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Stress, Telomeres, and Psychopathology: Toward a Deeper Understanding of a Triad of Early Aging
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Telomeres play an important part in aging and show relationships to lifetime adversity, particularly childhood adversity. Meta-analyses demonstrate reliable associations between psychopathology (primarily depression) and shorter telomere length, but the nature of this relationship has not been fully understood. Here, we review and evaluate the evidence for impaired telomere biology as a consequence of psychopathology or as a contributing factor, and the important mediating roles of chronic psychological stress and impaired allostasis. There is evidence for a triadic relationship among stress, telomere shortening, and psychiatric disorders that is positively reinforcing and unfolds across the life course and, possibly, across generations. We review the role of genetics and biobehavioral responses that may contribute to shorter telomere length, as well as the neurobiological impact of impaired levels of telomerase. These complex interrelationships are important to elucidate because they have implications for mental and physical comorbidity and, potentially, for the prevention and treatment of depression.
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“A recent comprehensive review provides support for the hypothesis that telomere length is most strongly related to stress-related psychiatric disorders and indexes both adversity exposure and future health risk.17”
From Telomere Length and Psychopathology: Specificity and Direction of Effects Within the Bucharest Early Intervention Project (2020) · cites this paper as [17]
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“alternatively, that the psychiatric and medical conditions may be primarily responsible for some of the telomere effect (Epel and Prather, 2018).”
Influential
Metadata
- Authors
- Epel, E. S., & Prather, A. A.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Annual Review of Clinical Psychology
- Publisher
- Annual Reviews
- Published
- 2018-05-07
- Volume
- 14
- Issue
- 1
- Pages
- 371-397
- ISSN
- 1548-5943 (ISSN-L)
- 1548-5951
- PMC
- PMC7039047
- OpenAlex
- W2792292383
- Cited by
- 153
- References
- 148
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 18 · 2023: 21 · 2022: 26 · 2021: 19 · 2020: 24 · 2019: 17 · 2018: 4
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Clinical Psychology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Aging (R01AG030424, R24AG048024)
- National Heart, Lung, and Blood Institute (K08HL112961)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Keywords
- telomeres, telomere length, psychological stress, childhood adversity, depression, psychopathology, allostasis, telomerase, aging, life course, intergenerational transmission, genetic factors
- MeSH terms
- Adverse Childhood Experiences, Animals, Mental Disorders, Humans, Stress, Psychological, Telomerase, Aging, Premature, Telomere Shortening
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