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The Hippo Signaling Pathway in Development and Cancer

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Pan, Duojia·2010·Developmental Cell

DOI 10.1016/j.devcel.2010.09.011

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Abstract

First discovered in Drosophila, the Hippo signaling pathway is a conserved regulator of organ size. Central to this pathway is a kinase cascade leading from the tumor suppressor Hippo (Mst1 and Mst2 in mammals) to the oncoprotein Yki (YAP and TAZ in mammals), a transcriptional coactivator of target genes involved in cell proliferation and survival. Here, I review recent progress in elucidating the molecular mechanism and physiological function of Hippo signaling in Drosophila and mammals. These studies suggest that the core Hippo kinase cascade integrates multiple upstream inputs, enabling dynamic regulation of tissue homeostasis in animal development and physiology.

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Self-citation
TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm
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“Sd directly binds to a minimal 26 bp Hippo response element (HRE) that confers Hippo-dependent transcriptional regulation of diap1, a well characterized Hippo target gene (Wu et al., 2008).”
BackgroundInfluentialSelf-citation
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Background
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Authors: Pan, D.
Venue: Developmental Cell
Publisher: Elsevier BV
Published: 2010-10
Volume: 19
Issue: 4
Pages: 491-505
ISSN: 1534-5807 (ISSN-L)
DOI: 10.1016/j.devcel.2010.09.011
OpenAlex: W2006778392
Cited by: 2,269
References: 14
FWCI: 39.75
Type: journal article
Language: en
Open access: bronze

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The Hippo Signaling Pathway in Development and Cancer

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