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Harnessing CRISPR/Cas systems for programmable transcriptional and post-transcriptional regulation

Mahas, Ahmed, Neal Stewart, C., Mahfouz, Magdy M.·2018·Biotechnology Advances
DOI 10.1016/j.biotechadv.2017.11.008
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Abstract

Genome editing has enabled broad advances and novel approaches in studies of gene function and structure; now, emerging methods aim to precisely engineer post-transcriptional processes. Developing precise, efficient molecular tools to alter the transcriptome holds great promise for biotechnology and synthetic biology applications. Different approaches have been employed for targeted degradation of RNA species in eukaryotes, but they lack programmability and versatility, thereby limiting their utility for diverse applications. The CRISPR/Cas9 system has been harnessed for genome editing in many eukaryotic species and, using a catalytically inactive Cas9 variant, the CRISPR/dCas9 system has been repurposed for transcriptional regulation. Recent studies have used other CRISPR/Cas systems for targeted RNA degradation and RNA-based manipulations. For example, Cas13a, a Type VI-A endonuclease, has been identified as an RNA-guided RNA ribonuclease and used for manipulation of RNA. Here, we discuss different modalities for targeted RNA interference with an emphasis on the potential applications of CRISPR/Cas systems as programmable transcriptional regulators for broad uses, including functional biology, biotechnology, and synthetic biology applications.

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Metadata

Authors
Mahas, A., Neal Stewart, C., & Mahfouz, M. M.
ORCID
Mahas, Ahmed
Venue
Biotechnology Advances
Publisher
Elsevier BV
Published
2018-01
Volume
36
Issue
1
Pages
295-310
ISSN
0734-9750
DOI
10.1016/j.biotechadv.2017.11.008
Cited by
110
References
17
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
King Abdullah University of Science and Technology ((CRG4))

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