Cited by 984Psychopathy, Forensic Psychiatry, Sexual OffendingNeurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

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Neurobiology of Aggression and Violence

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Siever, Larry J.·2008·American Journal of Psychiatry

DOI 10.1176/appi.ajp.2008.07111774PMC PMC4176893

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Abstract

Acts of violence account for an estimated 1.43 million deaths worldwide annually. While violence can occur in many contexts, individual acts of aggression account for the majority of instances. In some individuals, repetitive acts of aggression are grounded in an underlying neurobiological susceptibility that is just beginning to be understood. The failure of "top-down" control systems in the prefrontal cortex to modulate aggressive acts that are triggered by anger provoking stimuli appears to play an important role. An imbalance between prefrontal regulatory influences and hyper-responsivity of the amygdala and other limbic regions involved in affective evaluation are implicated. Insufficient serotonergic facilitation of "top-down" control, excessive catecholaminergic stimulation, and subcortical imbalances of glutamatergic/gabaminergic systems as well as pathology in neuropeptide systems involved in the regulation of affiliative behavior may contribute to abnormalities in this circuitry. Thus, pharmacological interventions such as mood stabilizers, which dampen limbic irritability, or selective serotonin reuptake inhibitors (SSRIs), which may enhance "top-down" control, as well as psychosocial interventions to develop alternative coping skills and reinforce reflective delays may be therapeutic.

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See all 984

Authors: Siever, L. J.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
Corresponding author: Siever, Larry J.
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 2008-04
Volume: 165
Issue: 4
Pages: 429-442
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/appi.ajp.2008.07111774
PMC: PMC4176893
OpenAlex: W2143884902
Cited by: 984
References: 268
Citations by year: 2026: 33 · 2025: 38 · 2024: 45 · 2023: 55 · 2022: 53 · 2021: 54 · 2020: 46 · 2019: 56 · 2018: 60 · 2017: 66 · 2016: 70 · 2015: 69 · 2014: 53 · 2013: 56 · 2012: 56
FWCI: 9.85
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Veterans Affairs
National Institutes of Health (MO1-RR-00071)
National Institute of Mental Health (R01MH063875, MO1-RR-00071, MH 56140, MH-63875, R01MH056140)
National Center for Research Resources (MO1RR00071, M01RR000071, M01-RR-00071)
NIH Clinical Center
Topics: Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: aggression, violence, neurobiology of aggression, prefrontal cortex, top-down control, amygdala, limbic system, serotonergic system, catecholaminergic system, neuropeptides, affiliative behavior, mood stabilizers, selective serotonin reuptake inhibitors, psychosocial interventions, coping strategies
MeSH terms: Aggression, Amygdala, Brain, Cognition Disorders, Disease Susceptibility, Kindling, Neurologic, Limbic System, Models, Neurological, Models, Psychological, Terminology as Topic, Violence, Prefrontal Cortex, Neurotransmitter Agents

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Neurobiology of Aggression and Violence

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