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Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor
Abstract
Mice harboring mutations in the obese ( ob ) and diabetes ( db ) genes display similar phenotypes, and it has been proposed that these genes encode the ligand and receptor, respectively, for a physiologic pathway that regulates body weight. The cloning of ob , and the demonstration that it encodes a secreted protein (leptin) that binds specifically to a receptor (OB-R) in the brain, have validated critical aspects of this hypothesis. Here it is shown by genetic mapping and genomic analysis that mouse db , rat fatty (a homolog of db ), and the gene encoding the OB-R are the same gene.
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Metadata
- Authors
- Chua, S. C., Chung, W. K., Wu-Peng, X. S., Zhang, Y., Liu, S.-M., Tartaglia, L., & Leibel, R. L.
- Venue
- Science
- Published
- 1996-02-16
- Volume
- 271
- Issue
- 5251
- Pages
- 994-996
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2055162678
- Cited by
- 1,075
- References
- 4
- FWCI
- 27.42
- Type
- journal article
- Language
- en
- Open access
- closed
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