Adipose tissue as an endocrine organ

Positional cloning of the mouse obese gene and its human homologue

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Obesity is associated with macrophage accumulation in adipose tissue

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Obesity induces a phenotypic switch in adipose tissue macrophage polarization

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Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

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TLR4 links innate immunity and fatty acid-induced insulin resistance

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Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

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Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

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A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

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Abnormal splicing of the leptin receptor in diabetic mice

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Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

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Adipose Tissue as an Endocrine Organ

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Forming functional fat: a growing understanding of adipocyte differentiation

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Metabolic Regulation of T Lymphocytes

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Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2.

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Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity

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ESPEN micronutrient guideline

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Adipokine dysregulation and adipose tissue inflammation in human obesity

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Mitochondrial dysfunction in obesity

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Type 2 diabetes mellitus and psychological stress — a modifiable risk factor

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Impaired adipogenesis and dysfunctional adipose tissue in human hypertrophic obesity

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How UV Light Touches the Brain and Endocrine System Through Skin, and Why

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Biomarkers of Nutrition for Development (BOND)-Vitamin A Review

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Obesity: Prevalence, causes, consequences, management, preventive strategies and future research directions

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The role of leptin/adiponectin ratio in metabolic syndrome and diabetes

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Inflammation and Skeletal Muscle Wasting During Cachexia

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Endothelial Dysfunction in Obesity-Induced Inflammation: Molecular Mechanisms and Clinical Implications

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The role of adipokines in inflammatory mechanisms of obesity

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Adipokines: New potential therapeutic target for obesity and metabolic, rheumatic, and cardiovascular diseases

Recinella, L., Orlando, G., Ferrante, C., Chiavaroli, A., Brunetti, L., & Leone, S. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.578966 · Cited by 261

Mitochondrial fatty acid oxidation in obesity

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Visceral adiposity, insulin resistance and cancer risk

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Leptin, adiponectin and other adipokines in gestational diabetes mellitus and pre‐eclampsia

Miehle, K., Stepan, H., & Fasshauer, M. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04234.x · Cited by 236

RBP4: a controversial adipokine

Kotnik, P., Fischer-Posovszky, P., & Wabitsch, M. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0431 · Cited by 233

‘Adipaging’: ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue

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GPER deficiency in male mice results in insulin resistance, dyslipidemia, and a proinflammatory state

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Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets

Macia, L., Tsai, V. W.-W., Nguyen, A. D., Johnen, H., Kuffner, T., Shi, Y.-C., Lin, S., Herzog, H., Brown, D. A., Breit, S. N., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034868 · Cited by 211

The impact of obesity on neurodegenerative diseases.

Mazon, J. N., de Mello, A. H., Ferreira, G. K., & Rezin, G. T. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.06.002 · Cited by 185

Growth Differentiation Factor 15 as a Novel Biomarker for Metformin

Gerstein, H. C., Pare, G., Hess, S., Ford, R. J., Sjaarda, J., Raman, K., McQueen, M., Lee, S., Haenel, H., & Steinberg, G. R. (2017) · Diabetes Care · doi:10.2337/dc16-1682 · Cited by 169

Advanced glycation endproducts and its receptor for advanced glycation endproducts in obesity

Gaens, K. H., Stehouwer, C. D., & Schalkwijk, C. G. (2013) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32835aea13 · Cited by 166

Physiological responses to food intake throughout the day

Johnston, J. D. (2014) · Nutrition Research Reviews · doi:10.1017/s0954422414000055 · Cited by 158

Gene-Environment Interactions Controlling Energy and Glucose Homeostasis and the Developmental Origins of Obesity

Bouret, S., Levin, B. E., & Ozanne, S. E. (2015) · Physiological Reviews · doi:10.1152/physrev.00007.2014 · Cited by 157

An Update on the Secretory Functions of Brown, White, and Beige Adipose Tissue: Towards Therapeutic Applications

Ghesmati, Z., Rashid, M., Fayezi, S., Gieseler, F., Alizadeh, E., & Darabi, M. (2024) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-023-09850-0 · Cited by 139

The Effect of chronic exercise training on leptin: A systematic review and meta-analysis of randomized controlled trials

Fedewa, M. V., Hathaway, E. D., Ward-Ritacco, C. L., Williams, T. D., & Dobbs, W. C. (2018) · Sports Medicine · doi:10.1007/s40279-018-0897-1 · Cited by 135

Systematic review and meta-analysis of randomized, controlled trials on the effect of exercise on serum leptin and adiponectin in overweight and obese individuals

Yu, N., Ruan, Y., Gao, X., & Sun, J. (2017) · Hormone and Metabolic Research · doi:10.1055/s-0042-121605 · Cited by 120

Signaling by vitamin A and retinol-binding protein in regulation of insulin responses and lipid homeostasis

Berry, D. C., & Noy, N. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.07.002 · Cited by 100

Early effects of a hypocaloric, Mediterranean diet on laboratory parameters in obese individuals

Greco, M., Chiefari, E., Montalcini, T., Accattato, F., Costanzo, F. S., Pujia, A., Foti, D., Brunetti, A., & Gulletta, E. (2014) · Mediators of Inflammation · doi:10.1155/2014/750860 · Cited by 98

The effects of weight loss approaches on bone mineral density in adults: a systematic review and meta-analysis of randomized controlled trials

Soltani, S., Hunter, G. R., Kazemi, A., & Shab-Bidar, S. (2016) · Osteoporosis International · doi:10.1007/s00198-016-3617-4 · Cited by 89

Mechanisms IN endocrinology: metabolic syndrome through the female life cycle

Vryonidou, A., Paschou, S. A., Muscogiuri, G., Orio, F., & Goulis, D. G. (2015) · European Journal of Endocrinology · doi:10.1530/eje-15-0275 · Cited by 88

Modulation of cytokines, resistin, and distribution of adipose tissue in C57BL/6 mice by different high-fat diets

Catta-Preta, M., Martins, M. A., Cunha Brunini, T. M., Mendes-Ribeiro, A. C., Mandarim-de-Lacerda, C. A., & Aguila, M. B. (2012) · Nutrition · doi:10.1016/j.nut.2011.05.011 · Cited by 83

Opposite effects of 17-Β estradiol and testosterone on mitochondrial biogenesis and adiponectin synthesis in white adipocytes

Capllonch-Amer, G., Lladó, I., Proenza, A. M., García-Palmer, F. J., & Gianotti, M. (2014) · Journal of Molecular Endocrinology · doi:10.1530/jme-13-0201 · Cited by 67

Estradiol signaling mediates gender difference in visceral adiposity via autophagy

Tao, Z., Zheng, L. D., Smith, C., Luo, J., Robinson, A., Almeida, F. A., Wang, Z., Olumi, A. F., Liu, D., & Cheng, Z. (2018) · Cell Death & Disease · doi:10.1038/s41419-018-0372-9 · Cited by 63

Adipose–Muscle Crosstalk in Age-Related Metabolic Disorders: The Emerging Roles of Adipo-Myokines

Fang, P., She, Y., Yu, M., Min, W., Shang, W., & Zhang, Z. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101829 · Cited by 62

Gastric inhibitory peptide controls adipose insulin sensitivity via activation of cAMP-response element-binding protein and p110β isoform of phosphatidylinositol 3-kinase

Mohammad, S., Ramos, L. S., Buck, J., Levin, L. R., Rubino, F., & McGraw, T. E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.289009 · Cited by 59

Developmental programming of offspring adipose tissue biology and obesity risk

Rodgers, A., & Sferruzzi-Perri, A. N. (2021) · International Journal of Obesity · doi:10.1038/s41366-021-00790-w · Cited by 57

Attenuated fibroblast growth factor 21 response to acute aerobic exercise in obese individuals

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Development of second generation peptides modulating cellular adiponectin receptor responses

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Hepatic Glucose Intolerance Precedes Hepatic Steatosis in the Male Aromatase Knockout (ArKO) Mouse

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Association between visceral adiposity index and risk of prediabetes: A meta‐analysis of observational studies

Wang, D., Fang, R., Han, H., Zhang, J., Chen, K., Fu, X., He, Q., & Yang, Y. (2022) · Journal of Diabetes Investigation · doi:10.1111/jdi.13685 · Cited by 25

Comparison of Metabolic Network between Muscle and Intramuscular Adipose Tissues in Hanwoo Beef Cattle Using a Systems Biology Approach

Lee, H.-J., Park, H.-S., Kim, W., Yoon, D., & Seo, S. (2014) · International Journal of Genomics · doi:10.1155/2014/679437 · Cited by 24

A Review of the Associations Between Obstructive Sleep Apnea and Gestational Diabetes Mellitus and Possible Mechanisms of Disease

Tong, X., Yang, L., Jiang, C., Weng, Z., Zu, A., Hou, Y., Fang, Y., Yang, W., & Sun, S. (2023) · Reproductive Sciences · doi:10.1007/s43032-022-00904-3 · Cited by 16

Comparison of Serum Cytokines Levels in Normal-Weight and Overweight Patients with First-Episode Drug-Naïve Major Depressive Disorder

Gao, W., Xu, Y., Liang, J., Sun, Y., Zhang, Y., Shan, F., Ge, J., & Xia, Q. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1048337 · Cited by 7