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The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension

Norman M. Kaplan·1989·Archives of Internal Medicine

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Abstract

The contribution of obesity to cardiovascular risk has not been adequately appreciated because of a failure to recognize the involvement of upper-body predominance of body weight with hypertension, diabetes, and hypertriglyceridemia even in the absence of significant overall obesity. This article examines the evidence that upper-body obesity, as usually induced by caloric excess in the presence of androgens, mediates these problems by way of hyperinsulinemia. Because of these interrelationships, there is a need to identify and prevent upper-body obesity or, failing that, to provide therapies that will control the associated problems without aggravating hyperinsulinemia.

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“(2) To explore the associations between serum ZAG levels and the MetS components.”
Background
Effect of Lactobacillus brevis 119-2 isolated from Tsuda kabu red turnips on cholesterol levels in cholesterol-administered rats
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Authors: Kaplan, N. M.
Venue: Archives of Internal Medicine
Publisher: American Medical Association (AMA)
Published: 1989-07-01
Volume: 149
Issue: 7
Pages: 1514
ISSN: 0003-9926 (ISSN-L)
DOI: 10.1001/archinte.149.7.1514
OpenAlex: W2069371982
Cited by: 1,516
References: 7
FWCI: 11.19
Type: journal article
Language: en
Open access: closed

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The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension

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