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The ESCRT Pathway
Open accessAbstract
Multivesicular bodies (MVBs) deliver cargo destined for degradation to the vacuole or lysosome. The ESCRT (endosomal sorting complex required for transport) pathway is a key mediator of MVB biogenesis, but it also plays critical roles in retroviral budding and cytokinetic abscission. Despite these diverse roles, the ESCRT pathway can be simply seen as a cargo-recognition and membrane-sculpting machine viewable from three distinct perspectives: (1) the ESCRT proteins themselves, (2) the cargo they sort, and (3) the membrane they deform. Here, we review ESCRT function from these perspectives and discuss how ESCRTs may drive vesicle budding.
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Cites
Doherty, G. J., & McMahon, H. T. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.081307.110540 · Cited by 3,075
Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding
Garrus, J. E., von Schwedler, U. K., Pornillos, O. W., Morham, S. G., Zavitz, K. H., Wang, H. E., Wettstein, D. A., Stray, K. M., Côté, M., Rich, R. L., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00506-2 · Cited by 1,369
Molecular mechanism of multivesicular body biogenesis by ESCRT complexes
Wollert, T., & Hurley, J. H. (2010) · Nature · doi:10.1038/nature08849 · Cited by 804
Parallels Between Cytokinesis and Retroviral Budding: A Role for the ESCRT Machinery
Carlton, J. G., & Martin-Serrano, J. (2007) · Science · doi:10.1126/science.1143422 · Cited by 764
A Modular Design for the Clathrin- and Actin-Mediated Endocytosis Machinery
Kaksonen, M., Toret, C. P., & Drubin, D. G. (2005) · Cell · doi:10.1016/j.cell.2005.09.024 · Cited by 726 · cited 1×
“…of the heterodimeric Bin/Amphiphysin/Rvs (BAR) domain-containing complex Rvs161/Rvs167 promotes scission by generating Developmental Cell 21, July 19, 2011 ª2011 Elsevier Inc. 83 a highly curved vesicle neck that is stressed by the pulling forces of actin polymerization (Kaksonen et al., 2005).”
BackgroundMartin-Serrano, J., Zang, T., & Bieniasz, P. D. (2001) · Nature Medicine · doi:10.1038/nm1201-1313 · Cited by 710
Role of LBPA and Alix in Multivesicular Liposome Formation and Endosome Organization
Matsuo, H., Chevallier, J., Mayran, N., Le Blanc, I., Ferguson, C., Fauré, J., Blanc, N. S., Matile, S., Dubochet, J., Sadoul, R., et al. (2004) · Science · doi:10.1126/science.1092425 · Cited by 705
Fab1p PtdIns(3)P 5-Kinase Function Essential for Protein Sorting in the Multivesicular Body
Odorizzi, G., Babst, M., & Emr, S. D. (1998) · Cell · doi:10.1016/s0092-8674(00)81707-9 · Cited by 656
Self-citationFilimonenko, M., Stuffers, S., Raiborg, C., Yamamoto, A., Malerød, L., Fisher, E. M. C., Isaacs, A., Brech, A., Stenmark, H., & Simonsen, A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200702115 · Cited by 626
Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55 Gag
VerPlank, L., Bouamr, F., LaGrassa, T. J., Agresta, B., Kikonyogo, A., Leis, J., & Carter, C. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.131059198 · Cited by 584
Cited by
Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles
Colombo, M., Raposo, G., & Théry, C. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122326 · Cited by 6,186
Pegtel, D. M., & Gould, S. J. (2019) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-013118-111902 · Cited by 2,682
Exosomes: biogenesis, biologic function and clinical potential
Zhang, Y., Liu, Y., Liu, H., & Tang, W. H. (2019) · Cell & Bioscience · doi:10.1186/s13578-019-0282-2 · Cited by 2,119
Syndecan–syntenin–ALIX regulates the biogenesis of exosomes
Baietti, M. F., Zhang, Z., Mortier, E., Melchior, A., Degeest, G., Geeraerts, A., Ivarsson, Y., Depoortere, F., Coomans, C., Vermeiren, E., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2502 · Cited by 1,899
Ectosomes and exosomes: shedding the confusion between extracellular vesicles
Cocucci, E., & Meldolesi, J. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.01.004 · Cited by 1,435
Zhang, Y., Bi, J., Huang, J., Tang, Y., Du, S., & Li, P. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s264498 · Cited by 1,323
The delivery of therapeutic oligonucleotides
Juliano, R. L. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw236 · Cited by 854
Pore-forming toxins: ancient, but never really out of fashion
Peraro, M. D., & van der Goot, F. G. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2015.3 · Cited by 788
Kou, M., Huang, L., Yang, J., Chiang, Z., Chen, S., Liu, J., Guo, L., Zhang, X., Zhou, X., Xu, X., et al. (2022) · Cell Death & Disease · doi:10.1038/s41419-022-05034-x · Cited by 640
Virus budding and the ESCRT pathway
Votteler, J., & Sundquist, W. I. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.08.012 · Cited by 547
Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal
Jia, J., Claude-Taupin, A., Gu, Y., Choi, S. W., Peters, R., Bissa, B., Mudd, M. H., Allers, L., Pallikkuth, S., Lidke, K. A., et al. (2020) · Developmental Cell · doi:10.1016/j.devcel.2019.10.025 · Cited by 434
Retromer: A Master Conductor of Endosome Sorting
Burd, C., & Cullen, P. J. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016774 · Cited by 435
Regulation of cargo selection in exosome biogenesis and its biomedical applications in cancer
Lee, Y. J., Shin, K. J., & Chae, Y. C. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01209-y · Cited by 427
The significance of exosomes in the development and treatment of hepatocellular carcinoma
Li, X., Li, C., Zhang, L., Wu, M., Cao, K., Jiang, F., Chen, D., Li, N., & Li, W. (2020) · Molecular Cancer · doi:10.1186/s12943-019-1085-0 · Cited by 395
Rab GTPase Function in Endosome and Lysosome Biogenesis
Langemeyer, L., Fröhlich, F., & Ungermann, C. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.06.007 · Cited by 394
Regulation of exosome production and cargo sorting
Wei, H., Chen, Q., Lin, L., Sha, C., Li, T., Liu, Y., Yin, X., Xu, Y., Chen, L., Gao, W., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.53671 · Cited by 385
Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling
McNally, K. E., Faulkner, R., Steinberg, F., Gallon, M., Ghai, R., Pim, D., Langton, P., Pearson, N., Danson, C. M., Nägele, H., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3610 · Cited by 346
ALIX and the multivesicular endosome: ALIX in Wonderland
Bissig, C., & Gruenberg, J. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.10.009 · Cited by 323
Tumbarello, D. A., Waxse, B. J., Arden, S. D., Bright, N. A., Kendrick-Jones, J., & Buss, F. (2012) · Nature Cell Biology · doi:10.1038/ncb2589 · Cited by 301
Iraci, N., Leonardi, T., Gessler, F., Vega, B., & Pluchino, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020171 · Cited by 301
Lin, Z., Wu, Y., Xu, Y., Li, G., Li, Z., & Liu, T. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01650-5 · Cited by 297
Ubiquitin and membrane protein turnover: from cradle to grave
MacGurn, J. A., Hsu, P.-C., & Emr, S. D. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060210-093619 · Cited by 287
Self-citationTicket to a bubble ride: Cargo sorting into exosomes and extracellular vesicles
Anand, S., Samuel, M., Kumar, S., & Mathivanan, S. (2019) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2019.02.005 · Cited by 284
Teasdale, R. D., & Collins, B. M. (2012) · Biochemical Journal · doi:10.1042/bj20111226 · Cited by 281
Exosome-Based Drug Delivery: Translation from Bench to Clinic
Koh, H. B., Kim, H. J., Kang, S.-W., & Yoo, T.-H. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15082042 · Cited by 259
Retromer in Alzheimer disease, Parkinson disease and other neurological disorders
Small, S. A., & Petsko, G. A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3896 · Cited by 227
Morel, E., Chamoun, Z., Lasiecka, Z. M., Chan, R. B., Williamson, R. L., Vetanovetz, C., Dall’Armi, C., Simoes, S., Point Du Jour, K. S., McCabe, B. D., et al. (2013) · Nature Communications · doi:10.1038/ncomms3250 · Cited by 222
Mycobacterium tuberculosis Type VII Secreted Effector EsxH Targets Host ESCRT to Impair Trafficking
Mehra, A., Zahra, A., Thompson, V., Sirisaengtaksin, N., Wells, A., Porto, M., Köster, S., Penberthy, K., Kubota, Y., Dricot, A., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003734 · Cited by 192
Anding, A. L., Wang, C., Chang, T.-K., Sliter, D. A., Powers, C. M., Hofmann, K., Youle, R. J., & Baehrecke, E. H. (2018) · Current Biology · doi:10.1016/j.cub.2017.11.064 · Cited by 172
Gascon, E., Lynch, K., Ruan, H., Almeida, S., Verheyden, J. M., Seeley, W. W., Dickson, D. W., Petrucelli, L., Sun, D., Jiao, J., et al. (2014) · Nature Medicine · doi:10.1038/nm.3717 · Cited by 183
Activity-dependent trafficking of lysosomes in dendrites and dendritic spines
Goo, M. S., Sancho, L., Slepak, N., Boassa, D., Deerinck, T. J., Ellisman, M. H., Bloodgood, B. L., & Patrick, G. N. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201704068 · Cited by 164
ALIX and ESCRT-I/II function as parallel ESCRT-III recruiters in cytokinetic abscission
Christ, L., Wenzel, E. M., Liestøl, K., Raiborg, C., Campsteijn, C., & Stenmark, H. (2016) · Journal of Cell Biology · doi:10.1083/jcb.201507009 · Cited by 163
Structural basis for activation, assembly and membrane binding of ESCRT-III Snf7 filaments
Tang, S., Henne, W. M., Borbat, P. P., Buchkovich, N. J., Freed, J. H., Mao, Y., Fromme, J. C., & Emr, S. D. (2015) · eLife · doi:10.7554/elife.12548 · Cited by 156
Self-citationCiliary ectosomes: transmissions from the cell's antenna
Wood, C. R., & Rosenbaum, J. L. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.12.008 · Cited by 153
The endocytic pathway in microglia during health, aging and Alzheimer’s disease
Solé-Domènech, S., Cruz, D. L., Capetillo-Zarate, E., & Maxfield, F. R. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.07.002 · Cited by 133
Emerging roles of PtdIns(4,5)P 2 – beyond the plasma membrane
Tan, X., Thapa, N., Choi, S., & Anderson, R. A. (2015) · Journal of Cell Science · doi:10.1242/jcs.175208 · Cited by 110
Extracellular vesicles and intercellular communication in the central nervous system
Lizarraga‐Valderrama, L. R., & Sheridan, G. K. (2021) · FEBS Letters · doi:10.1002/1873-3468.14074 · Cited by 107
Asgard archaea shed light on the evolutionary origins of the eukaryotic ubiquitin-ESCRT machinery
Hatano, T., Palani, S., Papatziamou, D., Salzer, R., Souza, D. P., Tamarit, D., Makwana, M., Potter, A., Haig, A., Xu, W., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30656-2 · Cited by 104
Exosomes as Emerging Pro-Tumorigenic Mediators of the Senescence-Associated Secretory Phenotype
Jakhar, R., & Crasta, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102547 · Cited by 98
The ESCRT machinery: new roles at new holes
Olmos, Y., & Carlton, J. (2016) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2015.12.001 · Cited by 98
Exosomal PD‐L1: New Insights Into Tumor Immune Escape Mechanisms and Therapeutic Strategies
Zhou, K., Guo, S., Li, F., Sun, Q., & Liang, G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.569219 · Cited by 99
SNX-1 and RME-8 oppose the assembly of HGRS-1/ESCRT-0 degradative microdomains on endosomes
Norris, A., Tammineni, P., Wang, S., Gerdes, J., Murr, A., Kwan, K. Y., Cai, Q., & Grant, B. D. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1612730114 · Cited by 90
Recognising the signals for endosomal trafficking
Weeratunga, S., Paul, B., & Collins, B. M. (2020) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2020.02.005 · Cited by 83
ESCRT proteins restrict constitutive NF-κB signaling by trafficking cytokine receptors
Mamińska, A., Bartosik, A., Banach-Orłowska, M., Pilecka, I., Jastrzębski, K., Zdżalik-Bielecka, D., Castanon, I., Poulain, M., Neyen, C., Wolińska-Nizioł, L., et al. (2016) · Science Signaling · doi:10.1126/scisignal.aad0848 · Cited by 74
Current advances in non‐viral gene delivery systems: Liposomes versus extracellular vesicles
Belhadj, Z., Qie, Y., Carney, R. P., Li, Y., & Nie, G. (2023) · BMEMat · doi:10.1002/bmm2.12018 · Cited by 79
PIP kinases define PI4,5P2 signaling specificity by association with effectors
Choi, S., Thapa, N., Tan, X., Hedman, A. C., & Anderson, R. A. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2015.01.009 · Cited by 75
HRS-WASH axis governs actin-mediated endosomal recycling and cell invasion
MacDonald, E., Brown, L., Selvais, A., Liu, H., Waring, T., Newman, D., Bithell, J., Grimes, D., Urbé, S., Clague, M. J., et al. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201710051 · Cited by 62
The postmitotic midbody: Regulating polarity, stemness, and proliferation
Peterman, E., & Prekeris, R. (2019) · Journal of Cell Biology · doi:10.1083/jcb.201906148 · Cited by 60
Song, J.-W., Zhu, J., Wu, X.-X., Tu, T., Huang, J.-Q., Chen, G.-Z., Liang, L.-Y., Zhou, C.-H., Xu, X., & Gong, L.-Y. (2021) · Cell Death & Disease · doi:10.1038/s41419-021-04265-8 · Cited by 51
Unravelling the pivotal role of Alix in MVB sorting and silencing of the activated EGFR
Sun, S., Zhou, X., Zhang, W., Gallick, G. E., & Kuang, J. (2015) · Biochemical Journal · doi:10.1042/bj20141156 · Cited by 37
Importance of viral late domains in budding and release of enveloped RNA viruses
Welker, L., Paillart, J.-C., & Bernacchi, S. (2021) · Viruses · doi:10.3390/v13081559 · Cited by 36
Cargo induces retromer-mediated membrane remodeling on membranes
Purushothaman, L. K., & Ungermann, C. (2018) · Molecular Biology of the Cell · doi:10.1091/mbc.e18-06-0339 · Cited by 35
Zhai, Q., Landesman, M. B., Robinson, H., Sundquist, W. I., & Hill, C. P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027466 · Cited by 31
A role for Vps13-mediated lipid transfer at the ER–endosome contact site in ESCRT-mediated sorting
(2024) · doi:10.1083/jcb.202307094 · Cited by 24
Mu, R., Dussupt, V., Jiang, J., Sette, P., Rudd, V., Chuenchor, W., Bello, N. F., Bouamr, F., & Xiao, T. S. (2012) · Structure · doi:10.1016/j.str.2012.03.001 · Cited by 23
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Li, T., Li, J., Wang, H., Zhao, J., Yan, M., He, H., & Yu, S. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.881794 · Cited by 18
Clinical Theragnostic Signature of Extracellular Vesicles in Traumatic Brain Injury (TBI)
Dey, A., Ghosh, S., Bhuniya, T., Koley, M., Bera, A., Guha, S., Chakraborty, K., Muthu, S., Gorai, S., Vorn, R., et al. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00386 · Cited by 16
Joseph, B. B., Edeen, P. T., Meadows, S., Binti, S., & Fay, D. S. (2022) · PLOS Genetics · doi:10.1371/journal.pgen.1010249 · Cited by 13
Marie, P. P., Fan, S.-J., Mendes, C. C., Wainwright, S. M., Harris, A. L., Goberdhan, D. C. I., & Wilson, C. (2020) · doi:10.1101/2020.06.18.158725 · Cited by 6
Metadata
- Authors
- Henne, W. M., Buchkovich, N. J., & Emr, S. D.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 21
- Issue
- 1
- Pages
- 77-91
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W1982606786
- Cited by
- 1,496
- References
- 15
- FWCI
- 38.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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