Astrocyte-derived extracellular vesicles: Neuroreparative properties and role in the pathogenesis of neurodegenerative disorders

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin‐Smith, G. K., et al. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1535750 · Cited by 11,099

Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework

Biomarkers Definitions Working Group (2001) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2001.113989 · Cited by 6,771

Astrocyte-endothelial interactions at the blood-brain barrier

Abbott, N. J., Rönnbäck, L., & Hansson, E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1824 · Cited by 5,595

Astrocytes: Biology and pathology

Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196

Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*

Pearson, G. W., Robinson, F. L., Gibson, T. B., Xu, B.-E., Karandikar, M. S., Berman, K. S., & Cobb, M. H. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.2.0428 · Cited by 4,111

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

Trajković, K., Hsu, C., Chiantia, S., Rajendran, L., Wenzel, D., Wieland, F., Schwille, P., Brügger, B., & Simons, M. (2008) · Science · doi:10.1126/science.1153124 · Cited by 3,760

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

Kowal, J., Arras, G., Colombo, M., Jouve, M., Morath, J. P., Primdal-Bengtson, B., Dingli, F., Loew, D., Tkach, M., & Théry, C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521230113 · Cited by 3,426

Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate

Rothstein, J. D., Dykes-Hoberg, M., Pardo, C. A., Bristol, L. A., Jin, L., Kuncl, R. W., Kanai, Y., Hediger, M. A., Wang, Y., Schielke, J. P., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80086-0 · Cited by 2,534

Long Noncoding RNAs: Cellular Address Codes in Development and Disease

Batista, P. J., & Chang, H. Y. (2013) · Cell · doi:10.1016/j.cell.2013.02.012 · Cited by 2,531

Tripartite synapses: glia, the unacknowledged partner

Araque, A., Parpura, V., Sanzgiri, R. P., & Haydon, P. G. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01349-6 · Cited by 2,529

Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the international society for extracellular vesicles.

Lötvall, J., Hill, A. F., Hochberg, F., Buzás, E. I., Di Vizio, D., Gardiner, C., Gho, Y. S., Kurochkin, I. V., Mathivanan, S., Quesenberry, P., et al. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.26913 · Cited by 2,451

Reactive Astrocytes: Production, Function, and Therapeutic Potential

Liddelow, S. A., & Barres, B. A. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.006 · Cited by 2,336

Astrocytes, from brain glue to communication elements: the revolution continues

Volterra, A., & Meldolesi, J. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1722 · Cited by 1,837

Localization of neuronal and glial glutamate transporters

Rothstein, J. D., Martin, L. J., Levey, A. I., Dykes‐Hoberg, M., Jin, L., Wu, D. M., Nash, N. R., & Kuncl, R. W. (1994) · Neuron · doi:10.1016/0896-6273(94)90038-8 · Cited by 1,703

HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine

Asea, A. A. A., Kraeft, S., Kurt‐Jones, E. A., Stevenson, M. A., Chen, L. B., Finberg, R. W., Koo, G. C., & Calderwood, S. K. (2000) · Nature Medicine · doi:10.1038/74697 · Cited by 1,642

Protoplasmic Astrocytes in CA1 Stratum Radiatum Occupy Separate Anatomical Domains

Bushong, E. A., Martone, M. E., Jones, Y. Z., & Ellisman, M. H. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00183.2002 · Cited by 1,578

Novel Signal Transduction Pathway Utilized by Extracellular HSP70

Asea, A., Rehli, M., Kabingu, E., Boch, J. A., Baré, O., Auron, P. E., Stevenson, M. A., & Calderwood, S. K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200497200 · Cited by 1,510

Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies

Akers, J. C., Gonda, D., Kim, R., Carter, B. S., & Chen, C. C. (2013) · Journal of Neuro-Oncology · doi:10.1007/s11060-013-1084-8 · Cited by 1,423

Astrocyte glutamate transport: Review of properties, regulation, and physiological functions

Anderson, C. M., & Swanson, R. A. (2000) · Glia · doi:10.1002/1098-1136(200010)32:1 · Cited by 1,241

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

Nagai, M., Re, D. B., Nagata, T., Chalazonitis, A., Jessell, T. M., Wichterle, H., & Przedborski, S. (2007) · Nature Neuroscience · doi:10.1038/nn1876 · Cited by 1,220

Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes

Tauro, B. J., Greening, D. W., Mathias, R. A., Ji, H. L., Mathivanan, S., Scott, A. M., & Simpson, R. J. (2012) · Methods · doi:10.1016/j.ymeth.2012.01.002 · Cited by 1,214

Astrocyte barriers to neurotoxic inflammation

Sofroniew, M. V. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3898 · Cited by 1,202

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

Yun, S. P., Kam, T.-I., Panicker, N., Kim, S., Oh, Y., Park, J.-S., Kwon, S.-H., Park, Y. J., Karuppagounder, S. S., Park, H., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0051-5 · Cited by 1,123

TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia

Mackenzie, I. R., Rademakers, R., & Neumann, M. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70195-2 · Cited by 1,012

Biological Roles of Fibroblast Growth Factor-2

Bikfalvi, A., Klein, S., Pintucci, G., & Rifkin, D. B. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.1.0292 · Cited by 962

HSP70 as Endogenous Stimulus of the Toll/Interleukin-1 Receptor Signal Pathway

Vabulas, R. M., Ahmad‐Nejad, P., Ghose, S., Kirschning, C. J., Issels, R. D., & Wagner, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111204200 · Cited by 956

The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis

van Niel, G., Charrin, S., Simoes, S., Romao, M., Rochin, L., Saftig, P., Marks, M. S., Rubinstein, E., & Raposo, G. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.08.019 · Cited by 950

Adult mouse astrocytes degrade amyloid-β in vitro and in situ

Wyss-Coray, T., Loike, J. D., Brionne, T. C., Lu, E., Anankov, R., Yan, F., Silverstein, S. C., & Husemann, J. (2003) · Nature Medicine · doi:10.1038/nm838 · Cited by 909

Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

Frühbeis, C., Fröhlich, D., Kuo, W. P., Amphornrat, J., Thilemann, S., Saab, A. S., Kirchhoff, F., Möbius, W., Goebbels, S., Nave, K.-A., et al. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001604 · Cited by 902

Biogenesis and function of extracellular vesicles in cancer

Bebelman, M. P., Smit, M. J., Pegtel, D. M., & Baglio, S. R. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.02.013 · Cited by 843

Complement activation by beta-amyloid in Alzheimer disease.

Rogers, J., Cooper, N. R., Webster, S., Schultz, J., McGeer, P. L., Styren, S. D., Civin, W. H., Brachova, L., Bradt, B., & Ward, P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10016 · Cited by 817

Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression

Doeppner, T. R., Herz, J., Görgens, A., Schlechter, J., Ludwig, A., Radtke, S., de Miroschedji, K., Horn, P. A., Giebel, B., & Hermann, D. M. (2015) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0078 · Cited by 789

Synaptic Islands Defined by the Territory of a Single Astrocyte

Halassa, M. M., Fellin, T., Takano, H., Dong, J.-H., & Haydon, P. G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1419-07.2007 · Cited by 767

Sorting it out: Regulation of exosome loading

Villarroya‐Beltri, C., Baixauli, F., Gutiérrez‐Vázquez, C., Sánchez‐Madrid, F., & Mittelbrunn, M. (2014) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2014.04.009 · Cited by 766

Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein

Nabhan, J. F., Hu, R., Oh, R. S., Cohen, S. N., & Lu, Q. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200448109 · Cited by 763

Trafficking and function of the tetraspanin CD63

Pols, M. S., & Klumperman, J. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.09.020 · Cited by 745

Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury

Zhang, Y., Chopp, M., Meng, Y., Katakowski, M., Xin, H., Mahmood, A., & Xiong, Y. (2015) · Journal of neurosurgery · doi:10.3171/2014.11.jns14770 · Cited by 737

HIV-associated neurocognitive disorder

Clifford, D. B., & Ances, B. M. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70269-x · Cited by 698

ESCRTs are everywhere

Hurley, J. H. (2015) · The EMBO Journal · doi:10.15252/embj.201592484 · Cited by 686

Astrocytes and Glioblastoma cells release exosomes carrying mtDNA

Guescini, M., Genedani, S., Stocchi, V., & Agnati, L. F. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0288-8 · Cited by 662

`The stress of dying': the role of heat shock proteins in the regulation of apoptosis

Beere, H. M. (2004) · Journal of Cell Science · doi:10.1242/jcs.01284 · Cited by 638

Acid sphingomyelinase activity triggers microparticle release from glial cells

Bianco, F., Perrotta, C., Novellino, L., Francolini, M., Riganti, L., Menna, E., Saglietti, L., Schuchman, E. H., Furlan, R., Clementi, E., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.45 · Cited by 615

Exosomes in bodily fluids are a highly stable resource of disease biomarkers

Boukouris, S., & Mathivanan, S. (2015) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201400114 · Cited by 598

The Intracellular Interactome of Tetraspanin-enriched Microdomains Reveals Their Function as Sorting Machineries toward Exosomes

Pérez-Hernández, D., Gutiérrez‐Vázquez, C., Jorge, I., López‐Martín, S., Ursa, Á., Sánchez‐Madrid, F., Vázquez, J., & Yáñez‐Mó, M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.445304 · Cited by 554

Synapsins as Regulators of Neurotransmitter Release

Hilfiker, S., Pieribone, V. A., Czernik, A. J., Kao, H.-T., Augustine, G. J., & Greengard, P. (1999) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1999.0378 · Cited by 537

ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion

Huang, Y.-W. A., Zhou, B., Wernig, M., & Südhof, T. C. (2017) · Cell · doi:10.1016/j.cell.2016.12.044 · Cited by 528

Required growth facilitators propel axon regeneration across complete spinal cord injury

Anderson, M. A., O’Shea, T. M., Burda, J. E., Ao, Y., Barlatey, S. L., Bernstein, A. M., Kim, J. H., James, N. D., Rogers, A. D., Kato, B., et al. (2018) · Nature · doi:10.1038/s41586-018-0467-6 · Cited by 528

Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses

Beg, A. A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02317-7 · Cited by 496

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

Dinkins, M. B., Dasgupta, S., Wang, G., Zhu, G., & Bieberich, E. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.02.012 · Cited by 494

Biological Roles of Fibroblast Growth Factor-2

Bikfalvi, A. (1997) · Endocrine Reviews · doi:10.1210/er.18.1.26 · Cited by 465

Mechanisms of Long Non-coding RNAs in Mammalian Nervous System Development, Plasticity, Disease, and Evolution

Briggs, J., Wolvetang, E. J., Mattick, J. S., Rinn, J. L., & Barry, G. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.045 · Cited by 456

Immunoglobulins and complement factors in senile plaques: An immunoperoxidase study

Eikelenboom, P., & Stam, F. C. (1982) · Acta Neuropathologica · doi:10.1007/bf00685397 · Cited by 454

Chromatographically isolated CD63 + CD81 + extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI

Kim, D.-K., Nishida, H., An, S. Y., Shetty, A. K., Bartosh, T. J., & Prockop, D. J. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522297113 · Cited by 436

Stress management – heat shock protein-70 and the regulation of apoptosis

Beere, H. M. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01874-2 · Cited by 435

Extracellular vesicles in neurodegenerative disease — pathogenesis to biomarkers

Thompson, A. G., Gray, E., Heman-Ackah, S. M., Mäger, I., Talbot, K., Andaloussi, S. E., Wood, M. J., & Turner, M. R. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.68 · Cited by 431

Human astrocytes: structure and functions in the healthy brain

Vasile, F., Dossi, E., & Rouach, N. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1383-5 · Cited by 428

A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord

Kaneko, S., Iwanami, A., Nakamura, M., Kishino, A., Kikuchi, K. M., Shibata, S., Okano, H. J., Ikegami, T., Moriya, A., Konishi, O., et al. (2006) · Nature Medicine · doi:10.1038/nm1505 · Cited by 413

Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus

Long, Q., Upadhya, D., Hattiangady, B., Kim, D.-K., An, S. Y., Shuai, B., Prockop, D. J., & Shetty, A. K. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1703920114 · Cited by 405

Astrocytes as secretory cells of the central nervous system: idiosyncrasies of vesicular secretion

Verkhratsky, A., Matteoli, M., Parpura, V., Mothet, J., & Zorec, R. (2016) · The EMBO Journal · doi:10.15252/embj.201592705 · Cited by 397

Exosomes derived from hypoxia-preconditioned mesenchymal stromal cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory responses in APP/PS1 mice

Cui, G., Wu, J., Mou, F., Xie, W., Wang, F., Wang, Q., Fang, J., Xu, Y., Dong, Y., Liu, J., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201700600r · Cited by 387

Cargo proteins of plasma astrocyte‐derived exosomes in Alzheimer's disease

Goetzl, E. J., Mustapic, M., Kapogiannis, D., Eitan, E., Lobach, I. V., Goetzl, L., Schwartz, J. B., & Miller, B. L. (2016) · The FASEB Journal · doi:10.1096/fj.201600756r · Cited by 386

Vascular endothelial growth factor: a neurovascular target in neurological diseases

Lange, C. M., Storkebaum, E., de Almodóvar, C. R., Dewerchin, M. A., & Carmeliet, P. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.88 · Cited by 384

TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets

Scotter, E. L., Chen, H.-J., & Shaw, C. E. (2015) · Neurotherapeutics · doi:10.1007/s13311-015-0338-x · Cited by 382

High complement levels in astrocyte‐derived exosomes of Alzheimer disease

Goetzl, E. J., Schwartz, J. B., Abner, E. L., Jicha, G. A., & Kapogiannis, D. (2018) · Annals of Neurology · doi:10.1002/ana.25172 · Cited by 373

Mechanisms of Glutamate Transport

Vandenberg, R. J., & Ryan, R. M. (2013) · Physiological Reviews · doi:10.1152/physrev.00007.2013 · Cited by 367

CD40, an extracellular receptor for binding and uptake of Hsp70–peptide complexes

Becker, T., Hartl, F. U., & Wieland, F. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200208083 · Cited by 356

Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural‐derived blood exosomes of preclinical Alzheimer's disease

Kapogiannis, D., Boxer, A. L., Schwartz, J. B., Abner, E. L., Biragyn, A., Masharani, U. B., Frassetto, L. A., Petersen, R. C., Miller, B. L., & Goetzl, E. J. (2014) · The FASEB Journal · doi:10.1096/fj.14-262048 · Cited by 345

Microglial activation and amyloid‐β clearance induced by exogenous heat‐shock proteins

Kakimura, J., Kitamura, Y., Takata, K., Umeki, M., Suzuki, S., Shibagaki, K., Taniguchi, T., Nomura, Y., Gebicke‐Haerter, P. J., Smith, M. A., et al. (2002) · The FASEB Journal · doi:10.1096/fj.01-0530fje · Cited by 333

TDP-43 is intercellularly transmitted across axon terminals

Feiler, M. S., Strobel, B., Freischmidt, A., Helferich, A. M., Kappel, J., Brewer, B. M., Li, D., Thal, D. R., Walther, P., Ludolph, A. C., et al. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201504057 · Cited by 329

Short-term synaptic plasticity is altered in mice lacking synapsin I

Rosahl, T. (1993) · Cell · doi:10.1016/0092-8674(93)90487-b · Cited by 328

Up-Regulated Production and Activation of the Complement System in Alzheimer's Disease Brain

Yasojima, K., Schwab, C., McGeer, E. G., & McGeer, P. L. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65340-0 · Cited by 328

Stem/progenitor cell proliferation factors FGF‐2, IGF‐1, and VEGF exhibit early decline during the course of aging in the hippocampus: Role of astrocytes

Shetty, A. K., Hattiangady, B., & Shetty, G. A. (2005) · Glia · doi:10.1002/glia.20187 · Cited by 325

Synapsin I Is an Oligomannose-Carrying Glycoprotein, Acts As an Oligomannose-Binding Lectin, and Promotes Neurite Outgrowth and Neuronal Survival When Released via Glia-Derived Exosomes

Wang, S., Cesca, F., Loers, G., Schweizer, M., Buck, F., Benfenati, F., Schachner, M., & Kleene, R. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6476-10.2011 · Cited by 324

Mutant Copper-Zinc Superoxide Dismutase (SOD1) Induces Protein Secretion Pathway Alterations and Exosome Release in Astrocytes

Basso, M., Pozzi, S., Tortarolo, M., Fiordaliso, F., Bisighini, C., Pasetto, L., Spaltro, G., Lidonnici, D., Gensano, F., Battaglia, E., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.425066 · Cited by 295

Interaction of Cellular Prion and Stress-Inducible Protein 1 Promotes Neuritogenesis and Neuroprotection by Distinct Signaling Pathways

Lopes, M. H., Hajj, G. N. M., Muras, A. G., Mancini, G. L., Castro, R. M. R. P. S., Ribeiro, K. B., Brentani, H., Linden, R., & Martins, V. R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2313-05.2005 · Cited by 286

Exosomes as nucleic acid nanocarriers

van den Boorn, J. G., Daßler, J., Coch, C., Schlee, M., & Hartmann, G. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.06.011 · Cited by 285

Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions

Dickens, A. M., Tovar-y-Romo, L. B., Yoo, S.-W., Trout, A. L., Bae, M., Kanmogne, M., Megra, B., Williams, D. W., Witwer, K. W., Gacias, M., et al. (2017) · Science Signaling · doi:10.1126/scisignal.aai7696 · Cited by 285

Voltage‐dependent ion channels in glial cells

Sontheimer, H. W. (1994) · Glia · doi:10.1002/glia.440110210 · Cited by 274

Mesenchymal stem cell-derived extracellular vesicles ameliorate inflammation-induced preterm brain injury

Drommelschmidt, K., Serdar, M., Bendix, I., Herz, J., Bertling, F., Prager, S., Keller, M., Ludwig, A., Duhan, V., Radtke, S., et al. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.11.011 · Cited by 273

Vascular endothelial growth factors (VEGFs) and stroke

Greenberg, D. A., & Jin, K. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1282-8 · Cited by 269

Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons

Söllvander, S., Nikitidou, E., Brolin, R., Söderberg, L., Sehlin, D., Lannfelt, L., & Erlandsson, A. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0098-z · Cited by 267

Fibroblast Growth Factor-2 Signaling in Neurogenesis and Neurodegeneration

Woodbury, M. E., & Ikezu, T. (2014) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9501-5 · Cited by 266

Regulation of heat shock protein 70 release in astrocytes: Role of signaling kinases

Taylor, A. R., Robinson, M., Gifondorwa, D. J., Tytell, M., & Milligan, C. E. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20559 · Cited by 261

Aging does not alter the number or phenotype of putative stem/progenitor cells in the neurogenic region of the hippocampus

Hattiangady, B., & Shetty, A. K. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.09.015 · Cited by 258

LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF‐κB activation

Verweij, F. J., van Eijndhoven, M. A. J., Hopmans, E. S., Vendrig, T., Würdinger, T., Cahir-McFarland, E. D., Kieff, E. D., Geerts, D., van der Kant, R., Neefjes, J., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.123 · Cited by 236

Apolipoprotein D is involved in the mechanisms regulating protection from oxidative stress

Ganfornina, M. D., Carmo, S. D., Lora, J. M., Torres‐Schumann, S., Vogel, M., Allhorn, M., González, C., Bastiani, M. J., Rassart, É., & Sánchez, D. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00395.x · Cited by 225

Human Neural Stem Cell Extracellular Vesicles Improve Recovery in a Porcine Model of Ischemic Stroke

Webb, R. L., Kaiser, E. E., Jurgielewicz, B. J., Spellicy, S. E., Scoville, S. L., Thompson, T. A., Swetenburg, R. L., Hess, D. C., West, F. D., & Stice, S. L. (2018) · Stroke · doi:10.1161/strokeaha.117.020353 · Cited by 219

Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72-ALS/FTD

Westergard, T., Jensen, B. K., Wen, X., Cai, J., Kropf, E., Iacovitti, L., Pasinelli, P., & Trotti, D. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.032 · Cited by 213

Extracellular Vesicles: Multimodal Envoys in Neural Maintenance and Repair

Holm, M. M., Kaiser, J., & Schwab, M. E. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.03.006 · Cited by 213

Exosome-mediated shuttling of microRNA-29 regulates HIV Tat and morphine-mediated Neuronal dysfunction

Hu, G., Yao, H., Chaudhuri, A. D., Duan, M., Yelamanchili, S. V., Wen, H., Cheney, P. D., Fox, H. S., & Buch, S. J. (2012) · Cell Death and Disease · doi:10.1038/cddis.2012.114 · Cited by 206

Dysregulation of astrocyte–motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis

Ferraiuolo, L., Higginbottom, A., Heath, P. R., Barber, S. C., Greenald, D., Kirby, J., & Shaw, P. J. (2011) · Brain · doi:10.1093/brain/awr193 · Cited by 204

Sphingolipid Metabolism and Neutral Sphingomyelinases

Airola, M. V., & Hannun, Y. A. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-7091-1368-4_3 · Cited by 194

Interaction of Heat Shock Protein 70 Peptide with NK Cells Involves the NK Receptor CD94

Groß, C. C., Hansch, D., Gastpar, R., & Multhoff, G. (2003) · Biological Chemistry · doi:10.1515/bc.2003.030 · Cited by 194

Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS

Varcianna, A., Myszczynska, M. A., Castelli, L. M., O'Neill, B., Kim, Y., Talbot, J., Nyberg, S., Nyamali, I., Heath, P. R., Stopford, M. J., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2018.11.067 · Cited by 194

Neuroimmune Crosstalk through Extracellular Vesicles in Health and Disease

Delpech, J.-C., Herron, S., Botros, M. B., & Ikezu, T. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.02.007 · Cited by 193

Exposure to ALS-FTD-CSF generates TDP-43 aggregates in glioblastoma cells through exosomes and TNTs-like structure

Ding, X., Ma, M., Teng, J., Teng, R. K. F., Zhou, S. Y., Yin, J., Fonkem, E., Huang, J. H., Wu, E., & Wang, X. (2015) · Oncotarget · doi:10.18632/oncotarget.4680 · Cited by 186

Neural stem cell derived extracellular vesicles: Attributes and prospects for treating neurodegenerative disorders

Vogel, A. D., Upadhya, R., & Shetty, A. K. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.11.026 · Cited by 186

Endurance exercise regimens induce differential effects on brain-derived neurotrophic factor, synapsin-I and insulin-like growth factor I after focal ischemia

Ploughman, M., Granter‐Button, S., Chernenko, G. A., Tucker, B. A., Mearow, K. M., & Corbett, D. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.037 · Cited by 184

Improvement of neuronal cell survival by astrocyte‐derived exosomes under hypoxic and ischemic conditions depends on prion protein

Guitart, K., Loers, G., Buck, F., Bork, U., Schachner, M., & KLEENE, R. B. (2016) · Glia · doi:10.1002/glia.22963 · Cited by 184

TNFα and IL-1β modify the miRNA cargo of astrocyte shed extracellular vesicles to regulate neurotrophic signaling in neurons

Chaudhuri, A. D., Dastgheyb, R. M., Yoo, S.-W., Trout, A., Talbot Jr, C. C., Hao, H., Witwer, K. W., & Haughey, N. J. (2018) · Cell Death & Disease · doi:10.1038/s41419-018-0369-4 · Cited by 184

New windows into the brain: Central nervous system-derived extracellular vesicles in blood

Shi, M., Sheng, L., Stewart, T., Zabetian, C. P., & Zhang, J. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.01.005 · Cited by 181

Current approaches to enhance glutamate transporter function and expression

Fontana, A. C. K. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13200 · Cited by 179

Extracellular Vesicles Secreted by Astroglial Cells Transport Apolipoprotein D to Neurons and Mediate Neuronal Survival Upon Oxidative Stress

Pascua‐Maestro, R., González, E., Lillo, C., Ganfornina, M. D., Falcón‐Pérez, J. M., & Sánchez, D. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00526 · Cited by 178

CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1

Silverman, J. M., Christy, D., Shyu, C. C., Moon, K., Fernando, S. M., Gidden, Z., Cowan, C. M., Ban, Y., Stacey, R. G., Grad, L. I., et al. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.004825 · Cited by 176

Astrocytic Aβ1‐42 uptake is determined by Aβ‐aggregation state and the presence of amyloid‐associated proteins

Nielsen, H. M., Mulder, S. D., Beliën, J. A. M., Musters, R. J. P., Eikelenboom, P., & Veerhuis, R. (2010) · Glia · doi:10.1002/glia.21004 · Cited by 170

Levels of Soluble Apolipoprotein E/Amyloid-β (Aβ) Complex Are Reduced and Oligomeric Aβ Increased with APOE4 and Alzheimer Disease in a Transgenic Mouse Model and Human Samples*

Tai, L. M., Bilousova, T., Jungbauer, L., Roeske, S. K., Youmans, K. L., Yu, C., Poon, W. W., Cornwell, L. B., Miller, C. A., Vinters, H. V., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.442103 · Cited by 165

Apolipoprotein D takes center stage in the stress response of the aging and degenerative brain

Dassati, S., Waldner, A., & Schweigreiter, R. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.01.148 · Cited by 163

Role of vascular endothelial growth factor in adult hippocampal neurogenesis: Implications for the pathophysiology and treatment of depression

Fournier, N. M., & Duman, R. S. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.04.022 · Cited by 159

Pathological Proteins Are Transported by Extracellular Vesicles of Sporadic Amyotrophic Lateral Sclerosis Patients

Sproviero, D., Salvia, S. L., Giannini, M., Crippa, V., Gagliardi, S., Bernuzzi, S., Diamanti, L., Ceroni, M., Pansarasa, O., Poletti, A., et al. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00487 · Cited by 159

Exosomes: Revisiting their role as “garbage bags”

Vidal, M. (2019) · Traffic · doi:10.1111/tra.12687 · Cited by 155

Intranasal Administration of Extracellular Vesicles Derived from Human Teeth Stem Cells Improves Motor Symptoms and Normalizes Tyrosine Hydroxylase Expression in the Substantia Nigra and Striatum of the 6-Hydroxydopamine-Treated Rats

Narbute, K., Piļipenko, V., Pupure, J., Dzirkale, Z., Jonavičė, U., Tunaitis, V., Kriaučiūnaitė, K., Jarmalavičiūtė, A., Jansone, B., Kluša, V., et al. (2019) · Stem Cells Translational Medicine · doi:10.1002/sctm.18-0162 · Cited by 150

VEGF Signaling in Neurological Disorders

Shim, J. W., & Madsen, J. R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010275 · Cited by 149

Amyloid-β-Induced Astrocytic Phagocytosis is Mediated by CD36, CD47 and RAGE

Jones, R. S., Minogue, A. M., Connor, T. J., & Lynch, M. A. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9427-3 · Cited by 147

Exogenous synapsin I promotes functional maturation of developing neuromuscular synapses

Lu, B., Greengard, P., & Poo, M.-M. (1992) · Neuron · doi:10.1016/0896-6273(92)90280-q · Cited by 146

Enhanced production and dendritic growth of new dentate granule cells in the middle‐aged hippocampus following intracerebroventricular FGF‐2 infusions

Rai, K. S., Hattiangady, B., & Shetty, A. K. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05820.x · Cited by 144

TLR4 participates in the transmission of ethanol-induced neuroinflammation via astrocyte-derived extracellular vesicles

Ibáñez, F., Montesinos, J., Ureña‐Peralta, J. R., Guerri, C., & Pascual, M. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1529-x · Cited by 144

Cellular prion protein expression in astrocytes modulates neuronal survival and differentiation

Lima, F. R. S., Arantes, C., Muras, A. G., Nomizo, R., Brentani, H., & Martins, V. R. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04904.x · Cited by 139

Astrocytes: Multitalented Stars of the Central Nervous System

Ransom, B. R., & Ransom, C. B. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-452-0_1 · Cited by 139

Emerging roles of extracellular vesicles in neurodegenerative disorders

You, Y., & Ikezu, T. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104512 · Cited by 138

Astrocytes shed extracellular vesicles that contain fibroblast growth factor-2 and vascular endothelial growth factor

Proia, P., Schiera, G., Mineo, M., Ingrassia, A. M. R., Santoro, G., Savettieri, G., & Liegro, I. D. (2008) · International Journal of Molecular Medicine · doi:10.3892/ijmm.21.1.63 · Cited by 136

HIV-1 Nef is released in extracellular vesicles derived from astrocytes: evidence for Nef-mediated neurotoxicity

Sarıbaş, A. S., Cicalese, S. M., Ahooyi, T. M., Khalili, K., Amini, S., & Sariyer, I. K. (2017) · Cell Death and Disease · doi:10.1038/cddis.2016.467 · Cited by 136

Stimulus‐dependent modifications in astrocyte‐derived extracellular vesicle cargo regulate neuronal excitability

Chaudhuri, A. D., Dastgheyb, R. M., Devine, L. R., Bi, H., Cole, R. N., & Haughey, N. J. (2019) · Glia · doi:10.1002/glia.23708 · Cited by 130

Extracellular Heat Shock Protein 70: A Critical Component for Motoneuron Survival

Robinson, M., Tidwell, J. L., Gould, T. W., Taylor, A. R., Newbern, J. M., Graves, J. T., Tytell, M., & Milligan, C. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1912-05.2005 · Cited by 123

Complement protein levels in plasma astrocyte‐derived exosomes are abnormal in conversion from mild cognitive impairment to Alzheimer's disease dementia

Winston, C. N., Goetzl, E. J., Schwartz, J. B., Elahi, F. M., & Rissman, R. A. (2018) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2018.11.002 · Cited by 120

Propagation of Tau via Extracellular Vesicles

Pérez, M., Avila, J., & Hernández, F. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00698 · Cited by 118

Astrocyte EV-Induced lincRNA-Cox2 Regulates Microglial Phagocytosis: Implications for Morphine-Mediated Neurodegeneration

Hu, G., Liao, K., Niu, F., Yang, L., Dallon, B. W., Callen, S. E., Tian, C., Shu, J., Cui, J., Sun, Z., et al. (2018) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2018.09.019 · Cited by 117

Intranasally Administered Human MSC-Derived Extracellular Vesicles Pervasively Incorporate into Neurons and Microglia in both Intact and Status Epilepticus Injured Forebrain

Kodali, M., de Castro, O. W., Kim, D.-K., Thomas, A., Shuai, B., Attaluri, S., Upadhya, R., Gitaí, D. L. G., Madhu, L. N., Prockop, D. J., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010181 · Cited by 115

Prion Protein: Orchestrating Neurotrophic Activities

Martins, V. R., Beraldo, F. H., Hajj, G. N. M., Lopes, M. H., Lee, K. S., Prado, M. A. M., & Linden, R. (2010) · Caister Academic Press eBooks · doi:10.21775/9781912530076.02 · Cited by 114

Synapsin-I- and synapsin-II-null mice display an increased age-dependent cognitive impairment

Corradi, A. M., Zanardi, A., Giacomini, C., Onofri, F., Valtorta, F., Zoli, M., & Benfenati, F. (2008) · Journal of Cell Science · doi:10.1242/jcs.035063 · Cited by 113

Intranasal delivery of bFGF with nanoliposomes enhances in vivo neuroprotection and neural injury recovery in a rodent stroke model

Zhao, Y., Lin, M., Lin, Q., Yang, W., Yu, X., Tian, F., Mao, K., Yang, J., Lu, C., & Wong, H. L. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.01.017 · Cited by 111

Astrocyte-Derived Exosomes Treated With a Semaphorin 3A Inhibitor Enhance Stroke Recovery via Prostaglandin D 2 Synthase

Hira, K., Ueno, Y., Tanaka, R., Miyamoto, N., Yamashiro, K., Inaba, T., Urabe, T., Okano, H., & Hattori, N. (2018) · Stroke · doi:10.1161/strokeaha.118.021272 · Cited by 110

Tetraspanin protein CD 9 interacts with metalloprotease CD 10 and enhances its release via exosomes

Mazurov, D. V., Barbashova, L., & Filatov, A. V. (2013) · FEBS Journal · doi:10.1111/febs.12110 · Cited by 109

Astrocytes’ Contribution to Adult Neurogenesis in Physiology and Alzheimer’s Disease

Cassé, F., Richetin, K., & Toni, N. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00432 · Cited by 109

Extracellular microvesicles from astrocytes contain functional glutamate transporters: regulation by protein kinase C and cell activation

Gosselin, R., Meylan, P., & Décosterd, I. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00251 · Cited by 105

MIRNAS in Astrocyte-Derived Exosomes as Possible Mediators of Neuronal Plasticity

Lafourcade, C., Ramírez, J. P., Luarte, A., Fernández, A., & Wyneken, Ú. (2016) · Journal of Experimental Neuroscience · doi:10.4137/jen.s39916 · Cited by 105

Behavior of neural stem cells in the Alzheimer brain

Waldau, B., & Shetty, A. K. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8053-y · Cited by 101

Zika virus propagation and release in human fetal astrocytes can be suppressed by neutral sphingomyelinase-2 inhibitor GW4869

Huang, Y., Li, Y., Zhang, H., Zhao, R., Jing, R., Xu, Y., He, M., Peer, J., Kim, Y. C., Luo, J., et al. (2018) · Cell Discovery · doi:10.1038/s41421-018-0017-2 · Cited by 97

Treatment with extracellular HSP70/HSC70 protein can reduce polyglutamine toxicity and aggregation

Novoselova, T. V., Margulis, B. A., Novoselov, S. S., Sapozhnikov, A. M., van der Spuy, J., Cheetham, M. E., & Guzhova, I. V. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03119.x · Cited by 94

Neuroinflammation in Gulf War Illness is linked with HMGB1 and complement activation, which can be discerned from brain-derived extracellular vesicles in the blood

Madhu, L. N., Attaluri, S., Kodali, M., Shuai, B., Upadhya, R., Gitaí, D. L. G., & Shetty, A. K. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.06.040 · Cited by 94

Astrocytes at the Hub of the Stress Response: Potential Modulation of Neurogenesis by miRNAs in Astrocyte-Derived Exosomes

Luarte, A., Cisternas, P., Caviedes, A., Bátiz, L. F., Lafourcade, C., Wyneken, Ú., & Henzi, R. (2017) · Stem Cells International · doi:10.1155/2017/1719050 · Cited by 91

Prion Protein Regulates Glutamate-Dependent Lactate Transport of Astrocytes

KLEENE, R. B., Loers, G., Langer, J., Frobert, Y., Buck, F., & Schachner, M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1358-07.2007 · Cited by 88

A roadmap to integrate astrocytes into Systems Neuroscience

Kastanenka, K. V., Moreno‐Bote, R., Pittà, M. D., Perea, G., Eraso‐Pichot, A., Masgrau, R., Poskanzer, K. E., & Galea, E. (2019) · Glia · doi:10.1002/glia.23632 · Cited by 88

Posttreatment with Intravenous Basic Fibroblast Growth Factor Reduces Histopathological Damage Following Fluid-Percussion Brain Injury in Rats

Dietrich, W. D., Alonso, O. F., Busto, R., & Finklestein, S. P. (1996) · Journal of Neurotrauma · doi:10.1089/neu.1996.13.309 · Cited by 87

Increased Dentate Neurogenesis After Grafting of Glial Restricted Progenitors or Neural Stem Cells in the Aging Hippocampus

Hattiangady, B., Shuai, B., Cai, J., Coksaygan, T., Rao, M. S., & Shetty, A. K. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0726 · Cited by 85

Administration of Hsp70 in vivo inhibits motor and sensory neuron degeneration

Tidwell, J. L., Houenou, L. J., & Tytell, M. (2004) · Cell Stress and Chaperones · doi:10.1379/csc-9r.1 · Cited by 81

Exploring the role of microglia in cortical spreading depression in neurological disease

Shibata, M., & Suzuki, N. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17690537 · Cited by 81

Exosomal miR-9 Released from HIV Tat Stimulated Astrocytes Mediates Microglial Migration

Yang, L., Niu, F., Yao, H., Liao, K., Chen, X., Kook, Y., Ma, R., Hu, G., & Buch, S. J. (2018) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-018-9779-4 · Cited by 79

Implication of Complement System and its Regulators in Alzheimers Disease

Kolev, M. V., Ruseva, M. M., Harris, C. L., Morgan, B. P., & Donev, R. (2009) · Current Neuropharmacology · doi:10.2174/157015909787602805 · Cited by 78

Neurotoxic astrocytes express the d-serine synthesizing enzyme, serine racemase, in Alzheimer's disease

Balu, D. T., Pantazopoulos, H., Huang, C. C., Muszynski, K., Harvey, T. L., Uno, Y., Rorabaugh, J. M., Galloway, C. R., Botz-Zapp, C. A., Berretta, S., et al. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104511 · Cited by 78

Secreted miR-34a in astrocytic shedding vesicles enhanced the vulnerability of dopaminergic neurons to neurotoxins by targeting Bcl-2

Mao, S., Sun, Q., Xiao, H., Zhang, C., & Li, L. (2015) · Protein & Cell · doi:10.1007/s13238-015-0168-y · Cited by 74

Regulation of Neurogenesis and Angiogenesis in Depression

Newton, S. S., & Duman, R. S. (2004) · Current Neurovascular Research · doi:10.2174/1567202043362388 · Cited by 72

Exosome-associated release, uptake, and neurotoxicity of HIV-1 Tat protein

Rahimian, P., & He, J. J. (2016) · Journal of NeuroVirology · doi:10.1007/s13365-016-0451-6 · Cited by 71

Extracellular Membrane Vesicles as Vehicles for Brain Cell-to-Cell Interactions in Physiological as well as Pathological Conditions

Schiera, G., Di Liegro, C. M., & Di Liegro, I. (2015) · BioMed Research International · doi:10.1155/2015/152926 · Cited by 70

Emerging roles for semaphorins and VEGFs in synaptogenesis and synaptic plasticity

Tillo, M., Ruhrberg, C., & Mackenzie, F. E. (2012) · Cell Adhesion & Migration · doi:10.4161/cam.22408 · Cited by 69

Increased Release of Apolipoprotein E in Extracellular Vesicles Following Amyloid-β Protofibril Exposure of Neuroglial Co-Cultures

Nikitidou, E., Khoonsari, P. E., Shevchenko, G., Ingelsson, M., Kultima, K., & Erlandsson, A. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-170278 · Cited by 68

Apolipoprotein D: An overview of its role in aging and age-related diseases

Muffat, J., & Walker, D. W. (2010) · Cell Cycle · doi:10.4161/cc.9.2.10433 · Cited by 67

The unconventional secretion of stress-inducible protein 1 by a heterogeneous population of extracellular vesicles

Hajj, G. N. M., Arantes, C., Dias, M. V. S., Roffé, M., Costa‐Silva, B., Lopes, M. H., Porto-Carreiro, I., Rabachini, T., Lima, F. R. S., Beraldo, F. H., et al. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1328-y · Cited by 66

Competition of Aβ amyloid peptide and apolipoprotein E for receptor-mediated endocytosis

Winkler, K., Scharnagl, H., Tisljar, U., Hoschützky, H., Friedrich, I., Hoffmann, M. M., Hüttinger, M., Wieland, H., & März, W. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32449-4 · Cited by 66

Promise of extracellular vesicles for diagnosis and treatment of epilepsy

Upadhya, D., & Shetty, A. K. (2019) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2019.106499 · Cited by 66

Temporal onset of synapsin I gene expression coincides with neuronal differentiation during the development of the nervous system

Melloni, R. H., & DeGennaro, L. J. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903420311 · Cited by 61

PrPC displays an essential protective role from oxidative stress in an astrocyte cell line derived from PrPC knockout mice

Bertuchi, F. R., Bourgeon, D., Landemberger, M. C., Martins, V. R., & Cerchiaro, G. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.12.098 · Cited by 54

Adenosine A2B receptor-mediated leukemia inhibitory factor release from astrocytes protects cortical neurons against excitotoxicity

Moidunny, S., Vinet, J., Wesseling, E. M., Bijzet, J., Shieh, C., van Ijzendoorn, S. C., Bezzi, P., Boddeke, H. W. G. M., & Biber, K. P. H. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-198 · Cited by 52

Extracellular Vesicles as Therapeutics for Brain Injury and Disease

Upadhya, D., & Shetty, A. K. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191014164950 · Cited by 51

Apolipoprotein D modulates amyloid pathology in APP/PS1 Alzheimer's disease mice

Li, H., Ruberu, K. R., Muñoz, S. S., Jenner, A. M., Spiro, A. S., Zhao, H., Rassart, É., Sánchez, D., Ganfornina, M. D., Karl, T., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.02.010 · Cited by 48

Brainwashed by extracellular vesicles: the role of extracellular vesicles in primary and metastatic brain tumour microenvironment

Morad, G., & Moses, M. A. (2019) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1627164 · Cited by 46

Aging without Apolipoprotein D: Molecular and cellular modifications in the hippocampus and cortex

Sánchez, D., Bajo‐Grañeras, R., del Caño-Espinel, M., García-Centeno, R. M., García‐Mateo, N., Pascua‐Maestro, R., & Ganfornina, M. D. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.04.003 · Cited by 44

Sustained up-regulation of Semaphorin 3A, Neuropilin1, and Doublecortin expression in ischemic mouse brain during long-term recovery

Hou, S., Keklikian, A., Slinn, J., O’Hare, M., Jiang, S. X., & Aylsworth, A. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.12.103 · Cited by 42

FGF-2 Overexpression Increases Excitability and Seizure Susceptibility but Decreases Seizure-Induced Cell Loss

Zucchini, S., Buzzi, A., Barbieri, M., Rodi, D., Paradiso, B., Binaschi, A., Coffin, J. D., Marzola, A., Cifelli, P., Belluzzi, O., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1472-08.2008 · Cited by 42

Basic Fibroblast Growth Factor Potentiates Myelin Repair Following Induction of Experimental Demyelination in Adult Mouse Optic Chiasm and Nerves

Dehghan, S., Javan, M., Pourabdolhossein, F., Mirnajafi‐Zadeh, J., & Baharvand, H. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9777-6 · Cited by 40

Deletion of Aquaporin-4 Curtails Extracellular Glutamate Elevation in Cortical Spreading Depression in Awake Mice

Enger, R., Dukefoss, D. B., Tang, W., Pettersen, K. H., Bjørnstad, D. M., Helm, P. J., Jensen, V., Sprengel, R., Vervaeke, K., Ottersen, O. P., et al. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw359 · Cited by 36

Role of Astrocytes in the Neurogenic Niches

Schneider, J., Karpf, J., & Beckervordersandforth, R. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9068-9_2 · Cited by 36

HIV-1 Nef Protein Structures Associated with Brain Infection and Dementia Pathogenesis

Lamers, S. L., Poon, A. F. Y., & McGrath, M. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016659 · Cited by 35

Role of Astrocytes in the Spreading Depression Signal Between Ischemic Core and Penumbra

Walz, W. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00003-6 · Cited by 35

Engineering the CNS Stem Cell Microenvironment

Williams, C. A., & Lavik, E. (2009) · Regenerative Medicine · doi:10.2217/rme.09.62 · Cited by 33

Slow Accumulation of Active Mitogen-Activated Protein Kinase During Thymocyte Differentiation Regulates the Temporal Pattern of Transcription Factor Gene Expression

Shao, H., Wilkinson, B., Lee, B., Han, P.-C., & Kaye, J. G. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.2.603 · Cited by 33

Quiescent Oct4+ Neural Stem Cells (NSCs) Repopulate Ablated Glial Fibrillary Acidic Protein+ NSCs in the Adult Mouse Brain

Reeve, R. L., Yammine, S. Z., Morshead, C. M., & van der Kooy, D. (2017) · Stem Cells · doi:10.1002/stem.2662 · Cited by 26

HIV-1 Nef increases astrocyte sensitivity towards exogenous hydrogen peroxide

Masanetz, S., & Lehmann, M. H. (2011) · Virology Journal · doi:10.1186/1743-422x-8-35 · Cited by 23

Prion protein regulates glutathione metabolism and neural glutamate and cysteine uptake via excitatory amino acid transporter 3

Guitart, K., Loers, G., Schachner, M., & Kleene, R. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13071 · Cited by 18

Expression Pattern of Myelin-Related Apolipoprotein D in Human Multiple Sclerosis Lesions

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Untitled work

Webster (1996) · doi:10.1002/(sici)1097-4547(19961001)46:1

Untitled work

(1996) · doi:10.1379/1466-1268(1996)001

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