Cited by 441Neurotransmitter Receptor Influence on BehaviorRegulation of Appetite and ObesityOlfactory and Sensory Function Studies

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Hedonic Hot Spots in the Brain

Peciña, Susana, Smith, Kyle S., Berridge, Kent C.·2006·The Neuroscientist

DOI 10.1177/1073858406293154

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Abstract

Hedonic “liking” for sensory pleasures is an important aspect of reward, and excessive ‘liking’ of particular rewards might contribute to excessive consumption and to disorders such as obesity. The present review aims to summarize recent advances in the identification of brain substrates for food ‘liking’ with a focus on opioid hot spots in the nucleus accumbens and ventral pallidum. Drug microinjection studies have shown that opioids in both areas amplify the ‘liking’ of sweet taste rewards. Modern neuroscience tools such as Fos plume mapping have further identified hedonic hot spots within the accumbens and pallidum, where opioids are especially tuned to magnify ‘liking’ of food rewards. Hedonic hot spots in different brain structures may interact with each other within the larger functional circuitry that interconnects them. Better understanding of how brain hedonic hot spots increase the positive affective impact of natural sensory pleasures will help characterize the neural mechanisms potentially involved in ‘liking’ for many rewards.

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Authors: Peciña, S., Smith, K. S., & Berridge, K. C.
Affiliations: University of Michigan (US)
Corresponding author: Peciña, Susana
ORCID: Smith, Kyle S.
Berridge, Kent C.
Venue: The Neuroscientist
Publisher: SAGE Publications
Published: 2006-12
Volume: 12
Issue: 6
Pages: 500-511
ISSN: 1073-8584 (ISSN-L)
1089-4098
DOI: 10.1177/1073858406293154
OpenAlex: W2016426141
Cited by: 441
References: 131
Citations by year: 2026: 4 · 2025: 13 · 2024: 9 · 2023: 32 · 2022: 17 · 2021: 13 · 2020: 28 · 2019: 16 · 2018: 30 · 2017: 18 · 2016: 24 · 2015: 17 · 2014: 29 · 2013: 27 · 2012: 32
FWCI: 2.64
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: The Neuroscientist (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH-63649, R01MH063649)
National Institute on Drug Abuse (DA015188, R01DA015188)
National Institute on Deafness and Other Communication Disorders (DC-00011)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Keywords: food liking, opioid signaling, nucleus accumbens, ventral pallidum, reward, sweet taste, neural circuits, obesity, overeating
MeSH terms: Animals, Behavior, Animal, Brain, Brain Mapping, Emotions, Globus Pallidus, Humans, Neural Pathways, Nucleus Accumbens, Reward

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