoV-2 Nsp16 activation mechanism and a cryptic pocket with pan-coronavirus antiviral potential

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De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking

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Dietary- and host-derived metabolites are used by diverse gut bacteria for anaerobic respiration

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pico‐ PLAZA , a genome database of microbial photosynthetic eukaryotes

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A conserved fertilization complex bridges sperm and egg in vertebrates

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Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor

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The Genome of Spironucleus salmonicida Highlights a Fish Pathogen Adapted to Fluctuating Environments

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