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Cited by 613

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Depression and Risk for Onset of Type II Diabetes: A prospective population-based study

Eaton, William W, Armenian, Haroutune, Gallo, Joseph, Pratt, Laurie, Ford, Daniel E·1996·Diabetes Care
DOI 10.2337/diacare.19.10.1097
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Abstract

OBJECTIVE: To determine whether depression is associated with an increased risk for onset of diabetes. RESEARCH DESIGN AND METHODS: In 1981, a total of 3,481 household-residing adults participated in the Epidemiologic Catchment Area (ECA) Program survey at the East Baltimore site. A follow-up of that cohort after 13 years completed 1,897 interviews, amounting to >72% of survivors. In 1981, depression was assessed with the National Institutes of Mental Health (NIMH) Diagnostic Interview Schedule and diabetes, by self-report. This prospective analysis focused on subjects at risk for onset of diabetes by removing from the analysis individuals with diabetes in 1981. RESULTS: There were 89 new cases of diabetes among 1,715 individuals at risk, yielding a 13-year cumulative incidence of diabetes of 5.2%. In logistic models, major depressive disorder, but not milder forms of depression or other forms of psychiatric disorder, predicted the onset of diabetes (estimated relative risk, 2.23; 95% CI 0.90–5.55). Controlling for age, race, sex, socioeconomic status, education, use of health services, other psychiatric disorders, and body weight did not weaken the relationship. CONCLUSIONS: Major depressive disorder signals increased risk for onset of type II diabetes. Limitations of the findings arise from the difficulty in determining temporal order with two chronic conditions, even when the temporal order of measurement is clear. In addition, even though control variables were introduced for the use of health services, it is possible that the treatment for depression led to an earlier diagnosis of diabetes in this sample.

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Authors
Eaton, W. W., Armenian, H., Gallo, J., Pratt, L., & Ford, D. E.
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
1996-10-01
Volume
19
Issue
10
Pages
1097-1102
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/diacare.19.10.1097
OpenAlex
W2003797333
Cited by
613
References
0
FWCI
3.94
Type
journal article
Language
en
Open access
closed

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