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Cited by 2,043

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Long-Term Follow-Up of Patients With Mild Coronary Artery Disease and Endothelial Dysfunction

Open access
Suwaidi, Jassim Al, Hamasaki, Shuichi, Higano, Stuart T., Nishimura, Rick A., Holmes, David R., Lerman, Amir·2000·Circulation
DOI 10.1161/01.cir.101.9.948
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Abstract

Background —Coronary endothelial dysfunction is characterized by vasoconstrictive response to the endothelium-dependent vasodilator acetylcholine. Although endothelial dysfunction is considered an early phase of coronary atherosclerosis, there is a paucity of information regarding the outcome of these patients. Thus, this study was designed to evaluate the outcome of patients with mild coronary artery disease on the basis of their endothelial function. Methods and Results —Follow-up was obtained in 157 patients with mildly diseased coronary arteries who had undergone coronary vascular reactivity evaluation by graded administration of intracoronary acetylcholine, adenosine, and nitroglycerin and intracoronary ultrasound at the time of diagnostic study. Patients were divided on the basis of their response to acetylcholine into 3 groups: group 1 (n=83), patients with normal endothelial function; group 2 (n=32), patients with mild endothelial dysfunction; and group 3 (n=42), patients with severe endothelial dysfunction. Over an average 28-month follow-up (range, 11 to 52 months), none of the patients from group 1 or 2 had cardiac events. However, 6 (14%) with severe endothelial dysfunction had 10 cardiac events ( P <0.05 versus groups 1 and 2). Cardiac events included myocardial infarction, percutaneous or surgical coronary revascularization, and/or cardiac death. Conclusions —Severe endothelial dysfunction in the absence of obstructive coronary artery disease is associated with increased cardiac events. This study supports the concept that coronary endothelial dysfunction may play a role in the progression of coronary atherosclerosis.

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Metadata

Authors
Suwaidi, J. A., Hamasaki, S., Higano, S. T., Nishimura, R. A., Holmes, D. R., & Lerman, A.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2000-03-07
Volume
101
Issue
9
Pages
948-954
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.101.9.948
OpenAlex
W2145899271
Cited by
2,043
References
1
FWCI
82.49
Type
journal article
Language
en
Open access
bronze

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