Cited by 784Neural dynamics and brain functionMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

Cross-Frequency Phase–Phase Coupling between Theta and Gamma Oscillations in the Hippocampus

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Belluscio, Mariano A., Mizuseki, Kenji, Schmidt, Robert, Kempter, Richard, Buzsáki, György·2012·The Journal of Neuroscience

Abstract

Neuronal oscillations allow for temporal segmentation of neuronal spikes. Interdependent oscillators can integrate multiple layers of information. We examined phase–phase coupling of theta and gamma oscillators in the CA1 region of rat hippocampus during maze exploration and rapid eye movement sleep. Hippocampal theta waves were asymmetric, and estimation of the spatial position of the animal was improved by identifying the waveform-based phase of spiking, compared to traditional methods used for phase estimation. Using the waveform-based theta phase, three distinct gamma bands were identified: slow gamma S(gamma S; 30–50 Hz), midfrequency gamma M(gamma M; 50–90 Hz), and fast gamma F(gamma F; 90–150 Hz or epsilon band). The amplitude of each sub-band was modulated by the theta phase. In addition, we found reliable phase–phase coupling between theta and both gamma S and gamma M but not gamma F oscillators. We suggest that cross-frequency phase coupling can support multiple time-scale control of neuronal spikes within and across structures.

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  1. Hebb DO The Organization of behaviour, a neuropsychological theory 1949 Wiley Oxford, England

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Authors
Belluscio, M. A., Mizuseki, K., Schmidt, R., Kempter, R., & Buzsáki, G.
Affiliations
  • Rutgers, The State University of New Jersey (US)
  • Humboldt-Universität zu Berlin (DE)
Venue
The Journal of Neuroscience
Published
2012-01-11
Volume
32
Issue
2
Pages
423-435
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W2044215073
Cited by
784
References
89
Citations by year
2026: 22 · 2025: 54 · 2024: 54 · 2023: 50 · 2022: 64 · 2021: 64 · 2020: 50 · 2019: 55 · 2018: 51 · 2017: 50 · 2016: 59 · 2015: 48 · 2014: 62 · 2013: 55 · 2012: 21
FWCI
30.43
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
Funders
  • National Science Foundation
  • James S. McDonnell Foundation
  • Bundesministerium für Bildung und Forschung (01GQ0410, 01GQ0972)
  • National Institute of Mental Health (R01MH054671, MH54671)
  • National Institute on Deafness and Other Communication Disorders (R01DC009947)
  • National Institute of Neurological Disorders and Stroke (R01NS034994, NS-34994)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
theta oscillations, gamma oscillations, hippocampus, CA1, maze exploration, REM sleep, neural oscillations
MeSH terms
Action Potentials, Animals, Biological Clocks, Male, Neurons, Sleep, REM, Theta Rhythm, Wakefulness, Rats, Long-Evans, Rats, CA1 Region, Hippocampal, Brain Waves

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