Cited by 109Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsDiabetes, Cardiovascular Risks, and Lipoproteins

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Type 2 diabetes mellitus, dyslipidemia, and Alzheimer’s disease

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Carlsson, Cynthia M.·2010·Journal of Alzheimer s Disease

DOI 10.3233/jad-2010-100012PMC PMC4235787

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Abstract

The prevalence of Alzheimer's disease (AD) is increasing rapidly, heightening the importance of finding effective preventive therapies for this devastating disease. Midlife vascular risk factors, including type 2 diabetes mellitus (T2DM), have been associated with increased risk of AD decades later and may serve as targets for AD prevention. Studies to date suggest that T2DM and hyperinsulinemia increase risk for AD, possibly through their effects on amyloid-beta metabolism and cerebrovascular dysfunction - two early findings in preclinical AD pathology. This paper reviews the evidence supporting a relationship between T2DM, hyperinsulinemia, and diabetic dyslipidemia on the development of AD, discusses DM treatment trials and their preliminary results on cognitive function, and proposes some strategies for optimizing future AD prevention trial design.

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Authors: Carlsson, C. M.
Affiliations: University of Wisconsin–Madison (US)
Corresponding author: Carlsson, Cynthia M.
ORCID: Carlsson, Cynthia M.
Venue: Journal of Alzheimer s Disease
Publisher: SAGE Publications
Published: 2010-05-26
Volume: 20
Issue: 3
Pages: 711-722
ISSN: 1387-2877 (ISSN-L)
1875-8908
DOI: 10.3233/jad-2010-100012
PMC: PMC4235787
OpenAlex: W1570302318
Cited by: 109
References: 103
Citations by year: 2025: 3 · 2024: 6 · 2023: 7 · 2022: 13 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 5 · 2017: 9 · 2016: 9 · 2015: 6 · 2014: 9 · 2013: 3 · 2012: 11
FWCI: 5.23
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Alzheimer s Disease (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Geriatric Research Education and Clinical Center
National Institute on Aging (K23AG026752, P50AG033514)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: type 2 diabetes, Alzheimer's disease
MeSH terms: Alzheimer Disease, Animals, Diabetes Mellitus, Type 2, Humans, Risk Factors, Diabetes Complications, Dyslipidemias

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