Summary of the Second Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)

Scott M. Grundy, David W. Bilheimer, Alan Chait, Luther T. Clark, Margo A. Denke, Richard J. Havel, William R. Hazzard, Stephen B. Hulley, Donald B. Hunninghake, Robert A. Kreisberg, Penny M. Kris‐Etherton, James M. McKenney, Michael A. Newman, Ernst J. Schaefer, Burton E. Sobel, Carolyn A. Somelofski, Milton C. Weinstein, H. Bryan Brewer, James I. Cleeman, Karen A. Donato, Nancy D. Ernst, Jeffrey M. Hoeg, Basil M. Rifkind, Jacques Rossouw, Christopher T. Sempos, Joanne M. Gallivan, Maureen N. Harris, Laurie Quint-Adler·1993·JAMA

DOI 10.1001/jama.269.23.3015

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Abstract

THE SECOND report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II, or ATP II) presents the National Cholesterol Education Program's updated recommendations for cholesterol management. It is similar to the first in general outline, and the fundamental approach to treatment of high blood cholesterol is comparable. This report continues to identify low-density lipoproteins (LDL) as the primary target of cholesterol-lowering therapy. As in the first report, the second report emphasizes the role of the clinical approach in primary prevention of coronary heart disease (CHD). Dietary therapy remains the first line of treatment of high blood cholesterol, and drug therapy is reserved for patients who are considered to be at high risk for CHD. However, the second report contains new features that distinguish it from the first. These include the following: Increased emphasis on See also pp 3002 and 3009.

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Pollin, T. I., Damcott, C. M., Shen, H., Ott, S. H., Shelton, J., Horenstein, R. B., Post, W., McLenithan, J. C., Bielak, L. F., Peyser, P. A., et al. (2008) · Science · doi:10.1126/science.1161524 · Cited by 688
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Sharma, A. M., & Kushner, R. F. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.2 · Cited by 687
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Chandola, T., Britton, A., Brunner, E., Hemingway, H., Malik, M., Kumari, M., Badrick, E., Kivimaki, M., & Marmot, M. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehm584 · Cited by 673
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Gabay, C., Emery, P., van Vollenhoven, R., Dikranian, A., Alten, R., Pavelka, K., Klearman, M., Musselman, D., Agarwal, S., Green, J., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60250-0 · Cited by 672
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Miettinen, H., Lehto, S., Salomaa, V., Mähönen, M., Niemelä, M., Haffner, S. M., Pyörälä, K., Tuomilehto, J., & The FINMONICA Myocardial Infarction Register Study Group (1998) · Diabetes Care · doi:10.2337/diacare.21.1.69 · Cited by 665
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Puri, P., Wiest, M. M., Cheung, O., Mirshahi, F., Sargeant, C., Min, H., Contos, M. J., Sterling, R. K., Fuchs, M., Zhou, H., et al. (2009) · Hepatology · doi:10.1002/hep.23229 · Cited by 655
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Morrison, J. A., Friedman, L. A., Wang, P., & Glueck, C. J. (2008) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2007.09.010 · Cited by 649
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Gonzalez-Quintela, A., Alende, R., Gude, F., Campos, J., Rey, J., Meijide, L. M., Fernandez-Merino, C., & Vidal, C. (2007) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2007.03545.x · Cited by 630
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Naci, H., & Ioannidis, J. P. A. (2013) · BMJ · doi:10.1136/bmj.f5577 · Cited by 630
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Egan, B. M., Zhao, Y., Axon, R. N., Brzezinski, W. A., & Ferdinand, K. C. (2011) · Circulation · doi:10.1161/circulationaha.111.030189 · Cited by 599
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Myers, J., Lee, M., & Kiratli, J. (2007) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0b013e31802f0247 · Cited by 585
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Wang, Y., Lam, K. S. L., Kraegen, E. W., Sweeney, G., Zhang, J., Tso, A. W., Chow, W.-S., Wat, N. M., Xu, J. Y., Hoo, R. L., et al. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2006.075614 · Cited by 578
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Boekholdt, S. M., Hovingh, G. K., Mora, S., Arsenault, B. J., Amarenco, P., Pedersen, T. R., LaRosa, J. C., Waters, D. D., DeMicco, D. A., Simes, R. J., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.02.615 · Cited by 581
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Zhang, Y., Li, X., Zou, D., Liu, W., Yang, J., Zhu, N., Huo, L., Wang, M., Hong, J., Wu, P., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2404 · Cited by 573
Socio‐economic differentials in peripheral biology: Cumulative allostatic load
Seeman, T., Epel, E., Gruenewald, T., Karlamangla, A., & McEwen, B. S. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05341.x · Cited by 579
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Bellosta, S., Paoletti, R., & Corsini, A. (2004) · Circulation · doi:10.1161/01.cir.0000131519.15067.1f · Cited by 578
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Frasure-Smith, N., & Lespérance, F. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.4 · Cited by 571
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The Diabetes Prevention Program Research Group (2005) · Diabetes Care · doi:10.2337/diacare.28.4.888 · Cited by 572
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Heiss, C., Keymel, S., Niesler, U., Ziemann, J., Kelm, M., & Kalka, C. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.12.074 · Cited by 573
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Collet, T.-H., Gussekloo, J., Bauer, D. C., den Elzen, W. P. J., Cappola, A. R., Balmer, P., Iervasi, G., Åsvold, B. O., Sgarbi, J. A., Völzke, H., et al. (2012) · Archives of Internal Medicine · doi:10.1001/archinternmed.2012.402 · Cited by 572
The obesity epidemic, metabolic syndrome and future prevention strategies
James, P. T., Rigby, N., Leach, R., & International Obesity Task Force (2004) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000114707.27531.48 · Cited by 570
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Rojas, L. B. A., & Gomes, M. B. (2013) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-5-6 · Cited by 567
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Thomas, G., Sehgal, A. R., Kashyap, S. R., Srinivas, T. R., Kirwan, J. P., & Navaneethan, S. D. (2011) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.02180311 · Cited by 553
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Authors: Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., Kris‐Etherton, P. M., McKenney, J. M., Newman, M. A., Schaefer, E. J., Sobel, B. E., Somelofski, C. A., Weinstein, M. C., Brewer, H. B., Cleeman, J. I., Donato, K. A., Ernst, N. D., Hoeg, J. M., Rifkind, B. M., Rossouw, J., Sempos, C. T., Gallivan, J. M., Harris, M. N., & Quint-Adler, L.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 1993-06-16
Volume: 269
Issue: 23
Pages: 3015
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.269.23.3015
OpenAlex: W4249825849
Cited by: 27,947
References: 0
FWCI: 282.04
Type: journal article
Language: en
Open access: closed

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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Summary of the Second Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)

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