U-shaped relation between plasma oxytocin levels and behavior in the trust game
Open accessAbstract
Trust underpins much of social and economic exchanges across human societies. In experimental economics, the Trust Game has served as the workhorse for the study of trust in a controlled incentivized setting. Recent evidence using intranasal drug administration, aka 'sniffing', suggests that oxytocin (OT) can function as a social hormone facilitating trust and other affiliative behaviors. Here we hypothesized that baseline plasma OT is a biomarker that partially predicts the degree of trust and trustworthiness observed in the trust game. Using a large sample of 1,158 participants, we observed a significant U-shaped relationship between plasma OT with the level of trust, and marginally with the level of trustworthiness, especially among males. Specifically, subjects with more extreme levels of plasma OT were more likely to be trusting as well as trustworthy than those with moderate levels of plasma OT. Our results contribute to a deeper understanding of the biological basis of human trust and underscore the usefulness of peripheral plasma OT measures in characterizing human social behavior.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Many papers have used an ELISA on unextracted plasma and obtained oxytocin values above 300 pg/ml.
“However, many papers have used an ELISA on unextracted plasma, yielding values of >300pg/ml (59)(60)(61)(62)(63)(64)(65).”
From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [60]
Most human studies report a lack of sex differences in plasma OT.
“most human studies report a lack of sex differences in plasma OT”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Zhong et al., 2012
Studies investigating a link between plasma oxytocin levels and trust behavior in experimental settings have yielded mixed results.
“However, studies investigating a link between plasma OT levels and trust behavior in experimental settings (trust game paradigms), have yielded mixed results with some studies reporting tentative links (Zak et al., 2005;Zhong et al., 2012), while others failed to reveal a significant correlation (Christensen et al., 2014).”
From Long-term oxytocin administration enhances the experience of attachment (2017) · cites this paper as Zhong et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Social Capital in the Creation of Human Capital
Coleman, J. S. (1988) · American Journal of Sociology · doi:10.1086/228943 · Cited by 26,975 · see citing works
Social Capital in the Creation of Human Capital
Coleman, J. S. (2000) · Elsevier eBooks · doi:10.1016/b978-0-7506-7222-1.50005-2 · Cited by 21,727 · see citing works
Trust, Reciprocity, and Social History
Berg, J., Dickhaut, J., & McCabe, K. (1995) · Games and Economic Behavior · doi:10.1006/game.1995.1027 · Cited by 5,548 · see citing works
Trust: making and breaking cooperative relations
Gambetta, D. (1989) · Choice Reviews Online · doi:10.5860/choice.26-3664 · Cited by 4,046 · see citing works
Behavioral Game Theory: Experiments in Strategic Interaction
Camerer, C. F. (2003) · Cited by 3,801 · see citing works
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690 · see citing works
Porges, S. W. (2007) · Biological Psychology · doi:10.1016/j.biopsycho.2006.06.009 · Cited by 3,415 · see citing works
(1979) · Medical Entomology and Zoology · Cited by 3,065 · see citing works
Zak, P. J., & Knack, S. (2001) · The Economic Journal · doi:10.1111/1468-0297.00609 · Cited by 2,742 · see citing works
Social effects of oxytocin in humans: context and person matter
Bartz, J. A., Zaki, J., Bolger, N., & Ochsner, K. N. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.05.002 · Cited by 1,572 · cited 2× · see citing works
“review [43], the effects of OT are constrained by features of situations – simply put ‘context matters’.”
BackgroundOxytocin improves “mind-reading” in humans
Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.015 · Cited by 1,298 · see citing works
An Experiment on Risk Taking and Evaluation Periods
Gneezy, U., & Potters, J. (1997) · The Quarterly Journal of Economics · doi:10.1162/003355397555217 · Cited by 1,288 · see citing works
The Neuropeptide Oxytocin Regulates Parochial Altruism in Intergroup Conflict Among Humans
De Dreu, C. K. W., Greer, L. L., Handgraaf, M. J. J., Shalvi, S., Van Kleef, G. A., Baas, M., Ten Velden, F. S., Van Dijk, E., & Feith, S. W. W. (2010) · Science · doi:10.1126/science.1189047 · Cited by 1,148 · see citing works
How to identify trust and reciprocity
Cox, J. C. (2003) · Games and Economic Behavior · doi:10.1016/s0899-8256(03)00119-2 · Cited by 1,065 · see citing works
Landgraf, R., & Neumann, I. D. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.05.001 · Cited by 1,059 · see citing works
Oxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037 · see citing works
Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders.
Guastella, A. J., Einfeld, S. L., Gray, K. M., Rinehart, N. J., Tonge, B. J., Lambert, T. J., & Hickie, I. B. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.020 · Cited by 962 · see citing works
Dendritic peptide release and peptide-dependent behaviours
Ludwig, M., & Leng, G. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1845 · Cited by 945 · see citing works
Promoting social behavior with oxytocin in high-functioning autism spectrum disorders.
Andari, E., Duhamel, J.-R., Zalla, T., Herbrecht, E., Leboyer, M., & Sirigu, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910249107 · Cited by 941 · see citing works
Trust in modern societies: the search for the bases of social order
(1996) · Choice Reviews Online · doi:10.5860/choice.34-1248 · Cited by 834 · see citing works
Feldman, R., Weller, A., Zagoory-Sharon, O., & Levine, A. (2007) · Psychological Science · doi:10.1111/j.1467-9280.2007.02010.x · Cited by 787 · see citing works
Gender and Culture: International Experimental Evidence from Trust Games
Croson, R. T. A., & Buchan, N. R. (1999) · American Economic Review · doi:10.1257/aer.89.2.386 · Cited by 636 · see citing works
Oxytocin is associated with human trustworthiness
ZAK, P., KURZBAN, R., & MATZNER, W. (2005) · Hormones and Behavior · doi:10.1016/j.yhbeh.2005.07.009 · Cited by 595 · see citing works
Polyandrous females avoid costs of inbreeding
Tregenza, T., & Wedell, N. (2002) · Nature · doi:10.1038/415071a · Cited by 525 · see citing works
Betrayal Aversion: Evidence from Brazil, China, Oman, Switzerland, Turkey, and the United States
Bohnet, I., Greig, F., Herrmann, B., & Zeckhauser, R. (2008) · American Economic Review · doi:10.1257/aer.98.1.294 · Cited by 481 · see citing works
Oxytocin and the development of parenting in humans
Gordon, I., Zagoory-Sharon, O., Leckman, J. F., & Feldman, R. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.02.005 · Cited by 469 · see citing works
Kok, B. E., & Fredrickson, B. L. (2010) · Biological Psychology · doi:10.1016/j.biopsycho.2010.09.005 · Cited by 453 · see citing works
Oxytocin can hinder trust and cooperation in borderline personality disorder
Bartz, J., Simeon, D., Hamilton, H., Kim, S., Crystal, S., Braun, A., Vicens, V., & Hollander, E. (2011) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsq085 · Cited by 452 · see citing works
Sex differences in oxytocin and vasopressin: Implications for autism spectrum disorders?
CARTER, C. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.08.025 · Cited by 432 · see citing works
Oxytocin and autistic disorder: alterations in peptide forms
Green, L., Fein, D., Modahl, C., Feinstein, C., Waterhouse, L., & Morris, M. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01139-8 · Cited by 404 · see citing works
Oxytocin, vasopressin and sociality
CARTER, C., GRIPPO, A., POURNAJAFINAZARLOO, H., RUSCIO, M., & PORGES, S. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00427-5 · Cited by 380 · see citing works
Van IJzendoorn, M. H., & Bakermans-Kranenburg, M. J. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.008 · Cited by 365 · see citing works
Evaluation of enzyme immunoassay and radioimmunoassay methods for the measurement of plasma oxytocin
Szeto, A., McCabe, P. M., Nation, D. A., Tabak, B. A., Rossetti, M. A., McCullough, M. E., Schneiderman, N., & Mendez, A. J. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31821df0c2 · Cited by 330 · see citing works
Genetics of Human Social Behavior
Ebstein, R. P., Israel, S., Chew, S. H., Zhong, S., & Knafo, A. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.020 · Cited by 323 · see citing works
Oxytocin: Behavioral Associations and Potential as a Salivary Biomarker
SUE CARTER, C., POURNAJAFI‐NAZARLOO, H., KRAMER, K. M., ZIEGLER, T. E., WHITE‐TRAUT, R., BELLO, D., & SCHWERTZ, D. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1384.006 · Cited by 323 · see citing works
The contributions of oxytocin and vasopressin pathway genes to human behavior
Ebstein, R. P., Knafo, A., Mankuta, D., Chew, S. H., & Lai, P. S. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.014 · Cited by 283 · see citing works
Self-citationDistinguishing trust from risk: An anatomy of the investment game
Houser, D. E., Schunk, D., & Winter, J. (2010) · Journal of Economic Behavior & Organization · doi:10.1016/j.jebo.2010.01.002 · Cited by 271 · see citing works
Evidence-based pharmacotherapy for attention-deficit hyperactivity disorder
Biederman, J., Spencer, T., & Wilens, T. (2004) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145703003973 · Cited by 253 · see citing works
Smeltzer, M. D., Curtis, J. T., Aragona, B. J., & Wang, Z. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.10.019 · Cited by 222 · see citing works
Phillips, A. (1994) · Medical Entomology and Zoology · Cited by 203 · see citing works
Bäckström, T., Haage, D., Löfgren, M., Johansson, I. M., Strömberg, J., Nyberg, S., Andréen, L., Ossewaarde, L., van Wingen, G. A., Turkmen, S., et al. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.03.061 · Cited by 169 · see citing works
Low- and High-Testosterone Individuals Exhibit Decreased Aversion to Economic Risk
Stanton, S. J., Mullette-Gillman, O. A., McLaurin, R. E., Kuhn, C. M., LaBar, K. S., Platt, M. L., & Huettel, S. A. (2011) · Psychological Science · doi:10.1177/0956797611401752 · Cited by 145 · see citing works
Sexually dimorphic expression of oxytocin binding sites in forebrain and spinal cord of the rat
Uhl-Bronner, S., Waltisperger, E., Martínez-Lorenzana, G., Condes Lara, M., & Freund-Mercier, M. J. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.05.025 · Cited by 123 · see citing works
Opacka‐Juffry, J., & Mohiyeddini, C. (2011) · Stress · doi:10.3109/10253890.2011.560309 · Cited by 122 · see citing works
De Dreu, C. K. W. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.10.003 · Cited by 114 · see citing works
Apicella, C. L., Cesarini, D. A., Johannesson, M., Dawes, C. T., Lichtenstein, P., Wallace, B., Beauchamp, J. P., & Westberg, L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011153 · Cited by 110 · see citing works
Bales, K. L., Pfeifer, L. A., & Carter, C. S. (2004) · Developmental Psychobiology · doi:10.1002/dev.10165 · Cited by 107 · see citing works
What You Don't Know Won't Hurt You: A Laboratory Analysis of Betrayal Aversion
Aimone, J. A., & Houser, D. E. (2009) · Experimental Economics · doi:10.1007/s10683-012-9314-z · Cited by 105 · see citing works
Holt-Lunstad, J., Birmingham, W., & Light, K. C. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.03.007 · Cited by 103 · see citing works
Angiotensin IV enhances LTP in rat dentate gyrus in vivo
Wayner, M. J., Armstrong, D. L., Phelix, C. F., Wright, J. W., & Harding, J. W. (2001) · Peptides · doi:10.1016/s0196-9781(01)00475-2 · Cited by 95 · see citing works
A novel form of oxytocin in New World monkeys
Lee, A. G., Cool, D. R., Grunwald, W. C., Neal, D. E., Buckmaster, C. L., Cheng, M. Y., Hyde, S. A., Lyons, D. M., & Parker, K. J. (2011) · Biology Letters · doi:10.1098/rsbl.2011.0107 · Cited by 91 · see citing works
Oxytocin response in a trust game and habituation of arousal
Kéri, S., & Kiss, I. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.11.011 · Cited by 72 · see citing works
Oxytocin is a precursor of potent behaviourally active neuropeptides
Burbach, J. P. H., Bohus, B., Kovács, G. L., Nispen, J. W. V., Greven, H. M., & de Wied, D. (1983) · European Journal of Pharmacology · doi:10.1016/0014-2999(83)90449-1 · Cited by 71 · see citing works
Calabrese, E. J. (2008) · Critical Reviews in Toxicology · doi:10.1080/10408440802004007 · Cited by 67 · see citing works
Michopoulos, V., Checchi, M., Sharpe, D. I., & Wilson, M. E. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.02.002 · Cited by 60 · see citing works
Boccia, M. M., Kopf, S. R., & Baratti, C. M. (1998) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1997.3817 · Cited by 59 · see citing works
Polymorphisms of candidate genes in Slovak autistic patients
Kelemenova, S., Schmidtova, E., Ficek, A., Celec, P., Kubranska, A., & Ostatnikova, D. (2010) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32833a1eb3 · Cited by 50 · see citing works
Bick, J. R., & Dozier, M. (2009) · Developmental Psychobiology · doi:10.1002/dev.20411 · Cited by 48 · see citing works
Razzoli, M., Cushing, B. S., Carter, C. S., & Valsecchi, P. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(03)00064-3 · Cited by 47 · see citing works
Aimone, J. A., & Houser, D. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017725 · Cited by 45 · see citing works
Oxytocin-Gly-Lys-Arg: A Novel Cardiomyogenic Peptide
Danalache, B. A., Gutkowska, J., Ślusarz, M. J., Berezowska, I., & Jankowski, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013643 · Cited by 24 · see citing works
Anxiolytic effect of motilin and reversal with GM-109, a motilin antagonist, in mice
Momose, K., Inui, A., Asakawa, A., Ueno, N., Nakajima, M., & Kasuga, M. (1998) · Peptides · doi:10.1016/s0196-9781(98)00131-4 · Cited by 23 · see citing works
Kastin, A. J., & Pan, W. (2008) · Critical Reviews in Toxicology · doi:10.1080/10408440802026372 · Cited by 23 · see citing works
Professor Zak’s empirical studies on trust and oxytocin
Conlisk, J. (2011) · Journal of Economic Behavior & Organization · doi:10.1016/j.jebo.2011.01.002 · Cited by 22 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Intranasal Oxytocin: Myths and Delusions
Leng, G., & Ludwig, M. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.003 · Cited by 615 · see citing works
Dumais, K. M., & Veenema, A. H. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.003 · Cited by 520 · see citing works
“, 1991; Ishunina and Swaab, 1999), and most human studies report a lack of sex differences in plasma OT (Zhong et al., 2012; Taylor et al., 2010; Grewen et al., 2005; Gordon et al., 2008; Gordon et al., 2010; Graugaard-Jensen et al., 2014; however see van Londen et al., 1997; Miller et al., 2013; Weisman et al., 2013).”
BackgroundProblems with measuring peripheral oxytocin: can the data on oxytocin and human behavior be trusted?
McCullough, M. E., Churchland, P. S., & Mendez, A. J. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.018 · Cited by 416 · see citing works
Does Oxytocin Increase Trust in Humans? A Critical Review of Research
Nave, G., Camerer, C., & McCullough, M. (2015) · Perspectives on Psychological Science · doi:10.1177/1745691615600138 · Cited by 309 · see citing works
Kagerbauer, S. M., Martin, J., Schuster, T., Blobner, M., Kochs, E. F., & Landgraf, R. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12038 · Cited by 212 · see citing works
Browsing the oldest antioxidant enzyme: catalase and its multiple regulation in cancer
Galasso, M., Gambino, S., Romanelli, M. G., Donadelli, M., & Scupoli, M. T. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.06.010 · Cited by 184 · see citing works
MacDonald, K., & Feifel, D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00035 · Cited by 181 · see citing works
Toward a Model of Interpersonal Trust Drawn from Neuroscience, Psychology, and Economics
Krüeger, F., & Meyer‐Lindenberg, A. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.10.004 · Cited by 158 · see citing works
Sex, Receptors, and Attachment: A Review of Individual Factors Influencing Response to Oxytocin
MacDonald, K. S. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00194 · Cited by 119 · see citing works
Alós‐Ferrer, C., & Farolfi, F. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00887 · Cited by 117 · see citing works
Oxytocin facilitates social approach behavior in women
Preckel, K., Scheele, D., Kendrick, K. M., Maier, W., & Hurlemann, R. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00191 · Cited by 111 · see citing works
Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders
Francis, S. M., Sagar, A., Levin-Decanini, T., Liu, W., Carter, C. S., & Jacob, S. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.021 · Cited by 101 · see citing works
The Effects of Oxytocin on Appetite Regulation, Food Intake and Metabolism in Humans
Kerem, L., & Lawson, E. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147737 · Cited by 94 · see citing works
Long-term oxytocin administration enhances the experience of attachment
Bernaerts, S., Prinsen, J., Berra, E., Bosmans, G., Steyaert, J., & Alaerts, K. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.01.010 · Cited by 90 · see citing works
Disentangling the molecular genetic basis of personality: From monoamines to neuropeptides
Montag, C., & Reuter, M. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.04.006 · Cited by 90 · see citing works
van den Akker, O. R., van Assen, M. A. L. M., van Vugt, M., & Wicherts, J. M. (2020) · Journal of Economic Psychology · doi:10.1016/j.joep.2020.102329 · Cited by 85 · see citing works
The Trust Game in neuroscience: A short review
Tzieropoulos, H. (2013) · Social Neuroscience · doi:10.1080/17470919.2013.832375 · Cited by 80 · see citing works
Lower Oxytocin Plasma Levels in Borderline Patients with Unresolved Attachment Representations
Jobst, A., Padberg, F., Mauer, M.-C., Daltrozzo, T., Bauriedl-Schmidt, C., Sabass, L., Sarubin, N., Falkai, P., Renneberg, B., Zill, P., et al. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00125 · Cited by 88 · see citing works
An association between belief in life after death and serum oxytocin in older people in rural Japan
Imamura, Y., Mizoguchi, Y., Nabeta, H., Haraguchi, Y., Matsushima, J., Kojima, N., Kawashima, T., Yamada, S., & Monji, A. (2017) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4453 · Cited by 21 · see citing works
Improving the precision of intranasal oxytocin research
Winterton, A., Westlye, L. T., Steen, N. E., Andreassen, O. A., & Quintana, D. S. (2020) · Nature Human Behaviour · doi:10.1038/s41562-020-00996-4 · Cited by 62 · see citing works
The role of oxytocin and vasopressin in emotional and social behaviors
Bachner‐Melman, R., & Ebstein, R. P. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-59602-4.00004-6 · Cited by 62 · see citing works
Trust, Sexual Trust, and Sexual Health: An Interrogative Review
Fortenberry, J. D. (2018) · The Journal of Sex Research · doi:10.1080/00224499.2018.1523999 · Cited by 58 · see citing works
Oxytocin Facilitates Social Learning by Promoting Conformity to Trusted Individuals
Xu, L., Becker, B., & Kendrick, K. M. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00056 · Cited by 53 · see citing works
The role of oxytocin in familiarization-habituation responses to social novelty
Mattie Tops, A., Huffmeijer, R., Linting, M., Grewen, K., Light, K. C., Koole, S. L., Bakermans‐Kranenburg, M. J., & van IJzendoorn, M. H. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00761 · Cited by 52 · see citing works
Plasma oxytocin explains individual differences in neural substrates of social perception
Lancaster, K., Carter, C. S., Pournajafi‐Nazarloo, H., Karaoli, T., Lillard, T. S., Jack, A., Davis, J. M., Morris, J. P., & Connelly, J. J. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00132 · Cited by 52 · see citing works
Nishina, K., Takagishi, H., Inoue‐Murayama, M., Takahashi, H., & Yamagishi, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137089 · Cited by 49 · see citing works
Cortisol, oxytocin, and quality of life in major depressive disorder
Tang, A. L., Thomas, S. J., & Larkin, T. (2019) · Quality of Life Research · doi:10.1007/s11136-019-02236-3 · Cited by 45 · see citing works
Connectome‐based model predicts individual differences in propensity to trust
Lu, X., Li, T., Xia, Z., Zhu, R., Wang, L., Luo, Y., Feng, C., & Krüeger, F. (2019) · Human Brain Mapping · doi:10.1002/hbm.24503 · Cited by 36 · see citing works
Suraev, A. S., Bowen, M. T., Ali, S. O., Hicks, C., Ramos, L., & McGregor, I. S. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.03.002 · Cited by 35 · see citing works
Horta de Macedo, L. R., Zuardi, A. W., Machado-de-Sousa, J. P., Chagas, M. H. N., & Hallak, J. E. C. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.07.082 · Cited by 35 · see citing works
Samuel, S., Hayton, B. C., Gold, I., Feeley, N., Carter, C. S., & Zelkowitz, P. (2015) · Attachment & Human Development · doi:10.1080/14616734.2015.1029951 · Cited by 34 · see citing works
Bhandari, R., Bakermans-Kranenburg, M. J., van der Veen, R., Parsons, C. E., Young, K. S., Grewen, K. M., Stein, A., Kringelbach, M. L., & van IJzendoorn, M. H. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.04.028 · Cited by 33 · see citing works
Crespi, B. J., & Procyshyn, T. L. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.05.004 · Cited by 31 · see citing works
Liu, C. M., Hsu, T. M., Suarez, A. N., Subramanian, K. S., Fatemi, R. A., Cortella, A. M., Noble, E. E., Roitman, M. F., & Kanoski, S. E. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104855 · Cited by 28 · see citing works
Weinstein, T. A. R., Bales, K. L., Maninger, N., Hostetler, C. M., & Capitanio, J. P. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00295 · Cited by 26 · see citing works
Rubin, L. H., Wehring, H. J., Demyanovich, H. K., Carter, C. S., Pournajafi‐Nazarloo, H., Feldman, S. M., Earl, A. K., August, S. M., Gold, J. M., & Kelly, D. L. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.09.041 · Cited by 26 · see citing works
Association of the oxytocin receptor gene with attitudinal trust: role of amygdala volume
Nishina, K., Takagishi, H., Fermin, A. S. R., Inoue‐Murayama, M., Takahashi, H., Sakagami, M., & Yamagishi, T. (2018) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsy075 · Cited by 25 · see citing works
You, D. S., Haney, R., Albu, S., & Meagher, M. W. (2017) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13213 · Cited by 22 · see citing works
de Jager, C. (2016) · Journal of Consumer Policy · doi:10.1007/s10603-016-9334-8 · Cited by 22 · see citing works
Otte, K. A., Schrank, I., Fröhlich, T., Arnold, G. J., & Laforsch, C. (2015) · Molecular Ecology · doi:10.1111/mec.13287 · Cited by 22 · see citing works
Balmuș, I.-M., Lefter, R. M., Ciobica, A. S., Antioch, I., Ababei, D. C., & Dobrin, R. (2018) · Psychiatria Danubina · doi:10.24869/psyd.2018.91 · Cited by 20 · see citing works
Levin, S. B. (2021) · doi:10.1093/oso/9780190051495.001.0001 · Cited by 18 · see citing works
Carrico, A. W., Cherenack, E. M., Rubin, L. H., McIntosh, R. C., Ghanooni, D., Chavez, J. V., Klatt, N. R., & Paul, R. H. (2022) · Psychosomatic Medicine · doi:10.1097/psy.0000000000001133 · Cited by 18 · see citing works
Risk and resistance perspectives in translation-oriented etiology research
Vanyukov, M. M., Tarter, R. E., Conway, K. P., Kirillova, G. P., Chandler, R. K., & Daley, D. C. (2015) · Translational Behavioral Medicine · doi:10.1007/s13142-015-0355-7 · Cited by 17 · see citing works
Reproductive experiential regulation of cognitive and emotional resilience
Kinsley, C. H., Bales, K. L., Bardi, M., & Stolzenberg, D. S. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.05.015 · Cited by 17 · see citing works
Genomic conflicts and sexual antagonism in human health: insights from oxytocin and testosterone
Mökkönen, M., & Crespi, B. J. (2015) · Evolutionary Applications · doi:10.1111/eva.12244 · Cited by 16 · see citing works
The (Null) Effect of Affective Touch on Betrayal Aversion, Altruism, and Risk Taking
Koppel, L., Andersson, D., Morrison, I., Västfjäll, D., & Tinghög, G. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00251 · Cited by 16 · see citing works
Response to unfairness across the suicide risk spectrum
Carbajal, J. M., Gamboa, J. L., Moore, J., Smith, F. M., Eads, L. A., Clothier, J. L., & Cáceda, R. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.08.071 · Cited by 16 · see citing works
Leu8 and Pro8 oxytocin agonism differs across human, macaque, and marmoset vasopressin 1a receptors
Mustoe, A. C., Schulte, N. A., Taylor, J. H., French, J. A., & Toews, M. L. (2019) · Scientific Reports · doi:10.1038/s41598-019-52024-9 · Cited by 15 · see citing works
Phuong, L. K., Bonetto, C., Buttery, J. P., Pernus, Y. B., Chandler, R. E., Goldenthal, K. L., Kucuku, M., Monaco, G., Pahud, B. A., Shulman, S. T., et al. (2016) · Vaccine · doi:10.1016/j.vaccine.2016.09.025 · Cited by 15 · see citing works
Dı́az, F., Allan, C. W., & Matzkin, L. M. (2018) · BMC Evolutionary Biology · doi:10.1186/s12862-018-1250-x · Cited by 13 · see citing works
Endogenous oxytocin predicts helping and conversation as a function of group membership
McClung, J., Triki, Z., Clément, F., Bangerter, A., & Bshary, R. (2018) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2018.0939 · Cited by 14 · see citing works
Pădurariu, M. (2018) · FARMACIA · doi:10.31925/farmacia.2018.3.6 · Cited by 12 · see citing works
A blueprint for research on Shankopathies: A view from research on autism spectrum disorder
Carbonetto, S. (2013) · Developmental Neurobiology · doi:10.1002/dneu.22150 · Cited by 12 · see citing works
The supraoptic and paraventricular nuclei in healthy aging and neurodegeneration
Stewart, C. A., & Finger, E. C. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-820107-7.00007-0 · Cited by 11 · see citing works
Temporal dynamics of intranasal oxytocin in human brain electrophysiology
Zelenina, M., Kosilo, M., da Cruz, J. N., Antunes, M. C. D. S., Figueiredo, P., Mehta, M. A., & Prata, D. P. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab404 · Cited by 11 · see citing works
Dumais, K. M., & Veenema, A. H. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-802114-9.00011-1 · Cited by 11 · see citing works
Bašić, J., Milošević, V., Stanković, M., Jevtović−Stoimenov, T., Cvetković, T., Despotović, M., & Pavlovic, D. D. (2018) · Archives of Biological Sciences · doi:10.2298/abs181206057b · Cited by 9 · see citing works
Measurement of Liability to Addiction: Dimensional Approaches
Vanyukov, M. M., Cornelius, M. D., Genna, N. M. D., Reynolds, M., Kirillova, G. P., Maher, B. S., & Kirisci, L. (2017) · The International Journal of Person Centered Medicine · doi:10.5750/ijpcm.v6i4.612 · Cited by 8 · see citing works
Is oxytocin a trust hormone? Salivary oxytocin is associated with caution but not with general trust
Shou, Q., Yamada, J., Nishina, K., Matsunaga, M., Kiyonari, T., & Takagishi, H. (2022) · PLoS ONE · doi:10.1371/journal.pone.0267988 · Cited by 7 · see citing works
van den Akker, O. R., van Assen, M. A. L. M., van Vugt, M., & Wicherts, J. M. (2018) · doi:10.31234/osf.io/5zbja · Cited by 6 · see citing works
Kumar, A., Kumar, P., Faiq, M. A., Sharma, V. K., Sesham, K., & Kulandhasamy, M. (2018) · Springer eBooks · doi:10.1007/978-3-319-47829-6_476-2 · Cited by 5 · see citing works
Zablocki‐Thomas, P., Lau, A. R., Witczak, L. R., Dufek, M. E., Wright, A., Savidge, L. E., Paulus, J. P., BAXTER, A. B., Karaskiewicz, C. L., Seelke, A. M. H., et al. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13339 · Cited by 3 · see citing works
Ebstein, R. P., Monakhov, M. V., Lu, Y., Jiang, Y., Lai, P. S., & Chew, S. H. (2015) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2015.1360 · Cited by 4 · see citing works
Serum Oxytocin Concentration in Patients Receiving Electroconvulsive Therapy
Barhale, C., Raju, M. S. V. K., Pawar, A. V., Kadam, K., Sousa, A. D., & Andrade, C. (2017) · Journal of Ect · doi:10.1097/yct.0000000000000388 · Cited by 3 · see citing works
Modeling the Genetics of Social Cognition in the Laboratory
Ebstein, R. P., Zhong, S., Chark, R., Lai, P. S., & Chew, S. H. (2014) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780199753888.013.017 · Cited by 3 · see citing works
Adegboro, C. O., Luo, W., Kabra, M., McAdams, R. M., York, N., Wijenayake, R. I., Suchla, K. M., Pillers, D. M., & Pattnaik, B. R. (2024) · Cells · doi:10.3390/cells13201735 · Cited by 2 · see citing works
Salivary Oxytocin Has Nonlinear Relationships with Trust and Reciprocity
Arai, S., Watabe, M., Kanari, K., Shou, Q., Krüeger, F., & Takagishi, H. (2023) · Games · doi:10.3390/g14010017 · Cited by 2 · see citing works
Yan, Z., & Kirsch, P. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108770880.018 · Cited by 2 · see citing works
The Utility of Screening Colonoscopy During Kidney Transplant Evaluation.
Zheng, Y., Chaung, K. V., Park, P., Augustine, J. J., Sarabu, N., Schulak, J. A., Sanchez, E. Q., Humphreville, V. R., Ammori, J. B., & Woodside, K. J. (2017) · Experimental and Clinical Transplantation · doi:10.6002/ect.2016.0214 · Cited by 2 · see citing works
Nogueira, G., Engroff, P., Gotllieb, M. G. V., von Gunten, A., Jardim, G. B. G., & Neto, A. C. (2021) · PAJAR - Pan-American Journal of Aging Research · doi:10.15448/2357-9641.2021.1.40965 · Cited by 1 · see citing works
Levin, S. B. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780190051495.003.0006 · Cited by 1 · see citing works
Oxytocin, Vasopressin, and Development of Social Behavior in Primates
Bales, K. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-804042-3.00094-4
Transhumanists’ Informational View of Being and Knowledge
Levin, S. B. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780190051495.003.0007
Utilitarian Commitments of Transhumanists and Their Sociopolitical Implications
Levin, S. B. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780190051495.003.0005
Why We Should Reject Transhumanists’ Entire Lens on the Mind and Brain
Levin, S. B. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780190051495.003.0003
Assessing Transhumanist Advocacy of Cognitive Bioenhancement
Levin, S. B. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780190051495.003.0002
Evaluating the Debate Thus Far over Moral Bioenhancement
Levin, S. B. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780190051495.003.0004
Living Virtuously as a Regulative Ideal
Levin, S. B. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780190051495.003.0008
Wootton, R. E. (2018) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0027868
Oxytocin – the prosocial molecule?
Preckel, K. (2015) · bonndoc (University of Bonn)
Krüeger, F. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108770880.017
Levin, S. B. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780190051495.003.0001
Kumar, A., Kumar, P., Faiq, M. A., Sharma, V., Sesham, K., & Kulandhasamy, M. (2018) · Springer eBooks · doi:10.1007/978-3-319-47829-6_476-1
Kumar, A., Kumar, P., Faiq, M. A., Sharma, V. K., Sesham, K., & Kulandhasamy, M. (2022) · Springer eBooks · doi:10.1007/978-3-319-55065-7_476
Study of Oxytocin in Biopolitics
Jung, S. (2022) · Emerald Group Publishing Limited eBooks · doi:10.1108/s2042-994020220000013009
Neurohypophyseal Hormones and Drugs of Misuse
Johnson, J. L., Johnson, M., & Buisman‐Pijlman, F. T. A. (2017) · Royal Society of Chemistry eBooks · doi:10.1039/9781782621577-00346
Levin, S. B. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780190051495.002.0003
Levin, S. B. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780190051495.002.0006
Oxytocin and Vasopressin in Autism and Genetic Syndromes
Levin‐Decanini, T., Francis, S. M., Sagar, A., Liu, W., Carter, C. S., & Jacob, S. (2015) · Contemporary clinical neuroscience · doi:10.1007/978-1-4939-2190-4_14
- Authors
- Zhong, S., Monakhov, M., Mok, H. P., Tong, T., Lai, P. S., Chew, S. H., & Ebstein, R. P.
- Affiliations
- National University of Singapore (SG)
- Corresponding author
- Ebstein, Richard P.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-12-05
- Volume
- 7
- Issue
- 12
- Pages
- e51095
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3515439
- OpenAlex
- W1984642682
- Cited by
- 90
- References
- 64
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 4 · 2021: 18 · 2020: 3 · 2019: 5 · 2018: 12 · 2017: 10 · 2016: 5 · 2015: 14 · 2014: 9 · 2013: 7
- FWCI
- 14.44
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- National University of Singapore (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Funders
- John Templeton Foundation
- Ministry of Education, India
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Social Sciences › Safety Research › Experimental Behavioral Economics Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Evolutionary Psychology and Human Behavior
- Keywords
- oxytocin, plasma oxytocin, trust, trust game, trustworthiness, U-shaped relationship, sex differences, social behavior, intranasal oxytocin
- MeSH terms
- Female, Games, Experimental, Humans, Male, Oxytocin, Social Behavior, Linear Models, Trust, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
