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Cited by 360Circadian rhythm and melatoninDietary Effects on HealthRegulation of Appetite and Obesity

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Timed high-fat diet resets circadian metabolism and prevents obesity

Sherman, Hadas, Genzer, Yoni, Cohen, Rotem, Chapnik, Nava, Madar, Zecharia, Froy, Oren·2012·The FASEB Journal
DOI 10.1096/fj.12-208868
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Abstract

Disruption of circadian rhythms leads to obesity and metabolic disorders. Timed restricted feeding (RF) provides a time cue and resets the circadian clock, leading to better health. In contrast, a high-fat (HF) diet leads to disrupted circadian expression of metabolic factors and obesity. We tested whether long-term (18 wk) clock resetting by RF can attenuate the disruptive effects of diet-induced obesity. Analyses included liver clock gene expression, locomotor activity, blood glucose, metabolic markers, lipids, and hormones around the circadian cycle for a more accurate assessment. Compared with mice fed the HF diet ad libitum, the timed HF diet restored the expression phase of the clock genes Clock and Cry1 and phase-advanced Per1, Per2, Cry2, Bmal1, Rorα, and Rev-erbα. Although timed HF-diet-fed mice consumed the same amount of calories as ad libitum low-fat diet-fed mice, they showed 12% reduced body weight, 21% reduced cholesterol levels, and 1.4-fold increased insulin sensitivity. Compared with the HF diet ad libitum, the timed HF diet led to 18% lower body weight, 30% decreased cholesterol levels, 10% reduced TNF-α levels, and 3.7-fold improved insulin sensitivity. Timed HF-diet-fed mice exhibited a better satiated and less stressed phenotype of 25% lower ghrelin and 53% lower corticosterone levels compared with mice fed the timed low-fat diet. Taken together, our findings suggest that timing can prevent obesity and rectify the harmful effects of a HF diet.

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Crossref · 10.1096/fj.12-208868

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Metadata

Authors
Sherman, H., Genzer, Y., Cohen, R., Chapnik, N., Madar, Z., & Froy, O.
Affiliations
Hebrew University of Jerusalem (IL)
Corresponding author
Froy, Oren
ORCID
Venue
The FASEB Journal
Publisher
Wiley
Published
2012-05-16
Volume
26
Issue
8
Pages
3493-3502
ISSN
  • 0892-6638 (ISSN-L)
  • 1530-6860
DOI
10.1096/fj.12-208868
OpenAlex
W2138503496
Cited by
360
References
40
Citations by year
2026: 15 · 2025: 14 · 2024: 20 · 2023: 26 · 2022: 38 · 2021: 32 · 2020: 39 · 2019: 33 · 2018: 24 · 2017: 29 · 2016: 20 · 2015: 27 · 2014: 22 · 2013: 18 · 2012: 3
FWCI
9.91
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • The FASEB Journal (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
high-fat diet, diet-induced obesity, circadian clock, clock gene expression, circadian metabolism, insulin sensitivity, cholesterol, ghrelin, corticosterone, TNF-α, locomotor activity, body weight
MeSH terms
Animals, Circadian Rhythm, Corticosterone, Diet, Eating, Insulin Resistance, Lipids, Male, Motor Activity, Mice, CLOCK Proteins, Diet, High-Fat

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