Cross-Frequency Phase–Phase Coupling between Theta and Gamma Oscillations in the Hippocampus
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Neuronal oscillations allow for temporal segmentation of neuronal spikes. Interdependent oscillators can integrate multiple layers of information. We examined phase–phase coupling of theta and gamma oscillators in the CA1 region of rat hippocampus during maze exploration and rapid eye movement sleep. Hippocampal theta waves were asymmetric, and estimation of the spatial position of the animal was improved by identifying the waveform-based phase of spiking, compared to traditional methods used for phase estimation. Using the waveform-based theta phase, three distinct gamma bands were identified: slow gamma S(gamma S; 30–50 Hz), midfrequency gamma M(gamma M; 50–90 Hz), and fast gamma F(gamma F; 90–150 Hz or epsilon band). The amplitude of each sub-band was modulated by the theta phase. In addition, we found reliable phase–phase coupling between theta and both gamma S and gamma M but not gamma F oscillators. We suggest that cross-frequency phase coupling can support multiple time-scale control of neuronal spikes within and across structures.
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The division into delta, theta, low-gamma, mid-gamma, high-gamma, and ripple frequency bands has been thoroughly described and proven to be functionally relevant for hippocampal electrographic recordings.
“This division has been thoroughly described and proven to be functionally relevant for hippocampal electrographic recordings38.”
From Local hippocampal fast gamma rhythms precede brain-wide hyperemic patterns during spontaneous rodent REM sleep (2018) · cites this paper as [38]
Hippocampal theta and gamma rhythms were confirmed by phase inversion across recording sites in successive hippocampal layers, time-frequency decomposition, and phase-amplitude cross-frequency coupling.
“Hippocampal theta and gamma rhythms were confirmed by phase inversion across recording sites in successive hippocampal layers, time-frequency decomposition, and phase-amplitude cross-frequency coupling37,38.”
From Local hippocampal fast gamma rhythms precede brain-wide hyperemic patterns during spontaneous rodent REM sleep (2018) · cites this paper as [38]
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- Authors
- Belluscio, M. A., Mizuseki, K., Schmidt, R., Kempter, R., & Buzsáki, G.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- Humboldt-Universität zu Berlin (DE)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-01-11
- Volume
- 32
- Issue
- 2
- Pages
- 423-435
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3293373
- OpenAlex
- W2044215073
- Cited by
- 784
- References
- 89
- Citations by year
- 2026: 22 · 2025: 54 · 2024: 54 · 2023: 50 · 2022: 64 · 2021: 64 · 2020: 50 · 2019: 55 · 2018: 51 · 2017: 50 · 2016: 59 · 2015: 48 · 2014: 62 · 2013: 55 · 2012: 21
- FWCI
- 30.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Funders
- National Science Foundation
- James S. McDonnell Foundation
- Bundesministerium für Bildung und Forschung (01GQ0410, 01GQ0972)
- National Institute of Mental Health (R01MH054671, MH54671)
- National Institute on Deafness and Other Communication Disorders (R01DC009947)
- National Institute of Neurological Disorders and Stroke (R01NS034994, NS-34994)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- theta oscillations, gamma oscillations, hippocampus, CA1, maze exploration, REM sleep, neural oscillations
- MeSH terms
- Action Potentials, Animals, Biological Clocks, Male, Neurons, Sleep, REM, Theta Rhythm, Wakefulness, Rats, Long-Evans, Rats, CA1 Region, Hippocampal, Brain Waves
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