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Maintaining embryonic stem cell pluripotency with Wnt signaling
Open accessAbstract
Wnt signaling pathways control lineage specification in vertebrate embryos and regulate pluripotency in embryonic stem (ES) cells, but how the balance between progenitor self-renewal and differentiation is achieved during axis specification and tissue patterning remains highly controversial. The context- and stage-specific effects of the different Wnt pathways produce complex and sometimes opposite outcomes that help to generate embryonic cell diversity. Although the results of recent studies of the Wnt/β-catenin pathway in ES cells appear to be surprising and controversial, they converge on the same conserved mechanism that leads to the inactivation of TCF3-mediated repression.
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Cites
Establishment in culture of pluripotential cells from mouse embryos
Evans, M. J., & Kaufman, M. H. (1981) · Nature · doi:10.1038/292154a0 · Cited by 8,607
Martin, G. R. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.12.7634 · Cited by 5,746
Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
MacDonald, B. T., Tamai, K., & He, X. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.016 · Cited by 5,583
Wnt/β-Catenin Signaling in Development and Disease
Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568
Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells
Boyer, L. A., Lee, T. I., Cole, M. F., Johnstone, S. E., Levine, S. S., Zucker, J. P., Guenther, M. G., Kumar, R. M., Murray, H. L., Jenner, R. G., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.020 · Cited by 4,505
Niwa, H., Miyazaki, J.-I., & Smith, A. G. (2000) · Nature Genetics · doi:10.1038/74199 · Cited by 3,596
The ground state of embryonic stem cell self-renewal
Ying, Q.-L., Wray, J., Nichols, J., Batlle-Morera, L., Doble, B., Woodgett, J., Cohen, P., & Smith, A. (2008) · Nature · doi:10.1038/nature06968 · Cited by 3,442
Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells
Chambers, I., Colby, D., Robertson, M., Nichols, J., Lee, S., Tweedie, S., & Smith, A. (2003) · Cell · doi:10.1016/s0092-8674(03)00392-1 · Cited by 3,255
The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
Mitsui, K., Tokuzawa, Y., Itoh, H., Segawa, K., Murakami, M., Takahashi, K., Maruyama, M., Maeda, M., & Yamanaka, S. (2003) · Cell · doi:10.1016/s0092-8674(03)00393-3 · Cited by 3,191
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells
Loh, Y.-H., Wu, Q., Chew, J.-L., Vega, V. B., Zhang, W., Chen, X., Bourque, G., George, J., Leong, B., Liu, J., et al. (2006) · Nature Genetics · doi:10.1038/ng1760 · Cited by 2,437
Sato, N., Meijer, L., Skaltsounis, L., Greengard, P., & Brivanlou, A. H. (2004) · Nature Medicine · doi:10.1038/nm979 · Cited by 2,109
GSK-3: tricks of the trade for a multi-tasking kinase
Doble, B. W., & Woodgett, J. R. (2003) · Journal of Cell Science · doi:10.1242/jcs.00384 · Cited by 2,084
Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells
Williams, R. L., Hilton, D. J., Pease, S., Willson, T. A., Stewart, C. L., Gearing, D. P., Wagner, E. F., Metcalf, D., Nicola, N. A., & Gough, N. M. (1988) · Nature · doi:10.1038/336684a0 · Cited by 1,997
Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides
Smith, A. G., Heath, J. K., Donaldson, D. D., Wong, G. G., Moreau, J., Stahl, M., & Rogers, D. (1988) · Nature · doi:10.1038/336688a0 · Cited by 1,855
XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos
Molenaar, M., van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destrée, O., & Clevers, H. (1996) · Cell · doi:10.1016/s0092-8674(00)80112-9 · Cited by 1,824
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
Korinek, V., Barker, N., Moerer, P., van Donselaar, E., Huls, G., Peters, P. J., & Clevers, H. (1998) · Nature Genetics · doi:10.1038/1270 · Cited by 1,581
Stem Cells, the Molecular Circuitry of Pluripotency and Nuclear Reprogramming
Jaenisch, R., & Young, R. (2008) · Cell · doi:10.1016/j.cell.2008.01.015 · Cited by 1,427
van de Wetering, M., Cavallo, R., Dooijes, D., van Beest, M., van Es, J., Loureiro, J., Ypma, A., Hursh, D., Jones, T., Bejsovec, A., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81925-x · Cited by 1,202
Towards an integrated view of Wnt signaling in development
van Amerongen, R., & Nusse, R. (2009) · Development · doi:10.1242/dev.033910 · Cited by 1,175
Proximal events in Wnt signal transduction
Angers, S., & Moon, R. T. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2717 · Cited by 1,112
van Genderen, C., Okamura, R. M., Fariñas, I., Quo, R. G., Parslow, T. G., Bruhn, L., & Grosschedl, R. (1994) · Genes & Development · doi:10.1101/gad.8.22.2691 · Cited by 965
Zeng, L., Fagotto, F., Zhang, T., Hsu, W., Vasicek, T. J., Perry, W. L., Lee, J. J., Tilghman, S. M., Gumbiner, B. M., & Costantini, F. (1997) · Cell · doi:10.1016/s0092-8674(00)80324-4 · Cited by 907
A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo
Rosner, M. H., Vigano, M. A., Ozato, K., Timmons, P. M., Poirie, F., Rigby, P. W. J., & Staudt, L. M. (1990) · Nature · doi:10.1038/345686a0 · Cited by 906
Requirement for Wnt3 in vertebrate axis formation
Liu, P., Wakamiya, M., Shea, M. J., Albrecht, U., Behringer, R. R., & Bradley, A. (1999) · Nature Genetics · doi:10.1038/11932 · Cited by 901
GSK3: a multifaceted kinase in Wnt signaling
Wu, D., & Pan, W. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.10.002 · Cited by 857
Cells keep a memory of their tissue origin during axolotl limb regeneration
Kragl, M., Knapp, D., Nacu, E., Khattak, S., Maden, M., Epperlein, H. H., & Tanaka, E. M. (2009) · Nature · doi:10.1038/nature08152 · Cited by 850
FORMATION AND FUNCTION OF SPEMANN'S ORGANIZER
Harland, R., & Gerhart, J. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.611 · Cited by 839
Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo
Arnold, S. J., & Robertson, E. J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2618 · Cited by 816 · cited 8×
“This is achieved primarily by cell-cell interactions mediated by the bone morphogenetic protein (BMP), fibroblast growth factor (FGF), Nodal and Wnt pathways, which constitute the major embryonic signaling pathways, the precise functions of which are still under investigation (Arnold and Robertson, 2009; Conlon et al.…”
BackgroundInfluentialWnt-3a regulates somite and tailbud formation in the mouse embryo
Takada, S. (1994) · Trends in Genetics · doi:10.1016/0168-9525(94)90090-6 · Cited by 789
Conlon, F. L., Lyons, K. M., Takaesu, N., Barth, K. S., Kispert, A., Herrmann, B., & Robertson, E. J. (1994) · Development · doi:10.1242/dev.120.7.1919 · Cited by 770
Drosophila Tcf and Groucho interact to repress Wingless signalling activity
Cavallo, R. A., Cox, R. T., Moline, M. M., Roose, J., Polevoy, G. A., Clevers, H., Peifer, M., & Bejsovec, A. (1998) · Nature · doi:10.1038/26982 · Cited by 730
Lack of β-catenin affects mouse development at gastrulation
Haegel, H., Larue, L., Ohsugi, M., Fedorov, L., Herrenknecht, K., & Kemler, R. (1995) · Development · doi:10.1242/dev.121.11.3529 · Cited by 711
Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues
Hanna, J. H., Saha, K., & Jaenisch, R. (2010) · Cell · doi:10.1016/j.cell.2010.10.008 · Cited by 698
The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors
Roose, J., Molenaar, M., Peterson, J., Hurenkamp, J., Brantjes, H., Moerer, P., van de Wetering, M., Destrée, O., & Clevers, H. (1998) · Nature · doi:10.1038/26989 · Cited by 674
Requirement for β-Catenin in Anterior-Posterior Axis Formation in Mice
Huelsken, J., Vogel, R., Brinkmann, V., Erdmann, B., Birchmeier, C., & Birchmeier, W. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.3.567 · Cited by 660
HEASMAN, J. (1994) · Cell · doi:10.1016/0092-8674(94)90069-8 · Cited by 643
Dickkopf1 Is Required for Embryonic Head Induction and Limb Morphogenesis in the Mouse
Mukhopadhyay, M., Shtrom, S., Rodriguez-Esteban, C., Chen, L., Tsukui, T., Gomer, L., Dorward, D. W., Glinka, A., Grinberg, A., Huang, S.-P., et al. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00041-7 · Cited by 635
Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse
Rossant, J., & Tam, P. P. L. (2009) · Development · doi:10.1242/dev.017178 · Cited by 631
Wallingford, J. B., Fraser, S. E., & Harland, R. M. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00197-1 · Cited by 613
Ueno, S., Weidinger, G., Osugi, T., Kohn, A. D., Golob, J. L., Pabon, L., Reinecke, H., Moon, R. T., & Murry, C. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702859104 · Cited by 613
Gadue, P., Huber, T. L., Paddison, P. J., & Keller, G. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603916103 · Cited by 560
Grigoryan, T., Wend, P., Klaus, A., & Birchmeier, W. (2008) · Genes & Development · doi:10.1101/gad.1686208 · Cited by 560
Daniels, D. L., & Weis, W. I. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb912 · Cited by 551
Wnt Signaling and the Polarity of the Primary Body Axis
Petersen, C. P., & Reddien, P. W. (2009) · Cell · doi:10.1016/j.cell.2009.11.035 · Cited by 550
An Oct4-Centered Protein Interaction Network in Embryonic Stem Cells
van den Berg, D. L. C., Snoek, T., Mullin, N. P., Yates, A., Bezstarosti, K., Demmers, J., Chambers, I., & Poot, R. A. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.02.014 · Cited by 542
Pluripotency Factors in Embryonic Stem Cells Regulate Differentiation into Germ Layers
Thomson, M., Liu, S. J., Zou, L.-N., Smith, Z., Meissner, A., & Ramanathan, S. (2011) · Cell · doi:10.1016/j.cell.2011.05.017 · Cited by 542
Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis
Pandur, P., Läsche, M., Eisenberg, L. M., & Kühl, M. (2002) · Nature · doi:10.1038/nature00921 · Cited by 539
Wray, J., Kalkan, T., Gomez-Lopez, S., Eckardt, D., Cook, A., Kemler, R., & Smith, A. (2011) · Nature Cell Biology · doi:10.1038/ncb2267 · Cited by 525
An HMG-box-containing T-cell factor required for thymocyte differentiation
Verbeek, S., Izon, D., Hofhuis, F., Robanus-Maandag, E., te Riele, H., Watering, M. V. D., Oosterwegel, M., Wilson, A., Robson MacDonald, H., & Clevers, H. (1995) · Nature · doi:10.1038/374070a0 · Cited by 514
Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells
Cole, M. F., Johnstone, S. E., Newman, J. J., Kagey, M. H., & Young, R. A. (2008) · Genes & Development · doi:10.1101/gad.1642408 · Cited by 514
Brunner, E., Peter, O., Schweizer, L., & Basler, K. (1997) · Nature · doi:10.1038/385829a0 · Cited by 493
Molecular Genetics of Axis Formation in Zebrafish
Schier, A. F., & Talbot, W. S. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.37.110801.143752 · Cited by 493
Comparative Aspects of Animal Regeneration
Brockes, J. P., & Kumar, A. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.24.110707.175336 · Cited by 490
Naito, A. T., Shiojima, I., Akazawa, H., Hidaka, K., Morisaki, T., Kikuchi, A., & Komuro, I. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605768103 · Cited by 480
Wnt Signaling Mediates Self-Organization and Axis Formation in Embryoid Bodies
ten Berge, D., Koole, W., Fuerer, C., Fish, M., Eroglu, E., & Nusse, R. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.013 · Cited by 477
Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells
ten Berge, D., Kurek, D., Blauwkamp, T., Koole, W., Maas, A., Eroglu, E., Siu, R. K., & Nusse, R. (2011) · Nature Cell Biology · doi:10.1038/ncb2314 · Cited by 468
Wnt3a-/--like phenotype and limb deficiency in Lef1-/-Tcf1-/- mice
Galceran, J., Farinas, I., Depew, M. J., Clevers, H., & Grosschedl, R. (1999) · Genes & Development · doi:10.1101/gad.13.6.709 · Cited by 462
Synergy Between Tumor Suppressor APC and the β-Catenin-Tcf4 Target Tcf1
Roose, J., Huls, G., Beest, M. V., Moerer, P., Horn, K. V. D., Goldschmeding, R., Logtenberg, T., & Clevers, H. (1999) · Science · doi:10.1126/science.285.5435.1923 · Cited by 456
Wnt Signaling Regulates B Lymphocyte Proliferation through a LEF-1 Dependent Mechanism
Reya, T., O'Riordan, M., Okamura, R., Devaney, E., Willert, K., Nusse, R., & Grosschedl, R. (2000) · Immunity · doi:10.1016/s1074-7613(00)00004-2 · Cited by 450
Doble, B. W., Patel, S., Wood, G. A., Kockeritz, L. K., & Woodgett, J. R. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.04.001 · Cited by 448
Diversity of LEF/TCF action in development and disease
Arce, L., Yokoyama, N. N., & Waterman, M. L. (2006) · Oncogene · doi:10.1038/sj.onc.1210056 · Cited by 438
Wnt Signaling Promotes Reprogramming of Somatic Cells to Pluripotency
Marson, A., Foreman, R., Chevalier, B., Bilodeau, S., Kahn, M., Young, R. A., & Jaenisch, R. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.06.019 · Cited by 436
Repressor activity of Headless/Tcf3 is essential for vertebrate head formation
Kim, C.-H., Oda, T., Itoh, M., Jiang, D., Artinger, K. B., Chandrasekharappa, S. C., Driever, W., & Chitnis, A. B. (2000) · Nature · doi:10.1038/35038097 · Cited by 396
Hsu, S.-C., Galceran, J., & Grosschedl, R. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.8.4807 · Cited by 363
Apc modulates embryonic stem-cell differentiation by controlling the dosage of β-catenin signaling
Kielman, M. F., Rindapää, M., Gaspar, C., van Poppel, N., Breukel, C., van Leeuwen, S., Taketo, M. M., Roberts, S., Smits, R., & Fodde, R. (2002) · Nature Genetics · doi:10.1038/ng1045 · Cited by 362
Babaie, Y., Herwig, R., Greber, B., Brink, T. C., Wruck, W., Groth, D., Lehrach, H., Burdon, T., & Adjaye, J. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0426 · Cited by 357
Dravid, G., Ye, Z., Hammond, H., Chen, G., Pyle, A., Donovan, P., Yu, X., & Cheng, L. (2005) · STEM CELLS · doi:10.1634/stemcells.2005-0034 · Cited by 342
Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm
Lindsley, R. C., Gill, J. G., Kyba, M., Murphy, T. L., & Murphy, K. M. (2006) · Development · doi:10.1242/dev.02551 · Cited by 341
Aubert, J., Dunstan, H., Chambers, I., & Smith, A. (2002) · Nature Biotechnology · doi:10.1038/nbt763 · Cited by 325
Kolligs, F. T., Hu, G., Dang, C. V., & Fearon, E. R. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.8.5696 · Cited by 319
Repression of Nanog Gene Transcription by Tcf3 Limits Embryonic Stem Cell Self-Renewal
Pereira, L., Yi, F., & Merrill, B. J. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00368-06 · Cited by 315
Wnt/β-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency
Miyabayashi, T., Teo, J.-L., Yamamoto, M., McMillan, M., Nguyen, C., & Kahn, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701331104 · Cited by 310
ten Berge, D., Brugmann, S. A., Helms, J. A., & Nusse, R. (2008) · Development · doi:10.1242/dev.023176 · Cited by 305
The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice
Kelly, O. G., Pinson, K. I., & Skarnes, W. C. (2004) · Development · doi:10.1242/dev.01137 · Cited by 290
Tcf3 Governs Stem Cell Features and Represses Cell Fate Determination in Skin
Nguyen, H., Rendl, M., & Fuchs, E. (2006) · Cell · doi:10.1016/j.cell.2006.07.036 · Cited by 287
Hao, J., Li, T.-G., Qi, X., Zhao, D.-F., & Zhao, G.-Q. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2005.11.011 · Cited by 285
Tbx3 improves the germ-line competency of induced pluripotent stem cells
Han, J., Yuan, P., Yang, H., Zhang, J., Soh, B. S., Li, P., Lim, S. L., Cao, S., Tay, J., Orlov, Y. L., et al. (2010) · Nature · doi:10.1038/nature08735 · Cited by 285
Yoshikawa, Y., Fujimori, T., McMahon, A. P., & Takada, S. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8502 · Cited by 284
Wnt signalling: variety at the core
Hoppler, S., & Kavanagh, C. L. (2007) · Journal of Cell Science · doi:10.1242/jcs.03363 · Cited by 279
Wnt Signaling and Stem Cell Control
Nusse, R., Fuerer, C., Ching, W., Harnish, K., Logan, C., Zeng, A., Berge, D. T., & Kalani, Y. (2008) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2008.73.035 · Cited by 249
Synergistic action of Wnt and LIF in maintaining pluripotency of mouse ES cells
Ogawa, K., Nishinakamura, R., Iwamatsu, Y., Shimosato, D., & Niwa, H. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.02.127 · Cited by 246
Wnt signals from the neural tube block ectopic cardiogenesis
Tzahor, E., & Lassar, A. B. (2001) · Genes & Development · doi:10.1101/gad.871501 · Cited by 246
Tcf3: a transcriptional regulator of axis induction in the early embryo
Merrill, B. J., Pasolli, H. A., Polak, L., Rendl, M., García-García, M. J., Anderson, K. V., & Fuchs, E. (2004) · Development · doi:10.1242/dev.00935 · Cited by 242
Lyashenko, N., Winter, M., Migliorini, D., Biechele, T., Moon, R. T., & Hartmann, C. (2011) · Nature Cell Biology · doi:10.1038/ncb2260 · Cited by 241
Wnt signaling in stem and cancer stem cells
Wend, P., Holland, J. D., Ziebold, U., & Birchmeier, W. (2010) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2010.09.004 · Cited by 237
β-Catenin Enhances Oct-4 Activity and Reinforces Pluripotency through a TCF-Independent Mechanism
Kelly, K. F., Ng, D. Y., Jayakumaran, G., Wood, G. A., Koide, H., & Doble, B. W. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2010.12.010 · Cited by 223
Wnt and FGF pathways cooperatively pattern anteroposterior neural ectoderm in Xenopus
McGrew, L. L., Hoppler, S., & Moon, R. T. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00160-3 · Cited by 222
The origin and identity of embryonic stem cells
Nichols, J., & Smith, A. (2011) · Development · doi:10.1242/dev.050831 · Cited by 210
Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia
Nguyen, H., Merrill, B. J., Polak, L., Nikolova, M., Rendl, M., Shaver, T. M., Pasolli, H. A., & Fuchs, E. (2009) · Nature Genetics · doi:10.1038/ng.431 · Cited by 201
Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex
Foley, A. C., & Mercola, M. (2005) · Genes & Development · doi:10.1101/gad.1279405 · Cited by 195
De Wetering, M. V., Castrop, J., Korinek, V., & Clevers, H. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.745 · Cited by 191
Pre-existent pattern in Xenopus animal pole cells revealed by induction with activin
Sokol, S., & Melton, D. A. (1991) · Nature · doi:10.1038/351409a0 · Cited by 190
Self-citationTam, W.-L., Lim, C. Y., Han, J., Zhang, J., Ang, Y.-S., Ng, H.-H., Yang, H., & Lim, B. (2008) · Stem Cells · doi:10.1634/stemcells.2007-1115 · Cited by 188
BMP-2/-4 and Wnt-8 cooperatively pattern the Xenopus mesoderm
Hoppler, S., & Moon, R. T. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00004-5 · Cited by 177
Yi, F., Pereira, L., & Merrill, B. J. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0229 · Cited by 164
Regulation of TCF3 by Wnt-Dependent Phosphorylation during Vertebrate Axis Specification
Hikasa, H., Ezan, J., Itoh, K., Li, X., Klymkowsky, M. W., & Sokol, S. Y. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.09.005 · Cited by 164
Self-citationAxis determination by inhibition of Wnt signaling in Xenopus
Itoh, K., & Sokol, S. Y. (1999) · Genes & Development · doi:10.1101/gad.13.17.2328 · Cited by 163
Self-citationβ-Catenin up-regulates Nanog expression through interaction with Oct-3/4 in embryonic stem cells
Takao, Y., Yokota, T., & Koide, H. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.12.072 · Cited by 158
Nagayoshi, S., Hayashi, E., Abe, G., Osato, N., Asakawa, K., Urasaki, A., Horikawa, K., Ikeo, K., Takeda, H., & Kawakami, K. (2007) · Development · doi:10.1242/dev.009050 · Cited by 157
Lluís, F., Pedone, E., Pepe, S., & Cosma, M. P. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.08.017 · Cited by 157
Schaniel, C., Ang, Y.-S., Ratnakumar, K., Cormier, C., James, T., Bernstein, E., Lemischka, I. R., & Paddison, P. J. (2009) · Stem Cells · doi:10.1002/stem.223 · Cited by 156
Wnt signaling and dorso-ventral axis specification in vertebrates
Sokol, S. Y. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80061-6 · Cited by 151
Self-citationHow do they do Wnt they do?: regulation of transcription by the Wnt/β‐catenin pathway
Archbold, H. C., Yang, Y., Chen, L., & Cadigan, K. M. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02293.x · Cited by 149
Anton, R., Kestler, H. A., & Kühl, M. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.10.012 · Cited by 129
Hindgut defects and transformation of the gastro‐intestinal tract in Tcf4−/−/Tcf1−/− embryos
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Houston, D. W., Kofron, M. J., Resnik, E., Langland, R., Destrée, O., Wylie, C. C., & Heasman, J. (2002) · Development · doi:10.1242/dev.129.17.4015 · Cited by 107
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Roël, G., Hamilton, F. S., Gent, Y. Y. J., Bain, A. A., Destrée, O., & Hoppler, S. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01280-0 · Cited by 61
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Metadata
- Authors
- Sokol, S. Y.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2011-10-15
- Volume
- 138
- Issue
- 20
- Pages
- 4341-4350
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2153004457
- Cited by
- 257
- References
- 132
- FWCI
- 8.70
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.