Hepatic FGF21 Expression Is Induced at Birth via PPARα in Response to Milk Intake and Contributes to Thermogenic Activation of Neonatal Brown Fat

FGF-21 as a novel metabolic regulator

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Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

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Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

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Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

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Fibroblast Growth Factor 21 Corrects Obesity in Mice

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Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans

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FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

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The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man

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Circulating Fibroblast Growth Factor-21 Is Elevated in Impaired Glucose Tolerance and Type 2 Diabetes and Correlates With Muscle and Hepatic Insulin Resistance

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Molecular cloning and expression analyses of mouse βklotho, which encodes a novel Klotho family protein

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Brown and beige fat: Development, function and therapeutic potential

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FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

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Adipose tissue browning and metabolic health

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Understanding the Physiology of FGF21

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Adaptive thermogenesis in adipocytes: Is beige the new brown?

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Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

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Adipose tissue in control of metabolism

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Brown adipose tissue as a secretory organ

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Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue

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White, Brown, Beige/Brite: Different Adipose Cells for Different Functions?

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Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

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FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss

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Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

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A New Era in Brown Adipose Tissue Biology: Molecular Control of Brown Fat Development and Energy Homeostasis

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Fibroblast growth factor 21 protects against cardiac hypertrophy in mice

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The adipose organ at a glance

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Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication

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FGF21 gene therapy as treatment for obesity and insulin resistance

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Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21

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MECHANISMS IN ENDOCRINOLOGY: White, brown and pink adipocytes: the extraordinary plasticity of the adipose organ

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A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21

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Distinction of white, beige and brown adipocytes derived from mesenchymal stem cells

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Fibroblast Growth Factor 21—Metabolic Role in Mice and Men

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The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue

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Adipocyte lineages: Tracing back the origins of fat

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Fibroblast growth factor 21 protects the heart from oxidative stress

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FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia

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Brown Adipose Tissue Responds to Cold and Adrenergic Stimulation by Induction of FGF21

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Mitochondrial fatty acid oxidation in obesity

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Interplay between FGF21 and insulin action in the liver regulates metabolism

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Direct Control of Brown Adipose Tissue Thermogenesis by Central Nervous System Glucagon-Like Peptide-1 Receptor Signaling

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Convertible visceral fat as a therapeutic target to curb obesity

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The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes

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Irisin is inversely associated with intrahepatic triglyceride contents in obese adults

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Effect of endurance training on skeletal muscle myokine expression in obese men: Identification of apelin as a novel myokine

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FGF21 contributes to neuroendocrine control of female reproduction

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Cellular Mechanisms by Which FGF21 Improves Insulin Sensitivity in Male Mice

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Brown adipose tissue and thermogenesis

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Adipose tissue plasticity from WAT to BAT and in between

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Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice

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FGF21 and the late adaptive response to starvation in humans

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A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain

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Brown adipose tissue activity as a target for the treatment of obesity/insulin resistance

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Beyond the Sympathetic Tone: The New Brown Fat Activators

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Hepatic NADH reductive stress underlies common variation in metabolic traits

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Pharmacologic Effects of FGF21 Are Independent of the “Browning” of White Adipose Tissue

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Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications

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Inventing new medicines: The FGF21 story

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Toward an understanding of how immune cells control brown and beige adipobiology

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TNF-α Represses β-Klotho Expression and Impairs FGF21 Action in Adipose Cells: Involvement of JNK1 in the FGF21 Pathway

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Functional Role of PPARs in Ruminants: Potential Targets for Fine-Tuning Metabolism during Growth and Lactation

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Preventing diet-induced obesity in mice by adipose tissue transformation and angiogenesis using targeted nanoparticles

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An endocrine role for brown adipose tissue?

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Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice

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Fibroblast Growth Factor 21 Induces Glucose Transporter-1 Expression through Activation of the Serum Response Factor/Ets-Like Protein-1 in Adipocytes

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Amelioration of Type 2 Diabetes by Antibody-Mediated Activation of Fibroblast Growth Factor Receptor 1

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The evolving view of thermogenic adipocytes — ontogeny, niche and function

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Brown adipose tissue

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Brown adipose tissue: Development, metabolism and beyond

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Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB

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Circadian Rhythm of Circulating Fibroblast Growth Factor 21 Is Related to Diurnal Changes in Fatty Acids in Humans

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FGF19 and FGF21 serum concentrations in human obesity and type 2 diabetes behave differently after diet- or surgically-induced weight loss

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The brain and brown fat

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Irisin as a muscle-derived hormone stimulating thermogenesis – A critical update

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Brown and Beige Adipose Tissues in Health and Disease

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Exercise-Released Myokines in the Control of Energy Metabolism

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Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1

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FGF21: A Novel Regulator of Glucose and Lipid Metabolism and Whole-Body Energy Balance

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Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesity

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Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor 4 alpha in mice

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Disruption of Thyroid Hormone Activation in Type 2 Deiodinase Knockout Mice Causes Obesity With Glucose Intolerance and Liver Steatosis Only at Thermoneutrality

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The miR‐379/miR‐410 cluster at the imprinted Dlk1‐Dio3 domain controls neonatal metabolic adaptation

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GPR120 controls neonatal brown adipose tissue thermogenic induction

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