Mechanisms and Functions of Inflammasomes

The Inflammasome

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A role for mitochondria in nlrp3 inflammasome activation

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Immunological and inflammatory functions of the interleukin-1 family

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

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NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

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Thioredoxin-interacting protein links oxidative stress to inflammasome activation

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Non-canonical inflammasome activation targets caspase-11

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The NALP3 inflammasome is involved in the innate immune response to amyloid-β

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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

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Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

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The NLRP3 Inflammasome: an overview of mechanisms of activation and regulation

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Inflammasomes: mechanism of action, role in disease, and therapeutics

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Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

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Periodontitis: from microbial immune subversion to systemic inflammation

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A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

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Pore-forming activity and structural autoinhibition of the gasdermin family

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Mechanism and Regulation of NLRP3 Inflammasome Activation

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Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

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Pyroptosis: Mechanisms and Diseases

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The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease

Youm, Y.-H., Nguyen, K. Y., Grant, R. W., Goldberg, E. L., Bodogai, M., Kim, D., D'Agostino, D., Planavsky, N., Lupfer, C., Kanneganti, T. D., et al. (2015) · Nature Medicine · doi:10.1038/nm.3804 · Cited by 2,172

Necroptosis and its role in inflammation

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Genetic regulation of the human plasma proteome in 54,306 UK Biobank participants

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Plasma proteomic associations with genetics and health in the UK Biobank

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Autophagy in major human diseases

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Immunopathogenesis of IBD: current state of the art

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Innate Immune Pattern Recognition: A Cell Biological Perspective

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Old, new and emerging functions of caspases

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NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

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GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

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Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

Chen, X., He, W.-T., Hu, L., Li, J., Fang, Y., Wang, X., Xu, X., Wang, Z., Huang, K., & Han, J. (2016) · Cell Research · doi:10.1038/cr.2016.100 · Cited by 831

Autophagy in inflammation, infection, and immunometabolism

Deretic, V. (2021) · Immunity · doi:10.1016/j.immuni.2021.01.018 · Cited by 862

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome

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Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome

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Inflammasomes in neuroinflammatory and neurodegenerative diseases

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Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease

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Regulated necrosis: disease relevance and therapeutic opportunities

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Polymicrobial synergy and dysbiosis in inflammatory disease

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The NLRP3 Inflammasome Pathway: A Review of Mechanisms and Inhibitors for the Treatment of Inflammatory Diseases

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Interleukin 1α and the inflammatory process

Di Paolo, N. C., & Shayakhmetov, D. M. (2016) · Nature Immunology · doi:10.1038/ni.3503 · Cited by 568

Autophagy balances inflammation in innate immunity

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A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion

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Regulated cell death and inflammation: an auto-amplification loop causes organ failure

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Mechanisms of inflammasome activation: recent advances and novel insights

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The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease

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Peptidoglycan recognition by the innate immune system

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The role of mitochondria in NLRP3 inflammasome activation

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Dying cells actively regulate adaptive immune responses

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Small Molecule-Driven NLRP3 Inflammation Inhibition via Interplay between Ubiquitination and Autophagy: Implications for Parkinson Disease

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The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection

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NLRP3 inflammasome-driven pathways in depression: clinical and preclinical findings

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Caspases Connect Cell-Death Signaling to Organismal Homeostasis

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Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome

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Cholesterol Efflux Pathways Suppress Inflammasome Activation, NETosis, and Atherogenesis

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Neuroinflammation in Alzheimer’s Disease

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Inflammasome-independent regulation of IL-1-family cytokines

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IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes

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Targeting inflammasome/IL-1 pathways for cancer immunotherapy

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Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation

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Non-canonical activation of inflammatory caspases by cytosolic LPS in innate immunity

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Macrophage Inflammation, Erythrophagocytosis, and Accelerated Atherosclerosis in Jak2 V617F Mice

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The Role of Interferons in Inflammation and Inflammasome Activation

Kopitar-Jerala, N. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00873 · Cited by 260

Foam Cells in Atherosclerosis: Novel Insights Into Its Origins, Consequences, and Molecular Mechanisms

Gui, Y., Zheng, H., & Cao, R. Y. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.845942 · Cited by 258

Mitochondrial dysfunction and damage associated molecular patterns (DAMPs) in chronic inflammatory diseases

Dela Cruz, C. S., & Kang, M.-J. (2018) · Mitochondrion · doi:10.1016/j.mito.2017.12.001 · Cited by 255

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

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Lytic cell death in metabolic liver disease

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The P2X7 receptor directly interacts with the NLRP3 inflammasome scaffold protein

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NLRP3 Inflammasome as a Molecular Marker in Diabetic Cardiomyopathy

Luo, B., Huang, F., Liu, Y., Liang, Y., Wei, Z., Ke, H., Zeng, Z., Huang, W., & He, Y. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00519 · Cited by 213

Virus-Induced Interferon-γ Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity

Šestan, M., Marinović, S., Kavazović, I., Cekinović, Đ., Wueest, S., Turk Wensveen, T., Brizić, I., Jonjić, S., Konrad, D., Wensveen, F. M., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.05.005 · Cited by 189

Cadmium induces NLRP3 inflammasome-dependent pyroptosis in vascular endothelial cells

Chen, H., Lu, Y., Cao, Z., Ma, Q., Pi, H., Fang, Y., Yu, Z., Hu, H., & Zhou, Z. (2016) · Toxicology Letters · doi:10.1016/j.toxlet.2016.01.014 · Cited by 165

Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages

Karasawa, T., Kawashima, A., Usui-Kawanishi, F., Watanabe, S., Kimura, H., Kamata, R., Shirasuna, K., Koyama, Y., Sato-Tomita, A., Matsuzaka, T., et al. (2018) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.117.310581 · Cited by 162

Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging

Luo, H., Mu, W.-C., Karki, R., Chiang, H.-H., Mohrin, M., Shin, J. J., Ohkubo, R., Ito, K., Kanneganti, T.-D., & Chen, D. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.101 · Cited by 161

The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype

Hari, P., Millar, F. R., Tarrats, N., Birch, J., Quintanilla, A., Rink, C. J., Fernández-Duran, I., Muir, M., Finch, A. J., Brunton, V. G., et al. (2019) · Science Advances · doi:10.1126/sciadv.aaw0254 · Cited by 154

AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity

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The Role of the Inflammasome in Neurodegenerative Diseases

Piancone, F., La Rosa, F., Marventano, I., Saresella, M., & Clerici, M. (2021) · Molecules · doi:10.3390/molecules26040953 · Cited by 144

A20 and cell death-driven inflammation

Priem, D., van Loo, G., & Bertrand, M. J. M. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.03.001 · Cited by 139

Inflammasomes and Cancer: The Dynamic Role of the Inflammasome in Tumor Development

Kantono, M., & Guo, B. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01132 · Cited by 133

Sex and gender differences in myocarditis and dilated cardiomyopathy: An update

Fairweather, D., Beetler, D. J., Musigk, N., Heidecker, B., Lyle, M. A., Cooper, L. T., & Bruno, K. A. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1129348 · Cited by 124

Immunology of the ageing kidney

Sato, Y., & Yanagita, M. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0185-9 · Cited by 126

Principles of inflammasome priming and inhibition: implications for psychiatric disorders

Herman, F. J., & Pasinetti, G. M. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.06.010 · Cited by 115

The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages

Moriwaki, K., Farias Luz, N., Balaji, S., De Rosa, M. J., O’Donnell, C. L., Gough, P. J., Bertin, J., Welsh, R. M., & Chan, F. K.-M. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501662 · Cited by 116

Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages

Ding, X., Kambara, H., Guo, R., Kanneganti, A., Acosta-Zaldívar, M., Li, J., Liu, F., Bei, T., Qi, W., Xie, X., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27034-9 · Cited by 115

TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson’s Disease Mice and LPS-Induced BV2 Cells

Huang, P., Zhang, Z., Zhang, P., Feng, J., Xie, J., Zheng, Y., Liang, X., Zhu, B., Chen, Z., Feng, S., et al. (2024) · Molecular Neurobiology · doi:10.1007/s12035-023-03713-0 · Cited by 111

A novel role of NLRP3-generated IL-1β in the acute-chronic transition of peripheral lipopolysaccharide-elicited neuroinflammation: implications for sepsis-associated neurodegeneration

Zhao, Z., Wang, Y., Zhou, R., Li, Y., Gao, Y., Tu, D., Wilson, B., Song, S., Feng, J., Hong, J.-S., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1728-5 · Cited by 109

Intestinal dysbiosis mediates cognitive impairment via the intestine and brain NLRP3 inflammasome activation in chronic sleep deprivation

Zhao, N., Chen, Q.-G., Chen, X., Liu, X.-T., Geng, F., Zhu, M.-M., Yan, F.-L., Zhang, Z.-J., & Ren, Q.-G. (2023) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2022.11.013 · Cited by 105

Emerging role of the P2X7-NLRP3-IL1β pathway in mood disorders

Bhattacharya, A., & Jones, D. N. C. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.08.015 · Cited by 105

Apoptin induces pyroptosis of colorectal cancer cells via the GSDME-dependent pathway

Liu, Z., Li, Y., Zhu, Y., Li, N., Li, W., Shang, C., Song, G., Li, S., Cong, J., Li, T., et al. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.64350 · Cited by 93

Expert insights: the potential role of the gut microbiome-bile acid-brain axis in the development and progression of alzheimer’s disease and hepatic encephalopathy

Jia, W., Rajani, C., Kaddurah‐Daouk, R., & Li, H. (2020) · Medicinal Research Reviews · doi:10.1002/med.21653 · Cited by 88

Frontline Science: Specialized proresolving lipid mediators inhibit the priming and activation of the macrophage NLRP3 inflammasome

Lopategi, A., Flores-Costa, R., Rius, B., López-Vicario, C., Alcaraz-Quiles, J., Titos, E., & Clària, J. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.3hi0517-206rr · Cited by 87

Extracellular vesicles from immortalized cardiosphere-derived cells attenuate arrhythmogenic cardiomyopathy in desmoglein-2 mutant mice

Lin, Y.-N., Mesquita, T., Sanchez, L., Chen, Y.-H., Liu, W., Li, C., Rogers, R., Wang, Y., Li, X., Wu, D., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab419 · Cited by 83

Inflammasome NLRP3 Potentially Links Obesity-Associated Low-Grade Systemic Inflammation and Insulin Resistance with Alzheimer’s Disease

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An Overview of Pathways of Regulated Necrosis in Acute Kidney Injury

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