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Dysregulation of protein trafficking in neurodegeneration

Wang, Xin, Huang, Timothy, Bu, Guojun, Xu, Huaxi·2014·Molecular Neurodegeneration
DOI 10.1186/1750-1326-9-31PMC PMC4237948
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Figure 1 Regulation of AD-associated proteins by sorting nexins and the retromer complex. SNX6, SNX12, SNX17 and SNX27 regulate cell surface delivery of several AD-associated proteins, including APP, BACE1, glutamate receptors and LRP. SNX33 inhibits APP endocytosis in a dynamin-dependent manner. Over-expression of SNX33 up-regulates cell surface APP levels and increases α-secretase cleavage of APP. The retromer complex regulates APP processing and Aβ generation through modulating BACE1 trafficking and activity.
Figure 1 Regulation of AD-associated proteins by sorting nexins and the retromer complex. SNX6, SNX12, SNX17 and SNX27 regulate cell surface delivery of several AD-associated proteins, including APP, BACE1, glutamate receptors and LRP. SNX33 inhibits APP endocytosis in a dynamin-dependent manner. Over-expression of SNX33 up-regulates cell surface APP levels and increases α-secretase cleavage of APP. The retromer complex regulates APP processing and Aβ generation through modulating BACE1 trafficking and activity.CC BY · PubMed Central

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Metadata

Authors
Wang, X., Huang, T., Bu, G., & Xu, H.
Venue
Molecular Neurodegeneration
Publisher
Springer Science and Business Media LLC
Published
2014-08-25
Volume
9
Issue
1
ISSN
1750-1326
DOI
10.1186/1750-1326-9-31
PMC
PMC4237948
Cited by
125
References
15
Language
en

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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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