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Mitochondria and Apoptosis

Green, Douglas R., Reed, John C.·1998·Science

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Abstract

REVIEW A variety of key events in apoptosis focus on mitochondria, including the release of caspase activators (such as cytochrome c), changes in electron transport, loss of mitochondrial transmembrane potential, altered cellular oxidation-reduction, and participation of pro- and antiapoptotic Bcl-2 family proteins. The different signals that converge on mitochondria to trigger or inhibit these events and their downstream effects delineate several major pathways in physiological cell death.

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Untitled work
(2001) · doi:10.1002/1097-0142(20010801)92:3<657::aid-cncr1367>3.0.co;2-d

Authors: Green, D. R., & Reed, J. C.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1998-08-28
Volume: 281
Issue: 5381
Pages: 1309-1312
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.281.5381.1309
OpenAlex: W2113999599
Cited by: 8,965
References: 1
FWCI: 177.27
Type: journal article
Language: en
Open access: closed

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Mitochondria and Apoptosis

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