Strategies for controlled delivery of growth factors and cells for bone regeneration

Bone: Formation by Autoinduction

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Effect of Parathyroid Hormone (1-34) on Fractures and Bone Mineral Density in Postmenopausal Women with Osteoporosis

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Surface treatments of titanium dental implants for rapid osseointegration

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ZnO – nanostructures, defects, and devices

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Hydrogels in controlled release formulations: Network design and mathematical modeling

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Polymeric system for dual growth factor delivery

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Synthetic Matrix Metalloproteinase-Sensitive Hydrogels for the Conduction of Tissue Regeneration: Engineering Cell-Invasion Characteristics

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Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover

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Natural–origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications

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Growth factor delivery-based tissue engineering: general approaches and a review of recent developments

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Gelatin as a delivery vehicle for the controlled release of bioactive molecules

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PEG Hydrogels for the Controlled Release of Biomolecules in Regenerative Medicine

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Osteogenesis and angiogenesis: The potential for engineering bone

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Bone remodeling during fracture repair: The cellular picture

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Current concepts of molecular aspects of bone healing

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THE ROLE OF GROWTH FACTORS IN THE REPAIR OF BONE: BIOLOGY AND CLINICAL APPLICATIONS

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Polymeric materials for bone and cartilage repair

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In situ gelling stimuli-sensitive block copolymer hydrogels for drug delivery

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Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone.

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Collagen sponges for bone regeneration with rhBMP-2

Geiger, M. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.08.010 · Cited by 751

Angiogenesis and bone repair

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Synergistic enhancement of bone formation and healing by stem cell–expressed VEGF and bone morphogenetic protein-4

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Bone graft substitutes

Laurencin, C., Khan, Y., & El-Amin, S. F. (2006) · Expert Review of Medical Devices · doi:10.1586/17434440.3.1.49 · Cited by 716

Matrices and scaffolds for delivery of bioactive molecules in bone and cartilage tissue engineering

Lee, S.-H., & Shin, H. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.03.016 · Cited by 706

Bone-Graft Substitutes: Facts, Fictions, and Applications

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Calcium phosphate cements as bone drug delivery systems: A review

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Calcium phosphate coatings for bio-implant applications: Materials, performance factors, and methodologies

Paital, S. R., & Dahotre, N. B. (2009) · Materials Science and Engineering: R: Reports · doi:10.1016/j.mser.2009.05.001 · Cited by 673

Stimuli‐Responsive Polymeric Systems for Biomedical Applications

Mano, J. F. (2008) · Advanced Engineering Materials · doi:10.1002/adem.200700355 · Cited by 665

Toward delivery of multiple growth factors in tissue engineering

Chen, F.-M., Zhang, M., & Wu, Z.-F. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.04.053 · Cited by 649

Effect of local sequential VEGF and BMP-2 delivery on ectopic and orthotopic bone regeneration

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Dual delivery of an angiogenic and an osteogenic growth factor for bone regeneration in a critical size defect model

Patel, Z. S., Young, S., Tabata, Y., Jansen, J. A., Wong, M. E. K., & Mikos, A. G. (2008) · Bone · doi:10.1016/j.bone.2008.06.019 · Cited by 580

Ceramic composites as matrices and scaffolds for drug delivery in tissue engineering

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High Doses of Bone Morphogenetic Protein 2 Induce Structurally Abnormal Bone and Inflammation In Vivo

Zara, J. N., Siu, R. K., Zhang, X., Shen, J., Ngo, R., Lee, M., Li, W., Chiang, M., Chung, J., Kwak, J., et al. (2011) · Tissue Engineering Part A · doi:10.1089/ten.tea.2010.0555 · Cited by 560

Autologous iliac crest bone graft: Should it still be the gold standard for treating nonunions?

Sen, M. K., & Miclau, T. (2007) · Injury · doi:10.1016/j.injury.2007.02.012 · Cited by 542

Bone regeneration using hyaluronic acid-based hydrogel with bone morphogenic protein-2 and human mesenchymal stem cells

Kim, J., Kim, I. S., Cho, T. H., Lee, K. B., Hwang, S. J., Tae, G., Noh, I., Lee, S. H., Park, Y., & Sun, K. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2006.11.050 · Cited by 519

Growth Factor Regulation of Fracture Repair

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An alginate-based hybrid system for growth factor delivery in the functional repair of large bone defects

Kolambkar, Y. M., Dupont, K. M., Boerckel, J. D., Huebsch, N., Mooney, D. J., Hutmacher, D. W., & Guldberg, R. E. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.08.074 · Cited by 500

Stimulation of new bone formation by direct transfer of osteogenic plasmid genes.

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Bioresponsive hydrogels

Ulijn, R. V., Bibi, N., Jayawarna, V., Thornton, P. D., Todd, S. J., Mart, R. J., Smith, A. M., & Gough, J. E. (2007) · Materials Today · doi:10.1016/s1369-7021(07)70049-4 · Cited by 484

Modulation of the Inflammatory Response for Enhanced Bone Tissue Regeneration

Mountziaris, P. M., & Mikos, A. G. (2008) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2008.0038 · Cited by 483

Growth factor gradients via microsphere delivery in biopolymer scaffolds for osteochondral tissue engineering

Wang, X., Wenk, E., Zhang, X., Meinel, L., Vunjak-Novakovic, G., & Kaplan, D. L. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.10.021 · Cited by 421

VEGF Improves, Whereas sFlt1 Inhibits, BMP2-Induced Bone Formation and Bone Healing Through Modulation of Angiogenesis

Peng, H., Usas, A., Olshanski, A., Ho, A. M., Gearhart, B., Cooper, G. M., & Huard, J. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050708 · Cited by 413

Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells

Simmons, C. A., Alsberg, E., Hsiong, S., Kim, W. J., & Mooney, D. J. (2004) · Bone · doi:10.1016/j.bone.2004.02.027 · Cited by 413

In vitro generated extracellular matrix and fluid shear stress synergistically enhance 3D osteoblastic differentiation

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Coating of VEGF-releasing scaffolds with bioactive glass for angiogenesis and bone regeneration

Kent Leach, J., Kaigler, D., Wang, Z., Krebsbach, P. H., & Mooney, D. J. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.01.033 · Cited by 411

Delivery of bone morphogenetic proteins for orthopedic tissue regeneration

Seeherman, H., & Wozney, J. M. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.05.001 · Cited by 389

Low oxygen tension inhibits osteogenic differentiation and enhances stemness of human MIAMI cells

D'Ippolito, G., Diabira, S., Howard, G. A., Roos, B. A., & Schiller, P. C. (2006) · Bone · doi:10.1016/j.bone.2006.02.061 · Cited by 388

Angiogenesis and Bone Growth

Gerber, H. (2000) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(00)00074-8 · Cited by 375

Technical Note: Design of a Flow Perfusion Bioreactor System for Bone Tissue-Engineering Applications

Bancroft, G. N., Sikavitsas, V. I., & Mikos, A. G. (2003) · Tissue Engineering · doi:10.1089/107632703322066723 · Cited by 371

A novel route in bone tissue engineering: Magnetic biomimetic scaffolds

Bock, N., Riminucci, A., Dionigi, C., Russo, A., Tampieri, A., Landi, E., Goranov, V. A., Marcacci, M., & Dediu, V. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.09.017 · Cited by 368

Molecular aspects of fracture healing:Which are the important molecules?

Tsiridis, E., Upadhyay, N., & Giannoudis, P. (2007) · Injury · doi:10.1016/j.injury.2007.02.006 · Cited by 365

Combined Angiogenic and Osteogenic Factor Delivery Enhances Bone Marrow Stromal Cell-Driven Bone Regeneration

Huang, Y.-C., Kaigler, D., Rice, K. G., Krebsbach, P. H., & Mooney, D. J. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.041226 · Cited by 365

Cell Delivery Mechanisms for Tissue Repair

Mooney, D. J., & Vandenburgh, H. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.02.005 · Cited by 357

Growth factor delivery through electrospun nanofibers in scaffolds for tissue engineering applications

Sahoo, S., Ang, L. T., Goh, J. C., & Toh, S. (2010) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32645 · Cited by 346

Hyaluronic acid hydrogels with controlled degradation properties for oriented bone regeneration

Patterson, J., Siew, R., Herring, S. W., Lin, A. S. P., Guldberg, R., & Stayton, P. S. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.05.047 · Cited by 346

VEGF Scaffolds Enhance Angiogenesis and Bone Regeneration in Irradiated Osseous Defects

Kaigler, D., Wang, Z., Horger, K., Mooney, D. J., & Krebsbach, P. H. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060120 · Cited by 340

Vascular Biology and the Skeleton

Brandi, M. L., & Collin-Osdoby, P. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050917 · Cited by 338

A review of materials, fabrication methods, and strategies used to enhance bone regeneration in engineered bone tissues

Stevens, B., Yang, Y., Mohandas, A., Stucker, B., & Nguyen, K. T. (2008) · Journal of Biomedical Materials Research Part B: Applied Biomaterials · doi:10.1002/jbm.b.30962 · Cited by 326

Cell-to-cell communication between osteogenic and endothelial lineages: implications for tissue engineering

Grellier, M., Bordenave, L., & Amédée, J. (2009) · Trends in Biotechnology · doi:10.1016/j.tibtech.2009.07.001 · Cited by 310

BMP-2 liberated from biomimetic implant coatings induces and sustains direct ossification in an ectopic rat model

LIU, Y., DEGROOT, K., & HUNZIKER, E. (2005) · Bone · doi:10.1016/j.bone.2005.02.005 · Cited by 306

Vascular Endothelial Growth Factor Gene-Activated Matrix (VEGF165-GAM) Enhances Osteogenesis and Angiogenesis in Large Segmental Bone Defects

Geiger, F., Bertram, H., Berger, I., Lorenz, H., Wall, O., Eckhardt, C., Simank, H.-G., & Richter, W. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050701 · Cited by 302

Bone tissue engineering bioreactors: Dynamic culture and the influence of shear stress

Yeatts, A. B., & Fisher, J. P. (2011) · Bone · doi:10.1016/j.bone.2010.09.138 · Cited by 298

Porous nano-HA/collagen/PLLA scaffold containing chitosan microspheres for controlled delivery of synthetic peptide derived from BMP-2

Niu, X., Feng, Q., Wang, M., Guo, X., & Zheng, Q. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.11.020 · Cited by 296

Potential applications and delivery strategies for bone morphogenetic proteins

Kirker-Head, C. (2000) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00078-8 · Cited by 294

Engineering Orthopedic Tissue Interfaces

Yang, P. J., & Temenoff, J. S. (2009) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2008.0371 · Cited by 294

The enhancement of osteogenesis by nano-fibrous scaffolds incorporating rhBMP-7 nanospheres

Wei, G., Jin, Q., Giannobile, W. V., & Ma, P. X. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2006.12.028 · Cited by 292

Biodegradable gelatin microparticles as delivery systems for the controlled release of bone morphogenetic protein-2

Patel, Z. S., Yamamoto, M., Ueda, H., Tabata, Y., & Mikos, A. G. (2008) · Acta Biomaterialia · doi:10.1016/j.actbio.2008.04.002 · Cited by 279

Retention of in vitro and in vivo BMP-2 bioactivities in sustained delivery vehicles for bone tissue engineering

Kempen, D. H. R., Lu, L., Hefferan, T. E., Creemers, L. B., Maran, A., Classic, K. L., Dhert, W. J. A., & Yaszemski, M. J. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.04.031 · Cited by 276

Simultaneous regeneration of articular cartilage and subchondral bone in vivo using MSCs induced by a spatially controlled gene delivery system in bilayered integrated scaffolds

Chen, J., Chen, H., Li, P., Diao, H., Zhu, S., Dong, L., Wang, R., Guo, T., Zhao, J., & Zhang, J. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.03.041 · Cited by 274

Affinity-based growth factor delivery using biodegradable, photocrosslinked heparin-alginate hydrogels

Jeon, O., Powell, C., Solorio, L. D., Krebs, M. D., & Alsberg, E. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.06.027 · Cited by 261

Dose Effect of Dual Delivery of Vascular Endothelial Growth Factor and Bone Morphogenetic Protein-2 on Bone Regeneration in a Rat Critical-Size Defect Model

Young, S., Patel, Z. S., Kretlow, J. D., Murphy, M. B., Mountziaris, P. M., Baggett, L. S., Ueda, H., Tabata, Y., Jansen, J. A., Wong, M., et al. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0510 · Cited by 255

Quantitative assessment of scaffold and growth factor‐mediated repair of critically sized bone defects

Oest, M. E., Dupont, K. M., Kong, H., Mooney, D. J., & Guldberg, R. E. (2007) · Journal of Orthopaedic Research · doi:10.1002/jor.20372 · Cited by 249

Osteogenic and chondrogenic differentiation of embryonic stem cells in response to specific growth factors

KAWAGUCHI, J., MEE, P., & SMITH, A. (2005) · Bone · doi:10.1016/j.bone.2004.07.019 · Cited by 244

Mineralization of Hydrogels for Bone Regeneration

Gkioni, K., Leeuwenburgh, S. C. G., Douglas, T. E. L., Mikos, A. G., & Jansen, J. A. (2010) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2010.0462 · Cited by 243

Delivery of osteoinductive growth factors from degradable PEG hydrogels influences osteoblast differentiation and mineralization

Burdick, J. A., Mason, M. N., Hinman, A. D., Thorne, K., & Anseth, K. S. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00181-5 · Cited by 240

The effect of the delivery of vascular endothelial growth factor and bone morphogenic protein-2 to osteoprogenitor cell populations on bone formation

Kanczler, J. M., Ginty, P. J., White, L., Clarke, N. M. P., Howdle, S. M., Shakesheff, K. M., & Oreffo, R. O. C. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2009.10.059 · Cited by 238

Mesenchymal stem cell proliferation and differentiation on an injectable calcium phosphate – Chitosan composite scaffold

Moreau, J. L., & Xu, H. H. K. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.01.022 · Cited by 231

Tunable dual growth factor delivery from polyelectrolyte multilayer films

Shah, N. J., Macdonald, M. L., Beben, Y. M., Padera, R. F., Samuel, R. E., & Hammond, P. T. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.04.036 · Cited by 226

Bioreactor Systems for Bone Tissue Engineering

Rauh, J., Milan, F., Günther, K.-P., & Stiehler, M. (2011) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2010.0612 · Cited by 225

The effect of platelet-rich plasma on healing in critical-size long-bone defects

Kasten, P., Vogel, J., Geiger, F., Niemeyer, P., Luginbühl, R., & Szalay, K. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.06.014 · Cited by 221

Degradable hydrogel scaffolds for in vivo delivery of single and dual growth factors in cartilage repair

Holland, T. A., Bodde, E. W. H., Cuijpers, V. M. J. I., Baggett, L. S., Tabata, Y., Mikos, A. G., & Jansen, J. A. (2007) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2006.07.006 · Cited by 220

Harnessing and Modulating Inflammation in Strategies for Bone Regeneration

Mountziaris, P. M., Spicer, P. P., Kasper, F. K., & Mikos, A. G. (2011) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2011.0182 · Cited by 217

The stimulation of healing within a rat calvarial defect by mPCL–TCP/collagen scaffolds loaded with rhBMP-2

Sawyer, A. A., Song, S. J., Susanto, E., Chuan, P., Lam, C. X. F., Woodruff, M. A., Hutmacher, D. W., & Cool, S. M. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.12.055 · Cited by 212

Delivering growth factors for therapeutics

Anitua, E., Sánchez, M., Orive, G., & Andia, I. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.10.010 · Cited by 211

Crosstalk between osteoblasts and endothelial cells co-cultured on a polycaprolactone–starch scaffold and the in vitro development of vascularization

Santos, M. I., Unger, R. E., Sousa, R. A., Reis, R. L., & Kirkpatrick, C. J. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.05.004 · Cited by 211

The effect of the co-immobilization of human osteoprogenitors and endothelial cells within alginate microspheres on mineralization in a bone defect

Grellier, M., Granja, P. L., Fricain, J.-C., Bidarra, S. J., Renard, M., Bareille, R., Bourget, C., Amédée, J., & Barbosa, M. A. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.02.033 · Cited by 210

PLGA/polymeric liposome for targeted drug and gene co-delivery

Wang, H., Zhao, P., Su, W., Wang, S., Liao, Z., Niu, R., & Chang, J. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.07.082 · Cited by 209

Surface engineering of titanium by collagen immobilization. Surface characterization and in vitro and in vivo studies

Morra, M., Cassinelli, C., Cascardo, G., Cahalan, P., Cahalan, L., Fini, M., & Giardino, R. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00360-0 · Cited by 209

Sequential growth factor delivery from complexed microspheres for bone tissue engineering

Buket Basmanav, F., Kose, G. T., & Hasirci, V. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.07.017 · Cited by 209

In vivo bone and soft tissue response to injectable, biodegradable oligo(poly(ethylene glycol) fumarate) hydrogels

Shin, H., Quinten Ruhé, P., Mikos, A. G., & Jansen, J. A. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00168-6 · Cited by 204

Osteogenic Differentiation of Mesenchymal Stem Cells on Pregenerated Extracellular Matrix Scaffolds in the Absence of Osteogenic Cell Culture Supplements

Thibault, R. A., Scott Baggett, L., Mikos, A. G., & Kasper, F. K. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0583 · Cited by 199

A biodegradable polymer scaffold for delivery of osteotropic factors

Whang, K., Goldstick, T. K., & Healy, K. E. (2000) · Biomaterials · doi:10.1016/s0142-9612(00)00122-8 · Cited by 197

Flow perfusion culture induces the osteoblastic differentiation of marrow stromal cell‐scaffold constructs in the absence of dexamethasone

Holtorf, H. L., Jansen, J. A., & Mikos, A. G. (2005) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30251 · Cited by 197

Nanoparticulate Systems for Growth Factor Delivery

Zhang, S., & Uludağ, H. (2009) · Pharmaceutical Research · doi:10.1007/s11095-009-9897-z · Cited by 196

Enhanced bone regeneration with BMP-2 loaded functional nanoparticle–hydrogel complex

Chung, Y.-I., Ahn, K.-M., Jeon, S.-H., Lee, S.-Y., Lee, J.-H., & Tae, G. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.05.029 · Cited by 195

The pro-angiogenic properties of multi-functional bioactive glass composite scaffolds

Gerhardt, L.-C., Widdows, K. L., Erol, M. M., Burch, C. W., Sanz-Herrera, J. A., Ochoa, I., Stämpfli, R., Roqan, I. S., Gabe, S., Ansari, T., et al. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.02.032 · Cited by 195

Novel PCL-based honeycomb scaffolds as drug delivery systems for rhBMP-2

Rai, B., Teoh, S. H., Hutmacher, D. W., Cao, T., & Ho, K. H. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.09.052 · Cited by 191

The effect of human osteoblasts on proliferation and neo-vessel formation of human umbilical vein endothelial cells in a long-term 3D co-culture on polyurethane scaffolds

Hofmann, A., Ritz, U., Verrier, S., Eglin, D., Alini, M., Fuchs, S., Kirkpatrick, C. J., & Rommens, P. M. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.07.024 · Cited by 189

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Induction of angiogenesis in tissue-engineered scaffolds designed for bone repair: A combined gene therapy–cell transplantation approach

Jabbarzadeh, E., Starnes, T., Khan, Y. M., Jiang, T., Wirtel, A. J., Deng, M., Lv, Q., Nair, L. S., Doty, S. B., & Laurencin, C. T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800069105 · Cited by 188

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Potentiation of the activity of bone morphogenetic protein-2 in bone regeneration by a PLA–PEG/hydroxyapatite composite

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Osteogenesis by human mesenchymal stem cells cultured on silk biomaterials: Comparison of adenovirus mediated gene transfer and protein delivery of BMP-2

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Homogeneous osteogenesis and bone regeneration by demineralized bone matrix loading with collagen-targeting bone morphogenetic protein-2

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Optimized bone regeneration based on sustained release from three‐dimensional fibrous PLGA/HAp composite scaffolds loaded with BMP‐2

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Heparin-functionalized chitosan–alginate scaffolds for controlled release of growth factor

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Bone Graft Harvest Using a New Intramedullary System

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Microvessel-Like Structures from Outgrowth Endothelial Cells from Human Peripheral Blood in 2-Dimensional and 3-Dimensional Co-Cultures with Osteoblastic Lineage Cells

Fuchs, S., Hofmann, A., & Kirkpatrick, C. J. (2007) · Tissue Engineering · doi:10.1089/ten.2007.0022 · Cited by 162

VEGF-Activated Angiogenesis During Bone Regeneration

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Mesenchymal Stem Cells Expressing Osteogenic and Angiogenic Factors Synergistically Enhance Bone Formation in a Mouse Model of Segmental Bone Defect

Kumar, S., Wan, C., Ramaswamy, G., Clemens, T. L., & Ponnazhagan, S. (2010) · Molecular Therapy · doi:10.1038/mt.2009.315 · Cited by 160

Enhanced Bone Regeneration With BMP-2 Loaded Functional Nanoparticle-Hydrogel Complex

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Direct deposited porous scaffolds of calcium phosphate cement with alginate for drug delivery and bone tissue engineering

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In vitro degradation rate of apatitic calcium phosphate cement with incorporated PLGA microspheres

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Controlled release of rhBMP-2 loaded poly(dl-lactic-co-glycolic acid)/calcium phosphate cement composites in vivo

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Sequential BMP‐2/BMP‐7 delivery from polyester nanocapsules

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Segmental bone regeneration using a load-bearing biodegradable carrier of bone morphogenetic protein-2

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The effect of mesenchymal populations and vascular endothelial growth factor delivered from biodegradable polymer scaffolds on bone formation

Kanczler, J. M., Ginty, P. J., Barry, J. J. A., Clarke, N. M. P., Howdle, S. M., Shakesheff, K. M., & Oreffo, R. O. C. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2007.12.031 · Cited by 152

Liposomal drugs dispersed in hydrogels

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Review: Gene- and Stem Cell–Based Therapeutics for Bone Regeneration and Repair

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Adenoviral VEGF‐A gene transfer induces angiogenesis and promotes bone formation in healing osseous tissues

Tarkka, T., Sipola, A., Jämsä, T. J., Soini, Y., Ylä‐Herttuala, S., Tuukkanen, J., & Hautala, T. (2003) · The Journal of Gene Medicine · doi:10.1002/jgm.392 · Cited by 145

Osteogenic differentiation of rabbit mesenchymal stem cells in thermo-reversible hydrogel constructs containing hydroxyapatite and bone morphogenic protein-2 (BMP-2)

Na, K., Kim, S. W., Sun, B. K., Woo, D. G., Yang, H. N., Chung, H., & Park, K. H. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.02.008 · Cited by 144

Modulation of differentiation and mineralization of marrow stromal cells cultured on biomimetic hydrogels modified with Arg‐Gly‐Asp containing peptides

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Nucleofection-Based Ex Vivo Nonviral Gene Delivery to Human Stem Cells as a Platform for Tissue Regeneration

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Injectable In Situ –Forming pH/Thermo-Sensitive Hydrogel for Bone Tissue Engineering

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MMPs-responsive release of DNA from electrospun nanofibrous matrix for local gene therapy: In vitro and in vivo evaluation

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Gene Therapy Platform for Bone Regeneration Using an Exogenously Regulated, AAV-2-Based Gene Expression System

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Bone Formation and Neovascularization Mediated by Mesenchymal Stem Cells and Endothelial Cells in Critical-Sized Calvarial Defects

Koob, S., Torio‐Padron, N., Stark, G. B., Hannig, C., Stanković, Z. B., & Finkenzeller, G. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2010.0338 · Cited by 132

Prospective evaluation of chronic pain associated with posterior autologous iliac crest bone graft harvest and its effect on postoperative outcome

Schwartz, C. E., Martha, J. F., Kowalski, P., Wang, D. A., Bode, R. K., Li, L., & Kim, D. H. (2009) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-7-49 · Cited by 132

Repair of segmental bone defects in rabbit tibiae using a complex of β-tricalcium phosphate, type I collagen, and fibroblast growth factor-2

Komaki, H., Tanaka, T., Chazono, M., & Kikuchi, T. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.05.031 · Cited by 131

Autograft and Nonunions: Morbidity with Intramedullary Bone Graft versus Iliac Crest Bone Graft

Conway, J. D. (2009) · Orthopedic Clinics of North America · doi:10.1016/j.ocl.2009.07.006 · Cited by 131

Directional BMP-2 for functionalization of titanium surfaces

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Osteogenic differentiation of human amniotic fluid-derived stem cells induced by bone morphogenetic protein-7 and enhanced by nanofibrous scaffolds

Sun, H., Feng, K., Hu, J., Söker, S., Atala, A., & Ma, P. X. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.10.030 · Cited by 129

Soluble osteogenic molecular signals and the induction of bone formation

Ripamonti, U. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.09.021 · Cited by 127

Active multilayered capsules for in vivo bone formation

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Human Osteoprogenitor Bone Formation Using Encapsulated Bone Morphogenetic Protein 2 in Porous Polymer Scaffolds

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Co-culture of Bone Marrow Fibroblasts and Endothelial Cells on Modified Polycaprolactone Substrates for Enhanced Potentials in Bone Tissue Engineering

Choong, C. S. N., Hutmacher, D. W., & Triffitt, J. T. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.2521 · Cited by 126

Heparin-Conjugated Fibrin as an Injectable System for Sustained Delivery of Bone Morphogenetic Protein-2

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Injectable and strong nano-apatite scaffolds for cell/growth factor delivery and bone regeneration

Xu, H. H. K., Weir, M. D., & Simon, C. G. (2008) · Dental Materials · doi:10.1016/j.dental.2008.02.001 · Cited by 125

Engineering Biomaterial Systems to Enhance Viral Vector Gene Delivery

Jang, J., Schaffer, D. V., & Shea, L. D. (2011) · Molecular Therapy · doi:10.1038/mt.2011.111 · Cited by 125

In vitro cellular responses to scaffolds containing two microencapulated growth factors

Chen, F., Chen, R., Wang, X., Sun, H., & Wu, Z. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.06.009 · Cited by 124

Fabrication of core–shell microcapsules using PLGA and alginate for dual growth factor delivery system

Choi, D. H., Park, C. H., Kim, I. H., Chun, H. J., Park, K., & Han, D. K. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.07.103 · Cited by 123

Enhanced Bone Regeneration at a Segmental Bone Defect by Controlled Release of Bone Morphogenetic Protein-2 from a Biodegradable Hydrogel

Yamamoto, M., Takahashi, Y., & Tabata, Y. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.1305 · Cited by 123

Reconstruction of goat tibial defects using an injectable tricalcium phosphate/chitosan in combination with autologous platelet-rich plasma

Bi, L., Cheng, W., Fan, H., & Pei, G. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.01.038 · Cited by 122

Biomimetic apatite-coated alginate/chitosan microparticles as osteogenic protein carriers

Lee, M., Li, W., Siu, R. K., et al. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.07.046 · Cited by 121

Effect of cell‐based VEGF gene therapy on healing of a segmental bone defect

Li, R., Stewart, D. J., von Schroeder, H. P., Mackinnon, E. S., & Schemitsch, E. H. (2008) · Journal of Orthopaedic Research® · doi:10.1002/jor.20658 · Cited by 118

Bone formation in transforming growth factor β‐1‐coated porous poly(propylene fumarate) scaffolds

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Future of local bone regeneration - Protein versus gene therapy.

Fischer, J., Kolk, A., Wolfart, S., Pautke, C., Warnke, P., Plank, C., & Smeets, R. (2011) · Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery · doi:10.1016/j.jcms.2010.03.016 · Cited by 117

New Era of Cell-Based Orthopedic Therapies

Caplan, A. I. (2009) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2008.0515 · Cited by 116

In vitro generation of an osteochondral construct using injectable hydrogel composites encapsulating rabbit marrow mesenchymal stem cells

Guo, X., Park, H., Liu, G., et al. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.01.048 · Cited by 116

Slow-Release Human Recombinant Bone Morphogenetic Protein-2 Embedded Within Electrospun Scaffolds for Regeneration of Bone Defect: In Vitro and In Vivo Evaluation

Srouji, S., Ben‐David, D., Lotan, R., Livne, E., Avrahami, R., & Zussman, E. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2010.0250 · Cited by 115

Human fetal placental endothelial cells have a mature arterial and a juvenile venous phenotype with adipogenic and osteogenic differentiation potential

Lang, I., Schweizer, A., Hiden, U., Ghaffari‐Tabrizi‐Wizsy, N., Hagendorfer, G., Bilban, M., Pabst, M. A., Korgun, E. T., Dohr, G., & Desoyé, G. (2008) · Differentiation · doi:10.1111/j.1432-0436.2008.00302.x · Cited by 115

Silk fibroin microparticles as carriers for delivery of human recombinant BMPs. Physical characterization and drug release

Bessa, P. C., Balmayor, E. R., Azevedo, H. S., Nürnberger, S., Casal, M., van Griensven, M., Reis, R. L., & Redl, H. R. (2010) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.245 · Cited by 113

A multi-center, randomized, clinical study to compare the effect and safety of autologous cultured osteoblast(Ossron™) injection to treat fractures

Kim, S.-J., Shin, Y.-W., Yang, K.-H., Kim, S.-B., Yoo, M.-J., Han, S.-K., Im, S.-A., Won, Y.-D., Sung, Y.-B., Jeon, T.-S., et al. (2009) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-10-20 · Cited by 111

Virus-based gene therapy strategies for bone regeneration

Phillips‐Cremins, J. E., Gersbach, C. A., & García, A. J. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.07.032 · Cited by 111

Nanoparticle technology in bone tissue engineering

Kim, K., & Fisher, J. P. (2007) · Journal of drug targeting · doi:10.1080/10611860701289818 · Cited by 111

Ultrasound-based nonviral gene delivery induces bone formation in vivo

Sheyn, D., Kimelman‐Bleich, N., Pelled, G., Zilberman, Y., Gazit, D., & Gazit, Z. (2007) · Gene Therapy · doi:10.1038/sj.gt.3303070 · Cited by 110

Bone induction by biomimetic PLGA-(PEG-ASP)n copolymer loaded with a novel synthetic BMP-2-related peptide in vitro and in vivo

Lin, Z., Duan, Z., Guo, X., Li, J., Lu, H.-W., Zheng, Q., Quan, D., & Yang, S. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.02.016 · Cited by 110

Use of collagen sponge incorporating transforming growth factor-β1 to promote bone repair in skull defects in rabbits

Ueda, H. R., Hong, L., Yamamoto, M., Shigeno, K., Inoue, M., Toba, T., Yoshitani, M., Nakamura, T., Tabata, Y., & Shimizu, Y. (2002) · Biomaterials · doi:10.1016/s0142-9612(01)00211-3 · Cited by 110

Bone Morphogenetic Protein But Not Transforming Growth Factor-β Enchances Bone Formation in Canine Diaphyseal Nonunions Implanted with a Biodegradable Composite Polymer*†

Heckman, J. D., Ehler, W., BROOKS, B. P., Aufdemorte, T. B., Lohmann, C. H., Morgan, T., & Boyan, B. D. (1999) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-199912000-00009 · Cited by 110

Titanium with Surface-Grafted Dextran and Immobilized Bone Morphogenetic Protein-2 for Inhibition of Bacterial Adhesion and Enhancement of Osteoblast Functions

Shi, Z., Neoh, K. G., Kang, E. T., Poh, C., & Wang, W. (2008) · Tissue Engineering Part A · doi:10.1089/ten.tea.2007.0415 · Cited by 109

A conceptually new type of bio-hybrid scaffold for bone regeneration

Tampieri, A., Landi, E., Valentini, F., et al. (2010) · Nanotechnology · doi:10.1088/0957-4484/22/1/015104 · Cited by 108

Creation of bony microenvironment with CaP and cell-derived ECM to enhance human bone-marrow MSC behavior and delivery of BMP-2

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Bone healing induced by local delivery of an engineered parathyroid hormone prodrug

Arrighi, I., Mark, S., Alvisi, M., von Rechenberg, B., Hubbell, J. A., & Schense, J. C. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.12.023 · Cited by 107

Gene Delivery in Bone Tissue Engineering: Progress and Prospects Using Viral and Nonviral Strategies

Partridge, K. A., & Oreffo, R. O. C. (2004) · Tissue Engineering · doi:10.1089/107632704322791934 · Cited by 105

Controlled delivery of platelet‐rich plasma‐derived growth factors for bone formation

Lu, H. H., Vo, J., Chin, H. S., Lin, J., Cozin, M., Tsay, R. C., Eisig, S. B., & Landesberg, R. (2008) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.31740 · Cited by 105

Comparison of Human Mesenchymal Stem Cells Derived From Adipose Tissue and Bone Marrow for Ex Vivo Gene Therapy in Rat Spinal Fusion Model

Miyazaki, M., Zuk, P. A., Zou, J., Yoon, S. H., Wei, F., Morishita, Y., Sintuu, C., & Wang, J. C. (2008) · Spine · doi:10.1097/brs.0b013e31816b45c3 · Cited by 103

Mandibular bone repair by implantation of rhBMP-2 in a slow release carrier of polylactic acid—An experimental study in rats

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Cell therapy for bone regeneration—Bench to bedside

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Bone inductive properties of rhBMP-2 loaded porous calcium phosphate cement implants inserted at an ectopic site in rabbits

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Electroporation-mediated transfer of Runx2 and Osterix genes to enhance osteogenesis of adipose stem cells

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The use of injectable, thermosensitive poly(organophosphazene)–RGD conjugates for the enhancement of mesenchymal stem cell osteogenic differentiation

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Gene therapy for new bone formation using adeno-associated viral bone morphogenetic protein-2 vectors

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Evaluation of osseointegration of dental implants coated with collagen, chondroitin sulphate and BMP-4: an animal study

Stadlinger, B., Pilling, E., Huhle, M., Mai, R., Bierbaum, S., Scharnweber, D., Kuhlisch, E., Loukota, R. A., & Eckelt, U. (2007) · International Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.ijom.2007.05.024 · Cited by 94

Survival of Transplanted Rat Bone Marrow-Derived Osteogenic Stem Cells In Vivo

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Three-Dimensional Porous Biodegradable Polymeric Scaffolds Fabricated with Biodegradable Hydrogel Porogens

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RHBMP-2 DELIVERED IN A CALCIUM PHOSPHATE CEMENT ACCELERATES BRIDGING OF CRITICAL-SIZED DEFECTS IN RABBIT RADII

Seeherman, H. J., Azari, K. K., Bidic, S. M., Rogers, L., Li, X. J., Hollinger, J. O., & Wozney, J. M. (2006) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200607000-00017 · Cited by 90

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Ramoshebi, L. N., Matsaba, T., Teare, J., Renton, L. F., Patton, J. C., & Ripamonti, U. (2002) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399402004969 · Cited by 87

Derivation of murine induced pluripotent stem cells (iPS) and assessment of their differentiation toward osteogenic lineage

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Fabrication of nano-fibrous collagen microspheres for protein delivery and effects of photochemical crosslinking on release kinetics

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Improved cellularization and angiogenesis using collagen scaffolds chemically conjugated with vascular endothelial growth factor

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The effects of carrier nature and pH on rhBMP-2-induced ectopic bone formation

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The kinetic and biological activity of different loaded rhBMP‐2 calcium phosphate cement implants in rats

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VEGF-controlled release within a bone defect from alginate/chitosan/PLA-H scaffolds

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