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The biology , function , and biomedical applications of exosomes
Open accessAbstract
Clinical uses of cellular communication: Exosomes are a type of extracellular vesicle that contain constituents (protein, DNA, and RNA) of the cells that secrete them. They are taken up by distant cells, where they can affect cell function and behavior. Intercellular communication through exosomes seems to be involved in the pathogenesis of various disorders, including cancer, neurodegeneration, and inflammatory diseases. In a Review, Kalluri and LeBleu discuss the biogenesis and function of exosomes in disease, highlighting areas where more research is needed. They also discuss the potential clinical applications of exosome profiling for diagnostics and exosome-mediated delivery of therapeutics to target disease cells. Science , this issue p. eaau6977
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“There are three major categories of EVs, namely exosomes, microvesicles, and apoptotic bodies, which are classified based on their biogenesis mechanism [39, 40].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [40]
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“In many prior research into EVs, EVs have been conventionally classified into three main categories: exosomes, microvesicles, and apoptotic bodies based on their biogenesis mechanism [39, 40].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [40]
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“Among the key proteins found in sEVs are tetraspanins (CD63, CD9, and CD81), membrane trafficking proteins (RAB proteins and annexins), and proteins involved in MVBs formation (ALIX, TSG101, and clathrin) [40].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [40]
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“The enclosure of the molecular components in EVs is mainly mediated by the Endosomal Sorting Complex Required for Transport (ESCRT)-dependent and ESCRT-independent pathways [40].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [40]
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In the citing paper
“Exosomes are, among them, endosomal-derived and are 10–150 nm in diameter [12,13].”
From Ferroptosis-dependent extracellular vesicles from macrophage contribute to asbestos-induced mesothelial carcinogenesis through loading ferritin (2021) · cites this paper as [13]
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“The content and function of EVs can differ significantly depending on their cell of origin, reflecting the cellular context and state, especially under disease conditions [40, 142].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [40]
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“Exosomes are naturally occurring nanovesicles that facilitate intercellular communication via paracrine or other signaling pathways [12].”
From Hydrogel scaffold encapsulating MSC-Exos and ZIF-8 promotes bone regeneration via coordinating osteogenesis and immunomodulation (2025) · cites this paper as [12]
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“In the model we found massive expression of CD63, a marker of EVs [12,13], inside and also outside of various cells, including macrophages, myofibroblasts and mesothelial cells.”
From Ferroptosis-dependent extracellular vesicles from macrophage contribute to asbestos-induced mesothelial carcinogenesis through loading ferritin (2021) · cites this paper as [13]
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“EVs also play a key role in maintaining tissue homeostasis (Kalluri and LeBleu, 2020, Lee and Schmitt, 2019, van Niel et al., 2018)”
From Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage (2020) · cites this paper as Kalluri and LeBleu, 2020
In the citing paper
“Exosomes are a key component of intercellular signaling networks, transporting polypeptides, metabolic products, and nucleic acids between both adjacent and remote cells [204].”
From Emerging role of exosomes in cancer therapy: progress and challenges (2025) · cites this paper as [204]
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Citations
Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin‐Smith, G. K., et al. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1535750 · Cited by 11,099
Self-citationShedding light on the cell biology of extracellular vesicles
van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369
Tumour exosome integrins determine organotropic metastasis
Hoshino, A., Costa-Silva, B., Shen, T.-L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., et al. (2015) · Nature · doi:10.1038/nature15756 · Cited by 5,101
Skog, J., Würdinger, T., van Rijn, S., Meijer, D. H., Gainche, L., Curry, W. T., Carter, B. S., Krichevsky, A. M., & Breakefield, X. O. (2008) · Nature Cell Biology · doi:10.1038/ncb1800 · Cited by 5,001
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930
Mathieu, M., Jaular, L. M., Lavieu, G., & Théry, C. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0250-9 · Cited by 3,894
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715
B lymphocytes secrete antigen-presenting vesicles.
Raposo, G., Nijman, H. W., Stoorvogel, W., Liejendekker, R., Harding, C. V., Melief, C. J., & Geuze, H. J. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.3.1161 · Cited by 3,546
Communication by Extracellular Vesicles: Where We Are and Where We Need to Go
Tkach, M., & Théry, C. (2016) · Cell · doi:10.1016/j.cell.2016.01.043 · Cited by 3,444
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Advances in oligonucleotide drug delivery
Roberts, T. C., Langer, R., & Wood, M. J. A. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0075-7 · Cited by 2,121
Extracellular vesicles as a next-generation drug delivery platform
Herrmann, I. K., Wood, M. J. A., & Fuhrmann, G. (2021) · Nature Nanotechnology · doi:10.1038/s41565-021-00931-2 · Cited by 1,948
The exosome journey: from biogenesis to uptake and intracellular signalling
Gurung, S., Perocheau, D. P. B., Touramanidou, L., & Baruteau, J. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00730-1 · Cited by 1,912
Pattern recognition receptors in health and diseases
Li, D., & Wu, M. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00687-0 · Cited by 1,961
Engineering exosomes for targeted drug delivery
Liang, Y., Duan, L., Lu, J., & Xia, J. (2021) · Theranostics · doi:10.7150/thno.52570 · Cited by 1,547
Zhang, Y., Bi, J., Huang, J., Tang, Y., Du, S., & Li, P. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s264498 · Cited by 1,323
Exosomes: key players in cancer and potential therapeutic strategy
Dai, J., Su, Y., Zhong, S., Cong, L., Liu, B., Yang, J., Tao, Y., He, Z., Chen, C., & Jiang, Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00261-0 · Cited by 1,186
The updated landscape of tumor microenvironment and drug repurposing
Jin, M.-Z., & Jin, W.-L. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00280-x · Cited by 1,262
Targeting STAT3 in Cancer Immunotherapy
Zou, S., Tong, Q., Liu, B., Huang, W., Tian, Y., & Fu, X. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01258-7 · Cited by 1,109
Liquid Biopsy: From Discovery to Clinical Application
Alix‐Panabières, C., & Pantel, K. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1311 · Cited by 1,006
Lipid Peroxidation and Iron Metabolism: Two Corner Stones in the Homeostasis Control of Ferroptosis
Rochette, L., Dogon, G., Rigal, E., Zeller, M., Cottin, Y., & Vergely, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010449 · Cited by 966
Microglia polarization from M1 to M2 in neurodegenerative diseases
Guo, S., Wang, H., & Yin, Y. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.815347 · Cited by 920
Exosomes as a new frontier of cancer liquid biopsy
Yu, D., Li, Y., Wang, M., Gu, J., Xu, W., Cai, H., Fang, X., & Zhang, X. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01509-9 · Cited by 855
Exosomes as mediators of intercellular crosstalk in metabolism
Isaac, R., Reis, F. C. G., Ying, W., & Olefsky, J. M. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.08.006 · Cited by 860
Plant Exosome-like Nanovesicles: Emerging Therapeutics and Drug Delivery Nanoplatforms
Dad, H. A., Gu, T.-W., Zhu, A.-Q., Huang, L., & Peng, L. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.11.030 · Cited by 772
Liquid biopsy in cancer: current status, challenges and future prospects
Ma, L., Guo, H., Zhao, Y., Liu, Z., Wang, C., Bu, J., Sun, T., & Wei, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02021-w · Cited by 820
Tumor biomarkers for diagnosis, prognosis and targeted therapy
Zhou, Y., Tao, L., Qiu, J., Xu, J., Yang, X., Zhang, Y., Tian, X., Guan, X., Cen, X., & Zhao, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01823-2 · Cited by 836
Therapeutically harnessing extracellular vesicles
Cheng, L., & Hill, A. F. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00410-w · Cited by 737
Challenges and advances in clinical applications of mesenchymal stromal cells
Zhou, T., Yuan, Z., Weng, J., Pei, D., Du, X., He, C., & Lai, P. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01037-x · Cited by 712
Clinical applications of stem cell-derived exosomes
Tan, F., Li, X., Wang, Z., Li, J., Shahzad, K., & Zheng, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01704-0 · Cited by 708
Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer
Han, Q.-F., Li, W.-J., Hu, K.-S., Gao, J., Zhai, W.-L., Yang, J.-H., & Zhang, S.-J. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01671-0 · Cited by 678
The role of extracellular vesicles in cancer
Kalluri, R., & McAndrews, K. M. (2023) · Cell · doi:10.1016/j.cell.2023.03.010 · Cited by 695
Self-citationDendritic cell subsets in cancer immunity and tumor antigen sensing
Prete, A. D., Salvi, V., Soriani, A., Laffranchi, M., Sozio, F., Bosisio, D., & Sozzani, S. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-00990-6 · Cited by 682
RNA-based therapeutics: an overview and prospectus
Zhu, Y., Zhu, L., Wang, X., & Jin, H. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05075-2 · Cited by 683
Kou, M., Huang, L., Yang, J., Chiang, Z., Chen, S., Liu, J., Guo, L., Zhang, X., Zhou, X., Xu, X., et al. (2022) · Cell Death & Disease · doi:10.1038/s41419-022-05034-x · Cited by 640
Exosome Processing and Characterization Approaches for Research and Technology Development
Lai, J. J., Chau, Z. L., Chen, S., Hill, J. J., Korpany, K. V., Liang, N., Lin, L., Lin, Y., Liu, J. K., Liu, Y., et al. (2022) · Advanced Science · doi:10.1002/advs.202103222 · Cited by 623
Exosomes─Nature’s Lipid Nanoparticles, a Rising Star in Drug Delivery and Diagnostics
Tenchov, R., Sasso, J. M., Wang, X., Liaw, W., Chen, C., & Zhou, Q. A. (2022) · ACS Nano · doi:10.1021/acsnano.2c08774 · Cited by 642
A review on exosomes application in clinical trials: perspective, questions, and challenges
Rezaie, J., Feghhi, M., & Etemadi, T. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-022-00959-4 · Cited by 629
Unlocking the promise of mRNA therapeutics
Rohner, E., Yang, R., Foo, K. S., Goedel, A., & Chien, K. R. (2022) · Nature Biotechnology · doi:10.1038/s41587-022-01491-z · Cited by 612
Release mechanisms of major DAMPs
Murao, A., Aziz, M., Wang, H., Brenner, M., & Wang, P. (2021) · APOPTOSIS · doi:10.1007/s10495-021-01663-3 · Cited by 590
Wang, S., Wang, J., Chen, Z., Luo, J., Guo, W., Sun, L., & Lin, L. (2024) · npj Precision Oncology · doi:10.1038/s41698-024-00522-z · Cited by 657
Current advance of nanotechnology in diagnosis and treatment for malignant tumors
Wang, B., Hu, S., Teng, Y., Chen, J., Wang, H., Xu, Y., Wang, K., Xu, J., Cheng, Y., & Gao, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01889-y · Cited by 641
The biology, function, and applications of exosomes in cancer
Liu, J., Ren, L., Li, S., Li, W., Zheng, X., Yang, Y., Fu, W., Yi, J., Wang, J., & Du, G. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.01.001 · Cited by 569
The evolving translational potential of small extracellular vesicles in cancer
Möller, A., & Lobb, R. J. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-00299-w · Cited by 550
Isolation and characterization of exosomes for cancer research
Zhu, L., Sun, H., Wang, S., Huang, S., Zheng, Y., Wang, C., Hu, B., Qin, W., Zou, T., Fu, Y., et al. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00987-y · Cited by 537
Review on Strategies and Technologies for Exosome Isolation and Purification
Chen, J., Li, P., Zhang, T., Xu, Z., Huang, X., Wang, R., & Du, L. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.811971 · Cited by 585
Design of therapeutic biomaterials to control inflammation
Tu, Z., Zhong, Y., Hu, H., Shao, D., Haag, R., Schirner, M., Lee, J., Sullenger, B. A., & Leong, K. W. (2022) · Nature Reviews Materials · doi:10.1038/s41578-022-00426-z · Cited by 533
Molecular mechanisms of tumor resistance to radiotherapy
Wu, Y., Song, Y., Wang, R., & Wang, T. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01801-2 · Cited by 527
The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors
Izci, M., Maksoudian, C., Manshian, B. B., & Soenen, S. J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00779 · Cited by 506
RAB31 marks and controls an ESCRT-independent exosome pathway
Wei, D., Zhan, W., Gao, Y., Huang, L., Gong, R., Wang, W., Zhang, R., Wu, Y., Gao, S., & Kang, T. (2020) · Cell Research · doi:10.1038/s41422-020-00409-1 · Cited by 512
Kugeratski, F. G., Hodge, K., Lilla, S., McAndrews, K. M., Zhou, X., Hwang, R. F., Zanivan, S. R., & Kalluri, R. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00693-y · Cited by 502
Self-citationLiquid biopsy in lung cancer: significance in diagnostics, prediction, and treatment monitoring
Li, W., Liu, J., Hou, L., Yu, F., Zhang, J., Wu, W., Tang, X.-M., Feng, S., Lu, H., Deng, J., et al. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01505-z · Cited by 462
Chronic inflammation and the hallmarks of aging
Baechle, J. J., Chen, N., Makhijani, P., Winer, S., Furman, D., & Winer, D. A. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101755 · Cited by 471
Current Strategies for Exosome Cargo Loading and Targeting Delivery
Zeng, H., Guo, S., Ren, X., Wu, Z., Liu, S., & Yao, X. (2023) · Cells · doi:10.3390/cells12101416 · Cited by 464
Engineered Extracellular Vesicles for Cancer Therapy
Zhang, X., Zhang, H., Gu, J., Zhang, J., Shi, H., Qian, H., Wang, D., Xu, W., Pan, J., & Santos, H. A. (2021) · Advanced Materials · doi:10.1002/adma.202005709 · Cited by 428
Gupta, D., Zickler, A. M., & Andaloussi, S. E. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113961 · Cited by 438
Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic applications
Mondal, J., Pillarisetti, S., Junnuthula, V., Saha, M., Hwang, S. R., Park, I.-K., & Lee, Y.-K. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.12.027 · Cited by 416
Erdbrügger, U., Blijdorp, C. J., Bijnsdorp, I. V., Borràs, F. E., Burger, D. E., Bussolati, B., Byrd, J. B., Clayton, A., Dear, J. W., Falcón‐Pérez, J. M., et al. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12093 · Cited by 422
Regulation of cargo selection in exosome biogenesis and its biomedical applications in cancer
Lee, Y. J., Shin, K. J., & Chae, Y. C. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01209-y · Cited by 427
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Brunet, A., Goodell, M. A., & Rando, T. A. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00510-w · Cited by 407
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Li, C., Ni, Y., Xu, H., Xiang, Q., Zhao, Y. Q., Zhan, J., He, J., Li, S., & Liu, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00779-x · Cited by 424
Jia, Y., Yu, L., Ma, T., Xu, W., Qian, H., Sun, Y., & Shi, H. (2022) · Theranostics · doi:10.7150/thno.74305 · Cited by 424
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Kim, J., Li, S., Zhang, S., & Wang, J. (2021) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2021.05.006 · Cited by 415
Liang, Y., Xu, X., Li, X., Xiong, J., Li, B., Duan, L., Wang, D., & Xia, J. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c10458 · Cited by 391
Regulation of exosome production and cargo sorting
Wei, H., Chen, Q., Lin, L., Sha, C., Li, T., Liu, Y., Yin, X., Xu, Y., Chen, L., Gao, W., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.53671 · Cited by 385
Molecular targeting therapies for neuroblastoma: Progress and challenges
Zafar, A., Wang, W., Liu, G., Wang, X., Xian, W., McKeon, F., Foster, J. H., Zhou, J., & Zhang, R. (2020) · Medicinal Research Reviews · doi:10.1002/med.21750 · Cited by 388
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Liu, Y., & Wang, C. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01103-6 · Cited by 425
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Teng, F., & Fussenegger, M. (2020) · Advanced Science · doi:10.1002/advs.202003505 · Cited by 401
Gurunathan, S., Kang, M.-H., & Kim, J. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s291956 · Cited by 397
A one-pot isothermal Cas12-based assay for the sensitive detection of microRNAs
Yan, H., Wen, Y., Tian, Z., Hart, N., Han, S., Hughes, S. J., & Zeng, Y. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-023-01033-1 · Cited by 380
Extracellular vesicles: A bright star of nanomedicine
Wu, P., Zhang, B., Ocansey, D. K. W., Xu, W., & Qian, H. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2020.120467 · Cited by 368
EMT‐associated microRNAs and their roles in cancer stemness and drug resistance
Pan, G., Liu, Y., Shang, L., Zhou, F., & Yang, S. (2021) · 癌症：英文版 · doi:10.1002/cac2.12138 · Cited by 362
Exosome engineering in cell therapy and drug delivery
Sadeghi, S., Tehrani, F. R., Tahmasebi, S., Shafiee, A., & Hashemi, S. M. (2023) · Inflammopharmacology · doi:10.1007/s10787-022-01115-7 · Cited by 351
Stem cell-derived exosomes: emerging therapeutic opportunities for wound healing
Zhou, C., Zhang, B., Yang, Y., Jiang, Q., Li, T., Gong, J., Tang, H., & Zhang, Q. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03345-0 · Cited by 344
Zhu, D., Li, Z., Huang, K., Caranasos, T. G., Rossi, J. S., & Cheng, K. (2021) · Nature Communications · doi:10.1038/s41467-021-21682-7 · Cited by 341
Cancer associated-fibroblast-derived exosomes in cancer progression
Li, C., Teixeira, A. F., Zhu, H., & ten Dijke, P. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01463-y · Cited by 352
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Chen, H., Wang, L., Zeng, X., Schwarz, H., Nanda, H. S., Peng, X., & Zhou, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.751079 · Cited by 349
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Li, Y.-J., Wu, J.-Y., Liu, J., Xu, W., Qiu, X., Huang, S., Hu, X.-B., & Xiang, D.-X. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00986-2 · Cited by 303
Liu, X., Gao, X., Yang, L., Zhao, Y., & Li, F. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c02286 · Cited by 336
Zhong, X., He, X., Wang, Y., Hu, Z., Huang, H., Zhao, S., Wei, P., & Li, D. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01358-5 · Cited by 356
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Verweij, F. J., Balaj, L., Boulanger, C. M., Carter, D. R. F., Compeer, E. B., D’Angelo, G., Andaloussi, S. E., Goetz, J. G., Gross, J. C., Hyenne, V., et al. (2021) · Nature Methods · doi:10.1038/s41592-021-01206-3 · Cited by 343
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Bordanaba-Florit, G., Royo, F., Kruglik, S. G., & Falcón‐Pérez, J. M. (2021) · Nature Protocols · doi:10.1038/s41596-021-00551-z · Cited by 335
Xu, Z., Chen, Y., Ma, L., Chen, Y., Liu, J., Guo, Y., Yu, T., Zhang, L., Zhu, L., & Shu, Y. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.01.046 · Cited by 337
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Du, S., Guan, Y., Xie, A., Yan, Z., Gao, S., Li, W., Rao, L., Chen, X., & Chen, T. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01973-5 · Cited by 343
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Sposato, L. A., Hilz, M. J., Aspberg, S., Murthy, S. B., Bahit, M. C., Hsieh, C., Sheppard, M. N., & Scheitz, J. F. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.10.009 · Cited by 333
Shen, K., Wang, X., Wang, Y., Jia, Y., Zhang, Y., Wang, K., Luo, L., Cai, W., Li, J., Li, S., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102655 · Cited by 323
Zou, J., Yang, W., Cui, W., Li, C., Ma, C., Ji, X., Hong, J., Qu, Z., Chen, J., Liu, A., et al. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01778-6 · Cited by 325
Visan, K. S., Lobb, R. J., Ham, S., Lima, L. G., Palma, C., Edna, C. P. Z., Wu, L., Gowda, H., Datta, K. K., Härtel, G., et al. (2022) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12266 · Cited by 315
Bella, M. A. D. (2022) · Biology · doi:10.3390/biology11060804 · Cited by 322
Shao, J., Zaro, J., & Shen, Y. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s281890 · Cited by 295
Cao, J.-Y., Wang, B., Tang, T., Wen, Y., Li, Z., Feng, S., Wu, M., Liu, D., Yin, D., Ma, K.-L., et al. (2021) · Theranostics · doi:10.7150/thno.54550 · Cited by 309
Wan, T. Y., Zhong, J., Pan, Q., Zhou, T., Yuan, P., & Liu, X. (2022) · Science Advances · doi:10.1126/sciadv.abp9435 · Cited by 314
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Zhou, H., Liu, Z., Wang, Y., Wen, X., Amador, E. H., Yuan, L., Ran, X., Xiong, L., Ran, Y., Chen, W., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00922-2 · Cited by 298
Lin, Z., Wu, Y., Xu, Y., Li, G., Li, Z., & Liu, T. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01650-5 · Cited by 297
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Li, J., Wang, J., & Chen, Z. (2025) · Molecular Cancer · doi:10.1186/s12943-024-02215-4 · Cited by 297
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Zhou, X., Xie, F., Wang, L., Zhang, L., Zhang, S., Fang, M., & Zhou, F. (2020) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-0391-1 · Cited by 294
Shen, Z., Kuang, S., Zhang, Y., Yang, M., Qin, W., Shi, X., & Lin, Z. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.07.002 · Cited by 295
Yuan, M., Liu, K., Jiang, T., Li, S., Chen, J., Wu, Z., Li, W., Tan, R., Wei, W., Yang, X., et al. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01354-4 · Cited by 304
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Ni, Z., Zhou, S., Li, S., Kuang, L., Chen, H., Luo, X., Ouyang, J., He, M., Du, X., & Chen, L. (2020) · Bone Research · doi:10.1038/s41413-020-0100-9 · Cited by 302
Wolf, M., Poupardin, R., Peking, P., Andrade, A. C., Blöchl, C., Obermayer, A., Gomes, F. G., Vári, B., Maeding, N., Eminger, E., et al. (2022) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12207 · Cited by 288
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Rädler, J., Gupta, D., Zickler, A. M., & Andaloussi, S. E. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2023.02.013 · Cited by 298
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Stejskal, P., Goodarzi, H., Srovnal, J., Hajdúch, M., Veer, L. V. ‘., & Magbanua, M. J. M. (2023) · Molecular Cancer · doi:10.1186/s12943-022-01710-w · Cited by 317
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Choi, H., Choi, Y., Yim, H. Y., Mirzaaghasi, A., Yoo, J., & Choi, C. (2021) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-021-00361-0 · Cited by 295
Xu, M., Ji, J., Jin, D., Wu, Y. H., Wu, T., Lin, R., Zhu, S., Jiang, F., Ji, Y., Bao, B., et al. (2022) · Genes & Diseases · doi:10.1016/j.gendis.2022.03.021 · Cited by 304
Bai, R., Li, Y., Jian, L., Yue-hui, Y., Zhao, L., & Wei, M. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01645-2 · Cited by 296
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Self-citationLiquid biopsies: Potential and challenges
Heidrich, I., Ačkar, L., Mohammadi, P. M., & Pantel, K. (2020) · International Journal of Cancer · doi:10.1002/ijc.33217 · Cited by 284
Metadata
- Authors
- Kalluri, R., & LeBleu, V. S.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Kalluri, Raghu
- Venue
- Science
- Published
- 2020-02-07
- Volume
- 367
- Issue
- 6478
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC7717626
- OpenAlex
- W3005104290
- Cited by
- 10,770
- References
- 244
- Citations by year
- 2026: 1781 · 2025: 2238 · 2024: 2222 · 2023: 1766 · 2022: 1430 · 2021: 996 · 2020: 328
- FWCI
- 108.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (CA213233, CA195733, CA231465)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- exosomes, extracellular vesicles, exosome biogenesis, endosomes, intercellular communication, biomarkers, liquid biopsy, exosome therapy, disease diagnosis
- MeSH terms
- Animals, Cardiovascular Diseases, Cell Communication, Humans, Infections, Metabolic Diseases, Neoplasms, Reproduction, Neurodegenerative Diseases, Exosomes
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