Cited by 172Mindfulness and Compassion InterventionsPsychotherapy Techniques and ApplicationsReligion, Spirituality, and Psychology

Mindfulness-Based Interventions in Psychiatry

Open access
Shapero, Benjamin G., Greenberg, Jonathan, Pedrelli, Paola, de Jong, Marasha, Desbordes, Gaelle·2018·Focus

Abstract

Mindfulness meditation has a longstanding history in eastern practices that has received considerable public interest in recent decades. Indeed, the science, practice, and implementation of Mindfulness Based Interventions (MBIs) have dramatically increased in recent years. At its base, mindfulness is a natural human state in which an individual experiences and attends to the present moment. Interventions have been developed to train individuals how to incorporate this practice into daily life. The current article will discuss the concept of mindfulness and describe its implementation in the treatment of psychiatric disorders. We further identify for whom MBIs have been shown to be efficacious and provide an up-to-date summary of how these interventions work. This includes research support for the cognitive, psychological, and neural mechanisms that lead to psychiatric improvements. This review provides a basis for incorporating these interventions into treatment.

Integrity signals

Registry

Crossref · 10.1176/appi.focus.20170039

Cites

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Statistics

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Claims the paper makes

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  • Premisecitation

    Segal and colleagues extended mindfulness meditation into psychiatry by creating MBCT, which combined cognitive-behavioral therapy and mindfulness for preventing depression relapse.

    “Subsequently, Zindel Segal and colleagues (2) extended the use of mindfulness meditation into psychiatry by developing a treatment program for the prevention of depression relapse that combined cognitive-behavioral therapy and mindfulness techniques and was named Mindfulness-Based Cognitive Therapy (MBCT; 2).”
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  • Interpretationnone given

    MBCT is the most widely studied MBI for treating psychiatric disorders.

    “The most widely examined MBI to treat psychiatric disorders is MBCT.”
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  • Premisecitation

    A meta-analysis found that the number of previous depressive episodes significantly predicts outcome.

    “A meta-analysis found the number of previous depressive episodes to be a significant predictor of outcome (23).”
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  • Interpretationcitation

    Group-based weekly programs such as MBSR and MBCT have the strongest evidence of clinical efficacy.

    “Group-based weekly mindfulness intervention programs such as MBSR and MBCT have the highest level of evidence of clinical efficacy”
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  • Interpretationcitation

    There is substantial evidence that MBCT lowers the risk of depressive relapse.

    “There is considerable evidence supporting the use of MBCT to decrease the risk of depressive relapse.”
    Quote in the paperSubstantial claim
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    Interpretationnone given

    The efficacy of MBCT for reducing MDD relapse is well-established.

    “while the efficacy of MBCT to reduce MDD relapse is well-established”
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    Interpretationreasoning

    The inclusion criteria of these studies focus on a specific disorder and exclude co-occurring disorders, which limits generalizability to clinical settings.

    “the inclusion criteria of these studies focus on the specific disorder of interest and exclude co-occurring disorders that may influence findings, which are less generalizable to the clinic.”
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    Interpretationreasoning

    MBCT may be effective but may not be superior to other active psychosocial interventions.

    “suggesting that while MBCT may be effective, it may not be superior to other active psychosocial interventions.”
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    Interpretationreasoning

    Taken together, MBIs are promising and appear beneficial across psychiatric disorders.

    “Taken together, MBIs are promising interventions as they appear to be beneficial across psychiatric disorders.”
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    Interpretationnone given

    Stressful life events or triggers may give rise to negative thinking patterns such as depressive rumination, worry, and self-criticism, which if persistent may escalate to depressive relapse.

    “Stressful life events or other triggers in everyday life may give rise to well-rehearsed negative thinking patterns such as depressive rumination, worry, and self-criticism which, if persistent, may escalate to depressive relapse.”
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    Premisecitation

    In that meta-analysis, the relapse rate was 32% for MBCT plus TAU and 60% for TAU alone.

    “The relapse rate among MBCT+TAU patients was 32% relative to 60% for the TAU control group (22).”
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    Interpretationcitation

    The use of MBIs for current psychiatric disorders is relatively new and should be considered preliminary.

    “The use of MBIs in the treatment of current psychiatric disorders is relatively new and should be considered preliminary in nature (95).”
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    Premisecitation

    Kabat-Zinn and colleagues first brought mindfulness meditation into Western treatment for chronic pain and created MBSR.

    “Jon Kabat-Zinn and colleagues (1) first introduced mindfulness meditative practices to treat chronic pain and developed a program named Mindfulness-Based Stress Reduction (MBSR; 1).”
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    Interpretationnone given

    Most studies of MBIs for current psychiatric disorders lack a comparison condition or use wait-list or treatment-as-usual controls.

    “Most of these studies generally do not have a comparison condition and if they do they employ a wait-list control or treatment as usual comparison group.”
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    Premisecitation

    Among patients with two or fewer depressive episodes there was no relapse risk reduction, while among those with three or more episodes recurrence risk fell by 43%.

    “While there was no risk reduction of relapse among patients with two or fewer episodes the risk of recurrence was reduced by 43% among those with three or more episodes (23).”
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    Premisecitation

    Multimodal MBIs appear effective for anorexia nervosa, while brief interventions may not be beneficial.

    “Specifically, multimodal MBIs appear effective, while brief interventions may not be beneficial in treating anorexia nervosa (35).”
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    Premisecitation

    Mindfulness-Based Relapse Prevention may reduce both substance use and craving.

    “Mindfulness-Based Relapse Prevention may be successful in reducing both substance use and craving (40)”
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    • cites [40] Daley DC, 2006

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    Premisecitation

    Recurrently depressed individuals have impaired cognitive functioning and diminished cognitive resources.

    “Recurrently depressed individuals’ vulnerability to depressogenic cognition is additionally exacerbated by impaired cognitive functioning and diminished cognitive resources.”
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    Interpretationreasoning

    It is possible that meditators had distinct brain anatomy for reasons other than meditation, such as genetic or environmental factors.

    “Indeed, it could have been the case that meditators possessed distinct features of brain anatomy for reasons other than meditation (e.g. genetic, environmental, etc.).”
    Quote in the paperSubstantial claim
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    Premisecitation

    After MBCT training, participants show improved self-reported mindfulness, reduced rumination and worry, improved meta-awareness, increased self-compassion, and reduced emotional reactivity.

    “Following MBCT training, participants exhibit improved self-reported mindfulness (43–50), reduced rumination (43, 45–48, 51–53) and worry (43, 47, 53), improved meta-awareness (52, 54, 55), increased self-compassion (56, 57), and reduced emotional reactivity (58).”
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    Interpretationnone given

    The specific impact of these cognitive improvements has not yet been established.

    “Although the specific impact of these cognitive improvements is yet to be established”
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    Interpretationcitation

    The non-judgmental stance conveyed across MBIs allows participants to recover from emotional states more quickly and increases flexibility in responding to stressful events.

    “The non-judgmental stance conveyed across MBIs allows participants to recover from one’s emotional state more quickly and increases the flexibility through which one can respond to stressful events (75).”
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    Premisecitation

    MBCT has been shown to augment suppression of currently irrelevant mental sets and promote cognitive flexibility and overall cognitive functioning, benefits that correlate with reduced depressive symptoms.

    “MBCT has additionally been shown to augment suppression of currently-irrelevant mental sets (74) and promote both cognitive flexibility and overall cognitive functioning (75), benefits which correlate with a reduction in depressive symptomology.”
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    Premisecitation

    Hölzel and colleagues also found that participants reported significant reduction in perceived stress, which correlated positively with decreased gray matter density in the right basolateral amygdala.

    “They also found that participants reported significant reduction in perceived stress that correlated positively with decrease in gray matter density in the right basolateral amygdala (89).”
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    Premisecitation

    These improvements at least partially mediated or predicted MBCT's effect on treatment outcome, with the strongest effects for mindfulness, rumination, worry, and emotional reactivity.

    “Moreover, these improvements at least partially mediated or predicted the effect of MBCT on treatment outcome (see 59–61 for reviews), with the strongest effects found for mindfulness, rumination, worry, and emotional reactivity.”
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    • cites [60] Melyani M, 2015, J Psychol

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    Premisecitation

    Studies of other MBIs in healthy participants indicate improvements in working memory, cognitive flexibility, and inhibition, with very limited evidence for attentional improvements.

    “Studies examining other MBIs with healthy participants similarly indicated improvements in cognitive abilities such as working memory (76–77), cognitive flexibility (78–79) and inhibition (80), with very limited evidence regarding attentional improvements (see (73) for a review).”
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    Interpretationcitation

    Through repeated meditation practices, MBIs develop body awareness, self-regulation, and emotion regulation skills.

    “Through repeated meditation practices MBIs develop body awareness, self-regulation, and emotion regulation skills (81–86).”
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  • Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based).

    Interpretationnone given

    The effects of mindfulness and meditation training on the brain have been investigated in over one hundred brain imaging studies.

    “The effects of mindfulness and meditation training on the brain have been investigated in over one hundred brain imaging studies”
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    Premisecitation

    MBCT has been shown to reduce overgeneral autobiographical memory, improve attention deployment during sad mood, and reduce attentional bias to negative emotional stimuli, although attentional improvements are not ubiquitous.

    “MBCT has been shown to reduce overgeneral autobiographical memory (55, 69, 70), improve attention deployment and maintenance during sad mood (71) and reduce attentional-bias towards negative emotional stimuli (72), although such attentional improvements are not ubiquitous (42, 48, 73).”
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    Premisecitation

    These individuals often show overgeneral autobiographical memory, impaired attention regulation, and difficulty suppressing competing or irrelevant thoughts and mental sets.

    “These individuals often exhibit overgeneral autobiographical memory (i.e. a difficulty in retrieving specific personal events), impairments in attention regulation, and difficulties suppressing competing or currently-irrelevant thoughts and mental sets, among other cognitive deficits (62–68).”
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  • Probably not a substantial claim: may not pass S4 (based). May combine two claims.

    Interpretationnone given

    Cognitive faculties are important for disengaging from negative thinking patterns in depression and may be vital for addressing cognitive deficits in numerous clinical conditions.

    “such cognitive faculties are important factors in facilitating the disengagement from negating thinking patterns associated with depression and may be vital in addressing the cognitive deficits associated with numerous clinical conditions.”
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    Interpretationnone given

    In sum, the science and practice of MBIs have proven clear benefit among those with psychiatric disorders.

    “In sum, the science and practice of MBIs have proven to have clear benefit among those with psychiatric disorders.”
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    Premisenone given

    These brain regions have been associated with learning and memory, emotion regulation, self-referential processing, and perspective taking.

    “These various brain regions have been associated with learning and memory processes, emotion regulation, self-referential processing, and perspective taking.”
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  • Classified as probably not a substantial claim.

    Interpretationnone given

    It is less clear whether mindfulness interventions can serve as an adjunctive treatment to current psychotherapy or psychopharmacological interventions.

    “Further, although mindfulness interventions may reduce psychiatric symptoms on their own, it is less clear whether they can serve as an adjunctive treatment to current psychotherapy or psychopharmacological interventions.”
    Quote in the paperSubstantial claim
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    Interpretationnone given

    Much is known about patient populations that may benefit from mindfulness training, but not about who benefits most from MBI treatment.

    “Although we know much about the patient populations that may benefit from receiving mindfulness training, we do not yet know for whom MBI treatment may work best.”
    Quote in the paperSubstantial claim
  • Classified as probably not a substantial claim. May combine two claims.

    Premisecitation

    A recent meta-analysis reviewed 78 functional neuroimaging studies and used activation likelihood estimation on 257 activation peak locations from 31 experiments involving 527 participants.

    “A recent meta-analysis reviewed 78 functional neuroimaging (fMRI and PET) studies of meditation, and used activation likelihood estimation to conduct a meta-analysis of 257 activation peak locations from 31 experiments involving 527 participants (90).”
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    Interpretationnone given

    Different types of meditation practices may influence different brain structures.

    “In line, different types of meditation practices may influence different brain structures.”
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    Premisecitation

    The meta-analysis categorized meditation practices into four main types-focused attention, mantra recitation, open monitoring, and compassion/loving-kindness-plus three less studied types.

    “This meta-analysis covered various meditation practice, which the authors categorized into four main types: 1) focused attention, 2) mantra recitation, 3) open monitoring, and 4) compassion/loving-kindness meditation; and three additional types that have been less studied: 1) visualization, 2) sense-withdrawal, and 3) non-dual awareness practices.”
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    Interpretationnone given

    MBIs reduce symptoms across psychiatric disorders, with mounting support for anxiety disorders, bipolar disorder, eating disorders, and substance use disorders.

    “In addition, these interventions reduce symptoms across psychiatric disorders with mounting support for anxiety disorders, bipolar disorder, eating disorders, and substance use disorders.”
    Quote in the paperSubstantial claim
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    Interpretationcitation

    Limited studies have examined the effectiveness of MBIs in real-life settings and how best to disseminate them into the community.

    “Additionally, limited studies have examined the effectiveness of MBIs in real-life settings (92) and how best to disseminate these efficacious interventions into the community.”
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    Interpretationreasoning

    It is likely that group-based MBI programs can be added to standard care, but research is needed before making strong recommendations for providers.

    “It is likely the case that these group based programs can be added to standard care, however research is needed in order to make strong recommendations for providers.”
    Quote in the paperSubstantial claim
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    Interpretationnone given

    Numerous investigations show MBIs are efficacious for reducing depression relapse and treating depression symptoms.

    “Numerous research investigations have shown that MBIs are efficacious for reducing depression relapse and treating depression symptoms.”
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    Premisecitation

    The meta-analysis authors concluded that convergence is the exception rather than the rule.

    “However, the authors conclude that “convergence is the exception rather than the rule” (90).”
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38 of 38
  • The paper relies on this without support.

    Mindfulness is a natural human state in which a person experiences and attends to the present moment.

    “At its base, mindfulness is a natural human state in which an individual experiences and attends to the present moment.”
  • The paper relies on this without support.

    Mindful acceptance is crucial for treatment effectiveness.

    “Mindful acceptance is deemed crucial for treatment effectiveness.”
2 of 2

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • All MIs reviewed aimed to teach participants to observe and accept their thoughts and feelings without emotionally reacting to them via a combination of cognitive, meditative, and breathing exercises.

    “All MIs reviewed in this study aimed to teach participants to observe and accept their thoughts and feelings without emotionally reacting to them via a combination of cognitive, meditative, and breathing exercises (Shapero et al ., 2018).”

    From Group-based mindfulness interventions in prisons: a selective critical review (2024) · cites this paper as Shapero et al., 2018

    The Treatment section describes mindfulness interventions as teaching people to attend to thoughts and emotions with an accepting, nonjudgmental attitude, and it describes meditation and an MBCT breathing exercise. The Introduction says MBCT combines cognitive-behavioral therapy with mindfulness, but the paper does not establish that every intervention reviewed in the citing study used a combination of cognitive, meditative, and breathing exercises. Page numbers are unavailable in our copy. (LLM, conf=0.85)

    Experimental — accuracy not yet measured
  • Cultivating mindfulness skills may address immediate symptoms and cultivate long-term resilience and adaptive coping mechanisms.

    “This suggests that cultivating mindfulness skills may not only address immediate symptoms but also cultivate long-term resilience and adaptive coping mechanisms (3,4).”

Cites

Flagged first, then by citations

Research works printed but not linked: 3

  1. Dunne J, J Am Psychiatr Nurses Assoc, doi: 10.1177/10 · DOI
  2. Daley DC, 2006, Overcoming Your Alcohol or Drug Problem: Effective Recovery Strategies: Therapist Guide
  3. Melyani M, 2015, J Psychol, 18, 393

Cited by

Sorted by citations

Authors
Shapero, B. G., Greenberg, J., Pedrelli, P., de Jong, M., & Desbordes, G.
Affiliations
  • Harvard University (US)
  • Dr. Shapero, Dr. Greenberg, and Dr. Pedrelli are with the Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston. Dr. de Jong is with the Department of Psychiatry and Psychology, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, the Netherlands. Dr. Desbordes is with the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston.
Venue
Focus
Published
2018-01
Volume
16
Issue
1
Pages
32-39
ISSN
  • 1541-4094 (ISSN-L)
  • 1541-4108
OpenAlex
W2786706117
Cited by
172
References
100
Citations by year
2026: 17 · 2025: 24 · 2024: 33 · 2023: 32 · 2022: 15 · 2021: 18 · 2020: 18 · 2019: 10 · 2018: 4
FWCI
14.69
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • FOCUS The Journal of Lifelong Learning in Psychiatry (publishedVersion)
  • Research Publications (Maastricht University) (publishedVersion, other-oa)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Center for Complementary and Integrative Health (K01AT008225)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
  • Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
  • Social Sciences › Health › Religion, Spirituality, and Psychology
Keywords
mindfulness-based interventions, mindfulness meditation, mental illness, treatment efficacy, cognitive mechanisms, neural mechanisms, psychological mechanisms, psychotherapy

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