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The Future of Genetic Studies of Complex Human Diseases

Risch, Neil, Merikangas, Kathleen·1996·Science

DOI 10.1126/science.273.5281.1516

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Abstract

The identification of the genetic basis of complex human diseases such as schizophrenia and diabetes has proven difficult. In their Perspective, Risch and Merikangas propose that we can best accomplish this goal by combining the power of the human genome project with association studies, a method for determining the basis of a genetic disease.

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Authors: Risch, N., & Merikangas, K.
Affiliations: Stanford Medicine (US)
Yale University (US)
ORCID: Risch, Neil
Merikangas, Kathleen
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1996-09-13
Volume: 273
Issue: 5281
Pages: 1516-1517
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.273.5281.1516
OpenAlex: W2042103448
Cited by: 5,355
References: 4
Citations by year: 2026: 41 · 2025: 46 · 2024: 73 · 2023: 74 · 2022: 66 · 2021: 70 · 2020: 85 · 2019: 108 · 2018: 92 · 2017: 108 · 2016: 116 · 2015: 114 · 2014: 149 · 2013: 162 · 2012: 190
FWCI: 92.45
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
Keywords: complex diseases, genetic susceptibility, schizophrenia, diabetes mellitus, genome-wide association study, Human Genome Project, genetic basis of disease
MeSH terms: Alleles, Genetic Techniques, Genotype, Heterozygote, Humans, Genetic Linkage, Polymorphism, Genetic, Probability, Genome, Human, Genetic Predisposition to Disease, Genetic Diseases, Inborn

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The Future of Genetic Studies of Complex Human Diseases

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