Cited by 688T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune responses and vaccinations

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Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance

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Steinert, Elizabeth M., Schenkel, Jason M., Fraser, Kathryn A., Beura, Lalit K., Manlove, Luke S., Igyártó, Botond Z., Southern, Peter J., Masopust, David·2015·Cell

DOI 10.1016/j.cell.2015.03.031PMC PMC4426972

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Abstract

Memory CD8 T cells protect against intracellular pathogens by scanning host cell surfaces; thus, infection detection rates depend on memory cell number and distribution. Population analyses rely on cell isolation from whole organs, and interpretation is predicated on presumptions of near complete cell recovery. Paradigmatically, memory is parsed into central, effector, and resident subsets, ostensibly defined by immunosurveillance patterns but in practice identified by phenotypic markers. Because isolation methods ultimately inform models of memory T cell differentiation, protection, and vaccine translation, we tested their validity via parabiosis and quantitative immunofluorescence microscopy of a mouse memory CD8 T cell population. We report three major findings: lymphocyte isolation fails to recover most cells and biases against certain subsets, residents greatly outnumber recirculating cells within non-lymphoid tissues, and memory subset homing to inflammation does not conform to previously hypothesized migration patterns. These results indicate that most host cells are surveyed for reinfection by segregated residents rather than by recirculating cells that migrate throughout the blood and body.

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Authors: Steinert, E. M., Schenkel, J. M., Fraser, K. A., Beura, L. K., Manlove, L. S., Igyártó, B. Z., Southern, P. J., & Masopust, D.
Affiliations: University of Minnesota (US)
Corresponding author: Masopust, David
ORCID: Steinert, Elizabeth M.
Schenkel, Jason M.
Fraser, Kathryn A.
Beura, Lalit K.
Manlove, Luke S.
Igyártó, Botond Z.
Southern, Peter J.
Masopust, David
Venue: Cell
Publisher: Elsevier BV
Published: 2015-05
Volume: 161
Issue: 4
Pages: 737-749
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2015.03.031
PMC: PMC4426972
OpenAlex: W1632859538
Cited by: 685
References: 46
Citations by year: 2026: 29 · 2025: 46 · 2024: 46 · 2023: 50 · 2022: 62 · 2021: 76 · 2020: 74 · 2019: 79 · 2018: 91 · 2017: 60 · 2016: 57 · 2015: 15
FWCI: 36.57
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 372 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (F31CA183226, P30CA077598)
National Institute of Allergy and Infectious Diseases (R01AI084913, R01AI111671, R37AI084913, T32AI083196)
National Institute of Diabetes and Digestive and Kidney Diseases (F30DK100159, F30-DK100159-02)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: memory CD8+ T cells, immune surveillance, parabiosis, lymphocyte isolation, tissue-resident memory T cells, effector memory T cells, central memory T cells, T cell migration, tissue inflammation, T cell differentiation, non-lymphoid tissues
MeSH terms: CD69 Antigens, Animals, Antigens, Differentiation, T-Lymphocyte, Arenaviridae Infections, Cell Movement, Immunologic Memory, Inflammation, Lymphocytic choriomeningitis virus, Mice, Inbred C57BL, Monitoring, Immunologic, Antigens, CD, T-Lymphocyte Subsets, CD8-Positive T-Lymphocytes, Lectins, C-Type, Mice

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Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance

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