Cited by 134Neurogenesis and neuroplasticity mechanismsPhysical Activity and HealthCardiovascular and exercise physiology

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Joggin’ the Noggin: Towards a Physiological Understanding of Exercise-Induced Cognitive Benefits

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Stimpson, Nikolas J., Davison, Glen, Javadi, Amir-Homayoun·2018·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2018.03.018

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Abstract

This narrative review examines literature pertaining to possible physiological explanations for observed cognitive benefits stemming from improvements to cardiovascular fitness following chronic aerobic exercise. Studies regarding exercise and cardiovascular fitness, angiogenesis, neuroinflammation in relation to IGF-1 signalling, regulation of neurotrophins, neurogenesis and plasticity, cognitive training, are briefly described. We propose that current evidence points towards a mechanism by which cardiovascular fitness improvements act to promote long-term angiogenesis and cerebral circulation. This important adaptation allows for increased delivery and upregulation of neurotrophins along with supporting factors to the brain, particularly to the hippocampal neurogenic niche, following acute exercise bouts. We propose a sequential timeline and approximate time scale for this mechanism, describing how these stages generate increased support for neurogenesis and brain plasticity in combination with cognitive training to provide long-term cognitive benefits and protection against age-related cognitive decline. Influences from age, gender and other variables are considered, and methodological factors that could be utilised in future studies to further clarify the proposed model are discussed.

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Authors: Stimpson, N. J., Davison, G., & Javadi, A.-H.
Affiliations: University College London (GB)
University of Kent (GB)
Corresponding author: Javadi, Amir-Homayoun
ORCID: Stimpson, Nikolas J.
Davison, Glen
Javadi, Amir-Homayoun
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2018-05
Volume: 88
Pages: 177-186
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2018.03.018
OpenAlex: W2792056933
Cited by: 134
References: 147
Citations by year: 2026: 7 · 2025: 14 · 2024: 18 · 2023: 13 · 2022: 18 · 2021: 20 · 2020: 16 · 2019: 20 · 2018: 8
FWCI: 2.01
Type: journal article
Language: en
Open access: green
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Kent Academic Repository (University of Kent) (submittedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords: cardiorespiratory fitness, aerobic exercise, angiogenesis, cerebral circulation, neurotrophins, IGF-1 signaling, neuroinflammation, hippocampal neurogenesis, neuroplasticity, cognitive training, age-related cognitive decline, acute exercise, sex differences
MeSH terms: Brain, Cognition, Humans, Neuronal Plasticity, Exercise, Neurogenesis, Cognitive Dysfunction

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Joggin’ the Noggin: Towards a Physiological Understanding of Exercise-Induced Cognitive Benefits

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