Cited by 869Schizophrenia research and treatmentSuicide and Self-Harm StudiesMental Health and Psychiatry

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Excess mortality of schizophrenia: A meta-analysis

Brown, Steve·1997·British Journal of Psychiatry

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Abstract

BACKGROUND: This paper presents a structured review of the published information on the mortality of schizophrenia. METHOD: A meta-analysis of the literature. RESULTS: Schizophrenia has a significantly increased mortality from natural and unnatural causes. Twenty-eight percent of the excess mortality is attributable to suicide and 12% to accidents. The rest of the excess mortality is from the same broad range of conditions which cause deaths in the general population. Further interpretation is hampered by confounding variables, wide confidence intervals and reservations about generalising from individual cohorts. CONCLUSIONS: The available evidence suggests that schizophrenia is associated with a large increased mortality from suicide and a moderate increased mortality from natural causes. A number of possible interventions have been identified, but we do not yet have reliable means of detecting any changes in mortality which might result.

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Authors: Brown, S.
Affiliations: Royal South Hants Hospital (GB)
Corresponding author: Brown, Steve
Venue: British Journal of Psychiatry
Publisher: Royal College of Psychiatrists
Published: 1997-12
Volume: 171
Issue: 6
Pages: 502-508
ISSN: 0007-1250 (ISSN-L)
1472-1465
DOI: 10.1192/bjp.171.6.502
OpenAlex: W2144334285
Cited by: 869
References: 54
Citations by year: 2026: 5 · 2025: 5 · 2024: 9 · 2023: 6 · 2022: 15 · 2021: 22 · 2020: 30 · 2019: 22 · 2018: 33 · 2017: 38 · 2016: 37 · 2015: 42 · 2014: 39 · 2013: 45 · 2012: 37
FWCI: 2.56
Type: journal article
Language: en
Open access: closed
Licence: www.cambridge.org/core/terms (unspecified, 7337 d)
Locations: The British Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
ePrints Soton (University of Southampton) (acceptedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords: schizophrenia, excess mortality, suicide, accidental death, natural death, mortality risk factors, confounding variables
MeSH terms: Accidents, Cause of Death, Follow-Up Studies, Homicide, Humans, Schizophrenia, Sex Factors, Suicide

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Excess mortality of schizophrenia: A meta-analysis

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