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Plant Antimicrobial Agents and Their Effects on Plant and Human Pathogens

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González-Lamothe, Rocío, Mitchell, Gabriel, Gattuso, Mariza, Diarra, Moussa S., Malouin, François, Bouarab, Kamal·2009·International Journal of Molecular Sciences
DOI 10.3390/ijms10083400
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Abstract

To protect themselves, plants accumulate an armoury of antimicrobial secondary metabolites. Some metabolites represent constitutive chemical barriers to microbial attack (phytoanticipins) and others inducible antimicrobials (phytoalexins). They are extensively studied as promising plant and human disease-controlling agents. This review discusses the bioactivity of several phytoalexins and phytoanticipins defending plants against fungal and bacterial aggressors and those with antibacterial activities against pathogens affecting humans such as Pseudomonas aeruginosa and Staphylococcus aureus involved in respiratory infections of cystic fibrosis patients. The utility of plant products as “antibiotic potentiators” and “virulence attenuators” is also described as well as some biotechnological applications in phytoprotection.

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  1. Bais, 2006, The role of root exudates in rhizosphere interactions with plants and other organisms, Annu. Rev. Plant Biol, 57, 233, 10.1146/annurev.arplant.57.032905.105159 · DOI · Paper page
  2. Grayer, 2001, Plant-fungal interactions: The search for phytoalexins and other antifungal compounds from higher plants, Phytochemistry, 56, 253, 10.1016/S0031-9422(00)00450-7 · DOI · Paper page
  3. Lindsay, 1993, Microbial recognition and activation of plant defense systems, Trends Microbiol, 1, 181, 10.1016/0966-842X(93)90088-9 · DOI
  4. Bednarek, 2009, Plant-microbe interactions: Chemical diversity in plant defense, Science, 324, 746, 10.1126/science.1171661 · DOI · Paper page
  5. 1940, Experimentelle Untersuchungen über die Phytophtora-Resistenz, Kartoffel [In German], Arb. Biol. Reichsanstalt. Landw. Forstw. Berlin, 23, 189
  6. Osbourn, 1996, Preformed antimicrobial compounds and plant defense against fungal attack, Plant Cell, 8, 1821, 10.2307/3870232 · doi:10.2307/3870232 · Paper page
  7. Osbourn, 2003, Saponins in cereals, Phytochemistry, 62, 1, 10.1016/S0031-9422(02)00393-X · DOI
  8. Osbourn, 1994, An oat species lacking avenacin is susceptible to infection by Gaeumannomyces graminis var. tritici, Physiol. Mol. Plant Pathol, 45, 457, 10.1016/S0885-5765(05)80042-6 · DOI
  9. Bowyer, 1995, Host range of a plant pathogenic fungus determined by a saponin detoxifying enzyme, Science, 267, 371, 10.1126/science.7824933 · DOI · Paper page
  10. Papadopoulou, 1999, Compromised disease resistance in saponin deficient plants, Proc. Natl. Acad. Sci. USA, 96, 12923, 10.1073/pnas.96.22.12923 · DOI · Paper page
  11. Mylona, 2008, Sad3 and sad4 are required for saponin biosynthesis and root development in oat, Plant Cell, 20, 201, 10.1105/tpc.107.056531 · DOI
  12. Dufresne, 2000, Effects of targeted replacement of the tomatinase gene on the interaction of Septoria lycopersici with tomato plants, Mol. Plant Microbe Interact, 13, 1301, 10.1094/MPMI.2000.13.12.1301 · DOI
  13. Maor, 2005, The arms race continues: Battle strategies between plants and fungal pathogens, Curr. Opin. Microbiol, 8, 399, 10.1016/j.mib.2005.06.008 · DOI
  14. Valle, 1997, Antifungal activity of scopoletin and its differential accumulation in Ulmus pumila and Ulmus campestris cell suspension cultures infected with Ophiostoma ulmi spores, Plant Sci, 125, 97, 10.1016/S0168-9452(97)00057-5 · doi:10.1016/s0168-9452(97)00057-5
  15. Chong, 2002, Downregulation of a pathogen-responsive tobacco UDP-Glc:phenylpropanoid glucosyltransferase reduces scopoletin glucoside accumulation, enhances oxidative stress, and weakens virus resistance, Plant Cell, 14, 1093, 10.1105/tpc.010436 · DOI · Paper page
  16. Matros, 2004, Ectopic expression of a UDP-glucose:phenylpropanoid glucosyl-transferase leads to increased resistance of transgenic tobacco plants against infection with Potato Virus Y, Plant Cell Physiol, 45, 1185, 10.1093/pcp/pch140 · DOI
  17. Costet, 2002, Scopoletin expression in elicitor-treated and tobacco mosaic virus-infected tobacco plants, Physiologia Plantarum, 115, 228, 10.1034/j.1399-3054.2002.1150208.x · doi:10.1034/j.1399-3054.2002.1150208.x
  18. Chong, 1999, An early salicylic acid-, pathogen- and elicitor-inducible tobacco glucosyltransferase: Role in compartmentalization of phenolics and H2O2 metabolism, FEBS Lett, 458, 204, 10.1016/S0014-5793(99)01154-0 · DOI
  19. Rakwal, 2000, Naringenin 7-O-methyltransferase involved in the biosynthesis of the flavanone phytoalexin sakuranetin from rice (Oryza sativa L.), Plant Science, 155, 213, 10.1016/S0168-9452(00)00223-5 · doi:10.1016/s0168-9452(00)00223-5
  20. Cartwright, 1981, Isolation and characterization of two phytoalexins from rice as momilactones A and B, Phytochemistry, 20, 535, 10.1016/S0031-9422(00)84189-8 · DOI
  21. Dillon, 1997, Difference in phytoalexins response among rice cultivars of different resistance to blast, Phytochemistry, 44, 599, 10.1016/S0031-9422(96)00619-X · DOI
  22. Rodrigues, 2004, Silicon enhances the accumulation of diterpenoid phytoalexins in rice: A potential mechanism for blast resistance, Phytopathology, 94, 177, 10.1094/PHYTO.2004.94.2.177 · DOI · Paper page
  23. Pedras, 2008, The chemical ecology of crucifers and their fungal pathogens: Boosting plant defenses and inhibiting pathogen invasion, Chem. Rec, 8, 109, 10.1002/tcr.20140 · DOI
  24. Pedras, 2007, The phytoalexins from Brassicaceae: Structure, biological activity, synthesis and biosynthesis, Nat. Prod. Commun, 2, 319
  25. Bendarek, 2009, A glucosinolate metabolism pathway in living plant cells mediates broad-spectrum antifungal defenses, Science, 323, 101, 10.1126/science.1163732 · DOI · Paper page
  26. Clay, 2009, Glucosinolate metabolites required for an Arabidopsis innate immune response, Science, 323, 95, 10.1126/science.1164627 · DOI · Paper page
  27. Glawischnig, 2007, Camalexin, Phytochemistry, 68, 401, 10.1016/j.phytochem.2006.12.005 · DOI · Paper page
  28. Schuhegger, 2007, Regulatory variability of camalexin biosynthesis, J. Plant Physiol, 164, 636, 10.1016/j.jplph.2006.04.012 · DOI
  29. Kliebenstein, 2005, Secondary metabolites influence Arabidopsis/Botrytis interactions: Variation in host production and pathogen sensitivity, Plant J, 44, 25, 10.1111/j.1365-313X.2005.02508.x · DOI · Paper page
  30. Schuhegger, 2006, CYP71B15 (PAD3) catalyzes the final step in camalexin biosynthesis, Plant Physiol, 141, 1248, 10.1104/pp.106.082024 · DOI · Paper page
  31. Rogers, 1996, Mode of action of the Arabidopsis thaliana phytoalexins camalexin and its role in Arabidopsis-pathogen interactions, Mol. Plant Microb. Interact, 9, 748, 10.1094/MPMI-9-0748 · DOI
  32. Thomma, 1999, Deficiency in phytoalexin production causes enhanced susceptibility of Arabidopsis thaliana to the fungus Alternaria brassicola, Plant J, 19, 163, 10.1046/j.1365-313X.1999.00513.x · DOI · Paper page
  33. Chassot, 2008, Wounding of Arabidopsis leaves causes a powerful but transient protection against Botrytis infection, Plant J, 55, 555, 10.1111/j.1365-313X.2008.03540.x · DOI
  34. Stefanato, 2009, The ABC transporter BcatrB from Botrytis cinerea exports camalexin and is a virulence factor on Arabidopsis thaliana, Plant J, 58, 499, 10.1111/j.1365-313X.2009.03794.x · DOI · Paper page
  35. Pedras, 2000, Biotransformation of the phytoalexins camalexin by the phytopathogen Rhizoctonia solani, Phytochemistry, 53, 59, 10.1016/S0031-9422(99)00479-3 · doi:10.1016/s0031-9422(99)00479-3
  36. Pedras, 2002, Probing the phytopathogenic stem rot fungus with phytoalexins and analogues: Unprecedented glucosylation of camalexin and 6-methoxycamalexin, Bioorg. Med. Chem, 10, 3307, 10.1016/S0968-0896(02)00208-0 · doi:10.1016/s0968-0896(02)00208-0
  37. Bais, 2005, Mediation of pathogen resistance by exudation of antimicrobial from roots, Nature, 434, 217, 10.1038/nature03356 · DOI · Paper page
  38. Shah, 2005, The need for new therapeutic agents: What is in the pipeline, Clin Microbiol Infect, 11, 36, 10.1111/j.1469-0691.2005.01141.x · DOI
  39. Talbot, 2006, Bad bugs need drugs: An update on the development pipeline from the antimicrobial availability task force of the infectious diseases society of america, Clin. Infect. Dis, 42, 657, 10.1086/499819 · DOI · Paper page
  40. Pauli, 2005, New perspectives on natural products in TB drug research, Life Sci, 78, 485, 10.1016/j.lfs.2005.09.004 · DOI
  41. Taguri, 2006, Antibacterial spectrum of plant polyphenols and extracts depending upon hydrogyphenyl structure, Biol. Pharm. Bull, 29, 2226, 10.1248/bpb.29.2226 · DOI · Paper page
  42. Kovacs, 2008, Natural phenanthrenes and their biological activity, Phytochem, 69, 1084, 10.1016/j.phytochem.2007.12.005 · DOI
  43. Cushnie, 2005, Antimicrobial activity of flavonoids, Int. J. Antimicrob. Agents, 26, 343, 10.1016/j.ijantimicag.2005.09.002 · DOI · Paper page
  44. Inou, 2004, The antibacterial effects of terpene alcohols on Staphylococcus aureus and their mode of action. FEMS Microbiol, Lett, 237, 325
  45. Kalemba, 2003, Antibacterial and antifungal properties of essential oils, Curr. Medic. Chem, 10, 813, 10.2174/0929867033457719 · DOI · Paper page
  46. Rios, 2005, Medicinal plants and antimicrobial activity, J. Ethnopharm, 100, 80, 10.1016/j.jep.2005.04.025 · DOI · Paper page
  47. Jaki, 2008, Purity-activity relationships of natural products: The case of anti-TB active ursolic acid, J. Nat. Prod, 71, 1742, 10.1021/np800329j · DOI
  48. Li, 2004, Efflux-mediated drug resistance in bacteria, Drugs, 64, 159, 10.2165/00003495-200464020-00004 · DOI · Paper page
  49. Masi, 2005, Inhibitors of efflux pumps in gram-negative bacteria, Trends Mol. Med, 11, 382, 10.1016/j.molmed.2005.06.006 · DOI
  50. Lewis, 2001, In search of natural substrates and inhibitors of MDR pumps, J. Mol. Microbiol. Biotechnol, 3, 247
  51. Roccaro, 2004, Epigallocatechin-gallate enhances the activity of tetracycline in Staphylococci by inhibiting its efflux from bacterial cells, Antimicrob. Agents Chemother, 48, 1968, 10.1128/AAC.48.6.1968-1973.2004 · DOI · Paper page
  52. Zhao, 2001, Mechanism of synergy between epigallocatechin gallate and β-lactams against methicillin-resistant Staphylococcus aureus, Antimicrob. Agents Chemother, 45, 1737, 10.1128/AAC.45.6.1737-1742.2001 · DOI · Paper page
  53. Fujita, 2005, Remarkable synergies between baicalein and tetracycline, and baicalein and β-lactams against methicillin-resistant Staphylococcus aureus, Microbiol. Immunol, 49, 391, 10.1111/j.1348-0421.2005.tb03732.x · DOI
  54. Stermitz, 2000, Synergy in a medicinal plant: Antimicrobial action of bergerine potentiated by 5’-methoxyhydnocarpin, a multidrug pump inhibitor, Proc. Natl. Acad. Sci. USA, 97, 1433, 10.1073/pnas.030540597 · DOI · Paper page
  55. Michalet, 2007, N-Caffeoylphenalkylamide derivatives as bacterial efflux pump inhibitors, Bioorg. Med. Chem. Lett, 17, 1755, 10.1016/j.bmcl.2006.12.059 · doi:10.1016/j.bmcl.2006.12.059
  56. Gibbons, 2008, Phytochemicals for bacterial resistance-strengths, weaknesses and opportunities, Planta Med, 74, 594, 10.1055/s-2008-1074518 · DOI
  57. Stavri, 2007, Bacterial efflux pump inhibitors from natural sources, J. Antimicrob. Chemother, 59, 1247, 10.1093/jac/dkl460 · DOI · Paper page
  58. Tegos, 2002, Multidrug pump inhibitors uncover remarkable activity of plant antimicrobials, Antimicrob. Agents Chemother, 46, 3133, 10.1128/AAC.46.10.3133-3141.2002 · DOI · Paper page
  59. Johnson, 2003, Sensitization of Staphylococcus aureus and Escherichia coli to antibiotics by the sesquiterpenoids nerolidol, farnesol, bisabolol, and apritone, Antimicrob. Agents Chemother, 47, 3357, 10.1128/AAC.47.10.3357-3360.2003 · DOI · Paper page
  60. Kuroda, 2007, Sesquiterpene farnesol inhibits recycling of the C55 lipid carrier of the murein monomer precursor contributing to increased susceptibility to β-lactams in methicillin-resistant Staphylococcus aureus, J Antimicrob Chemother, 59, 425, 10.1093/jac/dkl519 · DOI
  61. Bjarnsholt, 2007, Quorum-sensing blockade as a strategy for enhancing host defences against bacterial pathogens, Phil. Trans. R. Soc. B, 362, 1213, 10.1098/rstb.2007.2046 · DOI · Paper page
  62. Fuqua, 2001, Regulation of gene expression by cell-to-cell communication: Acyl-homoserine lactone quorum sensing, Ann. Rev. Genet, 35, 439, 10.1146/annurev.genet.35.102401.090913 · DOI · Paper page
  63. Novick, 2008, Quorum sensing in Staphylococci, Annu. Rev. Genet, 42, 541, 10.1146/annurev.genet.42.110807.091640 · DOI · Paper page
  64. Rasmussen, 2005, Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector, J. Bacteriol, 187, 1799, 10.1128/JB.187.5.1799-1814.2005 · DOI · Paper page
  65. Bjarnsholt, 2005, Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections, Microbiol, 151, 3873, 10.1099/mic.0.27955-0 · DOI · Paper page
  66. Collier, 2002, A bacterial cell to cell signal in the lungs of cystic fibrosis patients, FEMS Microbiol. Lett, 215, 41, 10.1111/j.1574-6968.2002.tb11367.x · DOI
  67. Erickson, 2002, Pseudomonas aeruginosa quorum-sensing systems may control virulence factor expression in the lungs of patients with cystic fibrosis, Infect. Immun, 70, 1783, 10.1128/IAI.70.4.1783-1790.2002 · DOI · Paper page
  68. Smith, 2002, The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl) homoserine lactone contributes to virulence and induces inflammation in vivo, J Bacteriol, 184, 1132, 10.1128/jb.184.4.1132-1139.2002 · DOI · Paper page
  69. Telford, 1998, The Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone has immunomodulatory activity, Infect. Immun, 66, 36, 10.1128/IAI.66.1.36-42.1998 · DOI · Paper page
  70. Yu, 2008, Global transcriptional response of Staphylococcus aureus to rhein, a natural plant product, J. Biotechnol, 135, 304, 10.1016/j.jbiotec.2008.04.010 · DOI
  71. Wang, 2008, Global transcriptional profiles of Staphylococcus aureus treated with berberine chloride, FEMS Microbiol. Lett, 279, 217, 10.1111/j.1574-6968.2007.01031.x · DOI
  72. Nohynek, 2005, Bioactive berry compounds–Novel tools against human pathogens, Appl. Microbiol. Biotechnol, 67, 8, 10.1007/s00253-004-1817-x · DOI · Paper page
  73. Germon, 2001, Energy-dependent conformational change in the TolA protein of Escherichia coli involves its N-terminal domain, TolQ, and TolR, J. Bacteriol, 183, 4110, 10.1128/JB.183.14.4110-4114.2001 · doi:10.1128/jb.183.14.4110-4114.2001
  74. Tramonti, 2006, Mechanisms of transcription activation exerted by GadX and GadW at the gadA and gadBC gene promoters of the glutamate-based acid resistance system in Echerichia coli, J. Bacteriol, 188, 8118, 10.1128/JB.01044-06 · DOI
  75. Gottesman, 2002, A small RNA regulates the expression of genes involved in iron metabolism in Escherichia coli, Proc. Natl. Acad. Sci. USA, 99, 4620, 10.1073/pnas.032066599 · DOI · Paper page
  76. Moisan, 2006, The transcription of virulence factors in Staphylococcus aureus small colony variants isolated from cystic fibrosis patients is influenced by SigB, J. Bacteriol, 188, 64, 10.1128/JB.188.1.64-76.2006 · DOI · Paper page
  77. Mitchell, 2008, Staphylococcus aureus SigB activity promotes a strong fibronectin-bacterium interaction which may sustain host tissue colonization by small-colony variants isolated from cystic fibrosis patients, Mol. Microbiol, 70, 1540, 10.1111/j.1365-2958.2008.06511.x · DOI
  78. Hain, 1993, Disease resistance results from foreign phytoalexins expression in a novel plant, Nature, 361, 153, 10.1038/361153a0 · DOI · Paper page
  79. VanEtten, 2001, Phytoalexin (and phytoanticipin) tolerance as a virulence trait: Why is it not required by all pathogens?, Physiol. Mol. Plant Pathol, 59, 83, 10.1006/pmpp.2001.0350 · DOI
  80. Pedras, 2008, Brassisin oxidase, a fungal detoxifying enzyme to overcome a plant defense-Purification, characterization and inhibition, FEBS J, 275, 3691, 10.1111/j.1742-4658.2008.06513.x · DOI
  81. Pedras, 2009, Synthetic inhibitors of the fungal detoxifying enzyme brassinin oxidase based on the phytoalexins camalexin scaffold, J. Agric. Food Chem, 57, 2429, 10.1021/jf803666s · doi:10.1021/jf803666s

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Metadata

Authors
González-Lamothe, R., Mitchell, G., Gattuso, M., Diarra, M. S., Malouin, F., & Bouarab, K.
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2009-07-31
Volume
10
Issue
8
Pages
3400-3419
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms10083400
OpenAlex
W2078429267
Cited by
413
References
8
FWCI
16.24
Type
journal article
Language
en
Open access
gold
Licence
creativecommons.org/licenses/by/3.0/ (vor)

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González-Lamothe, R., Mitchell, G., Gattuso, M., Diarra, M. S., Malouin, F., & Bouarab, K. (2009). Plant Antimicrobial Agents and Their Effects on Plant and Human Pathogens. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms10083400

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