Interactive Remote Patient Monitoring Devices for Managing Chronic Health Conditions: Systematic Review and Meta-analysis
Open accessAbstract
Background: Telemedicine is an expanding and feasible approach to improve medical care for patients with long-term conditions. However, there is a poor understanding of patients’ acceptability of this technology and their rate of uptake. Objective: The aim of this study was to systematically review the current evidence on telemonitoring in the management of patients with long-term conditions and evaluate the patients’ uptake and acceptability of this technology. Methods: MEDLINE, Scopus, and CENTRAL (the Cochrane Central Register of Controlled Trials) were searched from the date of inception to February 5, 2021, with no language restrictions. Studies were eligible for inclusion if they reported any of the following outcomes: intervention uptake and adherence; study retention; patient acceptability, satisfaction, and experience using the intervention; changes in physiological values; all-cause and cardiovascular-related hospitalization; all-cause and disease-specific mortality; patient-reported outcome measures; and quality of life. In total, 2 reviewers independently assessed the articles for eligibility. Results: A total of 96 studies were included, and 58 (60%) were pooled for the meta-analyses. Meta-analyses showed a reduction in mortality (risk ratio=0.71, 95% CI 0.56-0.89; P=.003; I2=0%) and improvements in blood pressure (mean difference [MD]=−3.85 mm Hg, 95% CI −7.03 to −0.68; P=.02; I2=100%) and glycated hemoglobin (MD=−0.33, 95% CI −0.57 to −0.09; P=.008; I2=99%) but no significant improvements in quality of life (MD=1.45, 95% CI −0.10 to 3; P=.07; I2=80%) and an increased risk of hospitalization (risk ratio=1.02, 95% CI 0.85-1.23; P=.81; I2=79%) with telemonitoring compared with usual care. A total of 12% (12/96) of the studies reported adherence outcomes, and 9% (9/96) reported on satisfaction and acceptance outcomes; however, heterogeneity in the assessment methods meant that a meta-analysis could not be performed. Conclusions: Telemonitoring is a valid alternative to usual care, reducing mortality and improving self-management of the disease, with patients reporting good satisfaction and adherence. Further studies are required to address some potential concerns regarding higher hospitalization rates and a lack of positive impact on patients’ quality of life. Trial Registration: PROSPERO CRD42021236291; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=236291
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Written from the paper’s full text.
TL;DR
This systematic review and meta-analysis of 96 studies found that interactive remote patient monitoring (telemonitoring) reduced 12-month all-cause mortality and improved blood pressure and glycated hemoglobin compared with usual care, but did not improve quality of life and showed no significant hospitalization difference. Patient adherence and satisfaction were generally favorable, though heterogeneous measurement prevented pooling.
Key findings
- Among 96 included studies (58 pooled), telemonitoring reduced 12-month all-cause mortality (risk ratio [RR]=0.71, 95% CI 0.56-0.89; P=.003; I²=0%) compared with usual care.
- Telemonitoring improved systolic blood pressure (mean difference [MD]=−3.85 mm Hg, 95% CI −7.03 to −0.68; P=.02; I²=100%) and glycated hemoglobin (MD=−0.33, 95% CI −0.57 to −0.09; P=.008; I²=99%).
- No significant quality-of-life improvement was found (MD=1.45, 95% CI −0.10 to 3; P=.07; I²=80%), and hospitalization was not significantly different (RR=1.02, 95% CI 0.85-1.23; P=.81; I²=79%); the abstract describes the latter as an increased risk.
- Adherence outcomes were reported in 12% (12/96) of studies and satisfaction in 9% (9/96); heterogeneity in assessment methods prevented meta-analysis, with 7/12 adherence studies and 5/9 satisfaction studies showing benefit of telemonitoring.
Methods
- Systematic review and meta-analysis registered on PROSPERO (CRD42021236291) and reported per PRISMA; MEDLINE, Scopus, and CENTRAL were searched from inception to February 5, 2021, with no language restrictions.
- Eligible studies included adults aged ≥18 years with cardiovascular disease, COPD, or diabetes mellitus; interventions required a digital device for remote patient monitoring with two-way exchange of information between patient and health care team.
- A total of 96 studies were included, and 58 (60%) were pooled using random-effects meta-analyses in RevMan; risk of bias was assessed with Cochrane RoB 2 for RCTs and ROBINS-I for nonrandomized studies, with narrative synthesis where data were too heterogeneous.
Limitations
- Stated: no studies reported intervention uptake or study retention outcomes; adherence and satisfaction were assessed with different tools, making comparison difficult; possible omission of papers due to heterogeneous key terms; no gray literature search; mortality, adherence, and satisfaction were infrequently reported (17/96, 12/96, and 9/96, respectively); COPD was underrepresented; usual care varied across studies.
- Evident from the text: several meta-analyses had very high heterogeneity (I²=100% for blood pressure, 99% for HbA1c, 79% for hospitalization), and most included RCTs (48/66, 73%) and non-RCTs (17/20, 85%) had some concerns or high risk of bias.
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Claims the paper makes
0 of 41 cited sources checked · 0 supported · 0 flagged
- Findingown data
Telemonitoring compared with usual care reduced mortality (risk ratio=0.71, 95% CI 0.56-0.89; P=.003; I2=0%).
“Meta-analyses showed a reduction in mortality (risk ratio=0.71, 95% CI 0.56-0.89; P=.003; I2=0%)”
Quote in the paperSubstantial claim- Rests on an assumption: The included studies are sufficiently comparable in populations, interventions, and outcome definitions to justify pooling in meta-analyses.
- Findingown data
Telemonitoring compared with usual care improved blood pressure (mean difference [MD]=−3.85 mm Hg, 95% CI −7.03 to −0.68; P=.02; I2=100%).
“improvements in blood pressure (mean difference [MD]=−3.85 mm Hg, 95% CI −7.03 to −0.68; P=.02; I2=100%)”
Quote in the paperSubstantial claim- Rests on an assumption: The included studies are sufficiently comparable in populations, interventions, and outcome definitions to justify pooling in meta-analyses.
- Findingown data
Telemonitoring compared with usual care was associated with a risk ratio for hospitalization of 1.02 (95% CI 0.85-1.23; P=.81; I2=79%).
“an increased risk of hospitalization (risk ratio=1.02, 95% CI 0.85-1.23; P=.81; I2=79%) with telemonitoring compared with usual care.”
Quote in the paperSubstantial claim- Rests on an assumption: The included studies are sufficiently comparable in populations, interventions, and outcome definitions to justify pooling in meta-analyses.
- Findingown data
The included studies had a total sample of 26,167 participants.
“with sample sizes ranging from 20 [36,99] to 3562 [102] participants and a total sample of 26,167 participants.”
Quote in the paperNot a substantial claim - Findingown data
9% (9/96) of the included studies reported satisfaction and acceptance outcomes.
“9% (9/96) reported on satisfaction and acceptance outcomes”
Quote in the paperNot a substantial claim
- Findingown data
Most studies (79/96, 82%) compared the intervention with usual care.
“Most studies (79/96, 82%) compared the intervention with usual care”
Quote in the paperNot a substantial claim - Findingown data
No study reporting outcomes related to intervention uptake, study retention, and patient acceptability were identified.
“No study reporting outcomes related to intervention uptake, study retention, and patient acceptability were identified in our search and, therefore, these outcomes could not be analyzed.”
Quote in the paperSubstantial claim - Findingown data
Telemonitoring compared with usual care did not significantly improve quality of life (MD=1.45, 95% CI −0.10 to 3; P=.07; I2=80%).
“no significant improvements in quality of life (MD=1.45, 95% CI −0.10 to 3; P=.07; I2=80%)”
Quote in the paperSubstantial claim- Rests on an assumption: The included studies are sufficiently comparable in populations, interventions, and outcome definitions to justify pooling in meta-analyses.
- Findingown data
Of the 12 studies, 7 (58%) demonstrated a benefit of telemonitoring on patient adherence when compared with a comparator.
“Of the 12 studies, 7 (58%) [13,36,42,48,58,59,92] demonstrated a benefit of telemonitoring on patient adherence when compared with a comparator”
Quote in the paperNot a substantial claim0 of 7 sources checked- cites [13] source
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- cites [36] source
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- cites [42] source
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- cites [48] source
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- cites [58] source
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- cites [59] source
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- cites [92] source
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- Findingown data
12% (12/96) of the included studies reported adherence outcomes.
“A total of 12% (12/96) of the studies reported adherence outcomes”
Quote in the paperNot a substantial claim - Findingown data
Heterogeneity in the assessment methods meant that a meta-analysis of adherence and satisfaction outcomes could not be performed.
“however, heterogeneity in the assessment methods meant that a meta-analysis could not be performed.”
Quote in the paperNot a substantial claim - Findingown data
There was no difference in QoL between telemonitoring and usual care groups as measured by EQ-5D at 12 months (weighted MD=0.01, 95% CI −0.04 to 0.06; P=.71; I2=0%).
“There was no difference in QoL between the groups (weighted MD=0.01, 95% CI −0.04 to 0.06; P=.71; I2=0%)”
Quote in the paperNot a substantial claim - Findingown data
Telemonitoring group showed greater improvements in QoL compared with comparator as measured by MLHFQ overall scores at 3 months (weighted MD=−7.42, 95% CI −13.45 to −1.39; P=.02; I2=0%).
“demonstrating that the telemonitoring group showed greater improvements in QoL (weighted MD=−7.42, 95% CI −13.45 to −1.39; P=.02; I2=0%) compared with the comparator.”
Quote in the paperNot a substantial claim - Findingcitation
One study compared 2 telemonitoring systems and showed that educational support combined with telemonitoring positively influenced adherence compared with telemonitoring alone.
“A total of 8% (1/12) of the studies [103] compared 2 telemonitoring systems and showed that educational support combined with telemonitoring positively influenced adherence compared with telemonitoring alone.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [103] source
Not checked in the free run.
- Findingown data
Of 13 studies not included in QoL meta-analysis, 4 reported significant improvement in QoL in telemonitoring group compared with usual care at 6 weeks, 6 months, or 12 months.
“Of these 13 studies, 4 (31%) reported a significant improvement in QoL in the telemonitoring group compared with usual care at 6 weeks [58], 6 months [92,100], and 12 months [43] measured using a variety of questionnaires”
Quote in the paperNot a substantial claim - Findingown data
There was a significantly lower risk of all-cause mortality with telemonitoring than with comparator at 12 months (RR=0.71, 95% CI 0.56-0.89; P=.003; I2=0%).
“There was a significantly lower risk of all-cause mortality with telemonitoring than with the comparator at 12 months (RR=0.71, 95% CI 0.56-0.89; P=.003; I2=0%; Figure 3).”
Quote in the paperSubstantial claim - Findingown data
There was no significant difference in risk of all-cause hospitalization between groups at 12 months (RR=0.97, 95% CI 0.70-1.33; P=.84; I2=79%).
“or 12 months (RR=0.97, 95% CI 0.70-1.33; P=.84; I2=79%; Figure 4).”
Quote in the paperSubstantial claim - Findingown data
5 (56%) of the 9 studies demonstrated a benefit of telemonitoring on patient satisfaction when compared with a comparator.
“A total of 56% (5/9) of the studies [22,28,42,78,91] demonstrated a benefit of telemonitoring on patient satisfaction when compared with a comparator”
Quote in the paperNot a substantial claim0 of 5 sources checked - Findingown data
There was no significant difference in risk of all-cause hospitalization between groups at 6 months (RR=1.09, 95% CI 0.85-1.40; P=.50; I2=46%).
“There was no significant difference in the risk of all-cause hospitalization between the groups at 6 months (RR=1.09, 95% CI 0.85-1.40; P=.50; I2=46%)”
Quote in the paperNot a substantial claim - Findingown data
Similar results were observed for SBP at 6 months (weighted MD=−3.85 mm Hg, 95% CI −7.03 to −0.68; P=.02; I2=100%) in favor of telemonitoring.
“similar results were observed for SBP at 6 months (weighted MD=−3.85 mm Hg, 95% CI −7.03 to −0.68; P=.02; I2=100%; Figure 5)”
Quote in the paperSubstantial claim - Findingown data
There was no difference in SF-36 mental component scores between telemonitoring and usual care at 12 months (weighted MD=1.06, 95% CI −0.12 to 2.25; P=.08; I2=0%).
“but no difference in mental component scores (weighted MD=1.06, 95% CI −0.12 to 2.25; P=.08; I2=0%; Figure 3 [15,39,40,50,60,64,84,96,101,105,107])”
Quote in the paperNot a substantial claim - Findingown data
Pooled estimate showed a reduction in mean change in HbA1c in telemonitoring group (n=1703; weighted MD=−0.33, 95% CI −0.57 to −0.09; P=.008; I2=99%).
“The pooled estimate showed a reduction in the mean change in HbA1c in the telemonitoring group (n=1703; weighted MD=−0.33, 95% CI −0.57 to −0.09; P=.008; I2=99%; Figure S5 in Multimedia Appendix 1).”
Quote in the paperSubstantial claim - Findingown data
Owing to variations in how adherence was defined, a meta-analysis was not performed.
“Owing to variations in how adherence was defined in the studies, a meta-analysis was not performed.”
Quote in the paperSubstantial claim - Findingown data
Of 13 studies not included in QoL meta-analysis, 9 reported no difference in QoL between telemonitoring and usual care at various time points from 4 weeks to 12 months.
“whereas 9 (69%) reported no difference in QoL between telemonitoring and usual care at 4 weeks [70], 6 weeks [65,103], 7 weeks [70], 3 months [36], 6 months [23,62,107], 9 months [108], and 12 months [36].”
Quote in the paperNot a substantial claim - Findingown data
4 (33%) of the 12 studies showed no difference in adherence when compared with a comparator.
“whereas 4 (33%) [30,51,66,84] showed no difference when compared with a comparator.”
Quote in the paperNot a substantial claim0 of 4 sources checked - Findingown data
There was no significant DBP reduction at 12 months (weighted MD=−1.09 mm Hg, 95% CI −4.76 to 2.57; P=.56; I2=97%).
“but not for DBP at 12 months (weighted MD=−1.09 mm Hg, 95% CI −4.76 to 2.57; P=.56; I2=97%; Figure S4 in Multimedia Appendix 1).”
Quote in the paperNot a substantial claim - Findingown data
Telemonitoring showed greater improvements compared with usual care on SF-36 physical component scores at 12 months (weighted MD=3.72, 95% CI 1.73-5.70; P<.001; I2=51%).
“From the meta-analysis, telemonitoring showed greater improvements compared with usual care on physical component scores (weighted MD=3.72, 95% CI 1.73-5.70; P<.001; I2=51%; Figure 2) compared with the comparator”
Quote in the paperNot a substantial claim - Findingown data
4 (44%) of the 9 studies showed no difference in satisfaction when compared with a comparator.
“whereas 44% (4/9) [30,43,44,95] showed no difference when compared with a comparator.”
Quote in the paperNot a substantial claim0 of 4 sources checked - Findingown data
Patient satisfaction was assessed in 9 studies.
“Patient satisfaction with the intervention was assessed in 9 studies”
Quote in the paperNot a substantial claim - Findingown data
Similar results were observed for SBP at 12 months (weighted MD=−3.85 mm Hg, 95% CI −7.03 to −0.68; P=.02; I2=100%) in favor of telemonitoring.
“and 12 months (weighted MD=−3.85 mm Hg, 95% CI −7.03 to −0.68; P=.02; I2=100%; Figure S3 in Multimedia Appendix 1) in favor of telemonitoring.”
Quote in the paperNot a substantial claim - Findingown data
Meta-analysis including longest time point demonstrated significant reduction in DBP in favor of telemonitoring (n=1218) compared with comparator (n=1255; weighted MD=−2.83 mm Hg, 95% CI −3.98 to −1.68; P<.001; I2=99%).
“A meta-analysis including the longest time point demonstrated a significant reduction in DBP in favor of telemonitoring (n=1218) compared with the comparator (n=1255; weighted MD=−2.83 mm Hg, 95% CI −3.98 to −1.68; P<.001; I2=99%; Figure S4 in Multimedia Appendix 1).”
Quote in the paperNot a substantial claim - Findingown data
Of 13 studies not included in QoL meta-analysis, 1 reported significant improvement in QoL in usual care group compared with telemonitoring at 2 and 6 months using St George's Respiratory Questionnaire.
“A total of 8% (1/13) of the studies [20] reported significant improvement in QoL in the usual care group compared with telemonitoring at 2 and 6 months using the St George’s Respiratory Questionnaire.”
Quote in the paperNot a substantial claim - Findingown data
Owing to variations in how satisfaction was defined, a meta-analysis was not performed.
“Owing to variations in how satisfaction was defined in the studies, a meta-analysis was not performed.”
Quote in the paperSubstantial claim - Findingown data
Meta-analysis including only patients with heart failure showed no difference in risk of hospitalization between telemonitoring and comparator groups (RR=0.99, 95% CI 0.81-1.22; P=.94; I2=69%).
“The meta-analysis that included only patients with heart failure showed no difference in the risk of hospitalization between the telemonitoring and comparator groups (RR=0.99, 95% CI 0.81-1.22; P=.94; I2=69%; Figure S2 in Multimedia Appendix 1).”
Quote in the paperNot a substantial claim - Findingown data
Subgroup analyses according to study time points showed no significant difference in change in HbA1c values between telemonitoring and comparator.
“Subgroup analyses according to study time points showed no significant difference in the change in HbA1c values between telemonitoring and the comparator (Figure S5 in Multimedia Appendix 1).”
Quote in the paperNot a substantial claim - Findingown data
SBP was significantly reduced in telemonitoring group (n=1477) compared with usual care group (n=1484; weighted MD=−5.34 mm Hg, 95% CI −7.81 to −2.86; P<.001; I2=100%).
“SBP was significantly reduced in the telemonitoring group (n=1477) compared with that in the usual care group (n=1484; weighted MD=−5.34 mm Hg, 95% CI −7.81 to −2.86; P<.001; I2=100%; Figure 5 [15,17,24,38,45,62,72,75,77,90]).”
Quote in the paperSubstantial claim - Findingown data
There was no significant difference in all-cause mortality between telemonitoring and comparator at 6 months (RR=0.86, 95% CI 0.68-1.07; P=.18; I2=35%).
“There was no significant difference in all-cause mortality between telemonitoring and the comparator at 6 months (risk ratio [RR]=0.86, 95% CI 0.68-1.07; P=.18; I2=35%; Figure 3).”
Quote in the paperNot a substantial claim - Findingown data
Similar result was observed for DBP reduction at 6 months (weighted MD=−5.44 mm Hg, 95% CI −9.00 to −1.87; P=.003; I2=100%) in favor of telemonitoring.
“In the subgroup analysis, a similar result was observed for DBP reduction at 6 months (weighted MD=−5.44 mm Hg, 95% CI −9.00 to −1.87; P=.003; I2=100%; Figure S4 in Multimedia Appendix 1) in favor of telemonitoring”
Quote in the paperNot a substantial claim - Study design and conductown data
Few RCTs (17/66, 26%) showed either some concerns or a high risk of bias in the measurement of the outcomes.
“Few RCTs (17/66, 26%) showed either some concerns or a high risk of bias in the measurement of the outcomes.”
Quote in the paperNot a substantial claim - Study design and conductown data
Most RCT studies (45/66, 68%) showed either some concerns or a high risk of bias in the randomization process as well as in the selection of the reported results.
“Most RCT studies (45/66, 68%) showed either some concerns or a high risk of bias in the randomization process as well as in the selection of the reported results.”
Quote in the paperNot a substantial claim - Interpretationown data
Telemonitoring is a valid alternative to usual care.
“Telemonitoring is a valid alternative to usual care”
Quote in the paperSubstantial claim- Rests on an assumption: The included studies are sufficiently comparable in populations, interventions, and outcome definitions to justify pooling in meta-analyses.
- Rests on an assumption: The risk of bias present in most included studies does not materially alter the pooled effect estimates.
- Interpretationnone given
Telemonitoring improves self-management of the disease.
“improving self-management of the disease”
Quote in the paperSubstantial claim- Rests on an assumption: The included studies are sufficiently comparable in populations, interventions, and outcome definitions to justify pooling in meta-analyses.
- Rests on an assumption: The risk of bias present in most included studies does not materially alter the pooled effect estimates.
- Study design and conductown data
Most non-RCTs (18/20, 90%) showed either some concerns or a high risk of bias in the bias due to confounding category.
“Most of the non-RCTs (18/20, 90%) showed either some concerns or a high risk of bias in the bias due to confounding category.”
Quote in the paperNot a substantial claim - Study design and conductown data
Few non-RCTs (9/20, 45%) showed either some concerns or a high risk of bias in the bias due to missing data category as well as in the bias due to deviations from the intended intervention category.
“Few of the non-RCTs (9/20, 45%) showed either some concerns or a high risk of bias in the bias due to missing data category as well as in the bias due to deviations from the intended intervention category.”
Quote in the paperNot a substantial claim - Premisereasoning
Recent umbrella reviews that consider older primary studies have potentially made conclusions based on noncontemporary data.
“recent umbrella reviews [10,11] that consider older primary studies have potentially made conclusions based on noncontemporary data.”
Quote in the paperSubstantial claim0 of 2 sources checked - Study design and conductown data
Some RCTs (18/66, 27%) showed either some concerns or a high risk of bias in missing outcome data.
“Some RCTs (18/66, 27%) showed either some concerns or a high risk of bias in missing outcome data.”
Quote in the paperNot a substantial claim - Interpretationown data
There was evidence to suggest that telemonitoring interventions may be associated with a higher rate of hospitalizations.
“Conversely, there was evidence to suggest that telemonitoring interventions may be associated with a higher rate of hospitalizations”
Quote in the paperSubstantial claim - Study design and conductown data
The result of no significant difference in hospitalization risk was consistent after exclusion of studies evaluated as having a high risk of bias.
“This result was also consistent after the exclusion of studies evaluated as having a high risk of bias (Figure S2 in Multimedia Appendix 1).”
Quote in the paperNot a substantial claim - Interpretationown data
The included studies did not report significant improvements in QoL of patients receiving telemonitoring compared with usual care.
“The included studies did not report significant improvements in the QoL of patients receiving a telemonitoring intervention compared with usual care.”
Quote in the paperSubstantial claim - Study design and conductown data
HbA1c results did not materially change after sensitivity analysis excluding studies at high risk of bias.
“The results did not materially change after the sensitivity analysis excluding studies at high risk of bias [58,87] (Figure S5 in Multimedia Appendix 1).”
Quote in the paperNot a substantial claim - Interpretationown data
There was evidence to suggest improvements in blood glucose control with telemonitoring.
“and blood glucose control”
Quote in the paperSubstantial claim - Interpretationown data
There was evidence to suggest improvements in BP with telemonitoring.
“and improvements in BP”
Quote in the paperSubstantial claim - Study design and conductown data
The finding of lower all-cause mortality at 12 months was consistent following exclusion of non-RCTs and studies evaluated as having a high risk of bias.
“This finding was consistent following the exclusion of non-RCTs and studies evaluated as having a high risk of bias (Figure S1 in Multimedia Appendix 1).”
Quote in the paperSubstantial claim - Interpretationown data
The reduced mortality rate with telemonitoring reported in this review suggests the effectiveness of telemonitoring for patients with chronic conditions.
“the reduced mortality rate with telemonitoring reported in our review suggests the effectiveness of telemonitoring for patients with chronic conditions.”
Quote in the paperSubstantial claim - Premisecitation
A recent umbrella review reported similar mortality findings for the cardiovascular population, where mortality rate was either reduced or unchanged compared with usual care.
“A recent umbrella review [170] examining the effects of telemonitoring on mortality in several clinical populations (cardiovascular, COPD, and neurological) reported similar findings for the cardiovascular population, where the mortality rate was either reduced in the telemedicine users or remained unchanged compared with usual care.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [170] source
Not checked in the free run.
- Interpretationown data
There was evidence to suggest reductions in all-cause mortality with telemonitoring.
“there was evidence to suggest reductions in all-cause mortality”
Quote in the paperSubstantial claim - Premisecitation
From qualitative reports, the convenience of decreased travel time and costs and the reassurance of being monitored are the most likely reasons for patients preferring telemonitoring over usual care.
“From qualitative reports, the convenience of decreased travel time and costs and the reassurance of being monitored are the most likely reasons for patients preferring telemonitoring over usual care [176].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [176] source
Not checked in the free run.
- Interpretationown data
These findings demonstrate the positive role of telemonitoring in improving patients' self-management of their conditions.
“These findings demonstrate the positive role of telemonitoring in improving patients’ self-management of their conditions.”
Quote in the paperSubstantial claim - Interpretationown data
This review did not demonstrate improvements in QoL with telemonitoring.
“Although this review did not demonstrate improvements in QoL with telemonitoring”
Quote in the paperSubstantial claim - Study design and conductown data
Sensitivity analysis at longest time point excluding studies with high risk of bias showed no significant reduction in DBP in telemonitoring group (weighted MD=−1.07 mm Hg, 95% CI −2.58 to 0.44; P=.16; I2=98%) compared with usual care.
“Sensitivity analyses at the longest time point excluding studies with high risk of bias (Figure S4 in Multimedia Appendix 1) showed no significant reduction in DBP in the telemonitoring group (weighted MD=−1.07 mm Hg, 95% CI −2.58 to 0.44; P=.16; I2=98%) compared with usual care.”
Quote in the paperNot a substantial claim - Study design and conductown data
Sensitivity analysis excluding studies with high risk of bias remained in favor of telemonitoring for SBP (weighted MD=-2.84 mm Hg, 95% CI −4.22 to −1.46; P<.001; I2=98%).
“The sensitivity analysis was also performed excluding studies with a high risk of bias (Figure S3 in Multimedia Appendix 1); the results remained in favor of telemonitoring (weighted MD=–2.84 mm Hg, 95% CI −4.22 to −1.46; P<.001; I2=98%).”
Quote in the paperNot a substantial claim - Study design and conductown data
Sensitivity analysis excluding studies where SD was not reported directly did not materially change the SBP results (weighted MD=−5.19 mm Hg, 95% CI −8.01 to −2.37; P<.001; I2=100%).
“The sensitivity analysis, excluding studies where the SD was not reported directly [38,45,90], did not materially change the results (weighted MD=−5.19 mm Hg, 95% CI −8.01 to −2.37; P<.001; I2=100%; Figure S3 in Multimedia Appendix 1).”
Quote in the paperNot a substantial claim - Premisecitation
The same umbrella review did not find any difference in mortality between telemonitoring and usual care in patients with COPD.
“The same review [170] did not find any difference in mortality between telemonitoring and usual care in patients with COPD.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [170] source
Not checked in the free run.
- Interpretationown data
The overall results of this review showed a higher risk of hospitalization among patients undergoing telemonitoring interventions.
“Surprisingly, the overall results of our review showed a higher risk of hospitalization among patients undergoing telemonitoring interventions.”
Quote in the paperNot a substantial claim - Study design and conductown data
The finding of no significant difference in all-cause mortality at 6 months was consistent when studies evaluated as having a high risk of bias were excluded.
“This finding was consistent when studies evaluated as having a high risk of bias were excluded (Figure S1 in Multimedia Appendix 1).”
Quote in the paperNot a substantial claim - Interpretationown data
Telemonitoring reduced all-cause mortality compared with usual care.
“and reduced all-cause mortality compared with usual care”
Quote in the paperSubstantial claim - Interpretationown data
There was no improvement in QoL with telemonitoring.
“there was no improvement in QoL”
Quote in the paperSubstantial claim - Interpretationnone given
Telemonitoring has been shown to be a viable alternative to usual care for the management of patients with long-term health conditions.
“Telemonitoring is expanding rapidly, more so since the COVID-19 pandemic, and has been shown to be a viable alternative to usual care for the management of patients with long-term health conditions.”
Quote in the paperSubstantial claim - Interpretationown data
Telemonitoring resulted in improvement in physiological parameters compared with usual care.
“Although telemonitoring resulted in improvement in physiological parameters”
Quote in the paperSubstantial claim - Interpretationown data
There was an increased risk of hospitalization with telemonitoring.
“and an increased risk of hospitalization with telemonitoring.”
Quote in the paperSubstantial claim
- Classified as probably not a substantial claim. 17
- May combine two claims. 21
- The quote only partly states this claim. 1
Probably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataThe review included 96 studies.
“A total of 96 studies were included”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataAdherence was assessed in 12 studies.
“Adherence was assessed in 12 studies at different time points”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataNo studies reported uptake and retention outcomes, so these outcomes could not be reported in this review.
“no studies reported uptake and retention outcomes and, therefore, these outcomes could not be reported in this review.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataMost outcomes analyzed in this review have been infrequently investigated in the literature: mortality was reported in 17/96 (18%) of included studies, adherence in 12/96 (12%), and satisfaction in 9/96 (9%).
“most outcomes analyzed in this review have been infrequently investigated in the literature (eg, mortality was reported only in 17/96, 18% of the included studies; adherence was reported in only 12/96, 12% of the studies; and satisfaction was reported in only 9/96, 9% of the studies)”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataMost included studies assessed similar outcomes but used different measurement tools, making comparison difficult, particularly for patient adherence and satisfaction.
“Most of the included studies assessed similar outcomes but used different measurement tools, thus making comparison difficult, particularly in studies investigating patient adherence [13,30,36,42,48,51,58,59,66,84,92,103] and satisfaction [22,28,30,42-44,78,91,95] with the intervention.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataSome conditions such as COPD were underrepresented as few studies were available, so a separate meta-analysis for each condition could not be conducted.
“some conditions (eg, COPD) were underrepresented as few studies investigating the effects of telemonitoring interventions on these populations were available; thus, we could not conduct a separate meta-analysis for each condition.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe type and quality of usual care varied throughout the included studies, which may have influenced the results in favor of or against telemonitoring.
“The type and quality of usual care also varied throughout the included studies, which may have influenced the results in favor of or against telemonitoring.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductown dataSix authors independently assessed individual studies for risk of bias in duplicate, with discrepancies resolved by discussion or referral to a third reviewer.
“Six authors (DGL, MC, BB, SH, MI, and DL) independently assessed the individual studies for risk of bias in duplicate, and any discrepancies were resolved via discussion or referral to a third reviewer, as required.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductcitationFunnel plots and Egger tests were performed only where at least 10 studies were available.
“Funnel plots and Egger tests were performed only where ≥10 studies were available [167].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [167] Higgins, JP, 2022, Cochrane Handbook for Systematic Reviews of Interventions. Version 6.3
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataData extraction was conducted independently by two reviewers.
“Data extraction was conducted independently by 2 reviewers (DGL and MC).”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
Study design and conductown dataFull texts of potentially relevant articles were independently assessed in duplicate.
“The full texts of all potentially relevant articles were retrieved and independently assessed by the reviewers in duplicate.”
Quote in the paperSubstantial claimMay combine two claims.
Study design and conductown dataOverall, most RCTs (48/66, 73%) and non-RCTs (17/20, 85%) included in this review showed either some concerns or a high risk of bias.
“Overall, most RCTs (48/66, 73%) and non-RCTs (17/20, 85%) included in this review showed either some concerns or a high risk of bias.”
Quote in the paperNot a substantial claimThe quote only partly states this claim.
Study design and conductown data50% (10/20) of non-RCTs showed either some concerns or a high risk of bias in the bias in measurement of outcomes category.
“A total of 50% (10/20) of the studies showed either some concerns or a high risk of bias in the bias in measurement of outcomes category.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone givenThe systematic review was registered on PROSPERO (CRD42021236291).
“This systematic review was registered on PROSPERO (International Prospective Register of Systematic Reviews; CRD42021236291)”
Quote in the paperNot a substantial claimMay combine two claims.
Interpretationown dataPatients report good satisfaction and adherence with telemonitoring.
“with patients reporting good satisfaction and adherence”
Quote in the paperSubstantial claim- Rests on an assumption: The risk of bias present in most included studies does not materially alter the pooled effect estimates.
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductcitationThe review was conducted in accordance with PRISMA guidelines.
“conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines [12].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [12] source
Not checked in the free run.
Classified as probably not a substantial claim. May combine two claims.
PremisecitationRecent evidence has deemed telemedicine feasible for patients with long-term conditions and effective in improving medical care.
“Recent evidence has deemed telemedicine feasible for patients with long-term conditions and effective in terms of improving medical care [10].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [10] source
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataTwo reviewers independently assessed articles for eligibility.
“In total, 2 reviewers independently assessed the articles for eligibility.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataTwo reviewers independently screened titles and abstracts.
“Two reviewers (MC and DGL) independently screened the titles and abstracts of the studies retrieved from the databases against the search criteria.”
Quote in the paperNot a substantial claimMay combine two claims.
Study design and conductown dataEgger test results revealed no evidence of publication bias for systolic blood pressure, glycated hemoglobin, or mortality.
“The Egger test results revealed no evidence of publication bias for SBP, HbA1c, or mortality.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim. May combine two claims.
Study design and conductnone givenFor RCTs, the Cochrane Risk of Bias version 2 tool was used; for nonrandomized studies, the Risk Of Bias In Non-randomized Studies of Interventions was used.
“For RCTs, the Cochrane Risk of Bias version 2 tool [164] was used. For nonrandomized studies, the Risk Of Bias In Non-randomized Studies of Interventions [165] was used.”
Quote in the paperSubstantial claim0 of 2 sources checkedMay combine two claims.
Study design and conductown dataDespite inclusion of studies with low methodological quality, sensitivity analyses were conducted where appropriate, reducing the potential for bias to affect the results of this review.
“Despite the inclusion of studies with low methodological quality, sensitivity analyses were conducted where appropriate, reducing the potential for bias to affect the results of this review.”
Quote in the paperNot a substantial claimMay combine two claims.
Interpretationown dataTelemonitoring interventions are associated with good patient adherence and satisfaction.
“Our results suggest that telemonitoring interventions are associated with good patient adherence and satisfaction.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationOther reviews have shown similar improvements in hypertension and type 2 diabetes self-management after telemonitoring interventions.
“This is in line with other reviews that have shown similar improvements in hypertension [168] and type 2 diabetes self-management [169] after telemonitoring interventions.”
Quote in the paperNot a substantial claim0 of 2 sources checkedProbably not a substantial claim: may not pass S3 (load-bearing).
InterpretationcitationThe results of this review are in line with previous systematic reviews assessing patient satisfaction with telemonitoring interventions.
“The results of this review are in line with those of previous systematic reviews assessing patient satisfaction with telemonitoring interventions [174,175].”
Quote in the paperNot a substantial claim0 of 2 sources checkedClassified as probably not a substantial claim.
Study design and conductnone givenThis review used a strict definition of telemonitoring, only including studies that used a device to collect health measures and facilitated 2-way communication or action between the patient and health care team.
“This review used a strict definition of telemonitoring, only including studies that used a device to collect health measures and facilitated 2-way communication or action between the patient and health care team.”
Quote in the paperSubstantial claimMay combine two claims.
InterpretationcitationThese findings confirm previous reviews while expanding the results to populations outside care homes and including study designs other than RCTs.
“Our findings confirm previous reviews [177,178] while expanding the results to populations outside care homes [178] and including study designs other than RCTs [177].”
Quote in the paperSubstantial claim0 of 2 sources checkedMay combine two claims.
PremisecitationPrevious literature is inconsistent on the role of telemonitoring in reducing rehospitalization, with some studies reporting no differences and others concluding it reduces all-cause hospitalization in adults with heart failure.
“There is inconsistency in the previous literature on the role that telemonitoring plays in reducing the risk of rehospitalization, with some studies reporting no differences compared with usual care [171] and others concluding that telemonitoring is an effective tool to reduce all-cause hospitalization in adults with heart failure [172].”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [171] Kalankesh, LR, 2016, Perspect Health Inf Manag
Not checked in the free run.
- cites [172] source
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationThurmond et al noted the importance of the type of telemonitoring intervention on its acceptability by patients and consequently their adherence, which when poor may influence the rate of rehospitalization.
“Thurmond et al [173] noted the importance that the type of telemonitoring intervention has on its acceptability by patients and, consequently, their adherence to it, which, when poor, may influence the rate of rehospitalization.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [173] Thurmond, VA, 2002, Online J Knowl Synth Nurs
Not checked in the free run.
May combine two claims.
InterpretationreasoningThe studies included in this review presented a wide range of telemonitoring interventions and populations, making the results highly generalizable.
“The studies included in this review presented a wide range of telemonitoring interventions that differed in the personnel involved, administration of the intervention, and technology used and that were examined in a variety of populations with different long-term conditions, thus making the results highly generalizable.”
Quote in the paperSubstantial claimMay combine two claims.
PremisecitationPatient satisfaction may differ with the type of telemonitoring device used; available evidence suggests higher patient satisfaction is reported for videoconferences and devices that allow automated data transmission.
“It is important to note that patient satisfaction may differ with the type of telemonitoring device used; indeed, available evidence suggests that higher patient satisfaction is reported for videoconferences and devices that allow for automated data transmission [174].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [174] source
Not checked in the free run.
May combine two claims.
Interpretationnone givenPatient satisfaction and adherence to telemonitoring appear, overall, to be promising.
“Patient satisfaction and adherence to telemonitoring appear, overall, to be promising.”
Quote in the paperSubstantial claimMay combine two claims.
Interpretationnone givenTelemonitoring is a promising tool to manage long-term conditions, with the potential to reduce associated costs and alleviate patient difficulties in accessing primary health care.
“Telemonitoring is a promising tool to manage long-term conditions, with the potential to reduce the associated costs and alleviate patient difficulties in accessing primary health care.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductnone givenA robust methodology was used, with independent screening and data extraction by 2 reviewers and risk of bias assessment in duplicate.
“A robust methodology was used, with independent screening and data extraction by 2 reviewers and risk of bias assessment in duplicate.”
Quote in the paperNot a substantial claim
The paper relies on this without support.
The included studies are sufficiently comparable in populations, interventions, and outcome definitions to justify pooling in meta-analyses.
“Meta-analyses were conducted on comparable studies.”
The paper relies on this without support.
The risk of bias present in most included studies does not materially alter the pooled effect estimates.
“Overall, most RCTs (48/66, 73%) and non-RCTs (17/20, 85%) included in this review showed either some concerns or a high risk of bias.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Several randomized controlled trials have demonstrated that RPM-HTN can be effective and cost-effective in managing hypertension, enhancing BP control, and mitigating cardiovascular disease events.
“Several randomized controlled trials have demonstrated that RPM-HTN can be effective and cost-effective in managing hypertension, enhancing BP control, and mitigating cardiovascular disease events.7–12”
From Program cost and return on investment analysis of remote patient monitoring for hypertension management in the cardiology department of a large healthcare system (2026) · cites this paper as [10]
The Results (Secondary Outcomes; page not provided) report significantly lower systolic BP with telemonitoring than with usual care, supporting the BP-control portion of the claim. The passages do not establish cost-effectiveness or a reduction in cardiovascular disease events specifically among patients with hypertension; the reported hospitalization analysis found no significant difference. (LLM, conf=0.87)
Experimental — accuracy not yet measuredPatient satisfaction was assessed in nine studies, with five concluding that patient satisfaction was improved by telemonitoring.
“Patient satisfaction was also assessed in nine studies, with five concluding that patient satisfaction was improved by telemonitoring.”
From Use of telemonitoring in patient self-management of chronic disease: a qualitative meta-synthesis (2023) · cites this paper as [15]
When compared to usual care, patient adherence was improved in telemonitoring groups in six of twelve studies assessed.
“When compared to usual care, patient adherence was improved in telemonitoring groups in six of twelve studies assessed.”
From Use of telemonitoring in patient self-management of chronic disease: a qualitative meta-synthesis (2023) · cites this paper as [15]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
QoL narrative categories total more than 13 studies
MinorThe narrative describes 4 studies favoring telemonitoring, 9 finding no difference, and 1 favoring usual care. Those counts total 14 rather than the stated 13 studies not included in the meta-analysis.
Reported 13 · recomputed 14
“A total of 14% (13/96) of the studies [20,23,36,43,58,62,65,70,92,100,103,107,108] could not be included in the meta-analysis”
Intervention-duration counts exceed the number of studies
MinorThe three stated duration groups contain 5, 20, and 76 studies, totaling 101, although each fraction uses 96 as the total number of studies.
Reported 96 · recomputed 101
“The length of the intervention was highly variable, with 5% (5/96) of the studies assessing it over a short period (7-45 days), 21% (20/96) assessing it over a 2- to 4-month period, and most interventions (76/96, 79%) lasting 6 to 12 months.”
Donate-Martinez women's percentage is incorrect
MinorTable 2 lists 25 women among 74 participants as 44%; the proportion is approximately 33.8%.
Reported 44 · recomputed 33.783784
“Manual upload of data on dedicated device or software, 74, mean 67.95 (SD 11.14), men: 49 (66); women: 25 (44)”
Kotooka intervention sex counts do not total 93
MinorThe intervention group is stated to have 93 participants, but its listed counts of 51 men and 39 women total 90.
Reported 93 · recomputed 90
“Automated upload of data on dedicated device or software, 93, mean 67.1 (SD 12.8), men: 51 (56); women: 39 (44)”
Kardas usual-care women's percentage is incorrect
MinorTable 1 lists 11 women among 30 usual-care participants as 47%; the proportion is approximately 36.7%.
Reported 47 · recomputed 36.666667
“Usual care, 30, mean 59 (SD 8.9), men: 19 (63); women: 11 (47)”
Bergenstal is classified both as a satisfaction benefit and as no difference
MinorThe satisfaction narrative counts study [22] among studies demonstrating a benefit, while Table 2 marks its impact as "=," defined in the table note as no difference.
“A total of 56% (5/9) of the studies [22,28,42,78,91] demonstrated a benefit of telemonitoring on patient satisfaction when compared with a comparator”
“Bergenstal et al [22], 2005, United States | 47 | Type 2 diabetes | Automated data transmitted via modem, 24, mean 44 (SD 17), 37 men; 63 womena | Data transmitted via telephone, 23, mean 45 (SD 13), 39 men; 61 womena | Satisfaction: 5-point questionnaire; 4.30 in the phone group and 4.52 in the modem group | 4 weeks | =b |”
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Flagged first, then by citations
Research works printed but not linked: 7
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Cited by
Sorted by citations
Use of telemonitoring in patient self-management of chronic disease: a qualitative meta-synthesis
Creber, A., Leo, D. G., Buckley, B. J. R., Chowdhury, M., Harrison, S. L., Isanejad, M., Lane, D. A., & on behalf of the TAILOR investigators (2023) · BMC Cardiovascular Disorders · doi:10.1186/s12872-023-03486-3 · Cited by 50 · see citing works
Self-citationZhang, D. S., Millet, L., Bellows, B. K., Lee, S., & Mann, D. (2026) · Journal of Telemedicine and Telecare · doi:10.1177/1357633x251403059
- Authors
- Leo, D. G., Buckley, B. J. R., Chowdhury, M., Harrison, S. L., Isanejad, M., Lip, G. Y. H., Wright, D. J., Lane, D. A., & the TAILOR investigators
- Affiliations
- University of Liverpool (GB)
- Corresponding author
- Lane, Deirdre A
- ORCID
- Venue
- Journal of Medical Internet Research
- Publisher
- JMIR Publications Inc.
- Published
- 2022-11-03
- Volume
- 24
- Issue
- 11
- Pages
- e35508
- ISSN
- 1438-8871 (ISSN-L)
- PMC
- PMC9673001
- OpenAlex
- W4225774496
- Cited by
- 62
- References
- 151
- Citations by year
- 2026: 21 · 2025: 20 · 2024: 11 · 2023: 10
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Journal of Medical Internet Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Liverpool John Moores University (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Telemedicine and Telehealth Implementation
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Social Sciences › Demography › Technology Use by Older Adults
- Keywords
- remote patient monitoring, telemedicine, chronic disease, patient acceptability, technology adoption, mortality, hospitalization, blood pressure, HbA1c, patient satisfaction, quality of life, self-management, adherence, patient retention, patient-reported outcomes, cardiovascular outcomes, usual care comparison, digital health interventions, patient-centered outcomes research, health technology assessment, cost-effectiveness
- MeSH terms
- Blood Pressure, Hospitalization, Humans, Monitoring, Physiologic, Quality of Life, Telemedicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Claims read by deepseek-v4.1-flash under definition version 3 (extract-v3) on 2026-10-06.
Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-10-06.
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