The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells
Open accessAbstract
Summary In adult skin, stem cells in the hair follicle bulge cyclically regenerate the follicle, whereas a distinct stem cell population maintains the epidermis. The degree to which all bulge cells have equal regenerative potential is not known. We found that Sonic hedgehog (Shh) from neurons signals to a novel population of cells in the telogen bulge marked by the Hedgehog response gene Gli1. Gli1-expressing bulge cells function as multipotent stem cells in their native environment and repeatedly regenerate the anagen follicle. Shh-responding perineural bulge cells incorporate into healing skin wounds where, notably, they can change their lineage into epidermal stem cells. The perineural niche (including Shh) is dispensable for follicle contributions to acute wound healing and skin homeostasis, but is necessary to maintain bulge cells capable of becoming epidermal stem cells. Thus nerves cultivate a microenvironment where Shh creates a molecularly and phenotypically distinct population of hair follicle stem cells.
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Cites
Cotsarelis, G., Sun, T.-T., & Lavker, R. M. (1990) · Cell · doi:10.1016/0092-8674(90)90696-c · Cited by 2,276
Blanpain, C., Lowry, W. E., Geoghegan, A., Polak, L., & Fuchs, E. (2004) · Cell · doi:10.1016/j.cell.2004.08.012 · Cited by 1,428
Epidermal homeostasis: a balancing act of stem cells in the skin
Blanpain, C., & Fuchs, E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2636 · Cited by 1,270
Lgr5 marks cycling, yet long-lived, hair follicle stem cells
Jaks, V., Barker, N., Kasper, M., van Es, J. H., Snippert, H. J., Clevers, H., & Toftgård, R. (2008) · Nature Genetics · doi:10.1038/ng.239 · Cited by 966
A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration
Greco, V., Chen, T., Rendl, M., Schober, M., Pasolli, H. A., Stokes, N., dela Cruz-Racelis, J., & Fuchs, E. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2008.12.009 · Cited by 800
Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin
Snippert, H. J., Haegebarth, A., Kasper, M., Jaks, V., van Es, J. H., Barker, N., van de Wetering, M., van den Born, M., Begthel, H., Vries, R. G., et al. (2010) · Science · doi:10.1126/science.1184733 · Cited by 751
Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway
Bai, C. B., Auerbach, W., Lee, J. S., Stephen, D., & Joyner, A. L. (2002) · Development · doi:10.1242/dev.129.20.4753 · Cited by 692
Self-citationSox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis
Driskell, R. R., Giangreco, A., Jensen, K. B., Mulder, K. W., & Watt, F. M. (2009) · Development · doi:10.1242/dev.038620 · Cited by 331
Slowly cycling (label‐retaining) epidermal cells behave like clonogenic stem cells in vitro
Morris, R. J., & Potten, C. S. (1994) · Cell Proliferation · doi:10.1111/j.1365-2184.1994.tb01425.x · Cited by 207
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Rhim, A. D., Oberstein, P. E., Thomas, D. H., Mirek, E. T., Palermo, C. F., Sastra, S. A., Dekleva, E. N., Saunders, T., Becerra, C. P., Tattersall, I. W., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.021 · Cited by 2,085
Extracellular matrix: A dynamic microenvironment for stem cell niche
Gattazzo, F., Urciuolo, A., & Bonaldo, P. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.01.010 · Cited by 1,294
Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis
Kramann, R., Schneider, R. K., DiRocco, D. P., Machado, F., Fleig, S., Bondzie, P. A., Henderson, J. M., Ebert, B. L., & Humphreys, B. D. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2014.11.004 · Cited by 922
“Consistent with this, nerve-derived Shh drives Gli1 in mouse incisor MSCs (Zhao et al., 2014) and a similar paradigm has been described for the hair follicle (Brownell et al., 2011).”
Plasticity of epithelial stem cells in tissue regeneration
Blanpain, C., & Fuchs, E. (2014) · Science · doi:10.1126/science.1242281 · Cited by 589
Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling
Hayakawa, Y., Sakitani, K., Konishi, M., Asfaha, S., Niikura, R., Tomita, H., Renz, B. W., Tailor, Y., Macchini, M., Middelhoff, M., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2016.11.005 · Cited by 573
Zhao, H., Feng, J., Seidel, K., Shi, S., Klein, O., Sharpe, P., & Chai, Y. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2013.12.013 · Cited by 461
Joost, S., Zeisel, A., Jacob, T., Sun, X., La Manno, G., Lönnerberg, P., Linnarsson, S., & Kasper, M. (2016) · Cell Systems · doi:10.1016/j.cels.2016.08.010 · Cited by 429
Skin and Its Regenerative Powers: An Alliance between Stem Cells and Their Niche
Gonzales, K. A. U., & Fuchs, E. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.10.001 · Cited by 414
Transit-Amplifying Cells Orchestrate Stem Cell Activity and Tissue Regeneration
Hsu, Y.-C., Li, L., & Fuchs, E. (2014) · Cell · doi:10.1016/j.cell.2014.02.057 · Cited by 379
Peterson, S. C., Eberl, M., Vagnozzi, A. N., Belkadi, A., Veniaminova, N. A., Verhaegen, M. E., Bichakjian, C. K., Ward, N. L., Dlugosz, A. A., & Wong, S. Y. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.02.006 · Cited by 368
Tissue Stem Cells: Architects of Their Niches
Fuchs, E., & Blau, H. M. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.09.011 · Cited by 332
The circadian molecular clock creates epidermal stem cell heterogeneity
Janich, P., Pascual, G., Merlos-Suárez, A., Batlle, E., Ripperger, J., Albrecht, U., Cheng, H.-Y. M., Obrietan, K., Di Croce, L., & Benitah, S. A. (2011) · Nature · doi:10.1038/nature10649 · Cited by 326
The Epidermis Comprises Autonomous Compartments Maintained by Distinct Stem Cell Populations
Page, M. E., Lombard, P., Ng, F., Göttgens, B., & Jensen, K. B. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.07.010 · Cited by 320
Nerve dependence in tissue, organ, and appendage regeneration
Kumar, A., & Brockes, J. P. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.003 · Cited by 290
Ciliary Hedgehog Signaling Restricts Injury-Induced Adipogenesis
Kopinke, D., Roberson, E. C., & Reiter, J. F. (2017) · Cell · doi:10.1016/j.cell.2017.06.035 · Cited by 260
Tumor Neurobiology and the War of Nerves in Cancer
Faulkner, S., Jobling, P., March, B., Jiang, C. C., & Hondermarck, H. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-1398 · Cited by 267
Changes in Regenerative Capacity through Lifespan
Yun, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161025392 · Cited by 216
The aging skin microenvironment dictates stem cell behavior
Ge, Y., Miao, Y., Gur-Cohen, S., Gomez, N., Yang, H., Nikolova, M., Polak, L., Hu, Y., Verma, A., Elemento, O., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901720117 · Cited by 190
Epidermal Development in Mammals: Key Regulators, Signals from Beneath, and Stem Cells
Liu, S., Zhang, H., & Duan, E. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140610869 · Cited by 110
Peripheral nerve Single-cell analysis identifies Mesenchymal Ligands that promote axonal growth
Toma, J. S., Karamboulas, K., Carr, M. J., Kolaj, A., Yuzwa, S. A., Mahmud, N., Storer, M. A., Kaplan, D. R., & Miller, F. D. (2020) · eneuro · doi:10.1523/eneuro.0066-20.2020 · Cited by 82
Hair organ regeneration via the bioengineered hair follicular unit transplantation
Asakawa, K., Toyoshima, K.-E., Ishibashi, N., Tobe, H., Iwadate, A., Kanayama, T., Hasegawa, T., Nakao, K., Toki, H., Noguchi, S., et al. (2012) · Scientific Reports · doi:10.1038/srep00424 · Cited by 81
Qiu, W., Chuong, C., & Lei, M. (2019) · Experimental Dermatology · doi:10.1111/exd.13856 · Cited by 78
Kretzschmar, K., Weber, C., Driskell, R. R., Calonje, E., & Watt, F. M. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.041 · Cited by 72
The nervous system orchestrates and integrates craniofacial development: a review
Adameyko, I., & Fried, K. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00049 · Cited by 69
Advancing insights into stem cell niche complexities with next-generation technologies
Heitman, N., Saxena, N., & Rendl, M. (2018) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2018.06.012 · Cited by 31
Epidermal stem cells: an update on their potential in regenerative medicine
Sun, X., Fu, X., Han, W., Zhao, M., & Chalmers, L. (2013) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2013.776036 · Cited by 10
Ivashkin, E., Voronezhskaya, E. E., & Adameyko, I. (2014) · Zoology · doi:10.1016/j.zool.2014.08.001 · Cited by 8
Metadata
- Authors
- Brownell, I., Guevara, E., Bai, C. B., Loomis, C. A., & Joyner, A. L.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 8
- Issue
- 5
- Pages
- 552-565
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2027275966
- Cited by
- 453
- References
- 9
- FWCI
- 37.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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