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Regulation of the Germinal Center Response by MicroRNA-155
Abstract
MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell–dependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo.
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(2012) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
Metadata
- Authors
- Thai, T.-H., Calado, D. P., Casola, S., Ansel, K. M., Xiao, C., Xue, Y., Murphy, A., Frendewey, D., Valenzuela, D., Kutok, J. L., Schmidt-Supprian, M., Rajewsky, N., Yancopoulos, G., Rao, A., & Rajewsky, K.
- Venue
- Science
- Published
- 2007-04-27
- Volume
- 316
- Issue
- 5824
- Pages
- 604-608
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2079294041
- Cited by
- 1,477
- References
- 2
- FWCI
- 39.11
- Type
- journal article
- Language
- en
- Open access
- closed
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