MicroRNA regulation of core apoptosis pathways in cancer

Apoptosis: A Review of Programmed Cell Death

Elmore, S. (2007) · Toxicologic Pathology · doi:10.1080/01926230701320337 · Cited by 13,853

Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

Lynch, T. J., Bell, D. W., Sordella, R., Gurubhagavatula, S., Okimoto, R. A., Brannigan, B. W., Harris, P. L., Haserlat, S. M., Supko, J. G., Haluska, F. G., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040938 · Cited by 11,486

EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

Paez, J. G., Jänne, P. A., Lee, J. C., Tracy, S., Greulich, H., Gabriel, S., Herman, P., Kaye, F. J., Lindeman, N., Boggon, T. J., et al. (2004) · Science · doi:10.1126/science.1099314 · Cited by 9,368

Oncomirs—MicroRNAs with a role in cancer

Esquela-Kerscher, A., & Slack, F. J. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1840 · Cited by 5,884

Caspases: the executioners of apoptosis

COHEN, G. M. (1997) · Biochemical Journal · doi:10.1042/bj3260001 · Cited by 4,719

MicroRNA genes are transcribed by RNA polymerase II

Lee, Y., Kim, M., Han, J., Yeom, K., Lee, S., Baek, S. H., & Kim, V. N. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600385 · Cited by 4,373

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

Calin, G. A., Sevignani, C., Dumitru, C. D., Hyslop, T., Noch, E., Yendamuri, S., Shimizu, M., Rattan, S., Bullrich, F., Negrini, M., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307323101 · Cited by 4,095

miR-15 and miR-16 induce apoptosis by targeting BCL2

Cimmino, A., Calin, G. A., Fabbri, M., Iorio, M. V., Ferracin, M., Shimizu, M., Wojcik, S. E., Aqeilan, R. I., Zupo, S., Dono, M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506654102 · Cited by 3,517

RNA interference is mediated by 21- and 22-nucleotide RNAs

Elbashir, S. M., Lendeckel, W., & Tuschl, T. (2001) · Genes & Development · doi:10.1101/gad.862301 · Cited by 3,310

Causes and consequences of microRNA dysregulation in cancer

Croce, C. M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2634 · Cited by 2,998

Processing of primary microRNAs by the Microprocessor complex

Denli, A. M., Tops, B. B. J., Plasterk, R. H. A., Ketting, R. F., & Hannon, G. J. (2004) · Nature · doi:10.1038/nature03049 · Cited by 2,784

Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis

Chang, T.-C., Wentzel, E. A., Kent, O. A., Ramachandran, K., Mullendore, M., Lee, K. H., Feldmann, G., Yamakuchi, M., Ferlito, M., Lowenstein, C. J., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.010 · Cited by 2,010

Untitled work

Johnstone (2002) · doi:10.1016/s0092-8674(02)00625-6 · Cited by 1,876

Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function

Chen, L., Willis, S. N., Wei, A., Smith, B. J., Fletcher, J. I., Hinds, M. G., Colman, P. M., Day, C. L., Adams, J. M., & Huang, D. C. S. (2005) · Molecular Cell · doi:10.1016/j.molcel.2004.12.030 · Cited by 1,816

MicroRNAs in Cancer

Garzon, R., Calin, G. A., & Croce, C. M. (2009) · Annual Review of Medicine · doi:10.1146/annurev.med.59.053006.104707 · Cited by 1,770

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

Letai, A., Bassik, M. C., Walensky, L. D., Sorcinelli, M. D., Weiler, S., & Korsmeyer, S. J. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00127-7 · Cited by 1,677

A microRNA in a Multiple-Turnover RNAi Enzyme Complex

Hutvágner, G., & Zamore, P. D. (2002) · Science · doi:10.1126/science.1073827 · Cited by 1,674

Targeting microRNAs in cancer: rationale, strategies and challenges

Garzon, R., Marcucci, G., & Croce, C. M. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3179 · Cited by 1,493

Transcriptional Activation of miR-34a Contributes to p53-Mediated Apoptosis

Raver-Shapira, N., Marciano, E., Meiri, E., Spector, Y., Rosenfeld, N., Moskovits, N., Bentwich, Z., & Oren, M. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.017 · Cited by 1,352

miR-34a repression of SIRT1 regulates apoptosis

Yamakuchi, M., Ferlito, M., & Lowenstein, C. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801613105 · Cited by 1,342

Overview of cell death signaling pathways

Jin, Z., & El-Deiry, W. S. (2005) · Cancer Biology & Therapy · doi:10.4161/cbt.4.2.1508 · Cited by 1,326

The miR-34 family in cancer and apoptosis

Hermeking, H. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2009.56 · Cited by 1,236

MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies

Liu, J., Valencia-Sanchez, M. A., Hannon, G. J., & Parker, R. (2005) · Nature Cell Biology · doi:10.1038/ncb1274 · Cited by 1,234

Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes

Xiao, C., Srinivasan, L., Calado, D. P., Patterson, H. C., Zhang, B., Wang, J., Henderson, J. M., Kutok, J. L., & Rajewsky, K. (2008) · Nature Immunology · doi:10.1038/ni1575 · Cited by 1,228

BH3 Domains of BH3-Only Proteins Differentially Regulate Bax-Mediated Mitochondrial Membrane Permeabilization Both Directly and Indirectly

Kuwana, T., Bouchier-Hayes, L., Chipuk, J. E., Bonzon, C., Sullivan, B. A., Green, D. R., & Newmeyer, D. D. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.02.003 · Cited by 1,185

MicroRNAs direct rapid deadenylation of mRNA

Wu, L., Fan, J., & Belasco, J. G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510928103 · Cited by 1,138

Apoptosis - the p53 network

Haupt, S., Berger, M., Goldberg, Z., & Haupt, Y. (2003) · Journal of Cell Science · doi:10.1242/jcs.00739 · Cited by 1,136

p53-Mediated Activation of miRNA34 Candidate Tumor-Suppressor Genes

Bommer, G. T., Gerin, I., Feng, Y., Kaczorowski, A. J., Kuick, R., Love, R. E., Zhai, Y., Giordano, T. J., Qin, Z. S., Moore, B. B., et al. (2007) · Current Biology · doi:10.1016/j.cub.2007.06.068 · Cited by 1,123

MicroRNA Expression Profiling in Human Ovarian Cancer: miR-214 Induces Cell Survival and Cisplatin Resistance by Targeting PTEN

Yang, H., Kong, W., He, L., Zhao, J.-J., O'Donnell, J. D., Wang, J., Wenham, R. M., Coppola, D., Kruk, P. A., Nicosia, S. V., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2488 · Cited by 1,051

Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c

Korsmeyer, S. J., Wei, M. C., Saito, M., Weiler, S., Oh, K. J., & Schlesinger, P. H. (2000) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4400783 · Cited by 1,034

Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways in Cancer Therapy

Kang, M. H., & Reynolds, C. P. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0144 · Cited by 1,016

miR‐21: a small multi‐faceted RNA

Krichevsky, A. M., & Gabriely, G. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00556.x · Cited by 987

p53 and metabolism

Vousden, K. H., & Ryan, K. M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2715 · Cited by 959

Perspective: machines for RNAi

Tomari, Y., & Zamore, P. D. (2005) · Genes & Development · doi:10.1101/gad.1284105 · Cited by 948

Awakening guardian angels: drugging the p53 pathway

Brown, C. J., Lain, S., Verma, C. S., Fersht, A. R., & Lane, D. P. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2763 · Cited by 881

mir-29 regulates Mcl-1 protein expression and apoptosis

Mott, J. L., Kobayashi, S., Bronk, S. F., & Gores, G. J. (2007) · Oncogene · doi:10.1038/sj.onc.1210436 · Cited by 834

E2F1-Regulated MicroRNAs Impair TGFβ-Dependent Cell-Cycle Arrest and Apoptosis in Gastric Cancer

Petrocca, F., Visone, R., Onelli, M. R., Shah, M. H., Nicoloso, M. S., de Martino, I., Iliopoulos, D., Pilozzi, E., Liu, C.-G., Negrini, M., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.02.013 · Cited by 831

MiR-15a and miR-16-1 cluster functions in human leukemia

Calin, G. A., Cimmino, A., Fabbri, M., Ferracin, M., Wojcik, S. E., Shimizu, M., Taccioli, C., Zanesi, N., Garzon, R., Aqeilan, R. I., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800121105 · Cited by 808

miR‐15b and miR‐16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells

Xia, L., Zhang, D., Du, R., Pan, Y., Zhao, L., Sun, S., Hong, L., Liu, J., & Fan, D. (2008) · International Journal of Cancer · doi:10.1002/ijc.23501 · Cited by 711

Genomic Profiling of MicroRNA and Messenger RNA Reveals Deregulated MicroRNA Expression in Prostate Cancer

Ambs, S., Prueitt, R. L., Yi, M., Hudson, R. S., Howe, T. M., Petrocca, F., Wallace, T. A., Liu, C.-G., Volinia, S., Calin, G. A., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0144 · Cited by 704

MicroRNA function: Multiple mechanisms for a tiny RNA?: FIGURE 1.

PILLAI, R. S. (2005) · RNA · doi:10.1261/rna.2248605 · Cited by 681

MicroRNA-125b is a novel negative regulator of p53

Le, M. T. N., Teh, C., Shyh-Chang, N., Xie, H., Zhou, B., Korzh, V., Lodish, H. F., & Lim, B. (2009) · Genes & Development · doi:10.1101/gad.1767609 · Cited by 655

miR-15a and miR-16-1 in cancer: discovery, function and future perspectives

Aqeilan, R. I., Calin, G. A., & Croce, C. M. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2009.69 · Cited by 648

MicroRNA-101, Down-regulated in Hepatocellular Carcinoma, Promotes Apoptosis and Suppresses Tumorigenicity

Su, H., Yang, J.-R., Xu, T., Huang, J., Xu, L., Yuan, Y., & Zhuang, S.-M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2886 · Cited by 612

miR-29 miRNAs activate p53 by targeting p85α and CDC42

Park, S.-Y., Lee, J. H., Ha, M., Nam, J.-W., & Kim, V. N. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1533 · Cited by 606

MicroRNA Expression Profiling of Thyroid Tumors: Biological Significance and Diagnostic Utility

Nikiforova, M. N., Tseng, G. C., Steward, D., Diorio, D., & Nikiforov, Y. E. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2696 · Cited by 582

Effects of Microrna-29 on Apoptosis, Tumorigenicity, and Prognosis of Hepatocellular Carcinoma

Xiong, Y., Fang, J.-H., Yun, J.-P., Yang, J., Zhang, Y., Jia, W.-H., & Zhuang, S.-M. (2010) · Hepatology · doi:10.1002/hep.23380 · Cited by 563

BIM Mediates EGFR Tyrosine Kinase Inhibitor-Induced Apoptosis in Lung Cancers with Oncogenic EGFR Mutations

Costa, D. B., Halmos, B., Kumar, A., Schumer, S. T., Huberman, M. S., Boggon, T. J., Tenen, D. G., & Kobayashi, S. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040315 · Cited by 499

Structural requirements for pre-microRNA binding and nuclear export by Exportin 5

Zeng, Y. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh824 · Cited by 495

p53 Enters the MicroRNA World

Hermeking, H. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.10.028 · Cited by 494

MiR-34, SIRT1, and p53: The feedback loop

Yamakuchi, M., & Lowenstein, C. J. (2009) · Cell Cycle · doi:10.4161/cc.8.5.7753 · Cited by 468

An Epstein-Barr virus–encoded microRNA targets PUMA to promote host cell survival

Choy, E. Y.-W., Siu, K.-L., Kok, K.-H., Lung, R. W.-M., Tsang, C. M., To, K.-F., Kwong, D. L.-W., Tsao, S. W., & Jin, D.-Y. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072581 · Cited by 462

Distinct microRNA expression profiles in acute myeloid leukemia with common translocations

Li, Z., Lu, J., Sun, M., Mi, S., Zhang, H., Luo, R. T., Chen, P., Wang, Y., Yan, M., Qian, Z., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808266105 · Cited by 457

Processing of Pre-microRNAs by the Dicer-1–Loquacious Complex in Drosophila Cells

Saito, K., Ishizuka, A., Siomi, H., & Siomi, M. C. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030235 · Cited by 440

The 14-3-3 cancer connection

Hermeking, H. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1230 · Cited by 437

MicroRNA-125b Confers the Resistance of Breast Cancer Cells to Paclitaxel through Suppression of Pro-apoptotic Bcl-2 Antagonist Killer 1 (Bak1) Expression

Zhou, M., Liu, Z., Zhao, Y., Ding, Y., Liu, H., Xi, Y., Xiong, W., Li, G., Lu, J., Fodstad, O., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.083337 · Cited by 424

The transcriptional targets of p53 in apoptosis control

Yu, J., & Zhang, L. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.189 · Cited by 420

Apoptosis-based therapies for hematologic malignancies

Reed, J. C., & Pellecchia, M. (2005) · Blood · doi:10.1182/blood-2004-07-2761 · Cited by 402

MicroRNA-375 Is Downregulated in Gastric Carcinomas and Regulates Cell Survival by Targeting PDK1 and 14-3-3ζ

Tsukamoto, Y., Nakada, C., Noguchi, T., Tanigawa, M., Nguyen, L. T., Uchida, T., Hijiya, N., Matsuura, K., Fujioka, T., Seto, M., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2777 · Cited by 392

Antagomir-17-5p Abolishes the Growth of Therapy-Resistant Neuroblastoma through p21 and BIM

Fontana, L., Fiori, M. E., Albini, S., Cifaldi, L., Giovinazzi, S., Forloni, M., Boldrini, R., Donfrancesco, A., Federici, V., Giacomini, P., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002236 · Cited by 385

MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTEN

Chun-zhi, Z., Lei, H., An-ling, Z., Yan-chao, F., Xiao, Y., Guang-xiu, W., Zhi-fan, J., Pei-yu, P., Qing-yu, Z., & Chun-sheng, K. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-367 · Cited by 382

An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells

Shi, X.-B., Xue, L., Yang, J., Ma, A.-H., Zhao, J., Xu, M., Tepper, C. G., Evans, C. P., Kung, H.-J., & deVere White, R. W. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706641104 · Cited by 378

The Promyelocytic Leukemia Zinc Finger–MicroRNA-221/-222 Pathway Controls Melanoma Progression through Multiple Oncogenic Mechanisms

Felicetti, F., Errico, M. C., Bottero, L., Segnalini, P., Stoppacciaro, A., Biffoni, M., Felli, N., Mattia, G., Petrini, M., Colombo, M. P., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2538 · Cited by 377

Caspase substrates

Timmer, J. C., & Salvesen, G. S. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402059 · Cited by 376

Profiling MicroRNA Expression in Hepatocellular Carcinoma Reveals MicroRNA-224 Up-regulation and Apoptosis Inhibitor-5 as a MicroRNA-224-specific Target

Wang, Y., Lee, A. T. C., Ma, J. Z. I., Wang, J., Ren, J., Yang, Y., Tantoso, E., Li, K.-B., Ooi, L. L. P. J., Tan, P., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707629200 · Cited by 363

Role of microRNAs in drug-resistant ovarian cancer cells

Sorrentino, A., Liu, C.-G., Addario, A., Peschle, C., Scambia, G., & Ferlini, C. (2008) · Gynecologic Oncology · doi:10.1016/j.ygyno.2008.08.017 · Cited by 354

p53 — a Jack of all trades but master of none

Junttila, M. R., & Evan, G. I. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2728 · Cited by 345

MicroRNAs: Predictors and modifiers of chemo- and radiotherapy in different tumour types

Hummel, R., Hussey, D. J., & Haier, J. (2010) · European Journal of Cancer · doi:10.1016/j.ejca.2009.10.027 · Cited by 344

The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma

Shimizu, S., Takehara, T., Hikita, H., Kodama, T., Miyagi, T., Hosui, A., Tatsumi, T., Ishida, H., Noda, T., Nagano, H., et al. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2009.12.024 · Cited by 343

Gefitinib-Induced Killing of NSCLC Cell Lines Expressing Mutant EGFR Requires BIM and Can Be Enhanced by BH3 Mimetics

Cragg, M. S., Kuroda, J., Puthalakath, H., Huang, D. C. S., & Strasser, A. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040316 · Cited by 343

Bim and Bad mediate imatinib-induced killing of Bcr/Abl + leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic

Kuroda, J., Puthalakath, H., Cragg, M. S., Kelly, P. N., Bouillet, P., Huang, D. C. S., Kimura, S., Ottmann, O. G., Druker, B. J., Villunger, A., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606176103 · Cited by 336

Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications

Brown, B. D., & Naldini, L. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2628 · Cited by 336

Bcl2 family proteins in carcinogenesis and the treatment of cancer

Frenzel, A., Grespi, F., Chmelewskij, W., & Villunger, A. (2009) · Apoptosis · doi:10.1007/s10495-008-0300-z · Cited by 331

Effects of miR-34a on cell growth and chemoresistance in prostate cancer PC3 cells

Fujita, Y., Kojima, K., Hamada, N., Ohhashi, R., Akao, Y., Nozawa, Y., Deguchi, T., & Ito, M. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.09.086 · Cited by 331

MicroRNA-21 Is a Downstream Effector of AKT That Mediates Its Antiapoptotic Effects via Suppression of Fas Ligand

Sayed, D., He, M., Hong, C., Gao, S., Rane, S., Yang, Z., & Abdellatif, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.109207 · Cited by 315

MiR-221 and miR-222 target PUMA to induce cell survival in glioblastoma

Zhang, C.-Z., Zhang, J.-X., Zhang, A.-L., Shi, Z.-D., Han, L., Jia, Z.-F., Yang, W.-D., Wang, G.-X., Jiang, T., You, Y.-P., et al. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-229 · Cited by 314

miR‐181b modulates multidrug resistance by targeting BCL2 in human cancer cell lines

Zhu, W., Shan, X., Wang, T., Shu, Y., & Liu, P. (2010) · International Journal of Cancer · doi:10.1002/ijc.25260 · Cited by 299

Dysregulation of apoptotic signaling in cancer: Molecular mechanisms and therapeutic opportunities

Plati, J., Bucur, O., & Khosravi‐Far, R. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21707 · Cited by 293

microRNAs: Master Regulators as Potential Therapeutics in Cancer

Garofalo, M., & Croce, C. M. (2011) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010510-100517 · Cited by 291

MicroRNA signatures of TRAIL resistance in human non-small cell lung cancer

Garofalo, M., Quintavalle, C., Di Leva, G., Zanca, C., Romano, G., Taccioli, C., Liu, C. G., Croce, C. M., & Condorelli, G. (2008) · Oncogene · doi:10.1038/onc.2008.6 · Cited by 289

The miR-106b-25 Polycistron, Activated by Genomic Amplification, Functions as an Oncogene by Suppressing p21 and Bim

Kan, T., Sato, F., Ito, T., Matsumura, N., David, S., Cheng, Y., Agarwal, R., Paun, B. C., Jin, Z., Olaru, A. V., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.002 · Cited by 266

Control of protein synthesis and mRNA degradation by microRNAs

Liu, J. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.01.006 · Cited by 264

miR-122 targets an anti-apoptotic gene, Bcl-w, in human hepatocellular carcinoma cell lines

Lin, C. J.-F., Gong, H.-Y., Tseng, H.-C., Wang, W.-L., & Wu, J.-L. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.07.154 · Cited by 256

Mitochondria as the target of the pro-apoptotic protein Bax

Er, E., Oliver, L., Cartron, P.-F., Juin, P., Manon, S., & Vallette, F. M. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.05.032 · Cited by 251

miR-24 Regulates Apoptosis by Targeting the Open Reading Frame (ORF) Region of FAF1 in Cancer Cells

Qin, W., Shi, Y., Zhao, B., Yao, C., Jin, L., Ma, J., & Jin, Y. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009429 · Cited by 247

Let-7a microRNA suppresses therapeutics-induced cancer cell death by targeting caspase-3

Tsang, W. P., & Kwok, T. T. (2008) · Apoptosis · doi:10.1007/s10495-008-0256-z · Cited by 247

Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration

Muñoz-Pinedo, C., Guío-Carrión, A., Goldstein, J. C., Fitzgerald, P., Newmeyer, D. D., & Green, D. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603007103 · Cited by 246

Pharmacological manipulation of cell death: clinical applications in sight?

Green, D. R. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26321 · Cited by 242

Oncogenic HPV infection interrupts the expression of tumor-suppressive miR-34a through viral oncoprotein E6

Wang, X., Wang, H.-K., McCoy, J. P., Banerjee, N. S., Rader, J. S., Broker, T. R., Meyers, C., Chow, L. T., & Zheng, Z.-M. (2009) · RNA · doi:10.1261/rna.1442309 · Cited by 237

Role of microRNA in anticancer drug resistance

Zheng, T., Wang, J., Chen, X., & Liu, L. (2010) · International Journal of Cancer · doi:10.1002/ijc.24782 · Cited by 233

MicroRNA-181a sensitizes human malignant glioma U87MG cells to radiation by targeting Bcl-2

Hu (2010) · Oncology Reports · doi:10.3892/or_00000725 · Cited by 232

Genome-Scale MicroRNA and Small Interfering RNA Screens Identify Small RNA Modulators of TRAIL-Induced Apoptosis Pathway

Ovcharenko, D., Kelnar, K., Johnson, C., Leng, N., & Brown, D. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1484 · Cited by 224

Curcumin reduces the expression of Bcl-2 by upregulating miR-15a and miR-16 in MCF-7 cells

Yang, J., Cao, Y., Sun, J., & Zhang, Y. (2010) · Medical Oncology · doi:10.1007/s12032-009-9344-3 · Cited by 219

Implication of microRNAs in drug resistance for designing novel cancer therapy

Sarkar, F. H., Li, Y., Wang, Z., Kong, D., & Ali, S. (2010) · Drug Resistance Updates · doi:10.1016/j.drup.2010.02.001 · Cited by 215

Oncogenic Role of miR-483-3p at the IGF2/483 Locus

Veronese, A., Lupini, L., Consiglio, J., Visone, R., Ferracin, M., Fornari, F., Zanesi, N., Alder, H., D'Elia, G., Gramantieri, L., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4456 · Cited by 210

microRNA-195 promotes apoptosis and suppresses tumorigenicity of human colorectal cancer cells

Liu, L., Chen, L., Xu, Y., Li, R., & Du, X. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.08.046 · Cited by 203

MicroRNA‐143 reduces viability and increases sensitivity to 5‐fluorouracil in HCT116 human colorectal cancer cells

Borralho, P. M., Kren, B. T., Castro, R. E., Moreira da Silva, I. B., Steer, C. J., & Rodrigues, C. M. P. (2009) · The FEBS Journal · doi:10.1111/j.1742-4658.2009.07383.x · Cited by 195

Bid, a BH3-only multi-functional molecule, is at the cross road of life and death

Yin, X.-M. (2006) · Gene · doi:10.1016/j.gene.2005.10.038 · Cited by 187

MicroRNA 133B targets pro-survival molecules MCL-1 and BCL2L2 in lung cancer

Crawford, M., Batte, K., Yu, L., Wu, X., Nuovo, G. J., Marsh, C. B., Otterson, G. A., & Nana-Sinkam, S. P. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.07.143 · Cited by 176

microRNA-143, down-regulated in osteosarcoma, promotes apoptosis and suppresses tumorigenicity by targeting Bcl-2

Ji (2010) · Oncology Reports · doi:10.3892/or_00000994 · Cited by 175

Tumour suppression by p53: the importance of apoptosis and cellular senescence

Zuckerman, V., Wolyniec, K., Sionov, R. V., Haupt, S., & Haupt, Y. (2009) · The Journal of Pathology · doi:10.1002/path.2584 · Cited by 170

MicroRNA Signature of Malignant Mesothelioma with Potential Diagnostic and Prognostic Implications

Busacca, S., Germano, S., De Cecco, L., Rinaldi, M., Comoglio, F., Favero, F., Murer, B., Mutti, L., Pierotti, M., & Gaudino, G. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2009-0060oc · Cited by 167

mir-200c Regulates Induction of Apoptosis through CD95 by Targeting FAP-1

Schickel, R., Park, S.-M., Murmann, A. E., & Peter, M. E. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.018 · Cited by 167

miR‐34c is downregulated in prostate cancer and exerts tumor suppressive functions

Hagman, Z., Larne, O., Edsjö, A., Bjartell, A., Ehrnström, R. A., Ulmert, D., Lilja, H., & Ceder, Y. (2010) · International Journal of Cancer · doi:10.1002/ijc.25269 · Cited by 162

Tumor microRNA expression patterns associated with resistance to platinum based chemotherapy and survival in ovarian cancer patients

Eitan, R., Kushnir, M., Lithwick-Yanai, G., David, M. B., Hoshen, M., Glezerman, M., Hod, M., Sabah, G., Rosenwald, S., & Levavi, H. (2009) · Gynecologic Oncology · doi:10.1016/j.ygyno.2009.04.024 · Cited by 161

Proapoptotic BH3-Only BCL-2 Family Protein BIM Connects Death Signaling from Epidermal Growth Factor Receptor Inhibition to the Mitochondrion

Deng, J., Shimamura, T., Perera, S., Carlson, N. E., Cai, D., Shapiro, G. I., Wong, K.-K., & Letai, A. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1961 · Cited by 158

Roles of Bim in Apoptosis of Normal and Bcr-Abl-Expressing Hematopoietic Progenitors

Kuribara, R., Honda, H., Matsui, H., Shinjyo, T., Inukai, T., Sugita, K., Nakazawa, S., Hirai, H., Ozawa, K., & Inaba, T. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.14.6172-6183.2004 · Cited by 156

hsa-miR-29c* Is Linked to the Prognosis of Malignant Pleural Mesothelioma

Pass, H. I., Goparaju, C. M. V., Ivanov, S. V., Donington, J. S., Carbone, M., Hoshen, M., Cohen, D., Chajut, A., Rosenwald, S., Dan, H., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3993 · Cited by 152

Functional Identification of Api5 as a Suppressor of E2F-Dependent Apoptosis In Vivo

Morris, E. J., Michaud, W. A., Ji, J., Moon, N.-S., Rocco, J. W., & Dyson, N. J. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020196 · Cited by 143

Curcumin promotes apoptosis in human lung adenocarcinoma cells through miR-186* signaling pathway

Zhang (2010) · Oncology Reports · doi:10.3892/or_00000975 · Cited by 141

Functional screening identifies a microRNA, miR‐491 that induces apoptosis by targeting Bcl‐XL in colorectal cancer cells

Nakano, H., Miyazawa, T., Kinoshita, K., Yamada, Y., & Yoshida, T. (2009) · International Journal of Cancer · doi:10.1002/ijc.25143 · Cited by 136

miR-212 Increases Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Sensitivity in Non–Small Cell Lung Cancer by Targeting the Antiapoptotic Protein PED

Incoronato, M., Garofalo, M., Urso, L., Romano, G., Quintavalle, C., Zanca, C., Iaboni, M., Nuovo, G., Croce, C. M., & Condorelli, G. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3341 · Cited by 136

Pharmacological manipulation of Bcl-2 family members to control cell death

Letai, A. G. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26250 · Cited by 134

Classic and novel roles of p53: prospects for anticancer therapy

Fuster, J. J., Sanz-Gonzalez, S. M., Moll, U. M., & Andrés, V. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.03.002 · Cited by 128

Derepression of MicroRNA-mediated Protein Translation Inhibition by Apolipoprotein B mRNA-editing Enzyme Catalytic Polypeptide-like 3G (APOBEC3G) and Its Family Members

Huang, J., Liang, Z.-H., Yang, B., Tian, H., Ma, J., & Zhang, H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705116200 · Cited by 128

Downregulations of B‐cell lymphoma 2 and myeloid cell leukemia sequence 1 by microRNA 153 induce apoptosis in a glioblastoma cell line DBTRG‐05MG

Xu, J., Liao, X., & Wong, C. (2009) · International Journal of Cancer · doi:10.1002/ijc.24823 · Cited by 119

microRNA-24a is required to repress apoptosis in the developing neural retina

McGann, J. C., & Harland, R. M. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.05.197 · Cited by 119

miR-149* induces apoptosis by inhibiting Akt1 and E2F1 in human cancer cells

Lin, R., Lin, Y.-C., & Yu, A. L.-T. (2010) · Molecular Carcinogenesis · doi:10.1002/mc.20647 · Cited by 118

Hepatitis C Virus Proteins Modulate MicroRNA Expression and Chemosensitivity in Malignant Hepatocytes

Braconi, C., Valeri, N., Gasparini, P., Huang, N., Taccioli, C., Nuovo, G. J., Suzuki, T., Croce, C. M., & Patel, T. C. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-2123 · Cited by 117

Inhibition of virus-induced neuronal apoptosis by Bax

Lewis, J. J., Oyler, G. A., Ueno, K., et al. (1999) · Nature Medicine · doi:10.1038/10556 · Cited by 108

Targeting p53 to mitochondria for cancer therapy

Galluzzi, L., Morselli, E., Kepp, O., Tajeddine, N., & Kroemer, G. (2008) · Cell Cycle · doi:10.4161/cc.7.13.6222 · Cited by 106

microRNA-Mediated Silencing Inside P Bodies

Chan, S., & Slack, F. J. (2006) · RNA Biology · doi:10.4161/rna.3.3.3499 · Cited by 101

High expression of microRNA-15b predicts a low risk of tumor recurrence following curative resection of hepatocellular carcinoma

Yoon (2009) · Oncology Reports · doi:10.3892/or_00000612 · Cited by 100

Follicular dendritic cell–dependent drug resistance of non-Hodgkin lymphoma involves cell adhesion–mediated Bim down-regulation through induction of microRNA-181a

Lwin, T., Lin, J., Choi, Y. S., Zhang, X., Moscinski, L. C., Wright, K. L., Sotomayor, E. M., Dalton, W. S., & Tao, J. (2010) · Blood · doi:10.1182/blood-2010-03-275925 · Cited by 96

Discovery, biology and therapeutic potential of RNA interference, microRNA and antagomirs

Yang, M., & Mattes, J. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.08.004 · Cited by 88

14-3-3ζ Down-regulates p53 in Mammary Epithelial Cells and Confers Luminal Filling

Danes, C. G., Wyszomierski, S. L., Lü, J., Neal, C. L., Yang, W., & Yu, D. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-3177 · Cited by 85

MicroRNA-128 downregulates Bax and induces apoptosis in human embryonic kidney cells

Adlakha, Y. K., & Saini, N. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0528-y · Cited by 84

Inhibition of c-FLIP expression by miR-512-3p contributes to Taxol-induced apoptosis in hepatocellular carcinoma cells

Chen (2010) · Oncology Reports · doi:10.3892/or_00000784 · Cited by 78

Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activation

París, R., Henry, R. E., Stephens, S. J., McBryde, M., & Espinosa, J. M. (2008) · Cell Cycle · doi:10.4161/cc.6420 · Cited by 62

Cellular FLICE-like inhibitory protein (c-FLIP): A novel target for Taxol-induced apoptosis

Day, T. W., Najafi, F., Wu, C., & Safa, A. R. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.02.015 · Cited by 61

Not miR-ly small RNAs: Big potential for microRNAs in therapy

Love, T. M., Moffett, H. F., & Novina, C. D. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.12.1167 · Cited by 60

Apoptomirs: small molecules have gained the license to kill

Vecchione, A. M., & Croce, C. M. (2009) · Endocrine Related Cancer · doi:10.1677/erc-09-0163 · Cited by 58

P-Bodies React to Stress and Nonsense

Bruno, I., & Wilkinson, M. (2006) · Cell · doi:10.1016/j.cell.2006.06.003 · Cited by 45

miR signatures and the role of miRs in acute myeloid leukaemia

Seca, H., Almeida, G. M., Guimarães, J. E., & Vasconcelos, M. H. (2010) · European Journal of Cancer · doi:10.1016/j.ejca.2010.03.031 · Cited by 35

miRNAs modulate the drug response of tumor cells

Wu, X., & Xiao, H. (2009) · Science in China Series C Life Sciences · doi:10.1007/s11427-009-0114-4 · Cited by 28

Regulation of pro-apoptotic BH3-only proteins and its contribution to cancer progression and chemoresistance

Fernández-Luna, J. L. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.04.015 · Cited by 26

Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis

Ouyang, L., Shi, Z., Zhao, S., Wang, F. ‐., Zhou, T. ‐., Liu, B., & Bao, J. ‐. (2012) · Cell Proliferation · doi:10.1111/j.1365-2184.2012.00845.x · Cited by 1,452

Apoptosis, autophagy, necroptosis, and cancer metastasis

Su, Z., Yang, Z., Xu, Y., Chen, Y., & Yu, Q. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0321-5 · Cited by 1,042

The mystery of BCL2 family: Bcl-2 proteins and apoptosis: an update

Siddiqui, W. A., Ahad, A., & Ahsan, H. (2015) · Archives of Toxicology · doi:10.1007/s00204-014-1448-7 · Cited by 696

MicroRNA regulation by RNA-binding proteins and its implications for cancer

van Kouwenhove, M., Kedde, M., & Agami, R. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3107 · Cited by 617

Molecular Mechanisms of Apoptosis and Roles in Cancer Development and Treatment

Goldar, S., Khaniani, M. S., Derakhshan, S. M., & Baradaran, B. (2015) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2015.16.6.2129 · Cited by 606